All Stories

  1. Data-Independent Acquisition: A Milestone and Prospect in Clinical Mass Spectrometry–Based Proteomics
  2. Mass Spectrometry-Based Proteomics of Poly(methylmethacrylate)-Embedded Bone
  3. Mass spectrometry‐based proteomic applications in dental implants research
  4. Proteometabolomics of initial and recurrent glioblastoma highlights an increased immune cell signature with altered lipid metabolism
  5. Alternative mRNA Splicing Controls the Functions of the Histone H3K27 Demethylase UTX/KDM6A
  6. An EOMES induced epigenetic deflection initiates lineage commitment at mammalian gastrulation
  7. Neoadjuvant Chemotherapy or Combined Chemo-Radiation Therapy of Pancreatic Ductal Adenocarcinoma Differentially Shift Immune Activation, ECM Composition, Energy Metabolism, and Ribosomal Proteins of the Residual Tumor Mass
  8. Characterization of Spatial Heterogeneity in Metastasized Colorectal Cancer by MALDI Imaging
  9. Targeted and explorative profiling of kallikrein proteases and global proteome biology of pancreatic ductal adenocarcinoma, chronic pancreatitis, and normal pancreas highlights disease-specific proteome remodelling
  10. Proteome-Wide Identification of RNA-Dependent Proteins in Lung Cancer Cells
  11. Targeted and Explorative Profiling of Kallikrein Proteases and Global Proteome Biology of Pancreatic Ductal Adenocarcinoma, Chronic Pancreatitis, and Normal Pancreas Highlights Disease-Specific Proteome Remodelling
  12. Proteome alterations during clonal isolation of established human pancreatic cancer cell lines
  13. Addition of Chromosome 17 Polysomy and HER2 Amplification Status Improves the Accuracy of Clinicopathological Factor-Based Progression Risk Stratification and Tumor Grading of Non-Muscle-Invasive Bladder Cancer
  14. MaxQuant and MSstats in Galaxy Enable Reproducible Cloud-Based Analysis of Quantitative Proteomics Experiments for Everyone
  15. NUP133 Controls Nuclear Pore Assembly, Transcriptome Composition, and Cytoskeleton Regulation in Podocytes
  16. MaxQuant and MSstats in Galaxy enable reproducible cloud-based analysis of quantitative proteomics experiments for everyone
  17. An adapted passive model of anti-MPO dependent crescentic glomerulonephritis reveals matrix dysregulation and is amenable to modulation by CXCR4 inhibition
  18. Democratizing data-independent acquisition proteomics analysis on public cloud infrastructures via the Galaxy framework
  19. Proteome biology of primary colorectal carcinoma and corresponding liver metastases
  20. Proteome biology of primary colorectal carcinoma and corresponding liver metastases
  21. Moving translational mass spectrometry imaging towards transparent and reproducible data analyses: A case study of an urothelial cancer cohort analyzed in the Galaxy framework
  22. Democratizing Data-Independent Acquisition Proteomics Analysis on Public Cloud Infrastructures Via The Galaxy Framework
  23. A Systematic Evaluation of Semispecific Peptide Search Parameter Enables Identification of Previously Undescribed N-Terminal Peptides and Conserved Proteolytic Processing in Cancer Cell Lines
  24. EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission
  25. Impact of DJ-1 and Helix 8 on the Proteome and Degradome of Neuron-Like Cells
  26. Origin and Expansion of the Serine Protease Repertoire in the Myelomonocyte Lineage
  27. Automation of peptide desalting for proteomic liquid chromatography – tandem mass spectrometry by centrifugal microfluidics
  28. Discovery of a novel small protein factor involved in the coordinated degradation of phycobilisomes in cyanobacteria
  29. Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death
  30. Accessible and reproducible mass spectrometry imaging data analysis in Galaxy
  31. Targeted Metabolic Profiling of Methionine Cycle Metabolites and Redox Thiol Pools in Mammalian Plasma, Cells and Urine
  32. Impact of left ventricular assist device therapy on the cardiac proteome and metabolome composition in ischemic cardiomyopathy
  33. Neuronal-specific microexon splicing of TAF1 mRNA is directly regulated by SRRM4/nSR100
  34. A human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins
  35. Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome
  36. Detection and Characterization of a Mycobacterial L-Arabinofuranose ABC Transporter Identified with a Rapid Lipoproteomics Protocol
  37. Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer
  38. Accessible and reproducible mass spectrometry imaging data analysis in Galaxy
  39. Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics
  40. ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma
  41. Infection of HeLa cells with Chlamydia trachomatis inhibits protein synthesis and causes multiple changes to host cell pathways
  42. Radiomic features from PSMA PET for non-invasive intraprostatic tumor discrimination and characterization in patients with intermediate- and high-risk prostate cancer - a comparison study with histology reference
  43. FOXG1 Regulates PRKAR2B Transcriptionally and Posttranscriptionally via miR200 in the Adult Hippocampus
  44. Proteome Profiling of Primary Pancreatic Ductal Adenocarcinomas Undergoing Additive Chemoradiation Link ALDH1A1 to Early Local Recurrence and Chemoradiation Resistance
  45. Dreidimensionale Rekonstruktion solider Tumoren
  46. Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer
  47. Multimodal imaging for radiation therapy planning in patients with primary prostate cancer
  48. Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics
