Analysing bioassay data from the public domain for human P-glycoprotein inhibitors and substrates

What is it about?

We annotate in vitro assays used for the determination of bioactivities of human P-glycoprotein inhibitors and substrates in public databases and show that it is possible to combine data coming from the same assay type under certain conditions.

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Why is it important?

For inhibitors of human P-glycoprotein it is possible to combine data coming from the same assay type, if the cell lines used are also identical. There is a need for larger chemical diverse datasets that have been measured in a panel of different assays as this would reduce the search for other inter-correlations between bioactivity data yielded by different assay setups.