All Stories

  1. Supramolecular Protein Assemblies: Building Blocks, Organism- or Cell-Specific Varieties, and Significance

    Article • Biomolecules, October 2024, MDPI AG

    Prof Victoria I Bunik

  2. Combined Administration of Metformin and Amprolium to Rats Affects Metabolism of Free Amino Acids in the Brain, Altering Behavior, and Heart Rate

    Article • Biochemistry (Moscow), October 2024, Pleiades Publishing Ltd

    Prof Victoria I Bunik

  3. A challenging interplay between basic research, technologies and medical education to provide therapies based on disease mechanisms

    Article • Frontiers in Medicine, August 2024, Frontiers

    Prof Victoria I Bunik

  4. Pharmacological Doses of Thiamine Benefit Patients with the Charcot–Marie–Tooth Neuropathy by Changing Thiamine Diphosphate Levels and Affecting Regulation of Thiamine-Dependent Enzymes

    Article • Biochemistry (Moscow), July 2024, Pleiades Publishing Ltd

    Prof Victoria I Bunik

  5. Posttranslational Acylations of the Rat Brain Transketolase Discriminate the Enzyme Responses to Inhibitors of ThDP-Dependent Enzymes or Thiamine Transport

    Article • November 2023, MDPI AG

    Prof Victoria I Bunik

  6. Posttranslational Acylations of the Rat Brain Transketolase Discriminate the Enzyme Responses to Inhibitors of ThDP-Dependent Enzymes or Thiamine Transport

    Article • October 2023, MDPI AG

    Prof Victoria I Bunik

  7. Pentylenetetrazole-Induced Seizures Are Increased after Kindling, Exhibiting Vitamin-Responsive Correlations to the Post-Seizures Behavior, Amino Acids Metabolism and Key Metabolic Regulators in the Rat Brain

    Article • International Journal of Molecular Sciences, August 2023, MDPI AG

    Prof Victoria I Bunik

  8. The Therapeutic Potential of Vitamins B1, B3 and B6 in Charcot–Marie–Tooth Disease with the Compromised Status of Vitamin-Dependent Processes

    Article • Biology, June 2023, MDPI AG

    Prof Victoria I Bunik

  9. Therapeutic Potential of Vitamins in Charcot-Marie-Tooth Disease with the Compromised Status of the Vitamin-Dependent Processes

    Article • April 2023, MDPI AG

    Prof Victoria I Bunik

  10. Inhibition of pyruvate dehydrogenase affects the brain protein acylation stronger than PDHA phosphorylation at Ser293

    Article • November 2022, Cold Spring Harbor Laboratory Press

    Prof Victoria I Bunik

  11. Phosphonate Inhibitors of Pyruvate Dehydrogenase Perturb Homeostasis of Amino Acids and Protein Succinylation in the Brain

    Article • International Journal of Molecular Sciences, October 2022, MDPI AG

    Prof Victoria I Bunik

  12. The Brain Protein Acylation System Responds to Seizures in the Rat Model of PTZ-Induced Epilepsy

    Article • International Journal of Molecular Sciences, October 2022, MDPI AG

    Prof Victoria I Bunik

  13. Phosphonate Inhibitors of Pyruvate Dehydrogenase Perturb Homeostasis of Amino Acids and Protein Succinylation in the Brain

    Article • October 2022, MDPI AG

    Prof Victoria I Bunik

  14. Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase

    Article • International Journal of Molecular Sciences, September 2022, MDPI AG

    Prof Victoria I Bunik

  15. Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase

    Article • August 2022, MDPI AG

    Prof Victoria I Bunik

  16. Acute Prenatal Hypoxia in Rats Affects Physiology and Brain Metabolism in the Offspring, Dependent on Sex and Gestational Age