  49. The two cathepsin B-like proteases of Arabidopsis thaliana are closely related enzymes with discrete endopeptidase and carboxydipeptidase activities
  50. Specificity profiling of human trypsin-isoenzymes
  51. N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration
  52. Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin
  53. Proteomic distinction of renal oncocytomas and chromophobe renal cell carcinomas
  54. Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin
  55. Nanoparticle decoration impacts airborne fungal pathobiology
  56. Morphology of Immunomodulation in Breast Cancer Tumor Draining Lymph Nodes Depends on Stage and Intrinsic Subtype
  57. The pleiotropic roles of ADAM9 in the biology of solid tumors
  58. Reproducible proteomics sample preparation for single FFPE tissue slices using acid-labile surfactant and direct trypsinization
  59. Identification of tissue damage, extracellular matrix remodeling and bacterial challenge as common mechanisms associated with high-risk cutaneous squamous cell carcinomas
  60. Proteomic Characterization of Prostate Cancer to Distinguish Nonmetastasizing and Metastasizing Primary Tumors and Lymph Node Metastases
  61. HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
  62. The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton
  63. HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication
  64. OpenMS – A platform for reproducible analysis of mass spectrometry data
  65. Proteome profiling of clear cell renal cell carcinoma in von Hippel-Lindau patients highlights upregulation of Xaa-Pro aminopeptidase-1, an anti-proliferative and anti-migratory exoprotease
  66. Differential effect of TGFβ on the proteome of cancer associated fibroblasts and cancer epithelial cells in a co-culture approach - a short report
  67. Determinants of Macromolecular Specificity from Proteomics-De rived Peptide Substrate Data
  68. Form follows function: Morphological and immunohistological insights into epithelial–mesenchymal transition characteristics of tumor buds
  69. The papain-like cysteine proteinases NbCysP6 and NbCysP7 are highly processive enzymes with substrate specificities complementary to Nicotiana benthamiana cathepsin B
  70. Proteomics highlights decrease of matricellular proteins in left ventricular assist device therapy†
  71. Identification of Protease Cleavage Sites by Charge-Based Enrichment of Protein N-Termini
  72. Profiling of Protease Cleavage Sites by Proteome-Derived Peptide Libraries and Quantitative Proteomics
  73. Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression
  74. System-Wide Profiling of Protein Amino Termini from Formalin-Fixed, Paraffin-Embedded Tissue Specimens for the Identification of Novel Substrates
  75. The Prognostic Impact of the Carcinoembryonic Antigen in Ampullary Cancer - A Retrospective Single Center Study
  76. Tenascin-C Orchestrates Glioblastoma Angiogenesis by Modulation of Pro- and Anti-angiogenic Signaling
  77. Proteomic analysis of silenced cathepsin B expression suggests non-proteolytic cathepsin B functionality
  78. Yeast membrane proteomics using leucine metabolic labelling: Bioinformatic data processing and exemplary application to the ER-intramembrane protease Ypf1
  79. OpenMS: a flexible open-source software platform for mass spectrometry data analysis
  80. The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity
  81. Proteomic Profiling of Cardiomyocyte-Specific Cathepsin A Overexpression Links Cathepsin A to the Oxidative Stress Response
  82. Comprehensive Proteomic Analysis of Nitrogen-Starved Mycobacterium smegmatis Δpup Reveals the Impact of Pupylation on Nitrogen Stress Response
  83. Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14
  84. Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels
  85. Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics
  86. Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR Are Based on Highly Similar Proteome and Degradome Alterations
  87. Formalin-Fixed, Paraffin-Embedded Tissues (FFPE) as a Robust Source for the Profiling of Native and Protease-Generated Protein Amino Termini
  88. Characterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses
  89. Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers
  90. Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses
  91. Mesopancreatic Stromal Clearance Defines Curative Resection of Pancreatic Head Cancer and Can Be Predicted Preoperatively by Radiologic Parameters
  92. Pregnancy Specific β-1 Glycoprotein 1 is Expressed in Pancreatic Ductal Adenocarcinoma and its Subcellular Localization Correlates with Overall Survival
  93. Taspase1: a 'misunderstood' protease with translational cancer relevance
  94. A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity
  95. An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation
  96. The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia
  97. Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations
  98. Quantitative proteomic analysis of formalin–fixed, paraffin–embedded clear cell renal cell carcinoma tissue using stable isotopic dimethylation of primary amines
  99. Toward improved peptide feature detection in quantitative proteomics using stable isotope labeling
  100. miR-200c dampens cancer cell migration via regulation of protein kinase A subunits
  101. Enrichment of protein N-termini by charge reversal of internal peptides
  102. The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells
