All Stories

  1. Computer-aided Drug Discovery Approaches in the Identification of Anticancer Drugs from Natural Products: A Review
  2. Molecular docking and molecular dynamics simulations discover curcumin analogs as potential wound healing agents
  3. Computational Screening of Some Phytochemicals to Identify Best Modulators for Ligand Binding Domain of Estrogen Receptor Alpha
  4. Fabrication of Quercetin-Functionalized Morpholine and Pyridine Motifs-Laden Silk Fibroin Nanofibers for Effective Wound Healing in Preclinical Study
  5. An In silico Investigation to Identify Promising Inhibitors for SARS-CoV-2 Mpro Target
  6. Recent Trends in Electrospun Antibacterial Nanofibers for Chronic Wound Management
  7. Screening Active Phytochemicals of Some Ayurvedic Medicinal Plants to Identify Potential Inhibitors against SARS-CoV-2 M pro by Computational Investigation
  8. Electrospun Scaffold-based Antibiotic Therapeutics for Chronic Wound Recovery
  9. Biodistribution of nanodiamonds is determined by surface functionalization
  10. Recent Developments in Electrospun Nanofibers as Delivery of Phytoconstituents for Wound Healing
  11. Pharmacophore modelling-based drug repurposing approaches for monkeypox therapeutics
  12. Isolation, Functionalization, In Silico Investigation, and Synthesis of 1,8-Cineole Analog as Antitubercular Agent Targeting InhA
  13. Drug Repurposing: An Effective Tool in Modern Drug Discovery
  14. Computational Search for Potential COVID-19 Drugs from Ayurvedic Medicinal Plants to Identify Potential Inhibitors against SARS-CoV-2 Targets
  15. Advances in electrospun chitosan nanofiber biomaterials for biomedical applications
  16. Emerging Trends in Curcumin Embedded Electrospun Nanofibers for Impaired Diabetic Wound Healing
  17. Design, Synthesis, and Structure–Activity Relationships of Novel N-Substituted-5-phenyl-[1,2,4]triazolo[1,5-c]quinazolin-2-amine for Their Anti-HIV and Antibacterial Activities
  18. Recent Advances in Silver Nanoparticles Containing Nanofibers for Chronic Wound Management
  19. Design, Synthesis, and Structure–Activity Relationships of Novel 1-(Substituted)-2-Methyl-3-(4-Oxo-2-Methylquinazolin-3(4H)-yl) Isothioureas for Their Anti-HIV and Antibacterial Activities
  20. Radionanotheranostics for breast cancer diagnosis and therapy: recent advances and future opportunities
  21. Concussion/Mild Traumatic Brain Injury (TBI) Induces Brain Insulin Resistance: A Positron Emission Tomography (PET) Scanning Study
  22. Pre-clinical study of IRDye800CW-nimotuzumab formulation, stability, pharmacokinetics, and safety
  23. 89Zr-Labeled Domain II-Specific scFv-Fc ImmunoPET Probe for Imaging Epidermal Growth Factor Receptor In Vivo
  24. Anti-HIV and Antibacterial Activities of Novel 2-(3-Substituted-4-oxo-3,4-dihydroquinazolin-2-yl)-2,3-dihydrophthalazine-1,4-diones
  25. Nimotuzumab Site-Specifically Labeled with 89Zr and 225Ac Using SpyTag/SpyCatcher for PET Imaging and Alpha Particle Radioimmunotherapy of Epidermal Growth Factor Receptor Positive Cancers
  26. Development and preclinical evaluation of cixutumumab drug conjugates in a model of insulin growth factor receptor I (IGF-1R) positive cancer
  27. Ultrasonic-Assisted Solid-Phase Peptide Synthesis of DOTA-TATE and DOTA-linker-TATE Derivatives as a Simple and Low-Cost Method for the Facile Synthesis of Chelator–Peptide Conjugates
  28. Design and Synthesis of 1-Substituted-4-(4-Nitrophenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-ones as a New Class of Antihistaminic Agents
  29. 111In- and 225Ac-Labeled Cixutumumab for Imaging and α-Particle Radiotherapy of IGF-1R Positive Triple-Negative Breast Cancer
  30. GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators
  31. Examination of novel 4-aminoquinoline derivatives designed and synthesized by a hybrid pharmacophore approach to enhance their anticancer activities
  32. Preclinical Evaluation of 111In-Labeled PEGylated Maytansine Nimotuzumab Drug Conjugates in EGFR-Positive Cancer Models