    Article • International Journal of Molecular Sciences, February 2022, MDPI AG

    Prof Victoria I Bunik

  17. Regulation of p53 Function by Formation of Non-Nuclear Heterologous Protein Complexes

    Article • Biomolecules, February 2022, MDPI AG

    Prof Victoria I Bunik

  18. Increasing Inhibition of the Rat Brain 2-Oxoglutarate Dehydrogenase Decreases Glutathione Redox State, Elevating Anxiety and Perturbing Stress Adaptation

    Article • Pharmaceuticals, January 2022, MDPI AG

    Prof Victoria I Bunik

  19. Thiamine‐dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo

    Article • Journal of Neurochemistry, January 2022, Wiley

    Prof Victoria I Bunik

  20. Characterization of Novel Pathogenic Variants Causing Pyridox(am)ine 5′-Phosphate Oxidase-Dependent Epilepsy

    Article • International Journal of Molecular Sciences, November 2021, MDPI AG

    Prof Victoria I Bunik

  21. Preparation of Affinity Purified Antibodies against ε-Glutaryl-Lysine Residues in Proteins for Investigation of Glutarylated Proteins in Animal Tissues

    Article • Biomolecules, August 2021, MDPI AG

    Prof Victoria I Bunik

  22. Physiological and Biochemical Markers of the Sex-Specific Sensitivity to Epileptogenic Factors, Delayed Consequences of Seizures and Their Response to Vitamins B1 and B6 in a Rat Model

    Article • Pharmaceuticals, July 2021, MDPI AG

    Prof Victoria I Bunik

  23. Daytime Dependence of the Activity of the Rat Brain Pyruvate Dehydrogenase Corresponds to the Mitochondrial Sirtuin 3 Level and Acetylation of Brain Proteins, All Regulated by Thiamine Administration Decreasing Phosphorylation of PDHA Ser293

    Article • International Journal of Molecular Sciences, July 2021, MDPI AG

    Prof Victoria I Bunik

  24. Physiological and Biochemical Markers of the Gender-specific Sensitivity to Epileptogenic Factors, Delayed Consequences of Seizures and Their Response to Vitamins B1 and B6 in a Rat Model of Epilepsy

    Article • May 2021, MDPI AG

    Prof Victoria I Bunik

  25. Positive correlation between rat brain glutamate concentrations and mitochondrial 2-oxoglutarate dehydrogenase activity

    Article • Analytical Biochemistry, July 2018, Elsevier

    Prof Victoria I Bunik

  26. Quantification of Rat Brain Amino Acids: Analysis of the Data Consistency

    Article • Current Analytical Chemistry, July 2016, Bentham Science Publishers

    Prof Victoria I Bunik

  27. Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner

    Article • Oncotarget, May 2016, Impact Journals, LLC

    Prof Victoria I Bunik, Andrzej Stepulak

  28. Production of superoxide/hydrogen peroxide by the mitochondrial 2-oxoadipate dehydrogenase complex

    Article • Free Radical Biology and Medicine, February 2016, Elsevier

    Prof Victoria I Bunik

  29. Mitochondrial Impairment May Increase Cellular NAD(P)H: Resazurin Oxidoreductase Activity, Perturbing the NAD(P)H-Based Viability Assays

    Article • Cells, August 2015, MDPI AG

    Prof Victoria I Bunik

  30. Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis

    Article • Scientific Reports, July 2015, Nature

    Prof Victoria I Bunik

  31. The RNA-binding protein HuR is essential for the B cell antibody response

    Article • Nature Immunology, February 2015, Nature

    Prof Victoria I Bunik

  32. P.1.g.080 The activity of brain 2-oxoglutarate dehydrogenase complex in non-pregnant and pregnant rats before and after hypoxic exposure

    Article • European Neuropsychopharmacology, October 2014, Elsevier

    Prof Victoria I Bunik

  33. The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates Than Complex I

    Article • Journal of Biological Chemistry, February 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Victoria I Bunik

