All Stories

  1. Proton co-transport and voltage dependence enforce unidirectional metal transport in an Nramp transporter

    Article • August 2018, Cold Spring Harbor Laboratory Press

    Rachelle Gaudet

  2. Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter

    Article • August 2018, Cold Spring Harbor Laboratory Press

    Rachelle Gaudet

  3. D-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domain

    Article • PLoS ONE, May 2017, PLOS

    Rachelle Gaudet

  4. A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases

    Article • eLife, May 2017, eLife

    Rachelle Gaudet

  5. A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15

    Article • Structure, February 2017, Elsevier

    Rachelle Gaudet

  6. Conserved methionine dictates substrate preference in Nramp-family divalent metal transporters

    Article • Proceedings of the National Academy of Sciences, August 2016, Proceedings of the National Academy of Sciences

    Rachelle Gaudet

  7. Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4

    Article • eLife, July 2016, eLife

    Rachelle Gaudet

  8. Antiparallel protocadherin homodimers use distinct affinity- and specificity mediating regions in cadherin repeats 1-4

    Article • July 2016, Cold Spring Harbor Laboratory Press

    Rachelle Gaudet

  9. Data publication with the structural biology data grid supports live analysis

    Article • Nature Communications, March 2016, Nature

    Rachelle Gaudet, Dr. Alexandre M.J.J. Bonvin

  10. Functional Modification of Bacterial Voltage-Gated Sodium Channels by Batrachotoxin

    Article • Biophysical Journal, February 2016, Elsevier

    Rachelle Gaudet

  11. Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity

    Article • Structure, November 2015, Elsevier

    Rachelle Gaudet

  12. Novel mutations highlight the key role of the ankyrin repeat domain inTRPV4-mediated neuropathy

    Article • Neurology Genetics, October 2015, Wolters Kluwer Health

    Rachelle Gaudet

  13. How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy

    Article • BioEssays, September 2015, Wiley

    Rachelle Gaudet

  14. The Touching Tail of a Mechanotransduction Channel

    Article • Cell, September 2015, Elsevier

    Rachelle Gaudet

  15. Structural characterization of the late competence protein ComFB from Bacillus subtilis

    Article • Bioscience Reports, March 2015, Portland Press Ltd.

    Rachelle Gaudet

  16. Insights into the molecular foundations of electrical excitation

    Article • Journal of Molecular Biology, January 2015, Elsevier

    Dr Daniel Minor, Rachelle Gaudet

  17. Structural Determinants of TRPV Channel Activation and Modulation

    Article • Biophysical Journal, January 2015, Elsevier

    Rachelle Gaudet

  18. Structural Study of a Novel Partial Calcium-Free Linker and a Positively Selected Variation in Protocadherin-15: Implications for Hearing and Cell Adhesion

    Article • Biophysical Journal, January 2015, Elsevier

    Rachelle Gaudet

  19. Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter

    Article • Nature Communications, November 2014, Nature

    Rachelle Gaudet

  20. Sorting out a promiscuous superfamily: towards cadherin connectomics

    Article • Trends in Cell Biology, September 2014, Elsevier

    Rachelle Gaudet

  21. Structural Biology of TRP Channels

    Article • January 2014, Springer Science + Business Media

    Rachelle Gaudet

  22. Molecular Mechanisms of Deafness Mutations Disrupting Tip-Link Function in Hair-Cell Mechanotransduction

    Article • Biophysical Journal, January 2014, Elsevier

    Rachelle Gaudet

  23. High-Resolution Views of TRPV1 and Their Implications for the TRP Channel Superfamily

    Article • January 2014, Springer Science + Business Media

    Rachelle Gaudet

  24. What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?

    Article • FEBS Journal, May 2013, Wiley

    Rachelle Gaudet

  25. Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli

    Article • Proceedings of the National Academy of Sciences, May 2013, Proceedings of the National Academy of Sciences

    Rachelle Gaudet

  26. Noddy, a Mouse Harboring a Missense Mutation in Protocadherin-15, Reveals the Impact of Disrupting a Critical Interaction Site between Tip-Link Cadherins in Inner Ear Hair Cells

    Article • Journal of Neuroscience, March 2013, Society for Neuroscience

    Rachelle Gaudet

  27. Structures and Simulated Dynamics of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction

    Article • Biophysical Journal, January 2013, Elsevier

    Rachelle Gaudet

  28. Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction

    Article • Nature, November 2012, Nature

    Rachelle Gaudet

  29. Distinct properties of Ca 2+ –calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel

    Article • The Journal of General Physiology, October 2012, Rockefeller University Press

