In Vitro Modeling of RSV Infection and Cytopathogenesis in Well-Differentiated Human Primary Airway Epithelial Cells (WD-PAECs)

What is it about?

This chapter provides comprehensive protocols of how to generate physiologically and morphologically authentic human airway epithelium cultures and the means to exploit them to study respiratory virus/human host interactions.

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Why is it important?

The protocols will help laboratories worldwide to initiate research on how human respiratory pathogens, especially viruses, interact with human airway epithelium. Human airway epithelium is the main target for many human viruses and understanding the interaction between viruses and the airway epithelium will help the discovery of novel drugs to treat diseases caused by the viruses.