  34. Benefits of Thiamin (Vitamin B1) Administration in Neurodegenerative Diseases may be Due to Both the Coenzyme and Non-coenzyme Roles of Thiamin

    Article • Journal of Alzheimer’s Disease & Parkinsonism, January 2014, OMICS Publishing Group

    Prof Victoria I Bunik

  35. Thiamin-dependent enzymes: new perspectives from the interface between chemistry and biology

    Article • FEBS Journal, November 2013, Wiley

    Prof Victoria I Bunik

  36. Thiamin diphosphate-dependent enzymes: from enzymology to metabolic regulation, drug design and disease models

    Article • FEBS Journal, October 2013, Wiley

    Prof Victoria I Bunik

  37. Translating Enzymology into Metabolic Regulation: The Case of the 2- Oxoglutarate Dehydrogenase Multienzyme Complex

    Article • April 2013, Bentham Science Publishers

    Prof Victoria I Bunik

  38. Up-regulation of 2-oxoglutarate dehydrogenase as a stress response

    Article • The International Journal of Biochemistry & Cell Biology, January 2013, Elsevier

    Prof Victoria I Bunik

  39. Ketoglutarate dehydrogenase in neurodegeneration

    Article • Current Medicinal Chemistry, November 2012, Bentham Science Publishers

    Prof Victoria I Bunik

  40. On the role of the mitochondrial 2-oxoglutarate dehydrogenase complex in amino acid metabolism

    Article • Amino Acids, September 2012, Springer Science + Business Media

    Prof Victoria I Bunik

  41. Phosphonate Analogs of 2-Oxoglutarate Perturb Metabolism and Gene Expression in Illuminated Arabidopsis Leaves

    Article • Frontiers in Plant Science, January 2012, Frontiers

    Prof Victoria I Bunik

  42. Chronic alcoholism in rats induces a compensatory response, preserving brain thiamine diphosphate, but the brain 2-oxo acid dehydrogenases are inactivated despite unchanged coenzyme levels

    Article • Journal of Neurochemistry, May 2011, Wiley

    Prof Victoria I Bunik

  43. Metabolic Networking through Enzymatic Sensing, Signaling and Response to Homeostatic Fluctuations

    Article • April 2011, IntechOpen

    Prof Victoria I Bunik

  44. A Survey of Oxidative Paracatalytic Reactions Catalyzed by Enzymes that Generate Carbanionic Intermediates: Implications for ROS Production, Cancer Etiology, and Neurodegenerative Diseases

    Article • February 2011, Wiley

    Prof Victoria I Bunik

  45. Tricarboxylic Acid Cycle Activity Regulates Tomato Root Growth via Effects on Secondary Cell Wall Production

    Article • PLANT PHYSIOLOGY, January 2010, American Society of Plant Biologists (ASPB)

    Prof Victoria I Bunik

  46. Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate: Implications into the Role of the Complex in Neurodegenerative Diseases

    Article • International Journal of Alzheimer s Disease, January 2010, Hindawi Publishing Corporation

    Prof Victoria I Bunik

  47. Role of 2-oxoglutarate dehydrogenase in brain pathologies involving glutamate neurotoxicity

    Article • Journal of Molecular Catalysis B Enzymatic, November 2009, Elsevier

    Prof Victoria I Bunik

  48. Metabolic control exerted by the 2-oxoglutarate dehydrogenase reaction: a cross-kingdom comparison of the crossroad between energy production and nitrogen assimilation

    Article • Biochemical Journal, September 2009, Portland Press Ltd.

