All Stories

  1. ConMedNP: a natural product library from Central African medicinal plants for drug discovery

    Article • RSC Advances, January 2014, Royal Society of Chemistry

    Professor Simon mbua Ngale Efange

  2. 1-Aryl-1,2,3,4-tetrahydroisoquinolines as potential antimalarials: synthesis, in vitro antiplasmodial activity and in silico pharmacokinetics evaluation

    Article • RSC Advances, January 2014, Royal Society of Chemistry

    Professor Simon mbua Ngale Efange

  3. How “drug-like” are naturally occurring anti-cancer compounds?

    Article • Journal of Molecular Modeling, January 2014, Springer Science + Business Media

    Professor Simon mbua Ngale Efange

  4. AfroDb: A Select Highly Potent and Diverse Natural Product Library from African Medicinal Plants

    Article • PLoS ONE, October 2013, PLOS

    Professor Simon mbua Ngale Efange, Dr Smith B. Babiaka, Humboldt Fellow

  5. Isolation and identification of an antiparasitic triterpenoid estersaponin from the stem bark of Pittosporum mannii (Pittosporaceae)

    Article • Asian Pacific Journal of Tropical Disease, October 2013, Elsevier

    Professor Simon mbua Ngale Efange, Professor Alain Meli Lannang

  6. In silico drug metabolism and pharmacokinetic profiles of natural products from medicinal plants in the Congo basin

    Article • In Silico Pharmacology, August 2013, Springer Science + Business Media

    Professor Simon mbua Ngale Efange

  7. Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification

    Article • BMC Complementary and Alternative Medicine, June 2013, Springer Science + Business Media

    Professor Simon mbua Ngale Efange

  8. CamMedNP: Building the Cameroonian 3D structural natural products database for virtual screening

    Article • BMC Complementary and Alternative Medicine, April 2013, Springer Science + Business Media

    Professor Simon mbua Ngale Efange

  9. Bioactive natural products derived from the Central African flora against neglected tropical diseases and HIV

    Article • Natural Product Reports, January 2013, Royal Society of Chemistry

    Professor Simon mbua Ngale Efange

  10. Assessing the pharmacokinetic profile of the CamMedNP natural products database: an in silico approach

    Article • Organic and Medicinal Chemistry Letters, January 2013, Springer Science + Business Media

    Professor Simon mbua Ngale Efange

  11. Bioassay-guided discovery of antibacterial agents: in vitro screening of Peperomia vulcanica, Peperomia fernandopoioana and Scleria striatinux

    Article • Annals of Clinical Microbiology and Antimicrobials, January 2012, Springer Science + Business Media

    Professor Simon mbua Ngale Efange

  12. ChemInform Abstract: Flexible N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Analogues: Synthesis and Monoamine Oxidase-Catalyzed Bioactivation.

    Article • ChemInform, August 2010, Wiley

    Professor Simon mbua Ngale Efange

  13. ChemInform Abstract: Interaction of Tetrahydrostilbazoles with Monoamine Oxidase A and B.

    Article • ChemInform, August 2010, Wiley

    Professor Simon mbua Ngale Efange

  14. Synthesis andin VitroBiological Evaluation of Carbonyl Group-Containing Inhibitors of Vesicular Acetylcholine Transporter

    Article • Journal of Medicinal Chemistry, April 2010, American Chemical Society (ACS)

    Robert H. Mach, Professor Simon mbua Ngale Efange

  15. UPLC/TOF-MS methodology for the on-line identification of secondary metabolites in four Scleria species (Cyperaceae): S. striatonux, S. verrucosa, S. boivinii and S. naumaniana

    Article • Planta Medica, July 2009, Thieme Publishing Group

    Professor Simon mbua Ngale Efange

  16. Synthesis and in Vitro and in Vivo Evaluation of 18F-Labeled Positron Emission Tomography (PET) Ligands for Imaging the Vesicular Acetylcholine Transporter

    Article • Journal of Medicinal Chemistry, February 2009, American Chemical Society (ACS)

