All Stories

  1. Dapsone is not a Pharmacodynamic Lead Compound for its Aryl Derivatives

    Article • Current Computer - Aided Drug Design, June 2020, Bentham Science Publishers

    prof stefan a laufer, Dr Thomas T. Scior, Hassan abdallah, Kenia Salvador Atonal

  2. Exploring electrostatic patterns of human, murine, equine and canine TLR4/MD-2 receptors

    Article • Innate Immunity, December 2019, SAGE Publications

    Dr Thomas T. Scior

  3. Mefloquine inhibits voltage dependent Nav1.4 channel by overlapping the local anaesthetic binding site

    Article • European Journal of Pharmacology, February 2017, Elsevier

    Dr Thomas T. Scior

  4. Characterization of specific allosteric effects of the Na+ channel β1 subunit on the Nav1.4 isoform

    Article • European Biophysics Journal, December 2016, Springer Science + Business Media

    Dr Thomas T. Scior

  5. Why Antidiabetic Vanadium Complexes are Not in the Pipeline of “Big Pharma” Drug Research? A Critical Review

    Article • Current Medicinal Chemistry, September 2016, Bentham Science Publishers

    Dr Thomas T. Scior

  6. Antiprotozoal Nitazoxanide Derivatives: Synthesis, Bioassays and QSAR Study Combined with Docking for Mechanistic Insight

    Article • Current Computer - Aided Drug Design, July 2015, Bentham Science Publishers

    Dr Thomas T. Scior

  7. 11-Keto-β-Boswellic Acids Prevent Development of Autoimmune Reactions, Insulitis and Reduce Hyperglycemia During Induction of Multiple Low-Dose Streptozotocin (MLD-STZ) Diabetes in Mice

    Article • Hormone and Metabolic Research, May 2015, Thieme Publishing Group

    Dr Thomas T. Scior

  8. How to Valorize Biodiversity? Letʼs Go Hashing, Extracting, Filtering, Mining, Fishing

    Article • Planta Medica, February 2015, Thieme Publishing Group

    Dr Thomas T. Scior

  9. Predicting a double mutant in the twilight zone of low homology modeling for the skeletal muscle voltage-gated sodium channel subunit beta-1 (Na v 1.4 β1)

    Article • Computational and Structural Biotechnology Journal, January 2015, Elsevier

    Dr Thomas T. Scior

  10. Theoretical study of the structure, IR and NMR of the bis-peroxo-oxovanadate species containing-histidine peptides

    Article • Inorganica Chimica Acta, August 2014, Elsevier

    Dr Thomas T. Scior

  11. Interference of Boswellic Acids with the Ligand Binding Domain of the Glucocorticoid Receptor

    Article • Journal of Chemical Information and Modeling, March 2014, American Chemical Society (ACS)

    Dr Thomas T. Scior

  12. Identification of Navβ1 Residues Involved in the Modulation of the Sodium Channel Nav1.4

    Article • PLoS ONE, December 2013, PLOS

    Dr Thomas T. Scior

  13. THREE-DIMENSIONAL MAPPING OF DIFFERENTIAL AMINO ACIDS OF HUMAN, MURINE, CANINE AND EQUINE TLR4/MD-2 RECEPTOR COMPLEXES CONFERRING ENDOTOXIC ACTIVATION BY LIPID A, ANTAGONISM BY ERITORAN AND SPECIES-DEPENDENT ACTIVITIES OF LIPID IVA IN THE MAMMALIAN LPS...

    Article • Computational and Structural Biotechnology Journal, May 2013, Elsevier

    Dr Thomas T. Scior

  14. REVIEWING AND IDENTIFYING AMINO ACIDS OF HUMAN, MURINE, CANINE AND EQUINE TLR4 / MD-2 RECEPTOR COMPLEXES CONFERRING ENDOTOXIC INNATE IMMUNITY ACTIVATION BY LPS/LIPID A, OR ANTAGONISTIC EFFECTS BY ERITORAN, IN CONTRAST TO SPECIES-DEPENDENT MODULATION BY...