    Prof Victoria I Bunik

  49. Regulation of Catalysis Within Cellular Network: Metabolic and Signaling Implications of the 2-Oxoglutarate Oxidative Decarboxylation

    Article • September 2009, Bentham Science Publishers

    Prof Victoria I Bunik

  50. Regulation of Catalysis Within Cellular Network: Metabolic and Signaling Implications of the 2-Oxoglutarate Oxidative Decarboxylation

    Article • Current Chemical Biology, September 2009, Bentham Science Publishers

    Prof Victoria I Bunik

  51. Phosphono Analogues of 2-Oxoglutarate Protect Cerebellar Granule Neurons upon Glutamate Excitotoxicity

    Article • Annals of the New York Academy of Sciences, August 2009, Wiley

    Prof Victoria I Bunik

  52. Succinyl phosphonate, a protector of the 2-oxoglutarate dehydrogenase complex, corrects behavioral impairments in rats exposed to hypoxia or ethanol

    Article • Alzheimer s & Dementia, July 2009, Elsevier

    Prof Victoria I Bunik

  53. Synthetic regulators of the 2-oxoglutarate oxidative decarboxylation alleviate the glutamate excitotoxicity in cerebellar granule neurons

    Article • Biochemical Pharmacology, May 2009, Elsevier

    Prof Victoria I Bunik

  54. α-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ

    Article • Neuroscience, January 2009, Elsevier

    Prof Victoria I Bunik

  55. Interaction of thioredoxins with target proteins: Role of particular structural elements and electrostatic properties of thioredoxins in their interplay with 2-oxoacid dehydrogenase complexes

    Article • Protein Science, December 2008, Wiley

    Prof Victoria I Bunik

  56. Inhibition of 2-Oxoglutarate Dehydrogenase in Potato Tuber Suggests the Enzyme Is Limiting for Respiration and Confirms Its Importance in Nitrogen Assimilation

    Article • PLANT PHYSIOLOGY, December 2008, American Society of Plant Biologists (ASPB)

    Prof Victoria I Bunik

  57. Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart

    Article • FEBS Journal, September 2008, Wiley

    Prof Victoria I Bunik

  58. P.1.d.011 Phosphonate analogue of ketoglutarate increases activity of ketoglutarate dehydrogenasecomplex in situ and in vivo

    Article • European Neuropsychopharmacology, August 2008, Elsevier

    Prof Victoria I Bunik

  59. Structure-function relationships in the 2-oxo acid dehydrogenase family: Substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins

    Article • Proteins Structure Function and Bioinformatics, May 2008, Wiley

    Prof Victoria I Bunik

  60. Enzyme-Catalyzed Side Reactions with Molecular Oxygen may Contribute to Cell Signaling and Neurodegenerative Diseases

    Article • Neurochemical Research, March 2007, Springer Science + Business Media

    Prof Victoria I Bunik

  61. Brain pyruvate and 2-oxoglutarate dehydrogenase complexes are mitochondrial targets of the CoA ester of the Refsum disease marker phytanic acid

    Article • FEBS Letters, May 2006, Wiley

    Prof Victoria I Bunik

  62. Inhibitors of the α-ketoglutarate dehydrogenase complex alter [1-13C]glucose and [U-13C]glutamate metabolism in cerebellar granule neurons

    Article • Journal of Neuroscience Research, February 2006, Wiley

    Prof Victoria I Bunik

  63. Phosphonate Analogues of α-Ketoglutarate Inhibit the Activity of the α-Ketoglutarate Dehydrogenase Complex Isolated from Brain and in Cultured Cells †

    Article • Biochemistry, August 2005, American Chemical Society (ACS)

    Prof Victoria I Bunik

  64. The α-Ketoglutarate–Dehydrogenase Complex: A Mediator Between Mitochondria and Oxidative Stress in Neurodegeneration

    Article • Molecular Neurobiology, January 2005, Springer Science + Business Media

    Prof Victoria I Bunik

  65. 2-Oxo acid dehydrogenase complexes in redox regulation. Role of the lipoate residues and thioredoxin

    Article • European Journal of Biochemistry, March 2003, Wiley

    Prof Victoria I Bunik

  66. 2-Oxo acid dehydrogenase complexes of multicellular organisms. Regulatory aspects

