All Stories

  1. A pharmacokinetic/pharmacodynamic analysis of intravenous tranexamic acid in adult patients undergoing elective total hip arthroplasty (ORACLE)

    Article • British Journal of Anaesthesia, January 2025, Elsevier

    Professor Robert L Medcalf

  2. Improving thrombolysis efficiency for acute ischaemic stroke

    Article • The Lancet Neurology, September 2024, Elsevier

    Professor Robert L Medcalf

  3. Development of endothelial-targeted CD39 as a therapy for ischemic stroke

    Article • Journal of Thrombosis and Haemostasis, August 2024, Elsevier

    Professor Robert L Medcalf

  4. Tranexamic acid in trauma: After 3 hours from injury, when is it safe and effective to use again?

    Article • Transfusion, March 2024, Wiley

    Professor Robert L Medcalf

  5. Plasma from patients with vaccine-induced immune thrombotic thrombocytopenia displays increased fibrinolytic potential and enhances tissue-type plasminogen activator but not urokinase-mediated plasminogen activation

    Article • Journal of Thrombosis and Haemostasis, March 2024, Elsevier

    Professor Robert L Medcalf

  6. Entry of cannabidiol into the fetal, postnatal and adult rat brain

    Article • Cell and Tissue Research, February 2024, Springer Science + Business Media

    Professor Robert L Medcalf

  7. A Coumarin-Based Array for the Discrimination of Amyloids

    Article • ACS Sensors, February 2024, American Chemical Society (ACS)

    Professor Robert L Medcalf

  8. The fibrinolysis renaissance

    Article • Journal of Thrombosis and Haemostasis, December 2023, Elsevier

    Professor Robert L Medcalf

  9. Tranexamic acid for haemostasis and beyond: does dose matter?

    Article • Thrombosis Journal, September 2023, Springer Science + Business Media

    Professor Robert L Medcalf

  10. Tranexamic acid in a mouse model of cerebral amyloid angiopathy: setting the stage for a novel stroke treatment approach

    Article • Research and Practice in Thrombosis and Haemostasis, August 2023, Elsevier

    Professor Robert L Medcalf

  11. Prehospital Tranexamic Acid for Severe Trauma

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, July 2023, New England Journal of Medicine (NEJM/MMS)

    Professor Robert L Medcalf

  12. N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection

    Article • Molecular & Cellular Proteomics, May 2023, Elsevier

    Dr Heung-Chin Cheng, Professor Robert L Medcalf

  13. Platelet-targeted thrombolysis for treatment of acute ischemic stroke

    Article • Blood Advances, February 2023, American Society of Hematology

    Professor Robert L Medcalf

  14. Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study

    Article • Critical Care, February 2023, Springer Science + Business Media

    Professor Robert L Medcalf

  15. Tissue-type plasminogen activator induces conditioned receptive field plasticity in the mouse auditory cortex

    Article • iScience, February 2023, Elsevier

    Professor Robert L Medcalf

  16. Anticoagulation Strategies in Non–Critically Ill Patients with Covid-19

    Article • NEJM Evidence, January 2023, New England Journal of Medicine (NEJM/MMS)

    Professor Robert L Medcalf

  17. A Novel Method for Measuring Plasminogen Activation Upon Plasma Clots

    Article • Research and Practice in Thrombosis and Haemostasis, July 2022, Wiley

    Jason Palazzolo, Professor Robert L Medcalf

  18. Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis

    Article • Journal of Thrombosis and Haemostasis, September 2019, Wiley

    Professor Robert L Medcalf

  19. Tranexamic Acid Influences the Immune Response, but not Bacterial Clearance in a Model of Post-Traumatic Brain Injury Pneumonia

    Article • Journal of Neurotrauma, August 2019, Mary Ann Liebert Inc

    Professor Robert L Medcalf

  20. Tranexamic acid modulates the immune response and reduces postsurgical infection rates

    Article • Blood Advances, May 2019, American Society of Hematology

    Professor Robert L Medcalf

  21. t-PA Suppresses the Immune Response and Aggravates Neurological Deficit in a Murine Model of Ischemic Stroke

    Article • Frontiers in Immunology, March 2019, Frontiers

    Professor Robert L Medcalf

  22. What concentration of tranexamic acid is needed to inhibit fibrinolysis? A systematic review of pharmacodynamics studies

    Article • Blood Coagulation & Fibrinolysis, January 2019, Wolters Kluwer Health

    Professor Robert L Medcalf

  23. A flowcytometric analysis to efficiently quantify multiple innate immune cells and T Cell subsets in human blood

    Article • Cytometry, March 2017, Wiley

    Professor Robert L Medcalf

  24. Protein aggregation or liberation during cell necrosis

    Article • Open Biology, November 2016, Royal Society Publishing

    Dr Andre L Samson, Professor Robert L Medcalf

  25. Plasminogen and stroke: more is better

    Article • Journal of Thrombosis and Haemostasis, August 2016, Wiley

    Professor Robert L Medcalf

  26. The Influence of Differentially Expressed Tissue-Type Plasminogen Activator in Experimental Autoimmune Encephalomyelitis: Implications for Multiple Sclerosis

