All Stories

  1. Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances

    Article • Journal of Pineal Research, January 2021, Wiley

    Professor Regina P Markus, George Anderson

  2. Rhythmic expression of the melatonergic biosynthetic pathway and its differential modulation in vitro by LPS and IL10 in bone marrow and spleen

    Article • Scientific Reports, March 2020, Springer Science + Business Media

    Professor Regina P Markus

  3. A representative metalloprotease induces PGE2 synthesis in fibroblast-like synoviocytes via the NF-κB/COX-2 pathway with amplification by IL-1β and the EP4 receptor

    Article • Scientific Reports, February 2020, Springer Science + Business Media

    Professor Regina P Markus

  4. Dysregulation of Circadian Rhythms in Autism Spectrum Disorders

    Article • Current Pharmaceutical Design, January 2020, Bentham Science Publishers

    Professor Regina P Markus

  5. Daily light and darkness onset and circadian rhythms metabolically synchronize hematopoietic stem cell differentiation and maintenance: The role of bone marrow norepinephrine, tumor necrosis factor, and melatonin cycles

    Article • Experimental Hematology, October 2019, Elsevier

    Professor Regina P Markus

  6. STAT1‐NFκB crosstalk triggered by interferon gamma regulates noradrenaline‐induced pineal hormonal production

    Article • Journal of Pineal Research, September 2019, Wiley

    Professor Regina P Markus

  7. Night work effects on salivary cytokines TNF, IL-1β and IL-6

    Article • Chronobiology International, September 2018, Taylor & Francis

    Professor Regina P Markus

  8. Melatonin modulates autophagy and inflammation protecting human placental trophoblast from hypoxia/reoxygenation

    Article • Journal of Pineal Research, September 2018, Wiley

    Professor Regina P Markus

  9. β-Adrenoceptors Trigger Melatonin Synthesis in Phagocytes

    Article • International Journal of Molecular Sciences, July 2018, MDPI AG

    Professor Regina P Markus

  10. Stopping TIME for initiating a DEFENSE response.

    Article • Bone Marrow Transplantation, December 2017, Wiley

    Professor Regina P Markus

  11. Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program

    Article • Scientific Reports, May 2017, Nature

    Professor Regina P Markus

  12. Molecular mechanism explains why macrophage melatonin synthesis occurs during the regulatory phase

    Article • Journal of Pineal Research, March 2016, Wiley

    Professor Regina P Markus, Sandra Muxel

  13. Does high ATP changes the pineal gland hormone from melatonin to NAS?

    Article • Journal of Pineal Research, January 2016, Wiley

    Professor Regina P Markus

  14. Light/Dark Environmental Cycle Imposes a Daily Profile in the Expression of microRNAs in Rat CD133+Cells

    Article • Journal of Cellular Physiology, January 2016, Wiley

    Professor Regina P Markus

  15. Melatonergic system-based two-gene index is prognostic in human gliomas

    Article • Journal of Pineal Research, November 2015, Wiley

    Sandra Muxel, Professor Regina P Markus

  16. Melatonin attenuatesLeishmania (L.) amazonensisinfection by modulating arginine metabolism

    Article • Journal of Pineal Research, October 2015, Wiley

    Professor Regina P Markus, Sandra Muxel

  17. beta-amyloid peptide impairs melatonin synthesis and melatonin receptor signaling

    Article • The FASEB Journal, March 2015, Federation of American Societies For Experimental Biology (FASEB)

    Professor Regina P Markus

  18. Melatonin (High Dose): A neglected aspect of managing the Ebola virus

    Article • Journal of Medical Virology, January 2015, Wiley

    Professor Regina P Markus, George Anderson

  19. The Cellular State Determines the Effect of Melatonin on the Survival of Mixed Cerebellar Cell Culture

    Article • PLoS ONE, September 2014, PLOS

    Professor Regina P Markus

  20. Selective protection of the cerebellum against intracerebroventricular LPS is mediated by local melatonin synthesis

    Article • Brain Structure and Function, December 2013, Springer Science + Business Media

    Professor Regina P Markus

  21. A Phase II, Randomized, Double-Blind, Placebo Controlled, Dose-Response Trial of the Melatonin Effect on the Pain Threshold of Healthy Subjects

    Article • PLoS ONE, October 2013, PLOS

    Professor Regina P Markus, WOLNEI Caumo

  22. Melatonin synthesis in human colostrum mononuclear cells enhances dectin-1-mediated phagocytosis by mononuclear cells

