All Stories

  1. Toward In Vivo CAR T Cell Therapy: Perfecting CAR and Lipid Nanoparticle Design

    Article • Nano Letters, February 2026, American Chemical Society (ACS)

    Professor Raymond Schiffelers

  2. Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH

    Article • Science Advances, September 2025, American Association for the Advancement of Science

    Professor Raymond Schiffelers

  3. Therapeutic Application of mRNA for Genetic Diseases

    Article • Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, May 2025, Wiley

    Professor Raymond Schiffelers

  4. Comparative Analysis of Methods for Assessing On-Target Gene Editing Efficiencies

    Article • Methods and Protocols, March 2025, MDPI AG

    Professor Raymond Schiffelers

  5. RUNX1::RUNX1T1 Depletion Eliminates Stemness and Induces Bidirectional Differentiation of Acute Myeloid Leukemia

    Article • February 2025, Cold Spring Harbor Laboratory Press

    Professor Raymond Schiffelers

  6. Nanoparticle-in-Hydrogel Delivery System for the Sequential Release of Two Drugs

    Article • Pharmaceutics, January 2025, MDPI AG

    Professor Raymond Schiffelers

  7. Lipid Nanoparticles for Nucleic Acid Delivery Beyond the Liver

    Article • Human Gene Therapy, September 2024, Mary Ann Liebert Inc

    Professor Raymond Schiffelers

  8. mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond

    Article • Advanced Drug Delivery Reviews, March 2024, Elsevier

    Professor Raymond Schiffelers

  9. Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial Administration

    Article • ACS Nano, November 2023, American Chemical Society (ACS)

    Professor Raymond Schiffelers

  10. Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery

    Article • Small, August 2021, Wiley

    Professor Raymond Schiffelers

  11. Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design

    Article • Advanced Drug Delivery Reviews, June 2021, Elsevier

    Professor Raymond Schiffelers

  12. Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles

    Article • Nano Letters, February 2021, American Chemical Society (ACS)

    Professor Raymond Schiffelers

  13. Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model

    Article • International Journal of Pharmaceutics X, December 2020, Elsevier

    Professor Raymond Schiffelers

  14. EVQuant; high-throughput quantification and characterization of extracellular vesicle (sub)populations

    Article • October 2020, Cold Spring Harbor Laboratory Press

    Professor Raymond Schiffelers

  15. Delivering the power of nanomedicine to patients today

    Article • Journal of Controlled Release, October 2020, Elsevier

    Ruth Schmid, Professor Raymond Schiffelers

  16. The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy

    Article • Bioconjugate Chemistry, August 2020, American Chemical Society (ACS)

    Professor Raymond Schiffelers

  17. Local release of siRNA using polyplex-loaded thermosensitive hydrogels

    Article • Nanoscale, January 2020, Royal Society of Chemistry

    Professor Raymond Schiffelers

  18. Drug Delivery with Extracellular Vesicles: From Imagination to Innovation

    Article • Accounts of Chemical Research, June 2019, American Chemical Society (ACS)

    Professor Raymond Schiffelers

  19. A head-to-head comparison of conjugation methods for VHHs: random maleimide-thiol coupling versus controlled click chemistry

    Article • International Journal of Pharmaceutics X, June 2019, Elsevier

    Professor Raymond Schiffelers

  20. Development and characterization of liposomal formulation of bortezomib

    Article • International Journal of Pharmaceutics X, March 2019, Elsevier

    Professor Raymond Schiffelers

  21. Liposomes with asymmetric bilayers produced from inverse emulsions for nucleic acid delivery

    Article • Journal of Drug Targeting, February 2019, Taylor & Francis

    Professor Raymond Schiffelers

  22. Thermosensitive liposomes for triggered release of cytotoxic proteins

    Article • European Journal of Pharmaceutics and Biopharmaceutics, November 2018, Elsevier

    Professor Raymond Schiffelers

  23. Liposomal drug delivery in an in vitro 3D bone marrow model for multiple myeloma

    Article • International Journal of Nanomedicine, November 2018, Dove Medical Press

    Professor Raymond Schiffelers, Maaike Braham

  24. Nanomedicines for the treatment of hematological malignancies

    Article • Journal of Controlled Release, October 2018, Elsevier

    Professor Raymond Schiffelers

  25. Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety

    Article • ACS Nano, September 2018, American Chemical Society (ACS)

    Professor Raymond Schiffelers

  26. Nanomechanics of Extracellular Vesicles Reveals Vesiculation Pathways

    Article • Small, August 2018, Wiley

    Professor Raymond Schiffelers

  27. Insights into maleimide-thiol conjugation chemistry: Conditions for efficient surface functionalization of nanoparticles for receptor targeting

