All Stories

  1. Chromatin architectural factor CTCF is essential for progesterone‐dependent uterine maturation

    Article • The FASEB Journal, July 2023, Wiley

    Sylvia Hewitt

  2. The estrogen receptor α cistrome in human endometrium and epithelial organoids

    Article • Endocrinology, July 2022, Endocrine Society

    Sylvia Hewitt

  3. Progesterone Signaling in Endometrial Epithelial Organoids

    Article • Cells, May 2022, MDPI AG

    Sylvia Hewitt

  4. The estrogen receptor α cistrome in human endometrium and epithelial organoids

    Article • April 2022, Cold Spring Harbor Laboratory Press

    Sylvia Hewitt

  5. Cell‐type specific analysis of physiological action of estrogen in mouse oviducts

    Article • The FASEB Journal, April 2021, Wiley

    Sylvia Hewitt

  6. Peri- and Postpubertal Estrogen Exposures of Female Mice Optimize Uterine Responses Later in Life

    Article • Endocrinology, July 2020, Endocrine Society

    Sylvia Hewitt

  7. Estrogen receptor α (ERα)-binding super enhancers drive key mediators that control uterine estrogen responses in mice

    Article • Journal of Biological Chemistry, April 2020, American Society for Biochemistry & Molecular Biology (ASBMB)

    Sylvia Hewitt

  8. Oviductal Retention of Embryos in Female Mice Lacking Estrogen Receptor α in the Isthmus and the Uterus

    Article • Endocrinology, December 2019, Endocrine Society

    Sylvia Hewitt

  9. A distal super enhancer mediates estrogen-dependent mouse uterine–specific gene transcription of Insulin-like growth factor 1 (Igf1)

    Article • Journal of Biological Chemistry, May 2019, American Society for Biochemistry & Molecular Biology (ASBMB)

    Sylvia Hewitt

  10. Control of RNA production is necessary for women's fertility

    Article • The FASEB Journal, February 2019, Federation of American Societies For Experimental Biology (FASEB)

    Sylvia Hewitt, Wipawee Winuthayanon

  11. Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes

    Article • Cell Reports, July 2018, Elsevier

    Sylvia Hewitt

  12. Estrogen Receptors: New Directions in the New Millennium

    Article • Endocrine Reviews, June 2018, Endocrine Society

    Sylvia Hewitt

  13. Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress

    Article • Journal of Biological Chemistry, January 2018, American Society for Biochemistry & Molecular Biology (ASBMB)

    Sylvia Hewitt

  14. Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation

    Article • Scientific Reports, August 2017, Springer Science + Business Media

    Sylvia Hewitt

  15. DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin

    Article • Endocrinology, July 2017, Endocrine Society

    Sylvia Hewitt

  16. Role of ERα in Mediating Female Uterine Transcriptional Responses to IGF1

    Article • Endocrinology, June 2017, Endocrine Society

    Sylvia Hewitt

  17. Hormone signaling and fatty liver in females: analysis of estrogen receptor α mutant mice

    Article • International Journal of Obesity, February 2017, Springer Science + Business Media

    Sylvia Hewitt

  18. SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24 + CD49f hi Mammary Stem Cell-Enriched Compartment

    Article • Stem Cell Reports, February 2017, Elsevier

    Sylvia Hewitt

  19. Estrogen Hormone Biology

    Article • January 2017, Elsevier

    Sylvia Hewitt

  20. Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

    Article • Science Translational Medicine, April 2016, American Association for the Advancement of Science

    Sylvia Hewitt

  21. Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus

    Article • Oncotarget, March 2016, Impact Journals, LLC

    Sylvia Hewitt

  22. What's new in estrogen receptor action in the female reproductive tract

    Article • January 2016, Bioscientifica

    Sylvia Hewitt

  23. Oviductal estrogen receptor α signaling prevents protease-mediated embryo death

    Article • eLife, December 2015, eLife

    Sylvia Hewitt

  24. Development of Phenotypic and Transcriptional Biomarkers to Evaluate Relative Activity of Potentially Estrogenic Chemicals in Ovariectomized Mice

    Article • Environmental Health Perspectives, January 2015, Environmental Health Perspectives

    Pierre R Bushel, Sylvia Hewitt

  25. Estrogen Receptor (ER)α-regulated Lipocalin 2 Expression in Adipose Tissue Links Obesity with Breast Cancer Progression

    Article • Journal of Biological Chemistry, December 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Sylvia Hewitt

  26. Uterine Epithelial Cell Estrogen Receptor Alpha-Dependent and -Independent Genomic Profiles That Underlie Estrogen Responses in Mice1

    Article • Biology of Reproduction, November 2014, Oxford University Press (OUP)

