All Stories

  1. Synthesis and evaluation of an AZD2461 [18F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant

    Article • Bioorganic Chemistry, March 2019, Elsevier

    Robert H. Mach

  2. TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death

    Article • Cell Death Discovery, January 2019, Springer Science + Business Media

    Robert H. Mach

  3. Cell-proliferation imaging for monitoring response to CDK4/6 inhibition combined with endocrine-therapy in breast cancer: Comparison of [18F]FLT and [18F]ISO-1 PET/CT

    Article • Clinical Cancer Research, January 2019, American Association for Cancer Research (AACR)

    Robert H. Mach

  4. Selectivity of probes for PET imaging of dopamine D3 receptors

    Article • Neuroscience Letters, January 2019, Elsevier

    Robert H. Mach

  5. Dopamine D3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors

    Article • Pharmacology Biochemistry and Behavior, December 2018, Elsevier

    Robert H. Mach

  6. Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex

    Article • Scientific Reports, November 2018, Springer Science + Business Media

    Robert H. Mach

  7. Validation of gallbladder absorbed radiation dose reduction simulation: human dosimetry of [18F]fluortriopride

    Article • EJNMMI Physics, October 2018, Springer Science + Business Media

    Robert H. Mach

  8. Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly(ADP-ribose) Polymerase-1 Inhibitors with Decreased P-Glycoprotein Interactions

    Article • ACS Omega, August 2018, American Chemical Society (ACS)

    Robert H. Mach

  9. Analogues of Arylamide Phenylpiperazine Ligands To Investigate the Factors Influencing D3 Dopamine Receptor Bitropic Binding and Receptor Subtype Selectivity

    Article • ACS Chemical Neuroscience, July 2018, American Chemical Society (ACS)

    Robert H. Mach

  10. Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity

    Article • Journal of Medicinal Chemistry, June 2018, American Chemical Society (ACS)

    Robert H. Mach

  11. Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules

    Article • ACS Chemical Neuroscience, May 2018, American Chemical Society (ACS)

    Robert H. Mach

  12. Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro

    Article • ACS Omega, April 2018, American Chemical Society (ACS)

    Robert H. Mach

  13. A PET imaging agent for evaluating PARP-1 expression in ovarian cancer

    Article • Journal of Clinical Investigation, April 2018, American Society for Clinical Investigation

    Robert H. Mach

  14. Open letter to journal editors on: International consensus radiochemistry nomenclature guidelines

    Article • Journal of Labelled Compounds, April 2018, Wiley

    Robert H. Mach

  15. Design, synthesis, and in vitro evaluation of quinolinyl analogues for α-synuclein aggregation

    Article • Bioorganic & Medicinal Chemistry Letters, April 2018, Elsevier

    Robert H. Mach

  16. Rapid Cu-Catalyzed [211At]Astatination and [125I]Iodination of Boronic Esters at Room Temperature

    Article • Organic Letters, March 2018, American Chemical Society (ACS)

    Robert H. Mach

  17. PET Imaging of Microglial Activation—Beyond Targeting TSPO

    Article • Molecules, March 2018, MDPI AG

    Robert H. Mach

  18. Synthesis and pharmacological evaluation of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as sigma-2 receptor ligands

    Article • European Journal of Medicinal Chemistry, March 2018, Elsevier

    Robert H. Mach

  19. Copper Loading of Preformed Nanoparticles for PET-Imaging Applications

    Article • ACS Applied Materials & Interfaces, January 2018, American Chemical Society (ACS)

    Robert H. Mach

  20. Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores

    Article • Journal of Medicinal Chemistry, November 2017, American Chemical Society (ACS)

    Robert H. Mach

  21. Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation

    Article • ACS Chemical Neuroscience, November 2017, American Chemical Society (ACS)

    Robert H. Mach

  22. Inflammation and DNA damage: Probing pathways to cancer and neurodegeneration

    Article • Drug Discovery Today Technologies, November 2017, Elsevier

    Robert H. Mach

  23. Challenges in the development of dopamine D2- and D3-selective radiotracers for PET imaging studies

    Article • Journal of Labelled Compounds, September 2017, Wiley

    Robert H. Mach

  24. Small Molecule Receptor Ligands for PET Studies of the Central Nervous System—Focus on G Protein Coupled Receptors

    Article • Seminars in Nuclear Medicine, September 2017, Elsevier

    Robert H. Mach

  25. Bacterial infection imaging with [ 18 F]fluoropropyl-trimethoprim

    Article • Proceedings of the National Academy of Sciences, July 2017, Proceedings of the National Academy of Sciences

    Robert H. Mach

  26. Sigma-2 ligands and PARP inhibitors synergistically trigger cell death in breast cancer cells

    Article • Biochemical and Biophysical Research Communications, May 2017, Elsevier

    Robert H. Mach

  27. The role of beta-arrestin2 in shaping fMRI BOLD responses to dopaminergic stimulation

    Article • Psychopharmacology, April 2017, Springer Science + Business Media

    Robert H. Mach

  28. [ 18 F](2 S ,4 R )4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition

