All Stories

  1. Synthetic cannabinoids induce acute lung inflammation via cannabinoid receptor 1 activation

    Article • ERJ Open Research, July 2020, European Respiratory Society (ERS)

    Dr Resat Cinar

  2. Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

    Article • Nature Chemical Biology, May 2020, Springer Science + Business Media

    Dr Resat Cinar, Joshua K. Park

  3. Interplay of Liver–Heart Inflammatory Axis and Cannabinoid 2 Receptor Signaling in an Experimental Model of Hepatic Cardiomyopathy

    Article • Hepatology, April 2020, Wiley

    Dr Resat Cinar

  4. Dual inhibition of cannabinoid CB 1 receptor and inducible NOS attenuates obesity‐induced chronic kidney disease

    Article • British Journal of Pharmacology, December 2019, Wiley

    Dr Resat Cinar, Joseph Tam

  5. Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid–CB1-R Signaling

    Article • JACC Basic to Translational Science, September 2019, Elsevier

    Dr Resat Cinar

  6. Bleomycin Induces Drug Efflux in Lungs: A pitfall for Pharmacological Studies of Pulmonary Fibrosis

    Article • American Journal of Respiratory Cell and Molecular Biology, August 2019, American Thoracic Society

    Dr Resat Cinar, Joshua K. Park

  7. Cannabinoid‐1 Receptor Antagonism Improves Glycemic Control and Increases Energy Expenditure Through Sirtuin‐1/Mechanistic Target of Rapamycin Complex 2 and 5′Adenosine Monophosphate–Activated Protein Kinase Signaling

    Article • Hepatology, March 2019, Wiley

    Dr Resat Cinar

  8. Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis

    Article • EBioMedicine, February 2019, Elsevier

    Dr Resat Cinar

  9. Crystal Structure of the Human Cannabinoid Receptor CB2

    Article • Cell, January 2019, Elsevier

    Dr Resat Cinar

  10. Disruption of Renal Arginine Metabolism Promotes Kidney Injury in Hepatorenal Syndrome in Mice

    Article • Hepatology, October 2018, Wiley

    Dr. Janos Paloczi, Dr Resat Cinar

  11. Synthesis of 13 C6 -labeled, dual-target inhibitor of cannabinoid-1 receptor (CB1 R) and inducible nitric oxide synthase (iNOS)

    Article • Journal of Labelled Compounds, June 2018, Wiley

    Dr Resat Cinar

  12. Feasibility Evaluation of Myocardial Cannabinoid Type 1 Receptor Imaging in Obesity

    Article • JACC Cardiovascular Imaging, February 2018, Elsevier

    Dr Resat Cinar

  13. Cannabinoid-1 receptor deletion in podocytes mitigates both glomerular and tubular dysfunction in a mouse model of diabetic nephropathy

    Article • Diabetes Obesity and Metabolism, December 2017, Wiley

    Dr. Janos Paloczi, Joshua K. Park, Dr Resat Cinar

  14. Decreasing CB 1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice

    Article • Molecular Metabolism, November 2017, Elsevier

    Dr Resat Cinar

  15. Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling

    Article • Molecular Metabolism, October 2017, Elsevier

    Dr Resat Cinar, Joseph Tam

  16. Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD

    Article • Journal of the American Society of Nephrology, August 2017, American Society of Nephrology

    Joseph Tam, Dr Resat Cinar

  17. Network analyses identify liver‐specific targets for treating liver diseases

    Article • Molecular Systems Biology, August 2017, EMBO

    Professor Adil Mardinoglu, Sunjae Lee, Tim Kuijpers, Joshua K. Park, Dr Resat Cinar, Professor Morten Grötli

  18. Synthesis of S -2-((S )-3-(4-chlorophenyl)-N '-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H -pyrazole-1-carboximidamido)-3-(methyl-d 3 )butanamide-d5 , octadeuterated JD5037

    Article • Journal of Labelled Compounds, August 2017, Wiley

    Dr Resat Cinar

  19. Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis

    Article • JCI Insight, April 2017, American Society for Clinical Investigation

    Joshua K. Park, Dr Resat Cinar

  20. β‐Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice

    Article • British Journal of Pharmacology, February 2017, Wiley

    Dr. Janos Paloczi, Dr Resat Cinar

  21. Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB1R Inverse Agonist/Inducible Nitric Oxide Synthase (iNOS) Inhibitors for the Treatment of Liver Fibrosis