    Sylvia Hewitt

  27. The role of genetics in estrogen responses: a critical piece of an intricate puzzle

    Article • The FASEB Journal, September 2014, Federation of American Societies For Experimental Biology (FASEB)

    Sylvia Hewitt

  28. Genetic Control of Ductal Morphology, Estrogen-Induced Ductal Growth, and Gene Expression in Female Mouse Mammary Gland

    Article • Endocrinology, August 2014, Endocrine Society

    Sylvia Hewitt

  29. Novel DNA Motif Binding Activity Observed In Vivo With an Estrogen Receptor α Mutant Mouse

    Article • Molecular Endocrinology, June 2014, Endocrine Society

    Sylvia Hewitt

  30. The Natural Estrogenic Compound Diarylheptanoid (D3): In Vitro Mechanisms of Action and in Vivo Uterine Responses via Estrogen Receptor α ...

    Article • Environmental Health Perspectives, April 2013, Environmental Health Perspectives

    Sylvia Hewitt

  31. Genetic control of estrogen-regulated transcriptional and cellular responses in mouse uterus

    Article • The FASEB Journal, January 2013, Federation of American Societies For Experimental Biology (FASEB)

    Sylvia Hewitt

  32. Role of Estrogen Receptor Signaling Required for Endometriosis-Like Lesion Establishment in a Mouse Model

    Article • Endocrinology, August 2012, Endocrine Society

    Sylvia Hewitt

  33. Research Resource: Whole-Genome Estrogen Receptor α Binding in Mouse Uterine Tissue Revealed by ChIP-Seq

    Article • Molecular Endocrinology, May 2012, Endocrine Society

    Pierre R Bushel, Sylvia Hewitt

  34. Correction for Ribas et al., Myeloid-specific estrogen receptor α deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development

    Article • Proceedings of the National Academy of Sciences, December 2011, Proceedings of the National Academy of Sciences

    Sylvia Hewitt

  35. Uterine Gland Formation in Mice Is a Continuous Process, Requiring the Ovary after Puberty, But Not after Parturition1

    Article • Biology of Reproduction, November 2011, Oxford University Press (OUP)

    Sylvia Hewitt

  36. Myeloid-specific estrogen receptor α deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development

    Article • Proceedings of the National Academy of Sciences, September 2011, Proceedings of the National Academy of Sciences

    Sylvia Hewitt

  37. A Hand to Support the Implantation Window

    Article • Science, February 2011, American Association for the Advancement of Science

    Sylvia Hewitt

  38. Estrogenic Activity of Bisphenol A and 2,2-bis( p -Hydroxyphenyl)-1,1,1-trichloroethane (HPTE) Demonstrated in Mouse Uterine Gene Profiles

    Article • Environmental Health Perspectives, January 2011, Environmental Health Perspectives

    Sylvia Hewitt

  39. Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses

    Article • Proceedings of the National Academy of Sciences, October 2010, Proceedings of the National Academy of Sciences

    Sylvia Hewitt

  40. Ex3αERKO male infertility phenotype recapitulates the αERKO male phenotype

    Article • Journal of Endocrinology, September 2010, Bioscientifica

    Sylvia Hewitt

  41. Biological and biochemical consequences of global deletion of exon 3 from the ER  gene

    Article • The FASEB Journal, July 2010, Federation of American Societies For Experimental Biology (FASEB)

    Sylvia Hewitt

  42. Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis

    Article • Proceedings of the National Academy of Sciences, June 2010, Proceedings of the National Academy of Sciences

    Sylvia Hewitt

  43. FOXA1 is an essential determinant of ER  expression and mammary ductal morphogenesis

    Article • Development, May 2010, The Company of Biologists

    Sylvia Hewitt

  44. Estrogen Down-regulation of theScxGene Is Mediated by the Opposing Strand-overlapping GeneBop1

    Article • Journal of Biological Chemistry, December 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Sylvia Hewitt

  45. Selective Disruption of ERα DNA-Binding Activity Alters Uterine Responsiveness to Estradiol

    Article • Molecular Endocrinology, December 2009, Endocrine Society

    Sylvia Hewitt

  46. Estrogen-mediated Regulation of Igf1 Transcription and Uterine Growth Involves Direct Binding of Estrogen Receptor α to Estrogen-responsive Elements

    Article • Journal of Biological Chemistry, November 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Sylvia Hewitt

  47. Profile of estrogen-responsive genes in an estrogen-specific mammary gland outgrowth model

    Article • Molecular Reproduction and Development, August 2009, Wiley

    Sylvia Hewitt

  48. Diarylheptanoid Phytoestrogens Isolated from the Medicinal Plant Curcuma comosa : Biologic Actions in Vitro and in Vivo Indicate Estrogen Receptor–Dependent Mechanisms...