  33. Design and synthesis of 4-piperazinyl quinoline derived urea/thioureas for anti-breast cancer activity by a hybrid pharmacophore approach
  34. A 89Zr-labeled lipoplex nanosystem for image-guided gene delivery: design, evaluation of stability and in vivo behavior
  35. A novel synthetic trivalent single chain variable fragment (tri-scFv) construction platform based on the SpyTag/SpyCatcher protein ligase system
  36. 99mTc(CO)3+ labeled domain I/II-specific anti-EGFR (scFv)2 antibody fragment for imaging EGFR expression
  37. An overview of quinazolines: Pharmacological significance and recent developments
  38. 89Zr-nimotuzumab for immunoPET imaging of epidermal growth factor receptor I
  39. Exploring the Binding of Barbital to a Synthetic Macrocyclic Receptor. A Charge Density Study
  40. Design and synthesis of novel quinacrine-[1,3]-thiazinan-4-one hybrids for their anti-breast cancer activity
  41. Design, synthesis and characterization of novel quinacrine analogs that preferentially kill cancer over non-cancer cells through the down-regulation of Bcl-2 and up-regulation of Bax and Bad
  42. Design and Synthesis of 3-Substituted-thiazolyl-2-iminothiazolidin-4-ones as a New Class of Anticonvulsants
  43. DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF 1-(4-OXO-3-(4-FLUOROPHENYL)-3H-QUINAZOLIN- 2-YL)-4-(SUBSTITUTED) THIOSEMICARBAZIDE DERIVATIVES
  44. Investigating the Role of Loop C Hydrophilic Residue ‘T244’ in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism
  45. Antimicrobial activities of some synthesized 1-(3-(2-methylphenyl)-4-Oxo-3H-quinazolin-2-yl-4-(substituted)thiosemicarbazide derivatives
  46. Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators
  47. The Direct Actions of GABA, 2’-Methoxy-6-Methylflavone and General Anaesthetics at β3γ2L GABAA Receptors: Evidence for Receptors with Different Subunit Stoichiometries
  48. VR23: A Quinoline–Sulfonyl Hybrid Proteasome Inhibitor That Selectively Kills Cancer via Cyclin E–Mediated Centrosome Amplification
  49. Synthesis of 1-Substituted-4-(Pyridin-4-yl) [1,2,4] Triazolo [4,3-a] Quinazolin-5(4H)-ones as a New Class of H1- Antihistaminic Agents
  50. Design and synthesis of quinazolinyl acetamides for their analgesic and anti-inflammatory activities
  51. Synthesis and antimicrobial activities of 1-(3-benzyl-4-oxo-3H-quinazolin-2-yl)-4-(substituted)thiosemicarbazide derivatives
  52. The potential of quinoline derivatives for the treatment of Toxoplasma gondii infection
  53. Design and synthesis of 3-(4-chlorophenyl)-2-(2-(4-substituted)-2-oxoethylthio)quinazolin-4(3H)-one as antihistamine agents
  54. Design, synthesis and biological evaluation of some isatin-linked chalcones as novel anti-breast cancer agents: A molecular hybridization approach
  55. Synthesis and biological evaluation of 2-(phenyl)-3H-benzo[d]imidazole-5-carboxylic acids and its methyl esters as potent anti-breast cancer agents
  56. Synthesis of novel 2-phenyl-3-[2-(substituted amino) ethylamino] quinazolin-4(3H)-ones as a new class of H1-antihistaminic agents
  57. Design and synthesis of 3-[(7-chloro-1-oxidoquinolin-4-ylamino)alkyl]-1,3-thiazolidin-4-ones as antimalarial agents
  58. Synthesis and Pharmacological Investigation of 5-Substituted-3-methylsulfanyl-1H-pyrazole-4-carboxylic Acid Ethyl Esters as New Analgesic and Anti-inflammatory Agents
  59. 2,3-Disubtituted Thiazolidin-4-ones: Novel Class of Anticonvulsant Agents
  60. Anti-breast cancer activity of heteroaryl chalcone derivatives
  61. Synthesis and Antibacterial Activity of Some Novel 1-(4-Oxo-3-(3- methoxyphenyl)-3H-quinazolin-2-yl)-4-(substituted) thiosemicarbazides
  62. Design, synthesis of 4-aminoquinoline-derived thiazolidines and their antimalarial activity and heme polymerization inhibition studies
  63. Synthesis and Pharmacological Evaluation of Some 3-(2-Methylphenyl)-2-Substituted Amino-quinazolin-4(3H)-ones as Analgesic and Anti-inflammatory Agents
  64. Design, synthesis and biological evaluation of some novel 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones as antimalarial agents
  65. Synthesis of Some Coumarinyl Chalcones and their Antiproliferative Activity Against Breast Cancer Cell Lines
