All Stories

  1. HYDIN variants cause primary ciliary dyskinesia in the Finnish population

    Article • Pediatric Pulmonology, September 2024, Wiley

    Thomas Burgoyne

  2. Daily Light Onset and Plasma Membrane Tethers Regulate Mitochondria Redistribution within the Retinal Pigment Epithelium

    Article • Cells, June 2024, MDPI AG

    Thomas Burgoyne

  3. Author Correction: Age-specific nasal epithelial responses to SARS-CoV-2 infection

    Article • Nature Microbiology, June 2024, Springer Science + Business Media

    Thomas Burgoyne

  4. HYDINvariants cause primary ciliary dyskinesia in the Finnish population

    Article • May 2024, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  5. Rescue of cone and rod photoreceptor function in a CDHR1-model of age-related retinal degeneration

    Article • Molecular Therapy, May 2024, Elsevier

    Thomas Burgoyne

  6. Age-specific nasal epithelial responses to SARS-CoV-2 infection

    Article • Nature Microbiology, April 2024, Springer Science + Business Media

    Thomas Burgoyne

  7. Combined approaches, including long-read sequencing, address the diagnostic challenge of HYDIN in primary ciliary dyskinesia

    Article • European Journal of Human Genetics, April 2024, Springer Science + Business Media

    Thomas Burgoyne

  8. Primary Ciliary Dyskinesia and Retinitis Pigmentosa: Novel RPGR Variant and Possible Modifier Gene

    Article • Cells, March 2024, MDPI AG

    Thomas Burgoyne

  9. Loss of REP1 impacts choroidal melanogenesis and vasculogenesis in choroideremia

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, February 2024, Elsevier

    Thomas Burgoyne

  10. Disruption of CFAP418 interaction with lipids causes widespread abnormal membrane-associated cellular processes in retinal degenerations

    Article • JCI Insight, January 2024, American Society for Clinical Investigation

    Thomas Burgoyne

  11. S83 Long-term effects of SARS-CoV-2 on ciliogenesis through altered expression of FOXJ1

    Article • November 2023, BMJ

    Thomas Burgoyne

  12. Tetherin antagonism by SARS‐CoV‐2 ORF3a and spike protein enhances virus release

    Article • EMBO Reports, October 2023, Springer Science + Business Media

    Thomas Burgoyne

  13. Combined approaches including long-read sequencing address the diagnostic challenge of HYDIN in primary ciliary dyskinesia

    Article • September 2023, European Respiratory Society (ERS)

    Thomas Burgoyne

  14. Increasing the diagnostic yield in Primary Ciliary Dyskinesia via whole gene sequencing

    Article • September 2023, European Respiratory Society (ERS)

    Thomas Burgoyne

  15. PCD-AID: artificial intelligence diagnosis of primary ciliary dyskinesia

    Article • September 2023, European Respiratory Society (ERS)

    Thomas Burgoyne

  16. Utilising computer vision artificial intelligence to identify defects in airway ciliary motility and mucociliary clearance

    Article • September 2023, European Respiratory Society (ERS)

    Thomas Burgoyne

  17. Impaired Lysosome Reformation in Chloroquine-Treated Retinal Pigment Epithelial Cells

    Article • Investigative Ophthalmology & Visual Science, August 2023, Association for Research in Vision and Ophthalmology (ARVO)

    Thomas Burgoyne

  18. Gold Particle Analyser: Detection and quantitative assessment of electron microscopy gold probes

    Article • PLoS ONE, July 2023, PLOS

    Thomas Burgoyne

  19. Automated Segmentation of Mitochondria in Virus-Infected Cells Using Deep Learning Models

    Article • Microscopy and Microanalysis, July 2023, Oxford University Press (OUP)

    Thomas Burgoyne

  20. Loss of REP1 impacts choroidal melanogenesis in choroideremia

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  21. Immunobiology of a rationally-designed AAV2 capsid following intravitreal delivery in mice

    Article • Gene Therapy, June 2023, Springer Science + Business Media

    Thomas Burgoyne

  22. Developmental Expression of the Cell Cycle Regulator p16INK4a in Retinal Glial Cells: A Novel Marker for Immature Ocular Astrocytes?