    Article • Journal of Controlled Release, July 2018, Elsevier

    Professor Raymond Schiffelers

  28. Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles

    Article • The EMBO Journal, June 2018, EMBO

    Professor Raymond Schiffelers

  29. Squeezing for Life – Properties of Red Blood Cell Deformability

    Article • Frontiers in Physiology, June 2018, Frontiers

    Professor Raymond Schiffelers, Dr Anna Bogdanova

  30. Quantitative measurement of red cell surface protein expression reveals new biomarkers for hereditary spherocytosis

    Article • International Journal of Laboratory Hematology, May 2018, Wiley

    Professor Raymond Schiffelers

  31. State-of-the-Art Design and Rapid-Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery

    Article • Small Methods, April 2018, Wiley

    Professor Raymond Schiffelers

  32. Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach

    Article • Nanoscale, January 2018, Royal Society of Chemistry

    Professor Raymond Schiffelers

  33. Polymers and hydrogels for local nucleic acid delivery

    Article • Journal of Materials Chemistry B, January 2018, Royal Society of Chemistry

    Professor Raymond Schiffelers

  34. Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology

    Article • Cardiovascular Research, November 2017, Oxford University Press (OUP)

    Professor Joost PG Sluijter, Professor Raymond Schiffelers

  35. Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis

    Article • Journal of Controlled Release, November 2017, Elsevier

    Professor Raymond Schiffelers

  36. Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: a Cost-Effective Alternative

    Article • Scientific Reports, October 2017, Springer Science + Business Media

    Professor Raymond Schiffelers

  37. Tumour-bound RNA-laden exosomes

    Article • Nature Biomedical Engineering, August 2017, Springer Science + Business Media

    Professor Raymond Schiffelers

  38. Microbubbles-Assisted Ultrasound Triggers the Release of Extracellular Vesicles

    Article • International Journal of Molecular Sciences, July 2017, MDPI AG

    Professor Raymond Schiffelers

  39. Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

    Article • Molecular Therapy, July 2017, Elsevier

    Professor Raymond Schiffelers

  40. In Situ Gelling Liquid Crystalline System as Local siRNA Delivery System

    Article • Molecular Pharmaceutics, March 2017, American Chemical Society (ACS)

    Professor Raymond Schiffelers

  41. Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction

    Article • Journal of Controlled Release, February 2017, Elsevier

    Professor Raymond Schiffelers

  42. Extracellular vesicles for nucleic acid delivery: progress and prospects for safe RNA-based gene therapy

    Article • Gene Therapy, January 2017, Springer Science + Business Media

    Professor Raymond Schiffelers

  43. Polyphosphate nanoparticles on the platelet surface trigger contact system activation

    Article • Blood, January 2017, American Society of Hematology

    Professor Raymond Schiffelers

  44. Clinical application of polymeric micelles for the treatment of cancer

    Article • Materials Chemistry Frontiers, January 2017, Royal Society of Chemistry

    Professor Raymond Schiffelers

  45. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper

    Article • Journal of Extracellular Vesicles, January 2017, Taylor & Francis

    Dr Muhammad Nawaz, Dr. Kenneth W Witwer, Professor Raymond Schiffelers, Dr. Sabine Bartel

  46. Interaction of Extracellular Vesicles with Endothelial Cells Under Physiological Flow Conditions

    Article • December 2016, Springer Science + Business Media

    Professor Raymond Schiffelers

  47. Liposomal prednisolone inhibits tumor growth in a spontaneous mouse mammary carcinoma model

    Article • Journal of Controlled Release, December 2016, Elsevier

    Professor Raymond Schiffelers

  48. ADDR editorial “Biologically-inspired drug delivery systems”

    Article • Advanced Drug Delivery Reviews, November 2016, Elsevier

    Professor Raymond Schiffelers

  49. Extracellular vesicles for drug delivery

    Article • Advanced Drug Delivery Reviews, November 2016, Elsevier

    Professor Raymond Schiffelers

  50. Modulation of tissue tropism and biological activity of exosomes and other extracellular vesicles: New nanotools for cancer treatment

    Article • Pharmacological Research, September 2016, Elsevier

    Professor Raymond Schiffelers

  51. Comparison of pharmaceutical nanoformulations for curcumin: Enhancement of aqueous solubility and carrier retention

    Article • International Journal of Pharmaceutics, June 2016, Elsevier

    Professor Raymond Schiffelers

  52. Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products In Vitro

    Article • PLOS One, May 2016, PLOS

    Professor Raymond Schiffelers

  53. Cetuximab treatment alters the content of extracellular vesicles released from tumor cells

    Article • Nanomedicine, April 2016, Future Medicine

    Professor Raymond Schiffelers

  54. PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

    Article • Journal of Controlled Release, February 2016, Elsevier

    Professor Raymond Schiffelers

  55. Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting

    Article • Journal of Extracellular Vesicles, January 2016, Taylor & Francis

    Professor Raymond Schiffelers

  56. Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency

    Article • Molecular Therapy — Nucleic Acids, January 2016, Elsevier

    Professor Raymond Schiffelers

  57. Silencing of protease-activated receptors attenuates synovitis and cartilage damage following a joint bleed in haemophilic mice

    Article • Haemophilia, July 2015, Wiley

    Professor Raymond Schiffelers

  58. An in situ gelling liquid crystalline system based on monoglycerides and polyethylenimine for local delivery of siRNAs