    Article • Cancer Research, February 2017, American Association for Cancer Research (AACR)

    Robert H. Mach

  29. Design and Investigation of a [18F]-Labeled Benzamide Derivative as a High Affinity Dual Sigma Receptor Subtype Radioligand for Prostate Tumor Imaging

    Article • Molecular Pharmaceutics, February 2017, American Chemical Society (ACS)

    Robert H. Mach

  30. PARP-1 Expression Quantified by [18F]FluorThanatrace: A Biomarker of Response to PARP Inhibition Adjuvant to Radiation Therapy

    Article • Cancer Biotherapy & Radiopharmaceuticals, February 2017, Mary Ann Liebert Inc

    Robert H. Mach

  31. PET of Poly (ADP-Ribose) Polymerase Activity in Cancer: Preclinical Assessment and First In-Human Studies

    Article • Radiology, February 2017, Radiological Society of North America (RSNA)

    Robert H. Mach

  32. The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer

    Article • Journal of Experimental & Clinical Cancer Research, January 2017, Springer Science + Business Media

    Robert H. Mach

  33. A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers

    Article • JCI Insight, January 2017, American Society for Clinical Investigation

    Robert H. Mach

  34. The Evolution of the Sigma-2 (σ2) Receptor from Obscure Binding Site to Bona Fide Therapeutic Target

    Article • January 2017, Springer Science + Business Media

    Robert H. Mach

  35. Quantitative PET Reporter Gene Imaging with [ 11 C]Trimethoprim

    Article • Molecular Therapy, January 2017, Elsevier

    Robert H. Mach

  36. Iodinated benzimidazole PARP radiotracer for evaluating PARP1/2 expression in vitro and in vivo

    Article • Nuclear Medicine and Biology, December 2016, Elsevier

    Robert H. Mach

  37. Comparative evaluation of 4 and 6-carbon spacer conformationally flexible tetrahydroisoquinolinyl benzamide analogues for imaging the sigma-2 receptor status of solid tumors

    Article • Nuclear Medicine and Biology, November 2016, Elsevier

    Robert H. Mach

  38. Automation of the Radiosynthesis of Six Different 18F-labeled radiotracers on the AllinOne

    Article • EJNMMI Radiopharmacy and Chemistry, October 2016, Springer Science + Business Media

    Robert H. Mach

  39. The effect of the sigma-1 receptor selective compound LS-1-137 on the DOI-induced head twitch response in mice

    Article • Pharmacology Biochemistry and Behavior, September 2016, Elsevier

    Robert H. Mach

  40. 4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies

    Article • Chemistry Central Journal, August 2016, Springer Science + Business Media

    Robert H. Mach

  41. A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy

    Article • Cancer Research, June 2016, American Association for Cancer Research (AACR)

    Robert H. Mach

  42. Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic

    Article • Oncotarget, May 2016, Impact Journals, LLC

    Robert H. Mach

  43. Novel Strategies for Breast Cancer Imaging: New Imaging Agents to Guide Treatment

    Article • Journal of Nuclear Medicine, February 2016, Society of Nuclear Medicine

    Robert H. Mach

  44. Molecular Probes for Imaging the Sigma-2 Receptor: In Vitro and In Vivo Imaging Studies

    Article • January 2016, Springer Science + Business Media

    Robert H. Mach

  45. Improved Automated Radiosynthesis of [11C]PBR28

    Article • Scientia Pharmaceutica, January 2015, MDPI AG

    Robert H. Mach

  46. Automated radiochemical synthesis and biodistribution of [11C]l-α-acetylmethadol ([11C]LAAM)

    Article • Applied Radiation and Isotopes, September 2014, Elsevier

    Robert H. Mach

  47. Characterization of [3H]LS‐3‐134, a novel arylamide phenylpiperazine D3 dopamine receptor selective radioligand

    Article • Journal of Neurochemistry, August 2014, Wiley

    Robert H. Mach

  48. Pharmacological modulation of abnormal involuntary DOI-induced head twitch response in male DBA/2J mice: I. Effects of D2/D3 and D2 dopamine receptor selective compounds

    Article • Neuropharmacology, August 2014, Elsevier

    Robert H. Mach

  49. Synthesis and Structure–Activity Relationship Studies of Conformationally Flexible Tetrahydroisoquinolinyl Triazole Carboxamide and Triazole Substituted Benzamide Analogues as σ2 Receptor Ligands

    Article • Journal of Medicinal Chemistry, May 2014, American Chemical Society (ACS)

    Robert H. Mach

  50. Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV‐134

    Article • Molecular Oncology, March 2014, Wiley

    Robert H. Mach

  51. Using SV119‐Gold Nanocage Conjugates to Eradicate Cancer Stem Cells Through a Combination of Photothermal and Chemo Therapies