    Article • Journal of Pineal Research, June 2013, Wiley

    Professor Regina P Markus

  23. Immune-Pineal Axis: Nuclear Factor κB (NF-kB) Mediates the Shift in the Melatonin Source from Pinealocytes to Immune Competent Cells

    Article • International Journal of Molecular Sciences, May 2013, MDPI AG

    Professor Regina P Markus

  24. The Concept of the Immune-Pineal Axis Tested in Patients Undergoing an Abdominal Hysterectomy

    Article • NeuroImmunoModulation, January 2013, Karger Publishers

    Professor Regina P Markus, WOLNEI Caumo

  25. NF-κB Drives the Synthesis of Melatonin in RAW 264.7 Macrophages by Inducing the Transcription of the Arylalkylamine-N-Acetyltransferase (AA-NAT) Gene

    Article • PLoS ONE, December 2012, PLOS

    Sandra Muxel, Professor Regina P Markus

  26. Endothelial cell adhesiveness is a function of environmental lighting and melatonin level

    Article • Journal of Pineal Research, July 2012, Wiley

    Professor Regina P Markus

  27. Glia-Pinealocyte Network: The Paracrine Modulation of Melatonin Synthesis by Tumor Necrosis Factor (TNF)

    Article • PLoS ONE, July 2012, PLOS

    Professor Regina P Markus

  28. Actions of translocator protein ligands on neutrophil adhesion and motility induced by G-protein coupled receptor signaling

    Article • Biochemical and Biophysical Research Communications, January 2012, Elsevier

    Professor Regina P Markus

  29. Daily rhythm of salivary IL-1ß, cortisol and melatonin in day and night workers

    Article • Work, January 2012, IOS Press

    Professor Regina P Markus

  30. Plasma corticosterone elevation inhibits the activation of nuclear factor kappa B (NFKB) in the Syrian hamster pineal gland

    Article • Stress, December 2011, Taylor & Francis

    Professor Regina P Markus

  31. 6-Sulfatoxymelatonin as a predictor of clinical outcome in depressive patients

    Article • Human Psychopharmacology Clinical and Experimental, June 2011, Wiley

    Professor Regina P Markus, WOLNEI Caumo

  32. Nitric oxide modulates lipopolysaccharide-induced endothelial platelet endothelial cell adhesion molecule expression via interleukin-10

    Article • Clinical & Experimental Immunology, May 2011, Wiley

    Professor Regina P Markus

  33. Molecular Basis for Defining the Pineal Gland and Pinealocytes as Targets for Tumor Necrosis Factor

    Article • Frontiers in Endocrinology, January 2011, Frontiers

    Sandra Muxel, Professor Regina P Markus

  34. The Immune-Pineal Axis: the Role of Pineal and Extra-Pineal Melatonin in Modulating Inflammation

    Article • Advances in Neuroimmune Biology, January 2011, IOS Press

    Professor Regina P Markus

  35. Long-Lasting Priming of Endothelial Cells by Plasma Melatonin Levels

    Article • PLoS ONE, November 2010, PLOS

    Professor Regina P Markus

  36. Purinergic signalling is involved in the malaria parasite Plasmodium falciparum invasion to red blood cells

    Article • Purinergic Signalling, October 2010, Springer Science + Business Media

    Professor Regina P Markus

  37. Role of α7 Nicotinic Acetylcholine Receptor in Calcium Signaling Induced by Prion Protein Interaction with Stress-inducible Protein 1

    Article • Journal of Biological Chemistry, September 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Regina P Markus

  38. TLR4 and CD14 receptors expressed in rat pineal gland trigger NFKB pathway

    Article • Journal of Pineal Research, June 2010, Wiley

    Professor Regina P Markus

  39. Is modulation of nicotinic acetylcholine receptors by melatonin relevant for therapy with cholinergic drugs?

    Article • Pharmacology & Therapeutics, June 2010, Elsevier

    Professor Regina P Markus

  40. Melatonin and the time window for the expression of the α8 nicotinic acetylcholine receptor in the membrane of chick retinal cells in culture

    Article • International Journal of Developmental Neuroscience, May 2010, Elsevier