    Article • European Journal of Pharmaceutical Sciences, July 2015, Elsevier

    Mrs Livia Neves Borgheti Cardoso, Professor Raymond Schiffelers

  59. In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

    Article • Cell, May 2015, Elsevier

    Professor Raymond Schiffelers

  60. Complete Regression of Xenograft Tumors upon Targeted Delivery of Paclitaxel via Π–Π Stacking Stabilized Polymeric Micelles

    Article • ACS Nano, April 2015, American Chemical Society (ACS)

    Professor Raymond Schiffelers

  61. Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics

    Article • Journal of Controlled Release, February 2015, Elsevier

    Professor Raymond Schiffelers

  62. Mechanics of Extracellular Vesicles from Red Blood Cells

    Article • Biophysical Journal, January 2015, Elsevier

    Professor Raymond Schiffelers

  63. Extracellular Vesicles: Potential Roles in Regenerative Medicine

    Article • Frontiers in Immunology, December 2014, Frontiers

    Professor Raymond Schiffelers

  64. Extracellular vesicles as drug delivery systems: Lessons from the liposome field

    Article • Journal of Controlled Release, December 2014, Elsevier

    Professor Raymond Schiffelers

  65. Intercalating quaternary nicotinamide-based poly(amido amine)s for gene delivery

    Article • Journal of Controlled Release, December 2014, Elsevier

    Professor Raymond Schiffelers

  66. EVpedia: a community web portal for extracellular vesicles research

    Article • Bioinformatics, November 2014, Oxford University Press (OUP)

    Professor Raymond Schiffelers, Dr Gabriella Pocsfalvi, Dr. Kenneth W Witwer

  67. 448 Exposure to EGFR inhibitors influences release of extracellular vesicles by tumor cells

    Article • European Journal of Cancer, November 2014, Elsevier

    Professor Raymond Schiffelers

  68. Microparticles as biomarkers of osteonecrosis of the hip in sickle cell disease

    Article • British Journal of Haematology, September 2014, Wiley

    Professor Raymond Schiffelers

  69. Anginex lipoplexes for delivery of anti-angiogenic siRNA

    Article • International Journal of Pharmaceutics, September 2014, Elsevier

    Professor Raymond Schiffelers

  70. Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma

    Article • Oncotarget, July 2014, Impact Journals, LLC

    Professor Raymond Schiffelers

  71. Hemocompatibility Assessment of two siRNA Nanocarrier Formulations

    Article • Pharmaceutical Research, May 2014, Springer Science + Business Media

    Dr Mark Roest, Professor Raymond Schiffelers

  72. Toward routine detection of extracellular vesicles in clinical samples

    Article • International Journal of Laboratory Hematology, April 2014, Wiley

    Professor Raymond Schiffelers

  73. Immunoglobulin free light chains are biomarkers of poor prognosis in basal-like breast cancer and are potential targets in tumor-associated inflammation

    Article • Oncotarget, March 2014, Impact Journals, LLC

    Professor Raymond Schiffelers

  74. Curcumin nanoformulations: A review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment

    Article • Biomaterials, March 2014, Elsevier

    Professor Raymond Schiffelers

  75. Targeting hepatocyte growth factor receptor (Met) positive tumor cells using internalizing nanobody-decorated albumin nanoparticles

    Article • Biomaterials, January 2014, Elsevier

    Professor Raymond Schiffelers

  76. Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

    Article • Journal of Controlled Release, November 2013, Elsevier

    Professor Raymond Schiffelers

  77. Inhibition of Tumor Growth by Targeted Anti-EGFR/IGF-1R Nanobullets Depends on Efficient Blocking of Cell Survival Pathways

    Article • Molecular Pharmaceutics, October 2013, American Chemical Society (ACS)

    Professor Raymond Schiffelers

  78. Trends in polymeric delivery of nucleic acids to tumors

    Article • Journal of Controlled Release, September 2013, Elsevier

    Professor Raymond Schiffelers

  79. Taxol®-induced phosphatidylserine exposure and microvesicle formation in red blood cells is mediated by its vehicle Cremophor®EL

    Article • Nanomedicine, July 2013, Future Medicine

    Professor Raymond Schiffelers

  80. Strategies for triggered drug release from tumor targeted liposomes

    Article • Expert Opinion on Drug Delivery, June 2013, Informa Healthcare

    Professor Raymond Schiffelers

  81. Red blood cell: barometer of cardiovascular health?

    Article • Cardiovascular Research, February 2013, European Society of Cardiology

    Professor Raymond Schiffelers

  82. Extracellular vesicles in the circulation: are erythrocyte microvesicles a confounder in the plasma haemoglobin assay?

    Article • Biochemical Society Transactions, February 2013, Portland Press Ltd.