    Article • Advanced Healthcare Materials, March 2014, Wiley

    Robert H. Mach

  52. Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein

    Article • Applied Sciences, March 2014, MDPI AG

    Robert H. Mach

  53. Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer

    Article • Molecular Cancer, March 2014, Springer Science + Business Media

    Robert H. Mach

  54. Functional assays to define agonists and antagonists of the sigma-2 receptor

    Article • Analytical Biochemistry, March 2014, Elsevier

    Robert H. Mach

  55. Synthesis, [18F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography

    Article • Bioorganic & Medicinal Chemistry, March 2014, Elsevier

    Robert H. Mach

  56. Development of a PET radiotracer for non-invasive imaging of the reactive oxygen species, superoxide, in vivo

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Robert H. Mach

  57. Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats

    Article • Neuroscience Letters, December 2013, Elsevier

    Robert H. Mach

  58. Quantitative Receptor-Based Imaging of Tumor Proliferation with the Sigma-2 Ligand [18F]ISO-1

    Article • PLoS ONE, September 2013, PLOS

    Robert H. Mach

  59. Fos expression in response to dopamine D3-preferring phenylpiperazine drugs given with and without cocaine

    Article • Synapse, July 2013, Wiley

    Robert H. Mach

  60. The σ2 Receptor: A Novel Protein for the Imaging and Treatment of Cancer

    Article • Journal of Medicinal Chemistry, June 2013, American Chemical Society (ACS)

    Robert H. Mach

  61. Evaluation of N-phenyl homopiperazine analogs as potential dopamine D3 receptor selective ligands

    Article • Bioorganic & Medicinal Chemistry, June 2013, Elsevier

    Robert H. Mach, Professor David E Reichert

  62. Development of <sup>18</sup>F-Labeled PET Probes for Imaging Cell Proliferation

    Article • Current Topics in Medicinal Chemistry, May 2013, Bentham Science Publishers

    Robert H. Mach

  63. Positron emission tomography imaging of dopamine D2 receptors using a highly selective radiolabeled D2 receptor partial agonist

    Article • NeuroImage, May 2013, Elsevier

    Robert H. Mach

  64. Binding of the Radioligand SIL23 to α-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson Disease Imaging Agent

    Article • PLoS ONE, February 2013, PLOS

    Robert H. Mach

  65. Synthesis and in vitro pharmacological evaluation of indolyl carboxylic amide analogues as D3 dopamine receptor selective ligands

    Article • MedChemComm, January 2013, Royal Society of Chemistry

    Robert H. Mach

  66. The Effect of SV 293, a D2 Dopamine Receptor-Selective Antagonist, on D2 Receptor-Mediated GIRK Channel Activation and Adenylyl Cyclase Inhibition

    Article • Pharmacology, January 2013, Karger Publishers

    Robert H. Mach

  67. Dopamine D1, D2, D3 Receptors, Vesicular Monoamine Transporter Type-2 (VMAT2) and Dopamine Transporter (DAT) Densities in Aged Human Brain

    Article • PLoS ONE, November 2012, PLOS

    Robert H. Mach

  68. Highly efficient click labeling using 2-[18F]fluoroethyl azide and synthesis of an 18FN-hydroxysuccinimide ester as conjugation agent

    Article • Nuclear Medicine and Biology, November 2012, Elsevier

    Robert H. Mach

  69. Comparison of the Binding and Functional Properties of Two Structurally Different D2 Dopamine Receptor Subtype Selective Compounds

    Article • ACS Chemical Neuroscience, October 2012, American Chemical Society (ACS)

    Robert H. Mach, Professor David E Reichert

  70. Synthesis, radiolabeling and initial in vivo evaluation of [11C]KSM-01 for imaging PPAR-α receptors

    Article • Bioorganic & Medicinal Chemistry Letters, October 2012, Elsevier

    Robert H. Mach

  71. Therapeutic targeting of pancreatic cancer utilizing sigma-2 ligands

    Article • Surgery, September 2012, Elsevier

    Robert H. Mach

  72. Exploration of ring size in a series of cyclic vicinal diamines with σ1 receptor affinity

    Article • Bioorganic & Medicinal Chemistry Letters, September 2012, Elsevier

    Robert H. Mach

  73. IC‐O3‐02: Development of a CAA‐specific amyloid imaging tracer

    Article • Alzheimer s & Dementia, July 2012, Wiley

    Robert H. Mach

  74. Development of a cerebral amyloid angiopathy–specific amyloid imaging tracer

    Article • Alzheimer s & Dementia, July 2012, Elsevier

    Robert H. Mach

  75. Neuroprotective effects of high affinity sigma 1 receptor selective compounds

    Article • Brain Research, March 2012, Elsevier

    Robert H. Mach

  76. No Differential Regulation of Dopamine Transporter (DAT) and Vesicular Monoamine Transporter 2 (VMAT2) Binding in a Primate Model of Parkinson Disease

