What is it about?
Cholesterol can be oxygenated to give a family of bioactive oxysterols with different chemical structures . We report here evidences that according to their chemical strutures certain oxysterols such as 7-ketocholesterol can accelerate aging processes while others like dendrogenins may slow down aging processes. The mechanism and the signalling pathways related to aging are detailed.
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Why is it important?
The populations of western countries are dramatically aging and the number of degenerative diseases linked to aging (neurodegenerative and cardiovascular diseases, cancer, ...) is growing accordingly. We identified pharmacological targets on the cholesterol metabolism pathways that could be exploited to develop drugs that could slow down aging processes. We also highlight cholesterol metabolites with anti-aging properties suggesting that metabolic deficiency complementation and dietary interventions could offer soft solutions. these two approaches are offering new strategies to fight aging.
Perspectives
This review highlights new original approaches to slow down aging process that deserve further investigations.
Dr Marc Etienne Poirot
Cancer Research Center of Toulouse UMR 1037 Inserm-university of Toulouse, France
Read the Original
This page is a summary of: Oxysterols are potential physiological regulators of ageing, Ageing Research Reviews, May 2022, Elsevier,
DOI: 10.1016/j.arr.2022.101615.
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