    Professor Regina P Markus

  41. DAILY VARIATION OF CONSTITUTIVELY ACTIVATED NUCLEAR FACTOR KAPPA B (NFKB) IN RAT PINEAL GLAND

    Article • Chronobiology International, February 2010, Taylor & Francis

    Professor Regina P Markus

  42. Melatonin inhibits LPS-induced NO production in rat endothelial cells

    Article • Journal of Pineal Research, April 2009, Wiley

    Professor Regina P Markus

  43. Acute increase in urinary 6-sulfatoximelatonin after clomipramine, as a predictive measure for emotional improvement

    Article • Journal of Psychopharmacology, March 2009, SAGE Publications

    Professor Regina P Markus

  44. Local Corticosterone Infusion Enhances Nocturnal Pineal Melatonin ProductionIn Vivo

    Article • Journal of Neuroendocrinology, February 2009, Wiley

    Professor Regina P Markus

  45. The Immune-Pineal Axis

    Article • Annals of the New York Academy of Sciences, February 2009, Wiley

    Professor Regina P Markus

  46. Age-related changes in cerebellar phosphatase-1 reduce Na,K-ATPase activity

    Article • Neurobiology of Aging, November 2008, Elsevier

    Professor Regina P Markus

  47. Intracellular Peptides as Natural Regulators of Cell Signaling

    Article • Journal of Biological Chemistry, July 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Regina P Markus

  48. Effect of antidepressants on melatonin metabolite in depressed patients

    Article • Journal of Psychopharmacology, June 2008, SAGE Publications

    Professor Regina P Markus

  49. Endogenous glucocorticoids control neutrophil mobilization from bone marrow to blood and tissues in non-inflammatory conditions

    Article • Bone Marrow Transplantation, December 2007, Wiley

    Professor Regina P Markus

  50. Pineal melatonin and the innate immune response: the TNF-? increase after cesarean section suppresses nocturnal melatonin production

    Article • Journal of Pineal Research, November 2007, Wiley

    Professor Regina P Markus

  51. Melatonin inhibits nitric oxide production by microvascular endothelial cellsin vivoandin vitro

    Article • Bone Marrow Transplantation, May 2007, Wiley

    Professor Regina P Markus

  52. Long-term primary culture of secretory cells of Bothrops jararaca venom gland for venom production in vitro

    Article • Nature Protocols, January 2007, Nature

    Professor Regina P Markus

  53. The Immune-Pineal Axis: A Shuttle between Endocrine and Paracrine Melatonin Sources

    Article • NeuroImmunoModulation, January 2007, Karger Publishers

    Professor Regina P Markus

  54. Effect of TNF-? on the melatonin synthetic pathway in the rat pineal gland: basis for a 'feedback' of the immune response on circadian timing

    Article • Journal of Pineal Research, November 2006, Wiley

    Professor Regina P Markus

  55. Melatonin inhibits endothelial nitric oxide production in vitro

    Article • Journal of Pineal Research, October 2006, Wiley

    Professor Regina P Markus

  56. Injury switches melatonin production source from endocrine (pineal) to paracrine (phagocytes) – melatonin in human colostrum and colostrum phagocytes

    Article • Journal of Pineal Research, September 2006, Wiley

    Professor Regina P Markus

  57. Melatonin levels in drug-free patients with major depression from the southern hemisphere

    Article • Psychoneuroendocrinology, July 2006, Elsevier

    Professor Regina P Markus

  58. Adrenal deficiency alters mechanisms of neutrophil mobilization

    Article • Molecular and Cellular Endocrinology, April 2006, Elsevier

    Professor Regina P Markus

  59. Melatonin effect on endothelial cells reduces vascular permeability increase induced by leukotriene B4

    Article • European Journal of Pharmacology, March 2006, Elsevier

    Professor Regina P Markus

  60. Venom production in long-term primary culture of secretory cells of the Bothrops jararaca venom gland

    Article • Toxicon, January 2006, Elsevier

    Professor Regina P Markus

  61. Melatonin modulates rat myotube-acetylcholine receptors by inhibiting calmodulin

    Article • European Journal of Pharmacology, November 2005, Elsevier

    Professor Regina P Markus

  62. Age-related changes in cyclic GMP and PKG-stimulated cerebellar Na,K-ATPase activity

    Article • Neurobiology of Aging, June 2005, Elsevier

    Professor Regina P Markus

  63. Corticosterone modulates noradrenaline-induced melatonin synthesis through inhibition of nuclear factor kappa B

    Article • Journal of Pineal Research, April 2005, Wiley

    Professor Regina P Markus

  64. Bimodal Daily Variation in the Serotonin Content in the Raphe Nuclei of Rats

    Article • Biological Rhythm Research, July 2004, Taylor & Francis

    Professor Regina P Markus

  65. Stimulation of the  -adrenoceptor triggers the venom production cycle in the venom gland of Bothrops jararaca

    Article • Journal of Experimental Biology, February 2004, The Company of Biologists

