All Stories

  1. Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s disease
  2. Natural Compounds for Bone Remodeling: A Computational and Experimental Approach Targeting Bone Metabolism-Related Proteins
  3. Clinical implementation of preemptive pharmacogenomics in psychiatry
  4. Data-Driven Drug Repurposing in Diabetes Mellitus through an Enhanced Knowledge Graph
  5. Cloudscreen: A “one-stop-shop” Platform for Drug Repurposing
  6. A quest for the stereo-electronic requirements for selective agonism for the neurotrophin receptors TrkA and TrkB in 17-spirocyclic-dehydroepiandrosterone derivatives
  7. A Robust Machine Learning Framework Built Upon Molecular Representations Predicts CYP450 Inhibition: Toward Precision in Drug Repurposing
  8. Bioenergetic Profiling in Glioblastoma Multiforme Patients with Different Clinical Outcomes
  9. A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study
  10. Development and Comparative In Vitro and In Vivo Study of BNN27 Mucoadhesive Liposomes and Nanoemulsions for Nose-to-Brain Delivery
  11. CAR Exosome-Based Therapeutics
  12. Pharmacometabolomics-Based Translational Biomarkers: How to Navigate the Data Ocean
  13. Untargeted Metabolomics for Disease-Specific Signatures
  14. Radiotherapy in Metastatic Urothelial Carcinoma: Rationale and Clinical Applications
  15. Diagnostic and Therapeutic Challenges in a Patient with Ureteral Metastases from a Triple Negative Breast Cancer
  16. A 3-miRNA Signature Enables Risk Stratification in Glioblastoma Multiforme Patients with Different Clinical Outcomes
  17. The clinical utility of polygenic risk scores in genomic medicine practices: a systematic review
  18. ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses
  19. Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity
  20. Three-Dimensional Cell Metabolomics Deciphers the Anti-Angiogenic Properties of the Radioprotectant Amifostine
  21. Exploiting the Role of Hypoxia-Inducible Factor 1 and Pseudohypoxia in the Myelodysplastic Syndrome Pathophysiology
  22. Bioenergetic Profiling of the Differentiating Human MDS Myeloid Lineage with Low and High Bone Marrow Blast Counts
  23. Clinical implementation of preemptive pharmacogenomics in psychiatry: Τhe “PREPARE” study
  24. The role of microRNAs in gliomas – Therapeutic implications
  25. VEGF-A and ICAM-1 Gene Polymorphisms as Predictors of Clinical Outcome to First-Line Bevacizumab-Based Treatment in Metastatic Colorectal Cancer
  26. Pharmacomicrobiomics informs clinical pharmacogenomics
  27. A Noninvasive Ocular (Tear) Sampling Method for Genetic Ascertainment of Transgenic Mice and Research Ethics Innovation
  28. New molecular diagnostic trends and biomarkers for amyotrophic lateral sclerosis
  29. Cost-effectiveness analysis of pharmacogenomics-guided clopidogrel treatment in Spanish patients undergoing percutaneous coronary intervention
  30. Role of Genomic Biomarkers in Increasing Fetal Hemoglobin Levels Upon Hydroxyurea Therapy and in β-Thalassemia Intermedia: A Validation Cohort Study
  31. Implementation of Genomic Medicine
  32. How far have we come with contextual data integration in drug discovery?
  33. Variants in TPMT, ITPA, ABCC4 And ABCB1 Genes as Predictors of 6-Mercaptopurine Induced Toxicity in Children with Acute Lymphoblastic Leukemia
  34. An Exploratory Study of Radiation Dermatitis in Breast Cancer Patients
  35. The New Age of -omics in Urothelial Cancer – Re-wording Its Diagnosis and Treatment
  36. Recent trends on the role of epigenomics, metabolomics and noncoding RNAs in rationalizing mood stabilizing treatment
  37. Searching for Clinically Relevant Biomarkers in Geriatric Oncology
  38. Multi-Omics for Biomarker Discovery and Target Validation in Biofluids for Amyotrophic Lateral Sclerosis Diagnosis
  39. Proteomics and Metabolomics Data Analysis for Translational Medicine
  40. A Review of Tools to Automatically Infer Chromosomal Positions From dbSNP and HGVS Genetic Variants
  41. Economic Evaluation and Cost-Effectiveness Analysis of Genomic Medicine Interventions in Developing and Emerging Countries
  42. Human Genomic Databases in Translational Medicine
  43. Translating Genomic Information to Rationalize Drug Use
  44. Advancing Global Precision Medicine: An Overview of Genomic Testing and Counseling Services in Malaysia
  45. Genomic variants in the FTO gene are associated with sporadic amyotrophic lateral sclerosis in Greek patients
  46. Genomic Medicine Without Borders: Which Strategies Should Developing Countries Employ to Invest in Precision Medicine? A New “Fast-Second Winner” Strategy
  47. Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients
  48. Cancer Genomics and Public Health
  49. Sensitive Monogenic Noninvasive Prenatal Diagnosis by Targeted Haplotyping
  50. Exploring public genomics data for population pharmacogenomics
  51. Pharmacometabolomics Informs Quantitative Radiomics for Glioblastoma Diagnostic Innovation
  52. Key Pharmacogenomic Considerations for Sickle Cell Disease Patients
  53. Editorial: (Pharmaco)Metabolomics in Drug Discovery and Individualisation of Treatment
  54. Correction: A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics
