All Stories

  1. Physiological processes underpinning the ubiquitous benefits and interactions of melatonin, butyrate and green tea in neurodegenerative conditions
  2. Polycystic Ovary Syndrome Pathophysiology: Integrating Systemic, CNS and Circadian Processes
  3. A More Holistic Perspective of Alzheimer's Disease: Roles of Gut Microbiome, Adipocytes, HPA Axis, Melatonergic Pathway and Astrocyte Mitochondria in the Emergence of Autoimmunity
  4. Role of the Night-Time Systemic Processes and the Astrocyte Tryptophan-Melatonin Pathway in the Regulation of α-Synuclein and Wider Parkinson’s Disease Pathophysiology
  5. Gut Microbiome and Circadian Interactions with Platelets Across Human Diseases, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, and Cancer
  6. Melatonin, BAG-1 and cortisol circadian interactions in tumor pathogenesis and patterned immune responses
  7. Melatonin modulates tumor metabolism and mitigates metastasis
  8. Redefining Autoimmune Disorders’ Pathoetiology: Implications for Mood and Psychotic Disorders’ Association with Neurodegenerative and Classical Autoimmune Disorders
  9. Type I Diabetes Pathoetiology and Pathophysiology: Roles of the Gut Microbiome, Pancreatic Cellular Interactions, and the ‘Bystander’ Activation of Memory CD8+ T Cells
  10. Why do anti-amyloid beta antibodies not work? Time to reconceptualize dementia pathophysiology by incorporating astrocyte melatonergic pathway desynchronization from amyloid-beta production
  11. Amyotrophic Lateral Sclerosis Pathoetiology and Pathophysiology: Roles of Astrocytes, Gut Microbiome, and Muscle Interactions via the Mitochondrial Melatonergic Pathway, with Disruption by Glyphosate-Based Herbicides
  12. Depression Pathophysiology: Astrocyte Mitochondrial Melatonergic Pathway as Crucial Hub
  13. Tumor Microenvironment and Metabolism: Role of the Mitochondrial Melatonergic Pathway in Determining Intercellular Interactions in a New Dynamic Homeostasis
  14. Clozapine and the aryl hydrocarbon receptor
  15. False Dogmas in Schizophrenia Research: Toward the Reification of Pathway Phenotypes and Pathway Classes
  16. Melatonin, Its Beneficial Effects on Embryogenesis from Mitigating Oxidative Stress to Regulating Gene Expression
  17. The melatonergic pathway and its interactions in modulating respiratory system disorders
  18. Tryptophan Metabolites and Aryl Hydrocarbon Receptor in Severe Acute Respiratory Syndrome, Coronavirus-2 (SARS-CoV-2) Pathophysiology
  19. Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances
  20. Sirtuins, mitochondria, and the melatonergic pathway in Alzheimer’s disease
  21. Tumour Microenvironment: Roles of the Aryl Hydrocarbon Receptor, O-GlcNAcylation, Acetyl-CoA and Melatonergic Pathway in Regulating Dynamic Metabolic Interactions across Cell Types—Tumour Microenvironment and Metabolism
  22. Role of Opioidergic System in Regulating Depression Pathophysiology
  23. Mitochondria and immunity in chronic fatigue syndrome
  24. Inflammation and Mitochondrial Dysfunction in Autism Spectrum Disorder
  25. Chronic fatigue and depression due to multiple sclerosis: Immune-inflammatory pathways, tryptophan catabolites and the gut-brain axis as possible shared pathways
  26. Preventive treatments to slow substantia nigra damage and Parkinson’s disease progression: A critical perspective review
  27. Aryl Hydrocarbon Receptor Role in Co-Ordinating SARS-CoV-2 Entry and Symptomatology: Linking Cytotoxicity Changes in COVID-19 and Cancers; Modulation by Racial Discrimination Stress
  28. Melatonin and cocaine: role of mitochondria, immunity, and gut microbiome
  29. COVID-19 pathophysiology: interactions of gut microbiome, melatonin, vitamin D, stress, kynurenine and the alpha 7 nicotinic receptor: Treatment implications
  30. Gut Dysbiosis Dysregulates Central and Systemic Homeostasis via Suboptimal Mitochondrial Function: Assessment, Treatment and Classification Implications
  31. Melatonin: Roles in influenza, Covid‐19, and other viral infections
  32. The Role of Prenatal Melatonin in the Regulation of Childhood Obesity
  33. Pathoetiology and pathophysiology of borderline personality: Role of prenatal factors, gut microbiome, mu- and kappa-opioid receptors in amygdala-PFC interactions
  34. The effects of melatonin on signaling pathways and molecules involved in glioma
  35. Integrating Autism Spectrum Disorder Pathophysiology: Mitochondria, Vitamin A, CD38, Oxytocin, Serotonin and Melatonergic Alterations in the Placenta and Gut