    Professor Regina P Markus

  66. Release of [3h]-l-glutamate by stimulation of nicotinic acetylcholine receptors in rat cerebellar slices

    Article • Neuroscience, January 2004, Elsevier

    Professor Regina P Markus

  67. Melatonin Nocturnal Surge Modulates Nicotinic Receptors and Nicotine-Induced [3H]Glutamate Release in Rat Cerebellum Slices

    Article • Journal of Pharmacology and Experimental Therapeutics, January 2003, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Regina P Markus

  68. P2Y1 Receptor Activation Enhances the Rate of Rat Pinealocyte-Induced Extracellular Acidification via a Calcium-Dependent Mechanism

    Article • Pharmacology, January 2003, Karger Publishers

    Professor Regina P Markus

  69. Melatonin and N-acetylserotonin inhibit leukocyte rolling and adhesion to rat microcirculation

    Article • European Journal of Pharmacology, November 2001, Elsevier

    Professor Regina P Markus

  70. Tertian and Quartan Fevers: Temporal Regulation in Malarial Infection

    Article • Journal of Biological Rhythms, October 2001, SAGE Publications

    Professor Regina P Markus

  71. Characterisation of P2Y1-like receptor in cultured rat pineal glands

    Article • European Journal of Pharmacology, March 2001, Elsevier

    Professor Regina P Markus

  72. Interaction between the adrenal and the pineal gland in chronic experimental inflammation induced by BCG in mice

    Article • Inflammation Research, February 2001, Springer Science + Business Media

    Professor Regina P Markus

  73. Article • Biogerontology, January 2001, Springer Science + Business Media

    Professor Regina P Markus

  74. Purinergic and noradrenergic cotransmission in the rat pineal gland

    Article • European Journal of Pharmacology, July 2000, Elsevier

    Professor Regina P Markus

  75. Article • Nature, June 2000, Nature

    Professor Regina P Markus

  76. Characterization of β-adrenoceptors responsible for venom production in the venom gland of the snake Bothrops jararaca

    Article • Life Sciences, June 2000, Elsevier

    Professor Regina P Markus

  77. Influence of age on nitric oxide modulatory action on Na+, K+-ATPase activity through cyclic GMP pathway in proximal rat trachea

    Article • European Journal of Pharmacology, January 2000, Elsevier

    Professor Regina P Markus

  78. Adenosine inhibits the renal plasma-membrane (Ca2+ + Mg2+)-ATPase through a pathway sensitive to cholera toxin and sphingosine

    Article • European Journal of Biochemistry, July 1999, Wiley

    Professor Regina P Markus

  79. Are imidazoline receptors involved in sympathetic neurotransmission in rat vas deferens

    Article • General Pharmacology The Vascular System, October 1996, Elsevier

    Professor Regina P Markus

  80. Acetylcholine-induced contraction in the rat vas deferens: diurnal variations

    Article • European Journal of Pharmacology, July 1990, Elsevier

    Professor Jose Cipolla-Neto, Professor Regina P Markus

  81. Crcadian and ultradian rhythms of superoxide dismutase in the pineal gland

    Article • European Journal of Pharmacology, July 1990, Elsevier

    Professor Regina P Markus

  82. Relationship between neuronal uptake and release of noradrenaline in the rat vas deferens

    Article • European Journal of Pharmacology, July 1990, Elsevier

    Professor Regina P Markus

  83. Neuronal uptake of noradrenaline in the rat isolated trachea: Effect of ageing

    Article • Comparative Biochemistry and Physiology Part C Comparative Pharmacology, January 1990, Elsevier

    Professor Regina P Markus

  84. Do differences in innervation result in different post-synaptic responses to exogenous agonists?

    Article • General Pharmacology The Vascular System, January 1989, Elsevier

    Professor Regina P Markus

  85. Age-related changes in the reactivity of the rat jejunum to cholinoceptor agonists

    Article • European Journal of Pharmacology, September 1985, Elsevier

    Professor Regina P Markus

  86. The effect of sexual hormones on the sulfated glycosaminoglycan pattern of male genital accessory organs

    Article • Archives of Biochemistry and Biophysics, July 1985, Elsevier

    Professor Regina P Markus

  87. Effect of full agonists following calcium deprivation in rat vas deferens

    Article • European Journal of Pharmacology, April 1975, Elsevier

    Professor Regina P Markus