    Article • Computational and Structural Biotechnology Journal, February 2013, Elsevier

    Dr Thomas T. Scior

  15. Modulating testosterone pathway: a new strategy to tackle male skin aging?

    Article • Clinical Interventions in Aging, September 2012, Taylor & Francis

    Thomas (alias Tom) Scior, Dr Thomas T. Scior

  16. A proline mimetic for enantioselective aldol reaction: a quantum chemical study of a catalytic reaction with a sterically hindered l‐prolinamide derivative

    Article • Journal of Physical Organic Chemistry, June 2012, Wiley

    Mr Alexander I Petrov, Dr Thomas T. Scior

  17. Recognizing Pitfalls in Virtual Screening: A Critical Review

    Article • Journal of Chemical Information and Modeling, April 2012, American Chemical Society (ACS)

    Dr Thomas T. Scior

  18. An In-Silico Approach to Primaquine Binding to Trp756 in the External Vestibule of Sodium Channel Nav 1.4

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Thomas T. Scior

  19. Analgesic effect of leaf extract from Ageratina glabrata in the hot plate test

    Article • Revista Brasileira de Farmacognosia, October 2011, Elsevier

    Dr Thomas T. Scior

  20. A residue W756 in the P-loop segment of the sodium channel is critical for primaquine binding

    Article • European Journal of Pharmacology, August 2011, Elsevier

    Dr Thomas T. Scior

  21. An in silico approach to primaquine binding to Trp756 in the external vestibule of sodium channel Nav 1.4

    Article • Journal of Receptor Ligand and Channel Research, July 2011, Taylor & Francis

    Thomas (alias Tom) Scior, Dr Thomas T. Scior

  22. Pharmacophore Design of p38α MAP Kinase Inhibitors with Either 2,4,5-Trisubstituted or 1,2,4,5-Tetrasubstituted Imidazole Scaffold

    Article • Current Medicinal Chemistry, April 2011, Bentham Science Publishers

    Dr Thomas T. Scior

  23. Elucidation of the fragmentation pathways of different phosphatidylinositol phosphate species (PIPx) using IRMPD implemented on a FT-ICR MS

    Article • Analytical and Bioanalytical Chemistry, October 2010, Springer Science + Business Media

    Dr Thomas T. Scior

  24. Integrating computational and mixture-based screening of combinatorial libraries

    Article • Journal of Molecular Modeling, September 2010, Springer Science + Business Media

    Dr Thomas T. Scior

  25. Reverse Pharmacognosy: Another Way to Harness the Generosity of Nature

    Article • Current Pharmaceutical Design, May 2010, Bentham Science Publishers

    Dr Thomas T. Scior

  26. A Residue (W756) in the P-Loop Segment of Sodium Channel is Critical for Primaquine Binding

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Thomas T. Scior

  27. Scaffold Diversity Analysis of Compound Data Sets Using an Entropy-Based Measure

    Article • QSAR & Combinatorial Science, December 2009, Wiley

    Dr Thomas T. Scior

  28. How to Recognize and Workaround Pitfalls in QSAR Studies: A Critical Review

    Article • Current Medicinal Chemistry, November 2009, Bentham Science Publishers

    Dr Thomas T. Scior

  29. ChemInform Abstract: Elucidating Isoniazid Resistance Using Molecular Modeling.

    Article • ChemInform, April 2009, Wiley

    Dr Thomas T. Scior

  30. Structure-function analysis of two variants of mumps virus hemagglutinin-neuraminidase protein

    Article • The Brazilian Journal of Infectious Diseases, February 2009, FapUNIFESP (SciELO)

    Dr Thomas T. Scior

  31. Structure-activity Relationship of Primaquine and Sodium Channel rNav 1.4

    Article • Biophysical Journal, February 2009, Elsevier

    Dr Thomas T. Scior

  32. Elucidating Isoniazid Resistance Using Molecular Modeling

    Article • Journal of Chemical Information and Modeling, January 2009, American Chemical Society (ACS)

    Dr Thomas T. Scior

  33. Application of Drug Repositioning Strategy to TOFISOPAM

    Article • Current Medicinal Chemistry, December 2008, Bentham Science Publishers

    Dr Thomas T. Scior

  34. Antidiabetic Bis-Maltolato-OxoVanadium(IV): Conversion of inactive trans- to bioactive cis-BMOV for possible binding to target PTP-1B