  36. Autism Spectrum Disorders: Role of Pre- and Post-Natal GammaDelta (γδ) T Cells and Immune Regulation
  37. Gut-Amygdala Interactions in Autism Spectrum Disorders: Developmental Roles via regulating Mitochondria, Exosomes, Immunity and microRNAs
  38. Autism Spectrum Disorder: Pathophysiology and Treatment Implications
  39. Early and very early‐onset schizophrenia compared with adult‐onset schizophrenia: French FACE‐SZ database
  40. Glioblastoma chemoresistance: roles of the mitochondrial melatonergic pathway
  41. The gut microbiome integrates immune-inflammatory processes in depression
  42. Daytime orexin and night-time melatonin regulation of mitochondria melatonin: roles in circadian oscillations systemically and centrally in breast cancer symptomatology
  43. Integrating Pathophysiology in Migraine: Role of the Gut Microbiome and Melatonin
  44. Multiple Sclerosis: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate in the Circadian Dysregulation of Mitochondria in Glia and Immune Cells
  45. The regulation of melatonin production within mitochondria reframes the nature of breast cancers
  46. The Role of Aberrations in the Immune-Inflammatory Response System (IRS) and the Compensatory Immune-Regulatory Reflex System (CIRS) in Different Phenotypes of Schizophrenia: the IRS-CIRS Theory of Schizophrenia
  47. Left Ventricular Hypertrophy: Roles of Mitochondria CYP1B1 and Melatonergic Pathways in Co-Ordinating Wider Pathophysiology
  48. Endometriosis Pathoetiology and Pathophysiology: Roles of Vitamin A, Estrogen, Immunity, Adipocytes, Gut Microbiome and Melatonergic Pathway on Mitochondria Regulation
  49. Mitochondria and the Gut as crucial hubs for the interactions of melatonin with sirtuins, inflammation, butyrate, tryptophan metabolites, and alpha 7 nicotinic receptor across a host of medical conditions.
  50. Mitochondria: the birth place, battle ground and the site of melatonin metabolism in cells
  51. Depression and neuroprogression: Sirtuins and mitochondria as crucial hubs
  52. Reframes nature of GBM and GSCs
  53. Common Environmental Factors May Underpin the Comorbidity Between Generalized Anxiety Disorder and Mood Disorders Via Activated Nitrooxidative Pathways
  54. The neurobiology of adaptation to seasons: Relevance and correlations in bipolar disorders
  55. Lowered quality of life in mood disorders is associated with increased neuro-oxidative stress and basal thyroid-stimulating hormone levels and use of anticonvulsant mood stabilizers
  56. In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life
  57. Reciprocal Interactions of Mitochondria and the Neuroimmunoendocrine System in Neurodegenerative Disorders: An Important Role for Melatonin Regulation
  58. Bright light and oxygen therapies decrease delirium risk in critically ill surgical patients by targeting sleep and acid-base disturbances
  59. A neuro-immune, neuro-oxidative and neuro-nitrosative model of prenatal and postpartum depression
  60. Associations between severity of anxiety and clinical and biological features of major affective disorders
  61. Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition
  62. Depressive, anxiety and hypomanic symptoms in schizophrenia may be driven by tryptophan catabolite (TRYCAT) patterning of IgA and IgM responses directed to TRYCATs
  63. Affective symptoms in schizophrenia are strongly associated with neurocognitive deficits indicating disorders in executive functions, visual memory, attention and social cognition
  64. The Biological Underpinnings of Mood Disorders Interact With Early Trauma, Sexual Abuse and Neuroticism: Implications for Psychiatric Classification and Treatment
  65. Changes in Tryptophan Catabolite (TRYCAT) Pathway Patterning Are Associated with Mild Impairments in Declarative Memory in Schizophrenia and Deficits in Semantic and Episodic Memory Coupled with Increased False-Memory Creation in Deficit Schizophrenia
  66. Psychosis: glia, immunity, and melatonin
  67. Shared metabolic and immune-inflammatory, oxidative and nitrosative stress pathways in the metabolic syndrome and mood disorders
  68. Oxidative and Nitrosative Stress, Immune Inflammation and Trptophan Catabolites in Driving Melatonergic Pathway Alterations in Depression: Treatment Implications
  69. IgA/IgM Responses to Gram-Negative Bacteria are not Associated with Perinatal Depression, but with Physio-somatic Symptoms and Activation of the Tryptophan Catabolite Pathway at the End of Term and Postnatal Anxiety