    Robert H. Mach, Professor Simon mbua Ngale Efange

  17. Okundoperoxide, a Bicyclic Cyclofarnesylsesquiterpene Endoperoxide from Scleria striatinux with Antiplasmodial Activity

    Article • Journal of Natural Products, February 2009, American Chemical Society (ACS)

    Professor Simon mbua Ngale Efange

  18. In vitro anti-Helicobacter pylori activity of extracts of selected medicinal plants from North West Cameroon

    Article • Journal of Ethnopharmacology, December 2007, Elsevier

    Professor Simon mbua Ngale Efange

  19. Isolation and structure eucidation of novel antimalarial compounds from the Cameroonian spice Scleria striatonux De Wild (Cyperaceae)

    Article • Planta Medica, January 2007, Thieme Publishing Group

    Professor Simon mbua Ngale Efange

  20. Nature-inspired indolyl-2-azabicyclo[2.2.2]oct-7-ene derivatives as promising agents for the attenuation of withdrawal symptoms: synthesis of 20-desethyl-20-hydroxymethyl-11-demethoxyibogaine

    Article • Natural Product Research, July 2006, Taylor & Francis

    Professor Simon mbua Ngale Efange

  21. Corporate Governance

    Article • September 2004, Oxford University Press (OUP)

    Professor Simon mbua Ngale Efange

  22. Natural Products: A Continuing Source of Inspiration for the Medicinal Chemist

    Article • ChemInform, July 2003, Wiley

    Professor Simon mbua Ngale Efange

  23. Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

    Article • Bioorganic & Medicinal Chemistry, March 2003, Elsevier

    Professor Simon mbua Ngale Efange

  24. Chromaproline and Chromaperidine, nicotine agonists, and Donepezil, cholinesterase inhibitor, enhance performance of memory tasks in ovariectomized rats

    Article • Pharmacology Biochemistry and Behavior, December 2002, Elsevier

    Professor Simon mbua Ngale Efange

  25. Natural products: a continuing source of inspiration for the medicinal chemist

    Article • January 2002, Elsevier

    Professor Simon mbua Ngale Efange

  26. 2-(2-Piperidyl)- and 2-(2-Pyrrolidyl)chromans as Nicotine Agonists:  Synthesis and Preliminary Pharmacological Characterization

    Article • Journal of Medicinal Chemistry, November 2001, American Chemical Society (ACS)

    Professor Simon mbua Ngale Efange

  27. Morphine-induced spinal cholinergic activation: in vivo imaging with positron emission tomography

    Article • Pain, March 2001, Wolters Kluwer Health

    Robert H. Mach, Professor Simon mbua Ngale Efange

  28. Invivoimaging of the vesicular acetylcholine transporter and the vesicular monoamine transporter

    Article • The FASEB Journal, December 2000, Wiley

    Professor Simon mbua Ngale Efange

  29. Synthesis and biological characterization of stable and radioiodinated (±)-trans-2-hydroxy-3-P{4-(3-iodophenyl)piperidyl}-1,2,3,4-tetrahydronaphthalene (3′-IBVM)

    Article • Nuclear Medicine and Biology, November 2000, Elsevier

    Professor Simon mbua Ngale Efange

  30. Late Shakespeare

    Article • January 2000, Oxford University Press (OUP)

    Professor Simon mbua Ngale Efange

  31. Cholinergic activity of aged rhesus monkeys revealed by positron emission tomography

    Article • Synapse, January 2000, Wiley

    Robert H. Mach, Professor Simon mbua Ngale Efange

  32. EVesamicolffects of a Novel Vesamicol Receptor Ligand, m-(Iodobenzyl)trozamicol, on the Canine Isolated, Blood-Perfused Atrioventricular Node Preparation.