  55. Genomic Medicine in Developing Countries and Resource-Limited Environments
  56. Genomic Databases
  57. Perspectives for Future DNA Sequencing Techniques and Applications
  58. Cancer Genomics and Public Health
  59. Application of the DruGeVar Database in Cancer Genomics and Pharmacogenomics
  60. Exosomes: A Cancer Theranostics Road Map
  61. Pharmacogenomics in Clinical Care and Drug Discovery
  62. Low- and Medium-Throughput Variant Detection Methods
  63. Pharmacogenomics education and research at the Department of Pharmacy, University of Patras, Greece
  64. Correlation of SIN3A genomic variants with β-hemoglobinopathies disease severity and hydroxyurea treatment efficacy
  65. Pharmacometabolomics Informs Viromics toward Precision Medicine
  66. Novel genetic risk variants for pediatric celiac disease
  67. Expanded national database collection and data coverage in the FINDbase worldwide database for clinically relevant genomic variation allele frequencies
  68. A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics
  69. ePGA: A Web-Based Information System for Translational Pharmacogenomics
  70. Development and validation of a UHPLC-UV method for the determination of a prostate secretory protein 94-derived synthetic peptide (PCK3145) in human plasma and assessment of its stability in human plasma
  71. Pharmacometabolomics-aided Pharmacogenomics in Autoimmune Disease
  72. Genomic variants in the ASS1 gene, involved in the nitric oxide biosynthesis and signaling pathway, predict hydroxyurea treatment efficacy in compound sickle cell disease/β-thalassemia patients
  73. Nutrigenomics 2.0: The Need for Ongoing andIndependentEvaluation and Synthesis of Commercial Nutrigenomics Tests' Scientific Knowledge Base for Responsible Innovation
  74. Allele and genotype frequencies of the two single nucleotide polymorphisms in the VKORC1 gene that are most important for warfarin treatment among Emiratis
  75. Computational approaches in target identification and drug discovery
  76. Pharmacometabolomics: Applications and Challenges
  77. Functional Analysis of anAγ-Globin Gene Promoter Variant (HBG1: g.-225_-222delAGCA) Underlines Its Role in Increasing Fetal Hemoglobin Levels Under Erythropoietic Stress
  78. Enabling pharmacogenomic services: Informatics and computational discovery aspects
  79. Identification of a novel homozygous SPG7 mutation by whole exome sequencing in a Greek family with a complicated form of hereditary spastic paraplegia
  80. TPMT gene expression is increased during maintenance therapy in childhood acute lymphoblastic leukemia patients in a TPMT gene promoter variable number of tandem repeat-dependent manner
  81. Drug-Induced Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis Call for Optimum Patient Stratification and Theranostics via Pharmacogenomics
  82. As solid scientific evidence is lacking, available nutrigenomics tests cannot be recommended
  83. The Implications of Metabotypes for Rationalizing Therapeutics in Infants and Children
  84. Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach
  85. Whole genome sequencing in pharmacogenomics
  86. Nutrigenomics: A controversy
  87. Pharmacogenomics for Haemoglobinopathies Therapeutics
  88. Circulating pEGFR Is a Candidate Response Biomarker of Cetuximab Therapy in Colorectal Cancer
  89. Deciphering next-generation pharmacogenomics: an information technology perspective
  90. Enhancing the Biological Relevance of Secretome-Based Proteomics by Linking Tumor Cell Proliferation and Protein Secretion
  91. Personalized pharmacogenomics profiling using whole-genome sequencing
  92. Individualizing fetal hemoglobin augmenting therapy for β-type hemoglobinopathies patients
  93. Assessment of the Pharmacogenomics Educational Environment in Southeast Europe
  94. DruGeVar: An Online Resource Triangulating Drugs with Genes and Genomic Biomarkers for Clinical Pharmacogenomics
  95. Ovarian malignant ascites-derived lymphocytes stimulated with prothymosin α or its immunoactive decapeptide lyse autologous tumour cells in vitro and retard tumour growth in SCID mice
  96. Rationally designed cyclic analogues of luteinizing hormone-releasing hormone: Enhanced enzymatic stability and biological properties
  97. 1077 Ovarian Malignant Ascites-derived Lymphocytes Stimulated With Prothymosin Alpha or Its Immunoactive Decapeptide Lyse Autologous Tumor Cells in Vitro and Retard Tumor Growth in SCID Mice
  98. Peptide and protein drugs: The study of their metabolism and catabolism by mass spectrometry
  99. Evaluation of a Stable Gonadotropin-Releasing Hormone Analog in Mice for the Treatment of Endocrine Disorders and Prostate Cancer
  100. Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis
  101. Simultaneous Absolute Quantification of the Glucose-Dependent Insulinotropic Polypeptides GIP1−42and GIP3−42in Mouse Plasma by LC/ESI-MS/MS: Preclinical Evaluation of DP-IV Inhibitors
  102. In vivoevaluation andin vitrometabolism of leuprolide in mice-mass spectrometry-based biomarker measurement for efficacy and toxicity
  103. Evaluation of gonadotropin-releasing hormone analogues in mice – pharmacokinetic studies and biomarker based efficacy by mass spetrometry