  70. IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (T...
  71. Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life
  72. How Immune-inflammatory Processes Link CNS and Psychiatric Disorders: Classification and Treatment Implications
  73. Deficit Schizophrenia Is Characterized by Defects in IgM-Mediated Responses to Tryptophan Catabolites (TRYCATs): a Paradigm Shift Towards Defects in Natural Self-Regulatory Immune Responses Coupled with Mucosa-Derived TRYCAT Pathway Activation
  74. Physio-somatic symptoms in schizophrenia: association with depression, anxiety, neurocognitive deficits and the tryptophan catabolite pathway
  75. Deficit, but Not Nondeficit, Schizophrenia Is Characterized by Mucosa-Associated Activation of the Tryptophan Catabolite (TRYCAT) Pathway with Highly Specific Increases in IgA Responses Directed to Picolinic, Xanthurenic, and Quinolinic Acid
  76. Breastfeeding and the gut-brain axis: is there a role for melatonin?
  77. Interactions of Tryptophan and Its Catabolites With Melatonin and the Alpha 7 Nicotinic Receptor in Central Nervous System and Psychiatric Disorders: Role of the Aryl Hydrocarbon Receptor and Direct Mitochondria Regulation
  78. Alpha 7 Nicotinic Receptor Agonist Modulatory Interactions with Melatonin: Relevance not only to Cognition, but to Wider Neuropsychiatric and Immune Inflammatory Disorders
  79. Gut Permeability and Microbiota in Parkinson’s Disease: Role of Depression, Tryptophan Catabolites, Oxidative and Nitrosative Stress and Melatonergic Pathways
  80. Multiple Sclerosis, Gut Microbiota and Permeability: Role of Tryptophan Catabolites, Depression and the Driving Down of Local Melatonin
  81. Intestinal Dysbiosis, Gut Hyperpermeability and Bacterial Translocation: Missing Links Between Depression, Obesity and Type 2 Diabetes
  82. A Role for the Regulation of the Melatonergic Pathways in Alzheimer’s Disease and Other Neurodegenerative and Psychiatric Conditions
  83. Single-Nucleotide Polymorphisms of Genes Involved in Repair of Oxidative DNA Damage and the Risk of Recurrent Depressive Disorder
  84. Hypothalamic-Pituitary-Adrenal Hypofunction in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) as a Consequence of Activated Immune-Inflammatory and Oxidative and Nitrosative Pathways
  85. Breast Feeding and Melatonin: Implications for Improving Perinatal Health
  86. T helper 17 cells may drive neuroprogression in major depressive disorder: Proposal of an integrative model
  87. IgA/IgM responses to tryptophan and tryptophan catabolites (TRYCATs) are differently associated with prenatal depression, physio-somatic symptoms at the end of term and premenstrual syndrome
  88. Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging
  89. Bipolar Disorder: The Role of the Kynurenine and Melatonergic Pathways
  90. Editorial (Thematic Issue: The Kynurenine and Melatonergic Pathways in Psychiatric and CNS Disorders)
  91. Glioma: Tryptophan Catabolite and Melatoninergic Pathways Link microRNA, 14-3- 3, Chromosome 4q35, Epigenetic Processes and other Glioma Biochemical Changes
  92. Overlapping the Tryptophan Catabolite (TRYCAT) and Melatoninergic Pathways in Alzheimer';s Disease
  93. The Many Neuroprogressive Actions of Tryptophan Catabolites (TRYCATs) that may be Associated with the Pathophysiology of Neuro-Immune Disorders
  94. Incidence of Diabetes in Colorectal Cancer Survivors
  95. Melatoninergic Pathways in Alzheimer's Disease
  96. Pharmaceutical and Nutritional Benefits in Alzheimer's Disease via Convergence on the Melatoninergic Pathways
  97. Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut–brain pathways
  98. The Toll-Like Receptor Radical Cycle Pathway: A New Drug Target in Immune-Related Chronic Fatigue
  99. The gut–brain axis: The role of melatonin in linking psychiatric, inflammatory and neurodegenerative conditions
  100. Multiple sclerosis: The role of melatonin and N-acetylserotonin
  101. Bipolar Disorder: Role of Immune-Inflammatory Cytokines, Oxidative and Nitrosative Stress and Tryptophan Catabolites