    Article • PLoS ONE, February 2012, PLOS

    Robert H. Mach

  77. Synthesis and evaluation of 18F-labeled PPARγ antagonists

    Article • Nuclear Medicine and Biology, January 2012, Elsevier

    Robert H. Mach

  78. SV119-gold nanocage conjugates: a new platform for targeting cancer cellsvia sigma-2 receptors

    Article • Nanoscale, January 2012, Royal Society of Chemistry

    Robert H. Mach

  79. Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody

    Article • Nuclear Medicine and Biology, January 2012, Elsevier

    Robert H. Mach

  80. PET imaging for attention deficit preclinical drug testing in neurofibromatosis-1 mice

    Article • Experimental Neurology, December 2011, Elsevier

    Robert H. Mach

  81. N-Arylalkyl-2-azaadamantanes as cage-expanded polycarbocyclic sigma (σ) receptor ligands

    Article • Bioorganic & Medicinal Chemistry Letters, September 2011, Elsevier

    Robert H. Mach

  82. Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A

    Article • European Journal of Medicinal Chemistry, September 2011, Elsevier

    Robert H. Mach

  83. Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum

    Article • Neuroreport, July 2011, Wolters Kluwer Health

    Robert H. Mach

  84. Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site

    Article • Nature Communications, July 2011, Springer Science + Business Media

    Robert H. Mach

  85. Effect of cyclosporin A on the uptake of D3-selective PET radiotracers in rat brain

    Article • Nuclear Medicine and Biology, July 2011, Elsevier

    Robert H. Mach

  86. Synthesis and characterization of selective dopamine D2 receptor ligands using aripiprazole as the lead compound

    Article • Bioorganic & Medicinal Chemistry, June 2011, Elsevier

    Robert H. Mach

  87. Sigma-2 Receptor as Potential Indicator of Stem Cell Differentiation

    Article • Molecular Imaging and Biology, May 2011, Springer Science + Business Media

    Robert H. Mach

  88. Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: Introduction of a hydrophilic group increases potency in a whole cell assay

    Article • Bioorganic & Medicinal Chemistry Letters, April 2011, Elsevier

    Robert H. Mach

  89. Endogenous dopamine (DA) competes with the binding of a radiolabeled D3 receptor partial agonist in vivo: A positron emission tomography study

    Article • Synapse, March 2011, Wiley

    Robert H. Mach

  90. p-Acetoxybenzyl Bromide

    Article • March 2011, Wiley

    Robert H. Mach

  91. Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain

    Article • Bioorganic & Medicinal Chemistry, March 2011, Elsevier

    Robert H. Mach

  92. Synthesis and Pharmacological Evaluation of Fluorine-Containing D3 Dopamine Receptor Ligands

    Article • Journal of Medicinal Chemistry, February 2011, American Chemical Society (ACS)

    Robert H. Mach

  93. Automated radiosynthesis of [11C]morphine for clinical investigation

    Article • Applied Radiation and Isotopes, February 2011, Elsevier

    Robert H. Mach

  94. Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy

    Article • Molecular Neurodegeneration, January 2011, Springer Science + Business Media

    Robert H. Mach

  95. Radiosynthesis and biological evaluation of a promising σ2-receptor ligand radiolabeled with fluorine-18 or iodine-125 as a PET/SPECT probe for imaging breast cancer

    Article • Applied Radiation and Isotopes, December 2010, Elsevier

    Robert H. Mach

  96. The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine

    Article • Molecular Cancer, November 2010, Springer Science + Business Media

    Robert H. Mach

  97. Synthesis and Evaluation of 15-(4-(2-[18F]Fluoroethoxy)phenyl)pentadecanoic Acid: A Potential PET Tracer for Studying Myocardial Fatty Acid Metabolism

    Article • Bioconjugate Chemistry, November 2010, American Chemical Society (ACS)

    Robert H. Mach

  98. Decreased striatal dopamine receptor binding in primary focal dystonia: A D2 or D3 defect?

    Article • Movement Disorders, October 2010, Wiley

    Robert H. Mach

  99. Subtype Selectivity of Dopamine Receptor Ligands: Insights from Structure and Ligand-Based Methods

    Article • Journal of Chemical Information and Modeling, October 2010, American Chemical Society (ACS)

    Robert H. Mach, Professor David E Reichert

  100. Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626

    Article • Bioorganic & Medicinal Chemistry, July 2010, Elsevier

    Robert H. Mach

  101. Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A: radiosynthesis, in vitro and in vivo evaluation

    Article • Nuclear Medicine and Biology, May 2010, Elsevier

    Robert H. Mach

  102. Synthesis andin VitroBiological Evaluation of Carbonyl Group-Containing Inhibitors of Vesicular Acetylcholine Transporter

    Article • Journal of Medicinal Chemistry, April 2010, American Chemical Society (ACS)

    Robert H. Mach, Professor Simon mbua Ngale Efange

  103. Radiochemical Synthesis, Rodent Biodistribution and Tumor Uptake, and Dosimetry Calculations of [11C] Methylated LY2181308

    Article • Molecular Imaging and Biology, April 2010, Springer Science + Business Media

    Robert H. Mach

  104. Challenges for Developing PET Tracers: Isotopes, Chemistry, and Regulatory Aspects

    Article • PET Clinics, April 2010, Elsevier

    Robert H. Mach

  105. Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system

    Article • Brain Research, March 2010, Elsevier

    Robert H. Mach

  106. [3H]4‐(dimethylamino)‐N‐(4‐(4‐(2‐methoxyphenyl)piperazin‐1‐yl) butyl)benzamide: A selective radioligand for dopamine D3 receptors. II. Quantitative analysis of dopamine D3 and D2 receptor density ratio...