    Article • Journal of Histochemistry & Cytochemistry, June 2023, SAGE Publications

    Thomas Burgoyne

  23. Axonemal structures reveal mechanoregulatory and disease mechanisms

    Article • Nature, May 2023, Springer Science + Business Media

    Thomas Burgoyne

  24. The emergence of goblet inflammatory or ITGB6hinasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  25. A persistent neutrophil-associated immune signature characterizes post–COVID-19 pulmonary sequelae

    Article • Science Translational Medicine, November 2022, American Association for the Advancement of Science

    Thomas Burgoyne

  26. Changes in Mitochondrial Size and Morphology in the RPE and Photoreceptors of the Developing and Ageing Zebrafish

    Article • Cells, November 2022, MDPI AG

    Thomas Burgoyne

  27. SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules

    Article • Proceedings of the National Academy of Sciences, October 2022, Proceedings of the National Academy of Sciences

    Thomas Burgoyne

  28. Erratum in: Functional Changes Within the Rod Inner Segment Ellipsoid in Wildtype Mice: An Optical Coherence Tomography and Electron Microscopy Study

    Article • Investigative Ophthalmology & Visual Science, September 2022, Association for Research in Vision and Ophthalmology (ARVO)

    Thomas Burgoyne

  29. Functional Changes Within the Rod Inner Segment Ellipsoid in Wildtype Mice: An Optical Coherence Tomography and Electron Microscopy Study

    Article • Investigative Ophthalmology & Visual Science, July 2022, Association for Research in Vision and Ophthalmology (ARVO)

    Thomas Burgoyne

  30. Disruption of CFAP418 interaction with lipids causes abnormal membrane-associated cellular processes in retinal degenerations

    Article • June 2022, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  31. Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

    Article • Diabetes, April 2022, American Diabetes Association

    Thomas Burgoyne

  32. Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium

    Article • Nature Communications, March 2022, Springer Science + Business Media

    Thomas Burgoyne

  33. A persistent neutrophil-associated immune signature characterises post-COVID19 pulmonary sequelae

    Article • February 2022, Research Square

    Thomas Burgoyne

  34. Fission of megamitochondria into multiple smaller well-defined mitochondria in the ageing zebrafish retina

    Article • December 2021, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  35. Zebrafish Motile Cilia as a Model for Primary Ciliary Dyskinesia

    Article • International Journal of Molecular Sciences, August 2021, MDPI AG

    Thomas Burgoyne

  36. UA-Zero as a Uranyl Acetate Replacement When Diagnosing Primary Ciliary Dyskinesia by Transmission Electron Microscopy

    Article • Diagnostics, June 2021, MDPI AG

    Thomas Burgoyne

  37. Glucose-dependent miR-125b is a negative regulator of β-cell function

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  38. Ultrastructural insight into SARS-CoV-2 attachment, entry and budding in human airway epithelium

    Article • April 2021, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  39. Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity

    Article • Journal of Extracellular Vesicles, April 2021, Wiley

    Thomas Burgoyne

  40. AMP-activated protein kinase is a key regulator of acute neurovascular permeability

    Article • Journal of Cell Science, April 2021, The Company of Biologists

    Thomas Burgoyne

  41. Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P‐GI.2) from Lagomorpha to Eurasian badger

    Article • Transboundary and Emerging Diseases, March 2021, Hindawi Publishing Corporation

    Thomas Burgoyne

  42. Increased transmission of SARS-CoV-2 lineage B.1.1.7 (VOC 2020212/01) is not accounted for by a replicative advantage in primary airway cells or antibody escape

    Article • February 2021, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  43. Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic

    Article • January 2021, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  44. PCD Detect: enhancing ciliary features through image averaging and classification

    Article • AJP Lung Cellular and Molecular Physiology, December 2020, American Physiological Society

    Thomas Burgoyne

  45. Chronically shortened rod outer segments accompany photoreceptor cell death in Choroideremia

    Article • PLoS ONE, November 2020, PLOS

    Thomas Burgoyne

  46. Improving Primary Ciliary Dyskinesia diagnosis using Artificial Intelligence

    Article • September 2020, European Respiratory Society (ERS)