    Professor Raymond Schiffelers

  83. Oligonucleotides

    Article • January 2013, Springer Science + Business Media

    Professor Raymond Schiffelers

  84. Red blood cell vesiculation in hereditary hemolytic anemia

    Article • Frontiers in Physiology, January 2013, Frontiers

    Professor Raymond Schiffelers

  85. International Society for Extracellular Vesicles: Second Annual Meeting, 17–20 April 2013, Boston, MA (ISEV 2013)

    Article • Journal of Extracellular Vesicles, January 2013, Taylor & Francis

    Professor Raymond Schiffelers

  86. Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells

    Article • Journal of Controlled Release, January 2013, Elsevier

    Professor Raymond Schiffelers

  87. Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

    Article • PLoS Biology, December 2012, PLOS

    Professor Raymond Schiffelers

  88. Antitumor efficacy of dexamethasone-loaded core-crosslinked polymeric micelles

    Article • Journal of Controlled Release, November 2012, Elsevier

    Professor Raymond Schiffelers

  89. 121 Tumor-targeted Nanobullets for Anti-cancer Combination Therapy

    Article • European Journal of Cancer, November 2012, Elsevier

    Professor Raymond Schiffelers

  90. MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model

    Article • Journal of Controlled Release, August 2012, Elsevier

    Professor Raymond Schiffelers

  91. Drug targeting systems for inflammatory disease: One for all, all for one

    Article • Journal of Controlled Release, July 2012, Elsevier

    Professor Raymond Schiffelers

  92. 1043 Novel Anti-angiogenic MiRNAs Reduce in Vivo Tumor Growth in Mouse Models

    Article • European Journal of Cancer, July 2012, Elsevier

    Professor Raymond Schiffelers

  93. Microvesicles and exosomes: Opportunities for cell-derived membrane vesicles in drug delivery

    Article • Journal of Controlled Release, July 2012, Elsevier

    Professor Raymond Schiffelers

  94. Glucocorticoid-Loaded Core-Cross-Linked Polymeric Micelles with Tailorable Release Kinetics for Targeted Therapy of Rheumatoid Arthritis

    Article • Angewandte Chemie, June 2012, Wiley

    Professor Raymond Schiffelers

  95. Glucocorticoid-Loaded Core-Cross-Linked Polymeric Micelles with Tailorable Release Kinetics for Targeted Therapy of Rheumatoid Arthritis

    Article • Angewandte Chemie, June 2012, Wiley

    Professor Raymond Schiffelers

  96. Critical factors in the development of tumor-targeted anti-inflammatory nanomedicines

    Article • Journal of Controlled Release, June 2012, Elsevier

    Professor Raymond Schiffelers

  97. Targeted delivery of small interfering RNA to angiogenic endothelial cells with liposome-polycation-DNA particles

    Article • Journal of Controlled Release, June 2012, Elsevier

    Professor Raymond Schiffelers

  98. Design of cyclic RKKH peptide-conjugated PEG liposomes targeting the integrin α2β1 receptor

    Article • International Journal of Pharmaceutics, May 2012, Elsevier

    Professor Raymond Schiffelers

  99. Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes

    Article • Journal of Extracellular Vesicles, April 2012, Co-Action Publishing

    Professor Raymond Schiffelers

  100. Abstract 1112: Identification of microRNA-based therapeutic candidates using a unique lentiviral microRNA overexpression library

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Professor Raymond Schiffelers

  101. Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment

    Article • Journal of Controlled Release, April 2012, Elsevier

    Professor Raymond Schiffelers

  102. Exosome mimetics: a novel class of drug delivery systems

    Article • International Journal of Nanomedicine, March 2012, Taylor & Francis

    Professor Raymond Schiffelers

  103. Targeting epidermal growth factor receptor in tumors: From conventional monoclonal antibodies via heavy chain-only antibodies to nanobodies

    Article • European Journal of Pharmaceutical Sciences, March 2012, Elsevier

    Professor Raymond Schiffelers

  104. Liposomes as carriers for colchicine-derived prodrugs: Vascular disrupting nanomedicines with tailorable drug release kinetics

    Article • European Journal of Pharmaceutical Sciences, March 2012, Elsevier

    Professor Raymond Schiffelers

  105. Polyplexes based on cationic polymers with strong nucleic acid binding properties

    Article • European Journal of Pharmaceutical Sciences, March 2012, Elsevier

    Professor Raymond Schiffelers

  106. Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery

    Article • International Journal of Nanomedicine, February 2012, Taylor & Francis

    Professor Alexander S. Sobolev, Professor Raymond Schiffelers

  107. Attaching the phage display-selected GLA peptide to liposomes: Factors influencing target binding

    Article • European Journal of Pharmaceutical Sciences, February 2012, Elsevier

    Professor Raymond Schiffelers

  108. Abstract A12: Identification of microRNA-based therapeutic candidates using a unique lentiviral microRNA overexpression library

    Article • Cancer Research, January 2012, American Association for Cancer Research (AACR)

    Professor Raymond Schiffelers

  109. Editorial [ Hot Topic:siRNA Based Approaches in Medicinal Chemistry and Drug Discovery (Guest Editor: Raymond M. Schiffelers )]

    Article • Current Topics in Medicinal Chemistry, January 2012, Bentham Science Publishers

    Professor Raymond Schiffelers

  110. Micro-Vesiculation and Disease, London, 13–14 September 2012

    Article • Journal of Extracellular Vesicles, January 2012, Taylor & Francis

    Professor Raymond Schiffelers

  111. Polymeric Carrier Systems for siRNA Delivery

    Article • Current Topics in Medicinal Chemistry, January 2012, Bentham Science Publishers