    Article • Synapse, February 2010, Wiley

    Robert H. Mach

  107. Cerebrospinal fluid tau and ptau 181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease

    Article • EMBO Molecular Medicine, November 2009, EMBO

    Robert H. Mach

  108. Using prepulse inhibition to detect functional D3 receptor antagonism: Effects of WC10 and WC44

    Article • Pharmacology Biochemistry and Behavior, August 2009, Elsevier

    Robert H. Mach

  109. Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography

    Article • Nuclear Medicine and Biology, August 2009, Elsevier

    Robert H. Mach

  110. Docking and 3D-QSAR Studies on Isatin Sulfonamide Analogues as Caspase-3 Inhibitors

    Article • Journal of Chemical Information and Modeling, July 2009, American Chemical Society (ACS)

    Robert H. Mach, Professor David E Reichert

  111. [3H]4‐(Dimethylamino)‐N‐[4‐(4‐(2‐methoxyphenyl)piperazin‐ 1‐yl)butyl]benzamide, a selective radioligand for dopamine D3 receptors. I. In vitro characterization

    Article • Synapse, May 2009, Wiley

    Robert H. Mach

  112. Evaluation of D2 and D3 dopamine receptor selective compounds on l-dopa-dependent abnormal involuntary movements in rats

    Article • Neuropharmacology, May 2009, Elsevier

    Robert H. Mach

  113. Synthesis and in Vitro Evaluation of Sulfonamide Isatin Michael Acceptors as Small Molecule Inhibitors of Caspase-6

    Article • Journal of Medicinal Chemistry, March 2009, American Chemical Society (ACS)

    Robert H. Mach

  114. Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma

    Article • Journal of Translational Medicine, March 2009, Springer Science + Business Media

    Robert H. Mach

  115. Design and Synthesis of 2-Amino-4-methylpyridine Analogues as Inhibitors for Inducible Nitric Oxide Synthase and in Vivo Evaluation of [18F]6-(2-Fluoropropyl)-4-methyl-pyridin-2-amine as a Potential PET Tracer for Inducible Nitric Oxide Synt...

    Article • Journal of Medicinal Chemistry, March 2009, American Chemical Society (ACS)

    Robert H. Mach

  116. Synthesis and in Vitro and in Vivo Evaluation of 18F-Labeled Positron Emission Tomography (PET) Ligands for Imaging the Vesicular Acetylcholine Transporter

    Article • Journal of Medicinal Chemistry, February 2009, American Chemical Society (ACS)

    Robert H. Mach, Professor Simon mbua Ngale Efange

  117. New N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs as σ2 receptor ligands: Synthesis, in vitro characterization, and evaluation as PET imaging and chemosensitization agents

    Article • Bioorganic & Medicinal Chemistry, February 2009, Elsevier

    Robert H. Mach

  118. Preface

    Article • PET Clinics, January 2009, Elsevier

    Robert H. Mach

  119. PET Radiotracers for Imaging the Proliferative Status of Solid Tumors

    Article • PET Clinics, January 2009, Elsevier

    Robert H. Mach

  120. O3‐02–02: Update on the relationship between in vivo amyloid imaging with C‐PIB and CSF Aβ42

    Article • Alzheimer s & Dementia, July 2008, Wiley

    Robert H. Mach

  121. QS306. A Pancreas Cancer Targeted Akt Inhibitor Induces Apoptosis

    Article • Journal of Surgical Research, February 2008, Elsevier

    Robert H. Mach

  122. P31. A Pancreas Cancer Targeted AkT Inhibitor Induces Apoptosis

    Article • Journal of Surgical Research, February 2008, Elsevier

    Robert H. Mach

  123. Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy

    Article • Molecular Cancer, July 2007, Springer Science + Business Media

    Robert H. Mach

  124. Isatin Sulfonamide Analogs Containing a Michael Addition Acceptor:  A New Class of Caspase 3/7 Inhibitors

    Article • Journal of Medicinal Chemistry, June 2007, American Chemical Society (ACS)

    Robert H. Mach

  125. Fluorine-18-Labeled Benzamide Analogues for Imaging the σ2 Receptor Status of Solid Tumors with Positron Emission Tomography

    Article • Journal of Medicinal Chemistry, June 2007, American Chemical Society (ACS)

    Robert H. Mach

  126. Imaging the proliferative status of tumors with PET

    Article • Journal of Labelled Compounds and Radiopharmaceuticals, April 2007, Wiley