    Article • European Journal of Biochemistry, March 2003, Wiley

    Prof Victoria I Bunik

  67. Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species

    Article • European Journal of Biochemistry, September 2002, Wiley

    Prof Victoria I Bunik

  68. Kinetic properties of the 2-oxoglutarate dehydrogenase complex from Azotobacter vinelandii

    Article • European Journal of Biochemistry, June 2000, Wiley

    Prof Victoria I Bunik

  69. Increased catalytic performance of the 2-oxoacid dehydrogenase complexes in the presence of thioredoxin, a thiol–disulfide oxidoreductase

    Article • Journal of Molecular Catalysis B Enzymatic, February 2000, Elsevier

    Prof Victoria I Bunik

  70. Structural Determinants for the Efficient and Specific Interaction of Thioredoxin with 2-Oxoacid Dehydrogenase Complexes

    Article • Applied Biochemistry and Biotechnology, January 2000, Springer Science + Business Media

    Prof Victoria I Bunik

  71. Inhibition of select mitochondrial enzymes in PC12 cells exposed to S-(1,1,2,2-tetrafluoroethyl)-l-cysteine

    Article • Biochemical Pharmacology, November 1999, Elsevier

    Prof Victoria I Bunik

  72. Subunit Interactions in the Mammalian  -Ketoglutarate Dehydrogenase Complex: EVIDENCE FOR DIRECT ASSOCIATION OF THE  -KETOGLUTARATE DEHYDROGENASE AND DIHYDROLIPOAMIDE DEHYDROGENASE COMPONENTS

    Article • Journal of Biological Chemistry, September 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Victoria I Bunik

  73. Homology Modelling of a Newly Discovered Thioredoxin Protein and Analysis of the Force Field and Electrostatic Properties

    Article • Journal of Molecular Modeling, August 1997, Springer Science + Business Media

    Prof Victoria I Bunik, Dr Thomas T. Scior

  74. Activation of Mitochondrial 2-Oxoacid Dehydrogenases by Thioredoxin

    Article • Biological Chemistry, January 1997, De Gruyter

    Prof Victoria I Bunik

  75. Characterization of thioredoxins by sodium dodecyl sulfate-slab gel electrophoresis and high performance capillary electrophoresis

    Article • Electrophoresis, January 1997, Wiley

    Prof Victoria I Bunik

  76. Succinyl phosphonate inhibits α-ketoglutarate oxidative decarboxylation, catalyzed by α-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle

    Article • FEBS Letters, March 1996, Wiley

    Prof Victoria I Bunik

  77. Using lipoate enantiomers and thioredoxin to study the mechanism of the 2-oxoacid-dependent dihydrolipoate production by the 2-oxoacid dehydrogenase complexes

    Article • FEBS Letters, September 1995, Wiley

    Prof Victoria I Bunik

  78. Thioredoxin reduction dependent on α-ketoacid oxidation by α-ketoacid dehydrogenase complexes

    Article • FEBS Letters, December 1993, Wiley

    Prof Victoria I Bunik

  79. Inactivation of α-ketoglutarate dehydrogenase during oxidative decarboxylation of α-ketoadipic acid

    Article • FEBS Letters, May 1993, Wiley

    Prof Victoria I Bunik

  80. Effect of α-ketoglutarate and its structural analogues on hysteretic properties of α-ketoglutarate dehydrogenase

    Article • FEBS Letters, January 1991, Wiley

    Prof Victoria I Bunik

  81. Engineering of functional supramacromolecular complexes of proteins (enzymes) using reversed micelles as matrix microreactors

    Article • Protein Engineering Design and Selection, January 1991, Oxford University Press (OUP)

    Prof Victoria I Bunik

  82. Change in α-ketoglutarate dehydrogenase cooperative properties due to dihydrolipoate and NADH

    Article • FEBS Letters, August 1990, Wiley

    Prof Victoria I Bunik