    Professor Raymond Schiffelers

  112. A role for activated endothelial cells in red blood cell clearance: implications for vasopathology

    Article • Haematologica, November 2011, Ferrata Storti Foundation (Haematologica)

    Professor Raymond Schiffelers

  113. A polymeric colchicinoid prodrug with reduced toxicity and improved efficacy for vascular disruption in cancer therapy

    Article • International Journal of Nanomedicine, November 2011, Taylor & Francis

    Professor Raymond Schiffelers

  114. Comparison of Polymeric siRNA Nanocarriers in a Murine LPS-Activated Macrophage Cell Line: Gene Silencing, Toxicity and Off-Target Gene Expression

    Article • Pharmaceutical Research, October 2011, Springer Science + Business Media

    Professor Raymond Schiffelers

  115. Circulation kinetics and biodistribution of dual-labeled polymersomes with modulated surface charge in tumor-bearing mice: Comparison with stealth liposomes

    Article • Journal of Controlled Release, October 2011, Elsevier

    Professor Raymond Schiffelers

  116. SiRNA delivery with functionalized carbon nanotubes

    Article • International Journal of Pharmaceutics, September 2011, Elsevier

    Professor Raymond Schiffelers, eric doris

  117. Preparation and characterization of liposomal formulations of neurotensin-degrading enzyme inhibitors

    Article • International Journal of Pharmaceutics, September 2011, Elsevier

    Professor Raymond Schiffelers

  118. Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes

    Article • International Journal of Pharmaceutics, September 2011, Elsevier

    Professor Raymond Schiffelers

  119. Physicochemical and Biological Evaluation of siRNA Polyplexes Based on PEGylated Poly(amido amine)s

    Article • Pharmaceutical Research, August 2011, Springer Science + Business Media

    Professor Raymond Schiffelers

  120. Examining the role of Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approach

    Article • Angiogenesis, July 2011, Springer Science + Business Media

    Professor Raymond Schiffelers

  121. Neovascular Age-Related Macular Degeneration

    Article • BioDrugs, June 2011, Springer Science + Business Media

    Professor Raymond Schiffelers

  122. Targeted Delivery of Kinase Inhibitors: A Nanomedicine Approach for Improved Selectivity in Cancer

    Article • Current Signal Transduction Therapy, May 2011, Bentham Science Publishers

    Professor Raymond Schiffelers

  123. Anti-tumor activity of liposomal glucocorticoids: The relevance of liposome-mediated drug delivery, intratumoral localization and systemic activity

    Article • Journal of Controlled Release, April 2011, Elsevier

    Professor Raymond Schiffelers

  124. Gene silencing activity of siRNA polyplexes based on biodegradable polymers

    Article • European Journal of Pharmaceutics and Biopharmaceutics, April 2011, Elsevier

    Professor Raymond Schiffelers

  125. Optimization of poly(amido amine)s as vectors for siRNA delivery

    Article • Journal of Controlled Release, March 2011, Elsevier

    Professor Raymond Schiffelers

  126. The VEGF/Rho GTPase signalling pathway: A promising target for anti-angiogenic/anti-invasion therapy

    Article • Drug Discovery Today, March 2011, Elsevier

    Professor Raymond Schiffelers

  127. Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity

    Article • Anti-Cancer Drugs, March 2011, Wolters Kluwer Health

    Professor Raymond Schiffelers

  128. Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain

    Article • Journal of Controlled Release, February 2011, Elsevier

    Professor Raymond Schiffelers

  129. Multi-parametric assessment of the anti-angiogenic effects of liposomal glucocorticoids

    Article • Angiogenesis, January 2011, Springer Science + Business Media

    Professor Raymond Schiffelers

  130. Disulfide-Based Poly(amido amine)s for siRNA Delivery: Effects of Structure on siRNA Complexation, Cellular Uptake, Gene Silencing and Toxicity

    Article • Pharmaceutical Research, December 2010, Springer Science + Business Media

    Professor Raymond Schiffelers

  131. Gene Silencing Activity of siRNA Polyplexes Based on Thiolated N , N , N -Trimethylated Chitosan

    Article • Bioconjugate Chemistry, December 2010, American Chemical Society (ACS)

    Professor Raymond Schiffelers

  132. Multimodal Clinical Imaging To Longitudinally Assess a Nanomedical Anti-Inflammatory Treatment in Experimental Atherosclerosis

    Article • Molecular Pharmaceutics, December 2010, American Chemical Society (ACS)

    Professor Raymond Schiffelers

  133. Liposomal pravastatin inhibits tumor growth by targeting cancer-related inflammation

    Article • Journal of Controlled Release, December 2010, Elsevier

    Professor Raymond Schiffelers

  134. A method for quantifying cellular uptake of fluorescently labeled siRNA

    Article • Journal of Controlled Release, November 2010, Elsevier

    Professor Raymond Schiffelers

  135. Poly(amido amine) copolymers derived from aminobutanol and ethylene diamine are excellent carriers for siRNA delivery