    Article • PLOS One, July 2016, PLOS

    Professor Robert L Medcalf

  27. The Fibrinolytic System—More Than Fibrinolysis?

    Article • Transfusion Medicine Reviews, April 2015, Elsevier

    Professor Robert L Medcalf

  28. Is plasminogen activator inhibitor type 2 really a plasminogen activator inhibitor after all?

    Article • Journal of Thrombosis and Haemostasis, October 2014, Elsevier

    Professor Robert L Medcalf

  29. Plasmin-Dependent Modulation of the Blood–Brain Barrier: A Major Consideration during tPA-Induced Thrombolysis?

    Article • Journal of Cerebral Blood Flow & Metabolism, June 2014, SAGE Publications

    Professor Robert L Medcalf

  30. Species-Specific Regulation of t-PA and PAI-1 Gene Expression in Human and Rat Astrocytes

    Article • Gene Regulation and Systems Biology, May 2014, Libertas Academica, Ltd.

    Professor Robert L Medcalf

  31. Improved Method for the Preparation of a Human Cell-based, Contact Model of the Blood-Brain Barrier

    Article • Journal of Visualized Experiments, November 2013, MyJove Corporation

    Professor Robert L Medcalf

  32. Plasminogen Activation and Thrombolysis for Ischemic Stroke

    Article • International Journal of Stroke, March 2012, SAGE Publications

    Professor Robert L Medcalf

  33. Desmoteplase: discovery, insights and opportunities for ischaemic stroke

    Article • Bone Marrow Transplantation, December 2011, Wiley

    Professor Robert L Medcalf

  34. Plasminogen Activation-Based Thrombolysis for Ischaemic Stroke: The Diversity of Targets may Demand New Approaches

    Article • Current Drug Targets, November 2011, Bentham Science Publishers

    Professor Robert L Medcalf

  35. Plasminogen Activator Inhibitor Type 2

    Article • January 2011, Elsevier

    Professor Robert L Medcalf

  36. Desmoteplase-mediated plasminogen activation and clot lysis are inhibited by the lysine analogue tranexamic acid

    Article • Blood Coagulation & Fibrinolysis, June 2008, Wolters Kluwer Health

    Professor Robert L Medcalf

  37. Tissue-Type Plasminogen Activator: A Multifaceted Modulator of Neurotransmission and Synaptic Plasticity

    Article • Neuron, June 2006, Elsevier

    Professor Robert L Medcalf, Dr Andre L Samson

  38. Meet the serpins

    Article • European Journal of Biochemistry, September 2005, Wiley

    Professor Robert L Medcalf

  39. The undecided serpin

    Article • European Journal of Biochemistry, September 2005, Wiley

    Professor Robert L Medcalf

  40. Transcriptional and posttranscriptional regulation of the plasminogen activator system

    Article • Thrombosis and Haemostasis, March 2005, Schattauer GmbH

    Professor Robert L Medcalf

  41. The urokinase-type-plasminogen-activator receptor (CD87) is a pleiotropic molecule

    Article • European Journal of Biochemistry, March 1998, Wiley

    Professor Robert L Medcalf

  42. 8 Destabilising properties of the uuauuuauu element in the 3' UTR of plasminogen activator inhibitor type 2 (PAI-2) mRNA

    Article • October 1997, Elsevier

    Professor Robert L Medcalf

  43. 14 Identification of endothelial nuclear factors which recognise the cre-like element in the human t-PA gene promoter

    Article • October 1997, Elsevier

    Professor Robert L Medcalf

  44. 19 Urokinase mediated induction of an interferon (IFN) responsive gene promoter may utilise IFN α-stimulated gene response elements (ISRE)

    Article • October 1997, Elsevier

    Professor Robert L Medcalf

  45. Identification of two repressor regions within the plasminogen activator inhibitor 2 (PAI-2) gene promoter

    Article • Fibrinolysis and Proteolysis, January 1994, Elsevier

    Professor Robert L Medcalf

  46. Regulation of Human Tissue-Type Plasminogen Activator Gene Transcription by Epidermal Growth Factor and 3′,5′-Cyclic Adenosine Monophosphate

    Article • Molecular Endocrinology, December 1991, Endocrine Society

    Professor Robert L Medcalf

  47. Thrombin increases proliferation and decreases fibrinolytic activity of kidney glomerular epithelial cells

    Article • Journal of Cellular Physiology, January 1991, Wiley

    Professor Robert L Medcalf

  48. Signal Transduction Chains Involved in the Control of the Fibrinolytic Enzyme Cascade

    Article • January 1990, Springer Science + Business Media

    Professor Robert L Medcalf

  49. Urokinase synthesis and binding by glomerular epithelial cells in culture

    Article • Kidney International, October 1989, Elsevier

    Professor Robert L Medcalf

  50. Deletion mutagenesis, DNAse 1 protection, and band shift analysis of human tissue-type plasminogen activator gene promoter reveals two functionally active protein binding domains

    Article • Fibrinolysis and Proteolysis, January 1989, Elsevier

    Professor Robert L Medcalf

  51. Human synovial fibroblasts produce urokinase-type plasminogen activator

    Article • Arthritis & Rheumatism, November 1986, Wiley

    Professor Robert L Medcalf

  52. Prejunctional β-adrenoceptors in human digital arteries

    Article • European Journal of Pharmacology, September 1982, Elsevier

    Professor Robert L Medcalf