    Article • Journal of Medicinal Chemistry, January 2017, American Chemical Society (ACS)

    Dr Resat Cinar

  22. Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes

    Article • Diabetes, January 2017, American Diabetes Association

    Joshua K. Park, Dr Resat Cinar

  23. Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader–Willi syndrome

    Article • Molecular Metabolism, December 2016, Elsevier

    Dr Resat Cinar, Yehuda Pollak

  24. Cannabinoid receptor signaling regulates liver development and metabolism

    Article • Development, February 2016, The Company of Biologists

    Dr Resat Cinar

  25. The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity

    Article • British Journal of Pharmacology, January 2016, Wiley

    Dr Resat Cinar

  26. Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization

    Article • Cell Reports, December 2015, Elsevier

    Professor Adil Mardinoglu, Dr Resat Cinar

  27. Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids

    Article • Neuropsychopharmacology, October 2015, Springer Science + Business Media

    Dr Resat Cinar

  28. Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue

    Article • Scientific Reports, October 2015, Springer Science + Business Media

    Dr Resat Cinar

  29. Structural Basis of Species-Dependent Differential Affinity of 6-Alkoxy-5-Aryl-3-Pyridinecarboxamide Cannabinoid-1 Receptor Antagonists

    Article • Molecular Pharmacology, May 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Resat Cinar

  30. Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms

    Article • Hepatology, February 2015, Wiley

    Dr Resat Cinar

  31. Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy

    Article • Proceedings of the National Academy of Sciences, November 2014, Proceedings of the National Academy of Sciences

    Dr Resat Cinar

  32. Role of adiponectin in the metabolic effects of cannabinoid type 1 receptor blockade in mice with diet-induced obesity

    Article • AJP Endocrinology and Metabolism, February 2014, American Physiological Society

    Dr Resat Cinar

  33. Lack of Regulatory Changes of µ-Opioid Receptors by 14-Methoxymetopon Treatment in Rat Brain. Further Evidence for Functional Selectivity

    Article • Current Pharmaceutical Design, January 2014, Bentham Science Publishers

    Dr Resat Cinar

  34. Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasingde novosynthesis of long-chain ceramides

    Article • Hepatology, November 2013, Wiley

    Dr Resat Cinar

  35. Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase

    Article • Proceedings of the National Academy of Sciences, November 2013, Proceedings of the National Academy of Sciences

    Dr Resat Cinar

  36. Chronic alcohol produces neuroadaptations to prime dorsal striatal learning

    Article • Proceedings of the National Academy of Sciences, August 2013, Proceedings of the National Academy of Sciences

    Dr Resat Cinar

  37. Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

    Article • Nature Medicine, August 2013, Springer Science + Business Media

    Dr Resat Cinar

  38. Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonists

    Article • BioMed Research International, January 2013, Hindawi Publishing Corporation

    Dr Resat Cinar

  39. Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

    Article • Cell Metabolism, August 2012, Elsevier

    Dr Resat Cinar

  40. Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

    Article • Molecular Psychiatry, June 2012, Springer Science + Business Media

    Dr Resat Cinar

  41. Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy

    Article • Diabetes, February 2012, American Diabetes Association

    Dr Resat Cinar

  42. Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB 1 ) receptors in the regenerating liver

    Article • Proceedings of the National Academy of Sciences, March 2011, Proceedings of the National Academy of Sciences

    Dr Resat Cinar

  43. Endocannabinoids in liver disease

    Article • Hepatology, January 2011, Wiley

    Dr Resat Cinar

  44. Inhibitor of Fatty Acid Amide Hydrolase Normalizes Cardiovascular Function in Hypertension without Adverse Metabolic Effects

    Article • Chemistry & Biology, November 2010, Elsevier

    Dr Resat Cinar

  45. CB1 Receptor-Independent Actions of SR141716 on G-Protein Signaling: Coapplication with the μ-Opioid Agonist Tyr-d-Ala-Gly-(NMe)Phe-Gly-ol Unmasks Novel, Pertussis Toxin-Insensitive Opioid Signaling in μ-Opioid Receptor-Chinese Hamster Ovary Cells

    Article • Journal of Pharmacology and Experimental Therapeutics, May 2009, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Resat Cinar

  46. Reciprocal inhibition of G-protein signaling is induced by CB1 cannabinoid and GABAB receptor interactions in rat hippocampal membranes

    Article • Neurochemistry International, June 2008, Elsevier

    Dr Resat Cinar