    Article • Journal of Controlled Release, November 2010, Elsevier

    Professor Raymond Schiffelers

  136. Photochemical internalization (PCI)-mediated enhancement of gene silencing efficiency of polymethacrylates and N,N,N-trimethylated chitosan (TMC) based siRNA polyplexes

    Article • Journal of Controlled Release, November 2010, Elsevier

    Professor Raymond Schiffelers

  137. Tumor vasculature as target for therapeutic intervention

    Article • Expert Opinion on Investigational Drugs, October 2010, Informa Healthcare

    Professor Raymond Schiffelers

  138. In Vivo Methods to Study Uptake of Nanoparticles into the Brain

    Article • Pharmaceutical Research, October 2010, Springer Science + Business Media

    Professor Raymond Schiffelers

  139. Liposomes targeting tumour stromal cells

    Article • Molecular Membrane Biology, October 2010, Taylor & Francis

    Professor Raymond Schiffelers

  140. Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin

    Article • Biomaterials, October 2010, Elsevier

    Professor Raymond Schiffelers

  141. Downregulation of EGFR by a novel multivalent nanobody-liposome platform

    Article • Journal of Controlled Release, July 2010, Elsevier

    Professor Raymond Schiffelers

  142. Abstract 5485: Modular nanotransporters: a chimeric multi-functional platform for drug deliveryin vivo

    Article • Cancer Research, April 2010, American Association for Cancer Research (AACR)

    Professor Raymond Schiffelers, Professor Alexander S. Sobolev

  143. Erythrophagocytosis by angiogenic endothelial cells is enhanced by loss of erythrocyte deformability

    Article • Experimental Hematology, April 2010, Elsevier

    Professor Raymond Schiffelers

  144. Identification of Peptide Ligands for Targeting to the Blood-Brain Barrier

    Article • Pharmaceutical Research, February 2010, Springer Science + Business Media

    Professor Raymond Schiffelers

  145. Recent advances in molecular imaging biomarkers in cancer: application of bench to bedside technologies

    Article • Drug Discovery Today, February 2010, Elsevier

    Professor Raymond Schiffelers

  146. Crosstalk Between Epidermal Growth Factor Receptor- and Insulin-Like Growth Factor-1 Receptor Signaling: Implications for Cancer Therapy

    Article • Current Cancer Drug Targets, September 2009, Bentham Science Publishers

    Professor Raymond Schiffelers

  147. Editorial [Hot Topic: Inflammation as Target for Pharmaceutical Intervention in Cancer (Executive Editors: R.M. Schiffelers and K.E. de Visser)]

    Article • Current Pharmaceutical Design, June 2009, Bentham Science Publishers

    Professor Raymond Schiffelers

  148. Targeted Delivery of Anti-Inflammatory Agents to Tumors

    Article • Current Pharmaceutical Design, June 2009, Bentham Science Publishers

    Professor Raymond Schiffelers

  149. Liposomal nanomedicines as anticancer therapeutics: Beyond targeting tumor cells

    Article • International Journal of Pharmaceutics, December 2008, Elsevier

    Professor Raymond Schiffelers

  150. Long circulating biodegradable polymeric micelles: Towards targeted drug delivery

    Article • Journal of Controlled Release, December 2008, Elsevier

    Professor Raymond Schiffelers

  151. Delivery of siRNA to the Target Cell Cytoplasm: Photochemical Internalization Facilitates Endosomal Escape and Improves Silencing Efficiency, In Vitro and In Vivo

    Article • Current Pharmaceutical Design, December 2008, Bentham Science Publishers

    Professor Raymond Schiffelers

  152. Liposomal encapsulation enhances the antitumour efficacy of the vascular disrupting agent ZD6126 in murine B16.F10 melanoma

    Article • British Journal of Cancer, September 2008, Nature

    Professor Raymond Schiffelers

  153. Liposomal glucocorticoids as tumor-targeted anti-angiogenic nanomedicine in B16 melanoma-bearing mice

    Article • The Journal of Steroid Biochemistry and Molecular Biology, July 2008, Elsevier

    Professor Raymond Schiffelers

  154. Investigation into the Role of Tumor-Associated Macrophages in the Antitumor Activity of Doxil

    Article • Pharmaceutical Research, June 2008, Springer Science + Business Media

    Professor Raymond Schiffelers

  155. L31 Thermosensitive and biodegradable polymeric micelles with transient stability for targeted drug delivery

    Article • European Journal of Pharmaceutical Sciences, June 2008, Elsevier

    Professor Raymond Schiffelers

  156. Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells

    Article • Blood, May 2008, American Society of Hematology

    Professor Raymond Schiffelers

  157. Antitumor activity and tumor localization of liposomal glucocorticoids in B16 melanoma-bearing mice

    Article • Journal of Controlled Release, April 2008, Elsevier

    Professor Raymond Schiffelers

  158. Antitumor Activity of Liposomal Prednisolone Phosphate Depends on the Presence of Functional Tumor-Associated Macrophages in Tumor Tissue