    Article • The Japanese Journal of Pharmacology, January 2000, Japanese Pharmacological Society

    Professor Simon mbua Ngale Efange

  33. Direct Cardiac Effects of a Novel Vesamicol Receptor Ligand, m-Iodobenzyl-Trozamicol, Assessed in the Canine Isolated, Blood-Perfused Heart Preparations

    Article • Journal of Cardiovascular Pharmacology, December 1999, Wolters Kluwer Health

    Professor Simon mbua Ngale Efange

  34. N-(3-iodophenyl)trozamicol (IPHT) and related inhibitors of vesicular acetylcholine transport: synthesis and preliminary biological characterization

    Article • Nuclear Medicine and Biology, August 1999, Elsevier

    Professor Simon mbua Ngale Efange

  35. Hydroxylated Decahydroquinolines as Ligands for the Vesicular Acetylcholine Transporter:  Synthesis and Biological Evaluation

    Article • Journal of Medicinal Chemistry, July 1999, American Chemical Society (ACS)

    Robert H. Mach, Professor Simon mbua Ngale Efange

  36. ChemInform Abstract: Modified Ibogaine Fragments: Synthesis and Preliminary Pharmacological Characterization of 3‐Ethyl‐5‐phenyl‐1,2,3,4,5,6‐hexahydroazepino[4,5‐b]benzothiophenes.

    Article • ChemInform, March 1999, Wiley

    Professor Simon mbua Ngale Efange

  37. (+)-p-([18F]fluorobenzyl)spirotrozamicol {(+)-[18F]Spiro-FBT}: synthesis and biological evaluation of a high-affinity ligand for the vesicular acetylcholine transporter (VAChT)

    Article • Nuclear Medicine and Biology, February 1999, Elsevier

    Professor Simon mbua Ngale Efange

  38. In Vivo Imaging of the Spinal Cord Cholinergic System with PET

    Article • Journal of Computer Assisted Tomography, January 1999, Wolters Kluwer Health

    Robert H. Mach, Professor Simon mbua Ngale Efange

  39. Modified Ibogaine Fragments:  Synthesis and Preliminary Pharmacological Characterization of 3-Ethyl-5-phenyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]benzothiophenes

    Article • Journal of Medicinal Chemistry, September 1998, American Chemical Society (ACS)

    Professor Simon mbua Ngale Efange

  40. N-Hydroxyalkyl Derivatives of 3β-Phenyltropane and 1-Methylspiro[1H-indoline-3,4‘-piperidine]:  Vesamicol Analogues with Affinity for Monoamine Transporters

    Article • Journal of Medicinal Chemistry, November 1997, American Chemical Society (ACS)

    Robert H. Mach, Professor Simon mbua Ngale Efange

  41. Pharmacological characterization of the vesamicol analogue (+)-[ ]MIBT in primate brain

    Article • European Journal of Pharmacology, November 1997, Elsevier

    Professor Simon mbua Ngale Efange

  42. Vesicular Acetylcholine Transporter Density and Alzheimer’s Disease

    Article • Neurobiology of Aging, July 1997, Elsevier

    Professor Simon mbua Ngale Efange

  43. Imaging of cholinergic terminals using the radiotracer [18F](+)-4-fluorobenzyltrozamicol: In vitro binding studies and positron emission tomography studies in nonhuman primates

    Article • Synapse, April 1997, Wiley

    Robert H. Mach, Professor Simon mbua Ngale Efange

  44. Vesicular acetylcholine transport inhibitor suppresses REM sleep

    Article • Neuroreport, January 1997, Wolters Kluwer Health

    Professor Simon mbua Ngale Efange

  45. Measurement of functional cholinergic innervation in rat heart with a novel vesamicol receptor ligand

    Article • Nuclear Medicine and Biology, October 1996, Elsevier

    Professor Simon mbua Ngale Efange

  46. The vesamicol receptor ligand (+)-meta-[1251]iodobenzyltrozamicol {(+)-[125¦]-MIBT} reveals blunting of the striatal cholinergic response to dopamine D2 receptor blockade in the 6-hydroxydopamine (6-OHDA)-lesioned rat: Possible implications for parkins...