    Thomas Burgoyne

  47. Membrane trafficking in the retinal pigment epithelium at a glance

    Article • Journal of Cell Science, August 2020, The Company of Biologists

    Thomas Burgoyne

  48. Ciliary Feature Counter: A program for the Quantitative Assessment of Cilia to Diagnose Primary Ciliary Dyskinesia

    Article • Diagnostics, July 2020, MDPI AG

    Thomas Burgoyne

  49. Physiological and Pathophysiological Aspects of Primary Cilia—A Literature Review with View on Functional and Structural Relationships in Cartilage

    Article • International Journal of Molecular Sciences, July 2020, MDPI AG

    Thomas Burgoyne

  50. Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1

    Article • Proceedings of the National Academy of Sciences, June 2020, Proceedings of the National Academy of Sciences

    Thomas Burgoyne

  51. NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

    Article • Nature Communications, September 2019, Springer Science + Business Media

    Thomas Burgoyne

  52. Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells

    Article • PLoS Biology, August 2019, PLOS

    Thomas Burgoyne

  53. Three-dimensional structure of the basketweave Z-band in midshipman fish sonic muscle

    Article • Proceedings of the National Academy of Sciences, July 2019, Proceedings of the National Academy of Sciences

    Professor Kenneth A. Taylor, Thomas Burgoyne

  54. Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease

    Article • Investigative Ophthalmology & Visual Science, June 2019, Association for Research in Vision and Ophthalmology (ARVO)

    Thomas Burgoyne

  55. Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1

    Article • May 2019, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  56. Phagosomal and mitochondrial alterations in RPE may contribute to KCNJ13 retinopathy

    Article • Scientific Reports, March 2019, Springer Science + Business Media

    Thomas Burgoyne

  57. Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration

    Article • Investigative Ophthalmology & Visual Science, January 2019, Association for Research in Vision and Ophthalmology (ARVO)

    Thomas Burgoyne

  58. Agonist binding affinity determines palmitoylation of the glucagon-like peptide-1 receptor and its functional interaction with plasma membrane nanodomains in pancreatic beta cells

    Article • December 2018, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  59. Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus

    Article • The American Journal of Human Genetics, December 2018, Elsevier

    Thomas Burgoyne

  60. ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation

    Article • Cell Reports, July 2018, Elsevier

    Thomas Burgoyne

  61. Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer

    Article • Cell Reports, June 2018, Elsevier

    Thomas Burgoyne

  62. Primary ciliary dyskinesia with normal ultrastructure: three-dimensional tomography detects absence of DNAH11

    Article • European Respiratory Journal, February 2018, European Respiratory Society (ERS)

    Thomas Burgoyne

  63. Correlative light and immuno-electron microscopy of retinal tissue cryostat sections

    Article • PLoS ONE, January 2018, PLOS

    Thomas Burgoyne

  64. Oxidation of Atg3 and Atg7 mediates inhibition of autophagy

    Article • Nature Communications, January 2018, Springer Science + Business Media

    Thomas Burgoyne

  65. HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model

    Article • EBioMedicine, January 2018, Elsevier

    Dr Oliver Schilling, Thomas Burgoyne

  66. Use of electron tomography to confirm the diagnosis of primary ciliary dyskinesia

    Article • September 2017, European Respiratory Society (ERS)

    Thomas Burgoyne

  67. Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer

    Article • August 2017, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  68. Endothelial MAPKs Direct ICAM-1 Signaling to Divergent Inflammatory Functions

    Article • The Journal of Immunology, May 2017, The American Association of Immunologists

    Thomas Burgoyne

  69. REEP6 deficiency leads to retinal degeneration through disruption of ER homeostasis and protein trafficking

    Article • Human Molecular Genetics, May 2017, Oxford University Press (OUP)

    Thomas Burgoyne

  70. Mutations in REEP6 Cause Autosomal-Recessive Retinitis Pigmentosa

    Article • The American Journal of Human Genetics, December 2016, Elsevier

    Thomas Burgoyne

  71. Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-resolution Microscopy

    Article • ACS Nano, November 2016, American Chemical Society (ACS)

    Thomas Burgoyne

  72. Multivesicular Bodies: Roles in Intracellular and Intercellular Signaling

    Article • August 2016, Wiley

    Thomas Burgoyne

  73. New light on photoreceptor renewal

    Article • Cell Cycle, May 2016, Taylor & Francis

    Thomas Burgoyne

  74. Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment

    Article • Proceedings of the National Academy of Sciences, December 2015, Proceedings of the National Academy of Sciences