    Article • Neoplasia, February 2008, Elsevier

    Professor Raymond Schiffelers

  159. Therapeutic nanomedicine: Liposomal corticosteroid as targeted antiinflammatory nanomedicine

    Article • European Journal of Nanomedicine, January 2008, De Gruyter

    Professor Raymond Schiffelers

  160. Utility of Targeted Glucocorticoids in Cancer Therapy

    Article • Journal of Liposome Research, January 2008, Taylor & Francis

    Professor Raymond Schiffelers

  161. Hydrolysable core-crosslinked thermosensitive polymeric micelles: Synthesis, characterisation and in vivo studies

    Article • Biomaterials, December 2007, Elsevier

    Professor Raymond Schiffelers

  162. Oligonucleotides

    Article • October 2007, Taylor & Francis

    Professor Raymond Schiffelers

  163. Targeting the retinal microcirculation to treat diabetic sight problems

    Article • Expert Opinion on Therapeutic Targets, October 2007, Informa Healthcare

    Professor Raymond Schiffelers

  164. Targeted drug delivery to enhance efficacy and shorten treatment duration in disseminated Mycobacterium avium infection in mice

    Article • Journal of Antimicrobial Chemotherapy, September 2007, Oxford University Press (OUP)

    Professor Raymond Schiffelers

  165. Delivery of Nucleic Acids

    Article • Pharmaceutical Research, June 2007, Springer Science + Business Media

    Professor Raymond Schiffelers

  166. Photochemical internalization enhances silencing of epidermal growth factor receptor through improved endosomal escape of siRNA

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, May 2007, Elsevier

    Professor Raymond Schiffelers

  167. Synthetic delivery systems for intravenous administration of nucleic acids

    Article • Nanomedicine, April 2007, Future Medicine

    Professor Raymond Schiffelers

  168. Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes

    Article • International Journal of Pharmaceutics, March 2007, Elsevier

    Professor Raymond Schiffelers

  169. Effect of cationic carriers on the pharmacokinetics and tumor localization of nucleic acids after intravenous administration

    Article • International Journal of Pharmaceutics, March 2007, Elsevier

    Professor Raymond Schiffelers

  170. Pharmaceutical Nanocarriers in Treatment and Imaging of Infection

    Article • September 2006, World Scientific Pub Co Pte Lt

    Professor Raymond Schiffelers

  171. Anti-angiogenic effects of liposomal prednisolone phosphate on B16 melanoma in mice

    Article • Journal of Controlled Release, June 2006, Elsevier

    Professor Raymond Schiffelers

  172. Molecular biology of epidermal growth factor receptor inhibition for cancer therapy

    Article • Expert Opinion on Biological Therapy, May 2006, Informa Healthcare

    Professor Raymond Schiffelers

  173. ICS-283: a system for targeted intravenous delivery of siRNA

    Article • Expert Opinion on Drug Delivery, April 2006, Informa Healthcare

    Professor Raymond Schiffelers

  174. Silencing Proteins: Nanotechnological Approaches to Deliver siRNA for Cancer Therapy

    Article • April 2006, World Scientific Pub Co Pte Lt

    Professor Raymond Schiffelers

  175. Targeted Delivery of siRNA

    Article • Journal of Biomedicine and Biotechnology, January 2006, Hindawi Publishing Corporation

    Professor Raymond Schiffelers

  176. Therapeutic Application of Long-Circulating Liposomal Glucocorticoids in Auto-Immune Diseases and Cancer

    Article • Journal of Liposome Research, January 2006, Taylor & Francis

    Professor Raymond Schiffelers

  177. Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate–containing RGD peptide liposomes inhibits experimental arthritis

    Article • Arthritis & Rheumatism, January 2006, Wiley

    Professor Raymond Schiffelers

  178. RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature

    Article • Drug Resistance Updates, December 2005, Elsevier

    Professor Raymond Schiffelers

  179. Transporting silence: Design of carriers for siRNA to angiogenic endothelium

    Article • Journal of Controlled Release, December 2005, Elsevier

    Professor Raymond Schiffelers, Dr. Archibald J Mixson

  180. Liposomal Targeting of Angiogenic Vasculature

    Article • Current Drug Delivery, October 2005, Bentham Science Publishers

    Professor Raymond Schiffelers

  181. 318. Tumor Growth Inhibition from Tumor Targeted Delivery of Diphtheria Toxin Gene

    Article • Molecular Therapy, May 2005, Elsevier

    Professor Raymond Schiffelers

  182. siRNA-mediated inhibition of angiogenesis

    Article • Expert Opinion on Biological Therapy, March 2005, Informa Healthcare

    Professor Raymond Schiffelers

  183. Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery

    Article • Journal of Controlled Release, March 2005, Elsevier

    Professor Raymond Schiffelers

  184. Liposome-Encapsulated Prednisolone Phosphate Inhibits Growth of Established Tumors in Mice

    Article • Neoplasia, February 2005, Elsevier

    Professor Raymond Schiffelers

  185. siRNA as a new drug: intellectual property

    Article • Expert Opinion on Therapeutic Patents, February 2005, Informa Healthcare