  103. The emerging role of the peptidome in biomarker discovery and degradome profiling
  104. Detailed analysis of epithelial-mesenchymal transition and tumor budding identifies predictors of long-term survival in pancreatic ductal adenocarcinoma
  105. Protein amino-terminal modifications and proteomic approaches for N-terminal profiling
  106. Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells
  107. Evolutionary divergence of Threonine Aspartase1 leads to species-specific substrate recognition
  108. The Yeast ER-Intramembrane Protease Ypf1 Refines Nutrient Sensing by Regulating Transporter Abundance
  109. Carboxyterminal Protein Processing in Health and Disease: Key Actors and Emerging Technologies
  110. Cancer cell invasion and EMT marker expression: a three-dimensional study of the human cancer-host interface
  111. Septins Arrange F-Actin-Containing Fibers on the Chlamydia trachomatis Inclusion and Are Required for Normal Release of the Inclusion by Extrusion
  112. Impact of routinely employed procedures for tissue processing on the proteomic analysis of formalin-fixed paraffin-embedded tissue
  113. Prognostic significance of Zinc finger E-box binding homeobox 1 (ZEB1) expression in cancer cells and cancer-associated fibroblasts in pancreatic head cancer
  114. Proteases and Disease
  115. Global remodelling of cellular microenvironment due to loss of collagen VII
  116. Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy
  117. Transmembrane Collagen XVII Modulates Integrin Dependent Keratinocyte Migration via PI3K/Rac1 Signaling
  118. Automated peptide mapping and protein-topographical annotation of proteomics data
  119. Proteomic identification of protease cleavage sites: cell-biological and biomedical applications
  120. Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells
  121. Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis
  122. Glycocapture-based proteomics for secretome analysis
  123. Limited and Degradative Proteolysis in the Context of Posttranslational Regulatory Networks: Current Technical and Conceptional Advances
  124. Deletion of Cysteine Cathepsins B or L Yields Differential Impacts on Murine Skin Proteome and Degradome
  125. Enhanced identification of peptides lacking basic residues by LC-ESI-MS/MS analysis of singly charged peptides
  126. NSP4, an elastase-related protease in human neutrophils with arginine specificity
  127. Proteomic Identification of Protease Cleavage Sites Characterizes Prime and Non-prime Specificity of Cysteine Cathepsins B, L, and S
  128. Correction to Proteomic Identification of Protease Cleavage Sites Characterizes Prime and Non-prime Specificity of Cysteine Cathepsins B, L, and S
  129. Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites
  130. Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts
  131. Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts
  132. Proteomic Analyses Reveal an Acidic Prime Side Specificity for the Astacin Metalloprotease Family Reflected by Physiological Substrates
  133. Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragmentsin Vivo
  134. Protease Specificity Profiling by Tandem Mass Spectrometry Using Proteome-Derived Peptide Libraries
  135. Identification and Relative Quantification of Native and Proteolytically Generated Protein C-Termini from Complex Proteomes: C-Terminome Analysis
  136. Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry
  137. Biological role of matrix metalloproteinases: a critical balance
  138. Proteomic techniques and activity-based probes for the system-wide study of proteolysis
  139. Proteome-wide analysis of protein carboxy termini: C terminomics
  140. Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products
  141. Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites
  142. Protease subsite profiling with proteome-derived peptide libraries (PICS)
  143. Metal Requirements and Phosphodiesterase Activity of tRNase Z Enzymes †
  144. Proteomic discovery of protease substrates
  145. The Crystal Structure of the Zinc Phosphodiesterase from Escherichia coli Provides Insight into Function and Cooperativity of tRNase Z-Family Proteins
  146. Exosite Modules Guide Substrate Recognition in the ZiPD/ElaC Protein Family
  147. Erratum to “Characterization of an Escherichia coli elaC deletion mutant” [Biochem. Biophys. Res. Commun. 320 (2004) 1365–1373]
  148. The tRNase Z family of proteins: physiological functions, substrate specificity and structural properties
  149. Zinc- and iron-dependent cytosolic metallo-β-lactamase domain proteins exhibit similar zinc-binding affinities, independent of an atypical glutamate at the metal-binding site
  150. Functional diversity and metal selectivity of proteins sharing the metallo-β-lactamase fold
  151. Characterization of an Escherichia coli elaC deletion mutant
  152. Identification of Metal Binding Residues for the Binuclear Zinc Phosphodiesterase Reveals Identical Coordination as Glyoxalase II
  153. The binding of iron and zinc to glyoxalase II occurs exclusively as di-metal centers and is unique within the metallo-β-lactamase family
  154. Flexible Metal Binding of the Metallo-β-lactamase Domain:  Glyoxalase II Incorporates Iron, Manganese, and Zinc in Vivo †
  155. Activation Mechanism of Pro-astacin: Role of the Pro-peptide, Tryptic and Autoproteolytic Cleavage and Importance of Precise Amino-terminal Processing
  156. The GCM domain is a Zn-coordinating DNA-binding domain
  157. ElaCEncodes a Novel Binuclear Zinc Phosphodiesterase