    Article • Environmental Health Perspectives, July 2009, Environmental Health Perspectives

    Sylvia Hewitt

  49. An Estrogen Receptor-α Knock-In Mutation Provides Evidence of Ligand-Independent Signaling and Allows Modulation of Ligand-Induced Pathwaysin Vivo

    Article • Endocrinology, June 2008, Endocrine Society

    Sylvia Hewitt

  50. The Five W’s of Progesterone Receptors A and B: Now We Know Where and When

    Article • Endocrinology, December 2006, Endocrine Society

    Sylvia Hewitt

  51. Estrogen-induced Proliferation of Uterine Epithelial Cells Is Independent of Estrogen Receptor α Binding to Classical Estrogen Response Elements

    Article • Journal of Biological Chemistry, July 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Sylvia Hewitt

  52. Estren Behaves as a Weak Estrogen Rather than a Nongenomic Selective Activator in the Mouse Uterus

    Article • Endocrinology, May 2006, Endocrine Society

    Sylvia Hewitt

  53. Upregulation of estrogen receptor expression in the uterus of ovariectomized B6C3F1 mice and Ishikawa cells treated with bromoethane

    Article • Toxicology and Applied Pharmacology, December 2005, Elsevier

    Sylvia Hewitt

  54. LESSONS IN ESTROGEN BIOLOGY FROM KNOCKOUT AND TRANSGENIC ANIMALS

    Article • Annual Review of Physiology, March 2005, Annual Reviews

    Sylvia Hewitt

  55. SIGNAL TRANSDUCTION: A New Mediator for an Old Hormone?

    Article • Science, March 2005, American Association for the Advancement of Science

    Sylvia Hewitt

  56. Global Uterine Genomicsin Vivo:Microarray Evaluation of the Estrogen Receptor α-Growth Factor Cross-Talk Mechanism

    Article • Molecular Endocrinology, March 2005, Endocrine Society

    Sylvia Hewitt

  57. Estradiol Regulates the Thioredoxin Antioxidant System in the Mouse Uterus

    Article • Endocrinology, December 2004, Endocrine Society

    Sylvia Hewitt

  58. Estrogen Receptor-Dependent Genomic Responses in the Uterus Mirror the Biphasic Physiological Response to Estrogen

    Article • Molecular Endocrinology, October 2003, Endocrine Society

    Sylvia Hewitt

  59. Update on animal models developed for analyses of estrogen receptor biological activity

    Article • The Journal of Steroid Biochemistry and Molecular Biology, September 2003, Elsevier

    Sylvia Hewitt

  60. Oestrogen receptor knockout mice: roles for oestrogen receptors alpha and beta in reproductive tissues

    Article • Reproduction, February 2003, Bioscientifica

    Sylvia Hewitt

  61. Article • Reviews in Endocrine and Metabolic Disorders, January 2002, Springer Science + Business Media

    Sylvia Hewitt

  62. Requirement of Estrogen Receptor-α in Insulin-like Growth Factor-1 (IGF-1)-induced Uterine Responses andin VivoEvidence for IGF-1/Estrogen Receptor Cross-talk

    Article • Journal of Biological Chemistry, December 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Sylvia Hewitt

  63. Abolition of male sexual behaviors in mice lacking estrogen receptors α and β (αβERKO)

    Article • Proceedings of the National Academy of Sciences, December 2000, Proceedings of the National Academy of Sciences

    Sylvia Hewitt

  64. Progesterone action and responses in the αERKO mouse

    Article • Steroids, November 2000, Elsevier

    Sylvia Hewitt

  65. Receptor null mice reveal contrasting roles for estrogen receptor α and β in reproductive tissues

    Article • The Journal of Steroid Biochemistry and Molecular Biology, November 2000, Elsevier

    Sylvia Hewitt

  66. Estrogen receptor transcription and transactivation Estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action

    Article • October 2000, Springer Science + Business Media

    Sylvia Hewitt

  67. Activation of a Uterine Insulin-Like Growth Factor I Signaling Pathway by Clinical and Environmental Estrogens: Requirement of Estrogen Receptor-α

    Article • Endocrinology, September 2000, Endocrine Society

    Sylvia Hewitt

  68. Induction of Mammary Gland Development in Estrogen Receptor-α Knockout Mice

    Article • Endocrinology, August 2000, Endocrine Society

    Sylvia Hewitt

  69. Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors  and  

    Article • Science, December 1999, American Association for the Advancement of Science

    Sylvia Hewitt

  70. Abstract

    Article • eLife

    Sylvia Hewitt