  102. Melatonin (High Dose): A neglected aspect of managing the Ebola virus
  103. Mechanisms Underlying Neurocognitive Dysfunctions in Recurrent Major Depression
  104. Oxidative & nitrosative stress in depression: Why so much stress?
  105. Local Melatonin Regulates Inflammation Resolution: A Common Factor in Neurodegenerative, Psychiatric and Systemic Inflammatory Disorders
  106. Oxidative/Nitrosative Stress and Immuno-inflammatory Pathways in Depression: Treatment Implications
  107. The Glutathione System: A New Drug Target in Neuroimmune Disorders
  108. Redox Regulation and the Autistic Spectrum: Role of Tryptophan Catabolites, Immuno-inflammation, Autoimmunity and the Amygdala
  109. Targeting classical IL-6 signalling or IL-6trans-signalling in depression?
  110. TRYCAT Pathways Link Peripheral Inflammation, Nicotine, Somatization and Depression in the Etiology and Course of Parkinson’s Disease
  111. Reconceptualizing Adult Neurogenesis: Role for Sphingosine-1-Phosphate and Fibroblast Growth Factor-1 in Co-Ordinating Astrocyte-Neuronal Precursor Interactions
  112. Increased IL-6 trans-signaling in depression: focus on the tryptophan catabolite pathway, melatonin and neuroprogression
  113. Immunolocalization of substance P and NK-1 receptor in hofbauer cells in human normal placenta
  114. Role of Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways in the Etiology of Depression: Therapeutic Implications
  115. Melatonin in the Etiology, Pathophysiology, and Management of Schizophrenia
  116. Metabolic Syndrome, Alzheimer Disease, Schizophrenia, and Depression: Role for Leptin, Melatonin, Kynurenine Pathways, and Neuropeptides
  117. Neurodegeneration in Parkinson's Disease: Interactions of Oxidative Stress, Tryptophan Catabolites and Depression with Mitochondria and Sirtuins
  118. In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation
  119. Biological phenotypes: somatization, depression, and chronic fatigue syndrome.
  120. Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression
  121. Coenzyme Q10 Depletion in Medical and Neuropsychiatric Disorders: Potential Repercussions and Therapeutic Implications
  122. Comment and reply on: ME is a distinct diagnostic entity, not part of a chronic fatigue spectrum
  123. The circadian clock circuitry and the AHR signaling pathway in physiology and pathology
  124. Prenatal infection important to etiology of schizophrenia
  125. Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways
  126. Immuno-inflammatory, oxidative and nitrosative stress, and neuroprogressive pathways in the etiology, course and treatment of schizophrenia
  127. Putative neuroprotective agents in neuropsychiatric disorders
  128. A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior
  129. Diagnosis of myalgic encephalomyelitis: where are we now?
  130. Postpartum depression: psychoneuroimmunological underpinnings and treatment
  131. Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells
  132. Hemochromatosis and bipolar disorder
  133. Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways
  134. Biological underpinnings of the commonalities in depression, somatization & Chronic Fatigue Syndrome
  135. Melatonin prevents the metabolic dysregulation by anti-psychotics
  136. The Role of Indoleamine 2,3-Dioxygenase in a Mouse Model of Neuroinflammation-Induced Depression
  137. Inflammation-Related Disorders in the Tryptophan Catabolite Pathway in Depression and Somatization
  138. Melatonin and Cognitive Deficits in Bipolar Disorder and Mild Cognitive Impairment
  139. Multiple sclerosis and seizures: possible role forHelicobacter pylori
  140. Melatonin, Agomelatine, and Alcoholism
  141. Amygdala has early postnatal role in regulation of cortex development
  142. Role of IL-18, IDO and melatonin in emergent seizures in MS patients
  143. Impact of prenatal corticosteroids and modulation by melatonin and vitamin D
  144. IL-18, IDO and quinolinic acid drive emergent seizures in Alzheimer's disease
  145. The role of melatonin in post-partum psychosis and depression associated with bipolar disorder
  146. Some applications of reversal theory to the explanation of gambling and gambling addictions
  147. First study to show heart rate increase in gamblers and correlated with personality
  148. Alcohol cues condition changes in arousal