    Robert H. Mach

  127. Strategies for the Labeling of Halogen-Substituted Peroxisome Proliferator-Activated Receptor γ Ligands:  Potential Positron Emission Tomography and Single Photon Emission Computed Tomography Imaging Agents

    Article • Bioconjugate Chemistry, February 2007, American Chemical Society (ACS)

    Robert H. Mach

  128. Synthesis and Binding Affinity of a Fluorine-Substituted Peroxisome Proliferator-Activated Gamma (PPARγ) Ligand as a Potential Positron Emission Tomography (PET) Imaging Agent

    Article • Bioconjugate Chemistry, February 2007, American Chemical Society (ACS)

    Robert H. Mach

  129. IN VIVO IMAGING IN A MURINE MODEL OF GLIOBLASTOMA

    Article • Neurosurgery, February 2007, Wolters Kluwer Health

    Robert H. Mach

  130. Synthesis of N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl carbamate analogs as σ2 receptor ligands

    Article • Bioorganic & Medicinal Chemistry, October 2006, Elsevier

    Robert H. Mach

  131. Synthesis and evaluation of a bromine-76-labeled PPARγ antagonist 2-bromo-5-nitro-N-phenylbenzamide

    Article • Nuclear Medicine and Biology, October 2006, Elsevier

    Robert H. Mach

  132. Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis

    Article • Bioorganic & Medicinal Chemistry Letters, October 2006, Elsevier

    Robert H. Mach

  133. PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys

    Article • Nature Neuroscience, July 2006, Springer Science + Business Media

    Robert H. Mach, Drake Morgan

  134. O3–01–07: Relationship between in vivo amyloid imaging with 11C–PIB and CSF Aβ42

    Article • Alzheimer s & Dementia, July 2006, Wiley

    Robert H. Mach

  135. IC–P–054: Relationship between in vivo amyloid imaging with 11C–PIB and CSF Aβ42

    Article • Alzheimer s & Dementia, July 2006, Wiley

    Robert H. Mach

  136. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans

    Article • Annals of Neurology, February 2006, Wiley

    Robert H. Mach

  137. Synthesis and characterization of selective dopamine D2 receptor antagonists

    Article • Bioorganic & Medicinal Chemistry, February 2006, Elsevier

    Robert H. Mach

  138. Characterization of a novel iodinated sigma-2 receptor ligand as a cell proliferation marker

    Article • Nuclear Medicine and Biology, February 2006, Elsevier

    Robert H. Mach

  139. N-Benzylisatin Sulfonamide Analogues as Potent Caspase-3 Inhibitors:  Synthesis, in Vitro Activity, and Molecular Modeling Studies

    Article • Journal of Medicinal Chemistry, November 2005, American Chemical Society (ACS)

    Robert H. Mach, Professor David E Reichert

  140. [3H]N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]-2-methoxy-5-methylbenzamide: A novel sigma-2 receptor probe

    Article • European Journal of Pharmacology, November 2005, Elsevier

    Robert H. Mach

  141. N‐[18F]4′‐fluorobenzylpiperidin‐4yl‐(2‐fluorophenyl) acetamide ([18F]FBFPA): A potential fluorine‐18 labeled PET radiotracer for imaging sigma‐1 receptors in the CNS

    Article • Synapse, October 2005, Wiley

    Robert H. Mach

  142. Carbon-11 labeled σ2 receptor ligands for imaging breast cancer

    Article • Nuclear Medicine and Biology, July 2005, Elsevier

    Robert H. Mach

  143. Synthesis and in vivo evaluation of [11C]PJ34, a potential radiotracer for imaging the role of PARP-1 in necrosis

    Article • Nuclear Medicine and Biology, July 2005, Elsevier

    Robert H. Mach

  144. Bioluminescence Imaging of Transcription Factor Activity in the Lungs

    Article • May 2005, Taylor & Francis

    Robert H. Mach

  145. Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands

    Article • Bioorganic & Medicinal Chemistry, January 2005, Elsevier

    Robert H. Mach

  146. Evaluation of the Quantitative Capability of a High-Resolution Positron Emission Tomography Scanner for Small Animal Imaging

    Article • Journal of Computer Assisted Tomography, November 2004, Wolters Kluwer Health

    Robert H. Mach

  147. P2-188 Labeling amyloid plaque-like structures by radioiodinated ligands in rhesus monkey brain

    Article • Neurobiology of Aging, July 2004, Elsevier

    Robert H. Mach

  148. Imaging Myocardium Enzymatic Pathways with Carbon-11 Radiotracers

    Article • January 2004, Elsevier

    Robert H. Mach

  149. Conformationally-flexible benzamide analogues as dopamine D3 and σ2 receptor ligands

    Article • Bioorganic & Medicinal Chemistry Letters, January 2004, Elsevier

    Robert H. Mach

  150. Progress in Developing D3 Dopamine Receptor Ligands as Potential Therapeutic Agents for Neurological and Neuropsychiatric Disorders