    Professor Raymond Schiffelers

  186. Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis

    Article • Arthritis & Rheumatism, January 2005, Wiley

    Professor Raymond Schiffelers

  187. Long-Circulating Sterically Stabilized Liposomes in the Treatment of Infections

    Article • January 2005, Elsevier

    Professor Raymond Schiffelers

  188. Inhibition of Ocular Angiogenesis by siRNA Targeting Vascular Endothelial Growth Factor Pathway Genes

    Article • American Journal Of Pathology, December 2004, Elsevier

    Professor Raymond Schiffelers

  189. Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

    Article • Nucleic Acids Research, October 2004, Oxford University Press (OUP)

    Professor Raymond Schiffelers

  190. Pharmaceutical Prospects for RNA Interference

    Article • Pharmaceutical Research, January 2004, Springer Science + Business Media

    Professor Raymond Schiffelers

  191. Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin

    Article • Journal of Controlled Release, August 2003, Elsevier

    Professor Raymond Schiffelers

  192. Innovations in liposomal formulations for antimicrobial therapy

    Article • Expert Opinion on Therapeutic Patents, August 2003, Informa Healthcare

    Professor Raymond Schiffelers

  193. Peptide-targeted PEG-liposomes in anti-angiogenic therapy

    Article • International Journal of Pharmaceutics, March 2003, Elsevier

    Professor Raymond Schiffelers

  194. Innovations in liposomal formulations for antimicrobial therapy

    Article • Expert Opinion on Therapeutic Patents, January 2003, Informa Healthcare

    Professor Raymond Schiffelers

  195. Biodistribution of long-circulating PEG-liposomes in a murine model of established subcutaneous abscesses

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, March 2002, Elsevier

    Professor Raymond Schiffelers

  196. Endothelial Cells at Inflammatory Sites as Target for Therapeutic Intervention

    Article • Endothelium, January 2002, Taylor & Francis

    Professor Raymond Schiffelers

  197. LIGAND-TARGETED LIPOSOMES DIRECTED AGAINST PATHOLOGICAL VASCULATURE

    Article • Journal of Liposome Research, January 2002, Taylor & Francis

    Professor Raymond Schiffelers

  198. LIPOSOME-ENABLED SYNERGISTIC INTERACTION OF ANTIMICROBIAL AGENTS

    Article • Journal of Liposome Research, January 2002, Taylor & Francis

    Professor Raymond Schiffelers

  199. Liposome-encapsulated aminoglycosides in pre-clinical and clinical studies

    Article • Journal of Antimicrobial Chemotherapy, September 2001, Oxford University Press (OUP)

    Professor Raymond Schiffelers

  200. Therapeutic Efficacy of Liposome-Encapsulated Gentamicin in Rat Klebsiella pneumoniae Pneumonia in Relation to Impaired Host Defense and Low Bacterial Susceptibility to Gentamicin

    Article • Antimicrobial Agents and Chemotherapy, February 2001, ASM Journals

    Professor Raymond Schiffelers

  201. Activity of mammalian secreted phospholipase A2 from inflammatory peritoneal fluid towards PEG-liposomes. Early indications

    Article • International Journal of Pharmaceutics, February 2001, Elsevier

    Professor Raymond Schiffelers

  202. Therapeutic efficacy of liposomal gentamicin in clinically relevant rat models

    Article • International Journal of Pharmaceutics, February 2001, Elsevier

    Professor Raymond Schiffelers

  203. Article • Pharmaceutical Research, January 2001, Springer Science + Business Media

    Professor Raymond Schiffelers

  204. Localization of sterically stabilized liposomes in experimental rat Klebsiella pneumoniae pneumonia: dependence on circulation kinetics and presence of poly(ethylene)glycol coating

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, September 2000, Elsevier

    Professor Raymond Schiffelers

  205. Targeting of Antibiotics in Bacterial Infections Using Pegylated Long-Circulating Liposomes

    Article • Journal of Liposome Research, January 2000, Taylor & Francis

    Professor Raymond Schiffelers

  206. Localization of sterically stabilized liposomes in Klebsiella pneumoniae-infected rat lung tissue: influence of liposome characteristics

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, October 1999, Elsevier

    Professor Raymond Schiffelers

  207. Effect of probucol on serum lipids, atherosclerosis and toxicology in fat-fed LDL receptor deficient mice

    Article • Atherosclerosis, December 1998, Elsevier

    Professor Raymond Schiffelers

  208. Diagnostic and Therapeutic Targeting of Infectious and Inflammatory Diseases Using Sterically Stabilized Liposomes

    Article • January 1998, Springer Science + Business Media

    Professor Raymond Schiffelers

  209. Quantitative Assessment of Aortic Atherosclerosis in APOE*3 Leiden Transgenic Mice and Its Relationship to Serum Cholesterol Exposure

    Article • Arteriosclerosis Thrombosis and Vascular Biology, August 1996, Wolters Kluwer Health

    Professor Raymond Schiffelers

  210. Lipid-Based Formulations for siRNA Delivery

    Article • Wiley

    Professor Raymond Schiffelers