    Article • Drug Design Development and Therapy, November 2008, Dove Medical Press

    Thomas (alias Tom) Scior, Dr Thomas T. Scior

  35. Large Compound Databases for Structure-Activity Relationships Studies in Drug Discovery

    Article • Mini-Reviews in Medicinal Chemistry, August 2007, Bentham Science Publishers

    Dr Thomas T. Scior

  36. Synthesis, Biological Testing, and Binding Mode Prediction of 6,9-Diarylpurin-8-ones as p38 MAP Kinase Inhibitors

    Article • Journal of Medicinal Chemistry, May 2007, American Chemical Society (ACS)

    Dr Thomas T. Scior

  37. In silico analysis identifies a C3HC4-RING finger domain of a putative E3 ubiquitin-protein ligase located at the C-terminus of a polyglutamine-containing protein

    Article • Brazilian Journal of Medical and Biological Research, March 2007, FapUNIFESP (SciELO)

    Dr Thomas T. Scior

  38. In silico analysis identifies a C3HC4-RING finger domain of a putative E3 ubiquitin-protein ligase located at the C-terminus of a polyglutamine-containing protein

    Article • Brazilian Journal of Medical and Biological Research, March 2007, FapUNIFESP (SciELO)

    Dr Thomas T. Scior

  39. Isoniazid is Not a Lead Compound for its Pyridyl Ring Derivatives,Isonicotinoyl Amides, Hydrazides, and Hydrazones: A Critical Review

    Article • Current Medicinal Chemistry, August 2006, Bentham Science Publishers

    Dr Thomas T. Scior

  40. In Silico Analysis Identifies a Novel C3HC4 Ring Finger Domain of an E3 Ubiquitin-Protein Ligase Located at the C-Terminus of a Polyglutamine-Containing Protein (AJ277365, AF525300, AY879229)

    Article • November 2005, Protein Data Bank, Rutgers University

    Dr Thomas T. Scior

  41. Are Vanadium Compounds Drugable? Structures and Effects of Antidiabetic Vanadium Compounds: A Critical Review

    Article • Mini-Reviews in Medicinal Chemistry, November 2005, Bentham Science Publishers

    Dr Thomas T. Scior

  42. Synthesis and Biological Testing of Purine Derivatives as Potential ATP-Competitive Kinase Inhibitors

    Article • Journal of Medicinal Chemistry, February 2005, American Chemical Society (ACS)

    Dr Thomas T. Scior

  43. On Rüdenberg’s Integral Approximations and Their Unrestricted and Combined Use in Crystal Orbital Theories of Hartree-Fock Type

    Article • Zeitschrift für Naturforschung A, January 2003, De Gruyter

    Dr Thomas T. Scior

  44. On the Restricted and Combined Use of Rüdenberg’s Approximations in Molecular Orbital Theories of Hartree-Fock Type

    Article • Zeitschrift für Naturforschung A, January 2003, De Gruyter

    Dr Thomas T. Scior

  45. Antitubercular Isoniazid and Drug Resistance of Mycobacterium tuberculosis — A Review

    Article • Archiv der Pharmazie, December 2002, Wiley

    Dr Thomas T. Scior

  46. Preliminary screening of some tropical plants for anti-tyrosinase activity

    Article • Journal of Ethnopharmacology, October 2002, Elsevier

    Dr Thomas T. Scior

  47. Ethnopharmacology and bioinformatic combination for leads discovery: application to phospholipase A2 inhibitors

    Article • Phytochemistry, November 2001, Elsevier

    Dr Thomas T. Scior

  48. Homology Modelling of a Newly Discovered Thioredoxin Protein and Analysis of the Force Field and Electrostatic Properties

    Article • Journal of Molecular Modeling, August 1997, Springer Science + Business Media

    Prof Victoria I Bunik, Dr Thomas T. Scior

  49. Molecular Modeling Study on Dapsone and Sulfonamides Comparing Structures and Properties with Respect to Anti-Leprosy Activity

    Article • Journal of Molecular Modeling, August 1997, Springer Science + Business Media

    Dr Thomas T. Scior

  50. Adenosine receptors and their modulators

    Article • Pharmaceutica Acta Helvetiae, September 1993, Elsevier

    Dr Thomas T. Scior