    Article • Life Sciences, March 1996, Elsevier

    Professor Simon mbua Ngale Efange

  47. Comparative tissue distribution of conformationally restricted radioiodinated vesamicol receptor ligands

    Article • Nuclear Medicine and Biology, May 1995, Elsevier

    Professor Simon mbua Ngale Efange

  48. Vesamicol analogues as sigma ligands

    Article • Biochemical Pharmacology, March 1995, Elsevier

    Robert H. Mach, Professor Simon mbua Ngale Efange

  49. Spirovesamicols: Conformationally Restricted Analogs of 2-(4-Phenylpiperidino)cyclohexanol (Vesamicol, AH5183) as Potential Modulators of Presynaptic Cholinergic Function

    Article • Journal of Medicinal Chemistry, August 1994, American Chemical Society (ACS)

    Professor Simon mbua Ngale Efange

  50. Oxidation Products Arising from the Action of Monoamine Oxidase B on 1‐Methyl‐4‐Benzyl‐1,2,3,6‐Tetrahydropyridine, a Nonneurotoxic Analogue of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine

    Article • Journal of Neurochemistry, May 1994, Wiley

    Professor Simon mbua Ngale Efange

  51. p-[18F]fluorobenzyltrozamicol ([18F]FBT): Molecular decomposition-reconstitution approach to vesamicol receptor radioligands for positron emission tomography

    Article • Applied Radiation and Isotopes, April 1994, Elsevier

    Professor Simon mbua Ngale Efange

  52. Interaction of tetrahydrostilbazoles with monoamine oxidase A and B

    Article • Journal of Medicinal Chemistry, January 1994, American Chemical Society (ACS)

    Professor Simon mbua Ngale Efange, Sergey Bachurin

  53. Synthesis and tissue distribution of iodine-125-labeled (m-[125I]iodobenzyl)trozamicol ([125I]MIBT): potential radioligand for mapping central cholinergic innervation

    Article • Journal of Medicinal Chemistry, June 1993, American Chemical Society (ACS)

    Professor Simon mbua Ngale Efange

  54. Synthesis and biological evaluation of radioiodinated N-2-(4-piperidyl)ethyl benzamides

    Article • Nuclear Medicine and Biology, May 1993, Elsevier

    Professor Simon mbua Ngale Efange

  55. Nonsymmetrical bipiperidyls as inhibitors of vesicular acetylcholine storage

    Article • Journal of Medicinal Chemistry, April 1993, American Chemical Society (ACS)

    Professor Simon mbua Ngale Efange

  56. Molecular size and flexibility as determinants of selectivity in the oxidation of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs by monoamine oxidase A and B

    Article • Journal of Medicinal Chemistry, April 1993, American Chemical Society (ACS)

    Professor Simon mbua Ngale Efange

  57. Lipophilic amino alcohols with calcium channel blocking activity

    Article • Biochemical Pharmacology, November 1992, Elsevier

    Professor Simon mbua Ngale Efange

  58. Computer-Aided Radiopharmaceutical Design

    Article • Investigative Radiology, August 1992, Wolters Kluwer Health

    Professor Simon mbua Ngale Efange

  59. Interaction of flexible analogs of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and of N-methyl-4-phenylpyridinium with highly purified monoamine oxidase A and B

    Article • Biochemistry, June 1992, American Chemical Society (ACS)

    Professor Simon mbua Ngale Efange

  60. Radioiodinated 2-hydroxy-3-(4-iodophenyl)-1-(4-phenylpiperidinyl)propane: Potential radiotracer for mapping central cholinergic innervation in vivo

    Article • International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology, April 1992, Elsevier

    Professor Simon mbua Ngale Efange

  61. Textbook of Radiopharmacy: Theory and Practice

    Article • Radiology, January 1992, Radiological Society of North America (RSNA)

    Professor Simon mbua Ngale Efange

  62. APPLICATIONS OF COMPUTATIONAL CHEMISTRY IN RADIOPHARMACEUTICAL DESIGNE

    Article • Investigative Radiology, December 1991, Wolters Kluwer Health

    Professor Simon mbua Ngale Efange

  63. APPLICATIONS OF COMPUTATIONAL CHEMISTRY IN RADIOPHARMACEUTICAL DESIGN

    Article • Investigative Radiology, December 1991, Wolters Kluwer Health

    Professor Simon mbua Ngale Efange

  64. Molecular determinants in the bioactivation of the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

    Article • Journal of Computer-Aided Molecular Design, October 1991, Springer Science + Business Media