    Article • Current Pharmaceutical Design, March 2003, Bentham Science Publishers

    Robert H. Mach

  151. Synthesis of 2-(5-Bromo-2,3-dimethoxyphenyl)-5-(aminomethyl)-1H-pyrrole analogues and their binding affinities for dopamine D2, D3, and D4 receptors

    Article • Bioorganic & Medicinal Chemistry, January 2003, Elsevier

    Robert H. Mach

  152. Cocaine- and food-maintained responding under a multiple schedule in rhesus monkeys: environmental context and the effects of a dopamine antagonist

    Article • Psychopharmacology, October 2002, Springer Science + Business Media

    Robert H. Mach, Drake Morgan

  153. PET Radiotracers for Imaging the Proliferative Status of Breast Tumors

    Article • June 2002, Defense Technical Information Center (DTIC)

    Robert H. Mach

  154. Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration

    Article • Nature Neuroscience, January 2002, Springer Science + Business Media

    Robert H. Mach, Drake Morgan

  155. Synthesis of 2-(2,3-dimethoxyphenyl)-4-(aminomethyl)imidazole analogues and their binding affinities for dopamine D2 and D3 receptors

    Article • Bioorganic & Medicinal Chemistry, December 2001, Elsevier

    Robert H. Mach

  156. Synthesis and Structure−Activity Relationships of N-(1-Benzylpiperidin-4-yl)arylacetamide Analogues as Potent σ1 Receptor Ligands

    Article • Journal of Medicinal Chemistry, November 2001, American Chemical Society (ACS)

    Robert H. Mach

  157. Preparation of a technetium‐99m SPECT agent for imaging the sigma‐2 receptor status of solid tumors

    Article • Journal of Labelled Compounds and Radiopharmaceuticals, September 2001, Wiley

    Robert H. Mach

  158. Development of a Tc-99m labeled sigma-2 receptor-specific ligand as a potential breast tumor imaging agent

    Article • Nuclear Medicine and Biology, August 2001, Elsevier

    Robert H. Mach

  159. Synthesis and Structure−Activity Relationships of Naphthamides as Dopamine D3 Receptor Ligands

    Article • Journal of Medicinal Chemistry, March 2001, American Chemical Society (ACS)

    Robert H. Mach

  160. Morphine-induced spinal cholinergic activation: in vivo imaging with positron emission tomography

    Article • Pain, March 2001, Wolters Kluwer Health

    Robert H. Mach, Professor Simon mbua Ngale Efange

  161. Characterization of 125I‐IABN, a novel azabicyclononane benzamide selective for D2‐like dopamine receptors

    Article • Synapse, December 2000, Wiley

    Robert H. Mach

  162. Characterization of125I-IABN, a novel azabicyclononane benzamide selective for D2-like dopamine receptors

    Article • Synapse, January 2000, Wiley

    Robert H. Mach

  163. Cholinergic activity of aged rhesus monkeys revealed by positron emission tomography

    Article • Synapse, January 2000, Wiley

    Robert H. Mach, Professor Simon mbua Ngale Efange

  164. Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter

    Article • Synapse, January 2000, Wiley

    Robert H. Mach

  165. Hydroxylated Decahydroquinolines as Ligands for the Vesicular Acetylcholine Transporter:  Synthesis and Biological Evaluation

    Article • Journal of Medicinal Chemistry, July 1999, American Chemical Society (ACS)

    Robert H. Mach, Professor Simon mbua Ngale Efange

  166. Dopamine D2/D3 receptors modulate cocaine’s reinforcing and discriminative stimulus effects in rhesus monkeys

    Article • Drug and Alcohol Dependence, April 1999, Elsevier

    Robert H. Mach

  167. The analgesic tropane analogue (±)-SM 21 has a high affinity for σ2 receptors

    Article • Life Sciences, January 1999, Elsevier

    Robert H. Mach

  168. In Vivo Imaging of the Spinal Cord Cholinergic System with PET

    Article • Journal of Computer Assisted Tomography, January 1999, Wolters Kluwer Health

    Robert H. Mach, Professor Simon mbua Ngale Efange

  169. AGE-RELATED CEREBRAL BLOOD FLOW RESPONSES DURING ISOFLURANE ANESTHESIA ASSESSED BY POSITRON EMISSION TOMOGRAPHY

    Article • Anesthesiology, September 1998, Wolters Kluwer Health

    Robert H. Mach

  170. Synthesis and Quantitative Structure−Activity Relationships of N-(1-Benzylpiperidin-4-yl)phenylacetamides and Related Analogues as Potent and Selective σ1 Receptor Ligands

    Article • Journal of Medicinal Chemistry, May 1998, American Chemical Society (ACS)

    Robert H. Mach

  171. Effect of social status on striatal dopamine D2 receptor binding characteristics in cynomolgus monkeys assessed with positron emission tomography

    Article • Synapse, May 1998, Wiley

    Robert H. Mach

  172. Effect of social status on striatal dopamine D2 receptor binding characteristics in cynomolgus monkeys assessed with positron emission tomography