  66. Quinoline as a Privileged Scaffold in Cancer Drug Discovery
  67. 4-Aminoquinoline derived antimalarials: Synthesis, antiplasmodial activity and heme polymerization inhibition studies
  68. Synthesis and analgesic, anti-inflammatory activities of 3-(3-methoxyphenyl)-2-substituted amino-quinazolin-4(3H)-ones
  69. Design and synthesis of chloroquine analogs with anti-breast cancer property
  70. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells
  71. Design and synthesis of anti-breast cancer agents from 4-piperazinylquinoline: A hybrid pharmacophore approach
  72. Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies
  73. Hybrid pharmacophore design and synthesis of isatin–benzothiazole analogs for their anti-breast cancer activity
  74. 3-(3-Ethylphenyl)-2-substituted hydrazino-3H-quinazolin-4-one Derivatives: New Class of Analgesic and Anti-Inflammatory Agents
  75. Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted hydrazino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents
  76. Synthesis and pharmacological investigation of novel 4-(3-ethylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones as a new class of H1-antihistaminic agents
  77. Topological descriptors in modelling antimalarial activity: N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine as prototype
  78. The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine
  79. Synthesis and Antimalarial Activity of Novel Side Chain Modified Antimalarial Agents Derived from 4-Aminoquinoline
  80. Synthesis of 3-(2-pyridyl)-2-substituted-quinazolin-4(3H)-ones as new analgesic and anti-inflammatory agents
  81. Synthesis and pharmacological evaluation of 3‐(4‐chloro phenyl)‐2‐substituted‐3H‐quinazolin‐4‐ones as analgesic and anti‐inflammatory agents
  82. Synthesis and pharmacological investigation of novel 4‐(4‐Ethyl phenyl)‐1‐substituted‐4H‐[1,2,4]triazolo[4,3‐a]‐quinazolin‐5‐ones as new class of H1‐antihistaminic agents
  83. Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives
  84. Design and synthesis of 3-(4-Ethylphenyl)-2-substituted amino-3H-quinazolin-4-ones as a novel class of analgesic and anti-inflammatory agents
  85. Synthesis of Novel 3-Butyl-2-Substituted Amino-3H-Quinazolin-4-ones as Analgesic and Anti-inflammatory Agents
  86. 4-Cyclohexyl-1-substituted-4H-[1,2,4]triazolo [4,3-a] quinazolin-5-ones: Novel Class of H1-antihistaminic Agents
  87. Synthesis and Pharmacological Investigation of 3‐Subsituted‐amino‐2‐methylsulfanyl‐5,6,7,8‐tetrahydro‐3H‐benzo[4,5]thieno[2,3‐d]pyrimidin‐4‐ones as Analgesic and Anti‐Inflammatory Agents
  88. Synthesis and pharmacological investigation of novel 4-benzyl-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H1-antihistaminic agents
  89. Synthesis of 2-mercapto-3-substituted-5,6-dimethylthieno[2,3-d] pyrimidin-4(3H)-ones as new analgesic, anti-inflammatory agents
  90. Synthesis of some novel 2-mercapto-3-(substituted amino)-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-ones as analgesic and anti-inflammatory agents
  91. Design and Synthesis of 2-Methylthio-3-substituted-5,6-dimethylthieno [2,3-d] pyrimidin-4(3H)-ones as Analgesic, Anti-Inflammatory and Antibacterial Agents
  92. Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-one as analgesic, anti-inflammatory agents
  93. Synthesis and Antimalarial Activity of Side Chain Modified 4-Aminoquinoline Derivatives
  94. Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-4(3H)-ones
  95. Design, Synthesis and Antimalarial Activity of a New Class of Iron Chelators
  96. Topological Descriptors in Modeling the HIV Inhibitory Activity of 2-Aryl-3- pyridyl-thiazolidin-4-ones
  97. Synthesis and QSAR Studies on Thiazolidinones as Anti-HIV Agents
  98. Design and synthesis of new antimalarial agents from 4-aminoquinoline
  99. Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of Some Novel 2-Butyl-3-substituted Quinazolin-4-(3H)-ones
  100. Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of Some Novel 2-Phenyl-3-substituted Quinazolin-4(3H) Ones.