    Professor Simon mbua Ngale Efange

  65. Synthesis and Biological Activity of 5-halo-2-Pyrimidinone 3′-Azido-2′,3′-Dideoxyribosides

    Article • Nucleosides and Nucleotides, October 1991, Taylor & Francis

    Professor Simon mbua Ngale Efange

  66. Acyclic analogs of 2-(4-phenylpiperidino)cyclohexanol (vesamicol): conformationally mobile inhibitors of vesicular acetylcholine transport

    Article • Journal of Medicinal Chemistry, August 1991, American Chemical Society (ACS)

    Professor Simon mbua Ngale Efange

  67. Characterization and Distribution of Transferrin Receptors in the Rat Brain

    Article • Journal of Neurochemistry, December 1990, Wiley

    Professor Simon mbua Ngale Efange

  68. THE CALCULATED EFFECTS OF N-FLUOROALKYLATION OF RACLOPRIDE ON MOLECULAR CONFORMATION AND ELECTRON DISTRIBUTION

    Article • Investigative Radiology, December 1990, Wolters Kluwer Health

    Professor Simon mbua Ngale Efange

  69. Flexible N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analog: synthesis and monoamine oxidase catalyzed bioactivation

    Article • Journal of Medicinal Chemistry, December 1990, American Chemical Society (ACS)

    Professor Simon mbua Ngale Efange

  70. Synthesis and Applications of Isotopically Labelled Compounds

    Article • Radiology, August 1990, Radiological Society of North America (RSNA)

    Professor Simon mbua Ngale Efange

  71. Potential environmental neurotoxins related to 1-methyl-4-phenylpyridinium: Selective toxicity of 1-methyl-4-(4′-acetamidophenyl)-pyridinium and 1-methyl-4-cyclohexylpyridinium for dopaminergic neurons in culture

    Article • Experimental Neurology, May 1990, Elsevier

    Professor Simon mbua Ngale Efange

  72. Pargyline-Sensitive selective accumulation of a radiolabeled MPTP analog in the primate cerebral cortex and basal ganglia

    Article • Synapse, January 1990, Wiley

    Professor Simon mbua Ngale Efange

  73. Radiopharmacy and Radiopharmacology Yearbook

    Article • Radiology, November 1989, Radiological Society of North America (RSNA)

    Professor Simon mbua Ngale Efange

  74. Selective Visualization of Rodent Locus Ceruleus by a Radiolabeled N‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Analog

    Article • Journal of Neurochemistry, August 1989, Wiley

    Professor Simon mbua Ngale Efange

  75. Anti-herpes simplex virus activity of 5-substituted 2-pyrimidinone nucleosides.

    Article • Antimicrobial Agents and Chemotherapy, March 1989, ASM Journals

    Professor Simon mbua Ngale Efange

  76. Synthesis and biodistribution of 99mTc-labeled piperidinyl bis(aminoethanethiol) complexes: potential brain perfusion imaging agents for single photon emission computed tomography

    Article • Journal of Medicinal Chemistry, May 1988, American Chemical Society (ACS)

    Professor Simon mbua Ngale Efange

  77. Toxicity of Structural Analogs of 1-methyl-4-Phenyl Pyridinium (MPP+) and Related Compounds on Dopaminergic Neurons in Culture

    Article • January 1988, Springer Science + Business Media

    Professor Simon mbua Ngale Efange

  78. Synthesis and biological activities of 2-Pyrimidinone Nucleosides. III.1,25-Alkynyl-2-Pyrimidinone 2′-Deoxyribosides

    Article • Nucleosides and Nucleotides, December 1985, Taylor & Francis

    Professor Simon mbua Ngale Efange

  79. Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribosides

    Article • Journal of Medicinal Chemistry, July 1985, American Chemical Society (ACS)

    Professor Simon mbua Ngale Efange

  80. Caney, Simon

    Article • Springer Science + Business Media

    Professor Simon mbua Ngale Efange