    Article • Synapse, May 1998, Wiley

    Robert H. Mach

  173. N-Hydroxyalkyl Derivatives of 3β-Phenyltropane and 1-Methylspiro[1H-indoline-3,4‘-piperidine]:  Vesamicol Analogues with Affinity for Monoamine Transporters

    Article • Journal of Medicinal Chemistry, November 1997, American Chemical Society (ACS)

    Robert H. Mach, Professor Simon mbua Ngale Efange

  174. Use of Positron Emission Tomography to Study the Dynamics of Psychostimulant-Induced Dopamine Release

    Article • Pharmacology Biochemistry and Behavior, July 1997, Elsevier

    Robert H. Mach

  175. Imaging of cholinergic terminals using the radiotracer [18F](+)-4-fluorobenzyltrozamicol: In vitro binding studies and positron emission tomography studies in nonhuman primates

    Article • Synapse, April 1997, Wiley

    Robert H. Mach, Professor Simon mbua Ngale Efange

  176. Social Stress, Depression, and Brain Dopamine in Female Cynomolgus Monkeys

    Article • Annals of the New York Academy of Sciences, January 1997, Wiley

    Robert H. Mach

  177. Comparison of two fluorine-18 labeled benzamide derivatives that bind reversibly to dopamine D2 receptors: In vitro binding studies and positron emission tomography

    Article • Synapse, December 1996, Wiley

    Robert H. Mach

  178. Ibogaine possesses a selective affinity for σ2 receptors

    Article • Life Sciences, June 1995, Elsevier

    Robert H. Mach

  179. Vesamicol analogues as sigma ligands

    Article • Biochemical Pharmacology, March 1995, Elsevier

    Robert H. Mach, Professor Simon mbua Ngale Efange

  180. Pet imaging studies of dopamine D2 receptors: Comparison of [18F]N‐Methylspiperone; and the benzamide analogues [18F]MABN and [18F]MBP in baboon brain

    Article • Synapse, March 1995, Wiley

    Robert H. Mach

  181. Fluorine-18 labeled benzamides for studying the dopamine D2 receptor with positron emission tomography

    Article • Journal of Medicinal Chemistry, November 1993, American Chemical Society (ACS)

    Robert H. Mach

  182. The use of [18F]4-fluorobenzyl iodide (FBI) in PET radiotracer synthesis: Model alkylation studies and its application in the design of dopamine D1 and D2 receptor-based imaging agents

    Article • Nuclear Medicine and Biology, August 1993, Elsevier

    Robert H. Mach

  183. Synthesis and in vivo evaluation of [18F]-N-(p-Nitrobenzyl)spiperone ([18F]PNBS) in rats

    Article • Nuclear Medicine and Biology, April 1993, Elsevier

    Robert H. Mach

  184. Effect of N-alkylation on the affinities of analogs of spiperone for dopamine D2 and serotonin 5-HT2 receptors

    Article • Journal of Medicinal Chemistry, February 1992, American Chemical Society (ACS)

    Robert H. Mach

  185. Mass spectral analysis diaminodithiol ligands used for the complexation of technetium‐99m

    Article • Organic Mass Spectrometry, May 1991, Wiley

    Robert H. Mach

  186. Synthesis and biodistribution of a new class of 99mTc-labeled fatty acid analogs for myocardial imaging

    Article • International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology, January 1991, Elsevier

    Robert H. Mach

  187. Antibodies with high affinity for spiroperidol—II. cross reactivity with iodobenzamide and domperidone

    Article • Molecular Immunology, July 1990, Elsevier

    Robert H. Mach

  188. Synthesis and chemical reactivity of c‐5 substituted 6,7‐bis‐(hydroxymethyl)‐1H‐pyrrolizine biscarbamate tumor inhibitors

    Article • Journal of Heterocyclic Chemistry, May 1990, Wiley

    Robert H. Mach

  189. Synthesis, characterization and biodistribution of neutral and lipid-soluble 99mTc-PAT-HM and 99mTc-TMR for brain imaging

    Article • International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology, January 1989, Elsevier

    Robert H. Mach

  190. Dopamine D-2 receptor imaging radiopharmaceuticals: synthesis, radiolabeling and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide

    Article • Journal of Medicinal Chemistry, May 1988, American Chemical Society (ACS)

    Robert H. Mach

  191. Vinylogous carbinolamine tumor inhibitors. 21. Synthesis, chemical reactivity, and antileukemic activity of 5-substituted 6,7-bis(hydroxymethyl)pyrrolo[1,2-c]thiazole biscarbamates and the corresponding sulfoxides and sulfones

    Article • Journal of Medicinal Chemistry, November 1987, American Chemical Society (ACS)

    Robert H. Mach

  192. Selective Reduction of Carboxylic Acid Esters in the Presence of a Five-Membered Cyclic Sulfone

    Article • Synthetic Communications, June 1986, Taylor & Francis

    Robert H. Mach