    Thomas Burgoyne

  75. Three-Dimensional Structure of Vertebrate Muscle Z-Band: The Small-Square Lattice Z-Band in Rat Cardiac Muscle

    Article • Journal of Molecular Biology, November 2015, Elsevier

    Thomas Burgoyne

  76. Retinal Pigment Epithelial Cells Mitigate the Effects of Complement Attack by Endocytosis of C5b-9

    Article • The Journal of Immunology, October 2015, The American Association of Immunologists

    Thomas Burgoyne

  77. Erratum to: Arum Palaestinum with isovanillin, linolenic acid and β-sitosterol inhibits prostate cancer spheroids and reduces the growth rate of prostate tumors in mice

    Article • BMC Complementary and Alternative Medicine, September 2015, Springer Science + Business Media

    Thomas Burgoyne

  78. Calcium signaling at ER membrane contact sites

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, September 2015, Elsevier

    Thomas Burgoyne

  79. Gene discovery for motile cilia disorders: mutation spectrum in primary ciliary dyskinesia and discovery of mutations in CCDC151

    Article • Cilia, July 2015, Springer Science + Business Media

    Thomas Burgoyne

  80. Phenotypic variability of CCDC103 mutation in British Pakistani children with Primary Ciliary Dyskinesia (PCD)

    Article • Cilia, July 2015, Springer Science + Business Media

    Thomas Burgoyne

  81. WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway

    Article • Nature Communications, June 2015, Springer Science + Business Media

    Thomas Burgoyne

  82. Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL

    Article • Journal of Cell Science, April 2015, The Company of Biologists

    Thomas Burgoyne

  83. CCDC151 Mutations Cause Primary Ciliary Dyskinesia by Disruption of the Outer Dynein Arm Docking Complex Formation

    Article • The American Journal of Human Genetics, September 2014, Elsevier

    Thomas Burgoyne

  84. Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers

    Article • Developmental Cell, September 2014, Elsevier

    Thomas Burgoyne

  85. Characterizing the ultrastructure of primary ciliary dyskinesia transposition defect using electron tomography

    Article • Cytoskeleton, March 2014, Wiley

    Amelia Shoemark, Thomas Burgoyne

  86. Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects

    Article • Human Molecular Genetics, February 2014, Oxford University Press (OUP)

    Thomas Burgoyne

  87. Expression of OA1 limits the fusion of a subset of MVBs with lysosomes – a mechanism potentially involved in the initial biogenesis of melanosomes

    Article • Journal of Cell Science, February 2014, The Company of Biologists

    Thomas Burgoyne

  88. Methamphetamine-induced nitric oxide promotes vesicular transport in blood–brain barrier endothelial cells

    Article • Neuropharmacology, February 2013, Elsevier

    Thomas Burgoyne

  89. Expression of OA1 limits the fusion of a subset of MVBs with lysosomes; a mechanism likely involved in the initial biogenesis of melanosomes

    Article • Journal of Cell Science, January 2013, The Company of Biologists

    Thomas Burgoyne

  90. Generation of a Three-Dimensional Ultrastructural Model of Human Respiratory Cilia

    Article • American Journal of Respiratory Cell and Molecular Biology, December 2012, American Thoracic Society

    Amelia Shoemark, Thomas Burgoyne

  91. Recessive HYDIN Mutations Cause Primary Ciliary Dyskinesia without Randomization of Left-Right Body Asymmetry

    Article • The American Journal of Human Genetics, October 2012, Elsevier

    Thomas Burgoyne

  92. The relationship between ER–multivesicular body membrane contacts and the ESCRT machinery

    Article • Biochemical Society Transactions, March 2012, Portland Press Ltd.

    Thomas Burgoyne

  93. A Comparison Between Chlamydomonas Flagella And Human Cilia By Electron Tomography

    Article • May 2010, American Thoracic Society

    Amelia Shoemark, Thomas Burgoyne

  94. The Study Of Primary Ciliary Dyskinesia In Difficult Cases Using Electron Tomography

    Article • May 2010, American Thoracic Society

    Amelia Shoemark, Thomas Burgoyne

  95. Visualization of cardiac muscle thin filaments and measurement of their lengths by electron tomography

    Article • Cardiovascular Research, January 2008, European Society of Cardiology

    Thomas Burgoyne