    Rachelle Gaudet

  30. Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel

    Article • Biochemistry, August 2012, American Chemical Society (ACS)

    Rachelle Gaudet

  31. Exome sequencing identifies a novel TRPV4 mutation in a CMT2C family

    Article • Neurology, June 2012, Wolters Kluwer Health

    Rachelle Gaudet

  32. Chicken TAP genes are polymorphic and co-evolve with the dominantly-expressed class I gene

    Article • Molecular Immunology, May 2012, Elsevier

    Susan M Lea, Rachelle Gaudet

  33. Biophysical Characterization of TRPV2 Ion Channel

    Article • Biophysical Journal, January 2012, Elsevier

    PhD Ismael Mingarro, Rachelle Gaudet

  34. Structural Comparison of Ankyrin Repeat Domain of TRPV Channels

    Article • Biophysical Journal, February 2011, Elsevier

    Rachelle Gaudet

  35. Molecular Mechanics of Tip-Link Cadherins

    Article • January 2011, American Institute of Physics

    Rachelle Gaudet

  36. Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies

    Article • Brain, May 2010, Oxford University Press (OUP)

    Rachelle Gaudet

  37. Structural Determinants of Cadherin-23 Function in Hearing and Deafness

    Article • Neuron, April 2010, Elsevier

    Rachelle Gaudet

  38. Heat and Spice: Setting the Sensitivity of TRPV Channels

    Article • Biophysical Journal, January 2010, Elsevier

    Rachelle Gaudet

  39. Structural Determinants of Cadherin-23 Function in Hearing and Deafness

    Article • Biophysical Journal, January 2010, Elsevier

    Rachelle Gaudet

  40. Characterization and Structural Studies of the Plasmodium falciparum Ubiquitin and Nedd8 Hydrolase UCHL3

    Article • Journal of Biological Chemistry, December 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Rachelle Gaudet

  41. Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C

    Article • Nature Genetics, December 2009, Nature

    Rachelle Gaudet

  42. Differential Regulation of TRPV1, TRPV3, and TRPV4 Sensitivity through a Conserved Binding Site on the Ankyrin Repeat Domain

    Article • Journal of Biological Chemistry, October 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Rachelle Gaudet

  43. Divide and Conquer: High Resolution Structural Information on TRP Channel Fragments

    Article • The Journal of General Physiology, February 2009, Rockefeller University Press

    Rachelle Gaudet

  44. Antigen processing and presentation: TAPping into ABC transporters

    Article • Current Opinion in Immunology, February 2009, Elsevier

    Rachelle Gaudet

  45. The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter

    Article • The FASEB Journal, January 2009, Federation of American Societies For Experimental Biology (FASEB)

    Rachelle Gaudet

  46. The ABCs of trans(porter) inhibition

    Article • Nature Methods, August 2008, Nature

    Rachelle Gaudet

  47. TRP channels entering the structural era

    Article • The Journal of Physiology, July 2008, Wiley

    Rachelle Gaudet

  48. Functionally Important Interactions between the Nucleotide-Binding Domains of an Antigenic Peptide Transporter †

    Article • Biochemistry, May 2008, American Chemical Society (ACS)

    Rachelle Gaudet

  49. Structural Analyses of the Ankyrin Repeat Domain of TRPV6 and Related TRPV Ion Channels † , ‡

    Article • Biochemistry, February 2008, American Chemical Society (ACS)

    Rachelle Gaudet

  50. A primer on ankyrin repeat function in TRP channels and beyond

    Article • Molecular BioSystems, January 2008, Royal Society of Chemistry

    Rachelle Gaudet

  51. Genome-wide detection and characterization of positive selection in human populations

    Article • Nature, October 2007, Nature

    Rachelle Gaudet, Dr Zhaohui S. Qin

  52. The Role of the N Terminus and Transmembrane Domain of TRPM8 in Channel Localization and Tetramerization

    Article • Journal of Biological Chemistry, October 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Rachelle Gaudet

  53. The Ankyrin Repeats of TRPV1 Bind Multiple Ligands and Modulate Channel Sensitivity

    Article • Neuron, June 2007, Elsevier

    Rachelle Gaudet

  54. Insights into the Roles of Conserved and Divergent Residues in the Ankyrin Repeats of TRPV Ion Channels

    Article • Channels, May 2007, Taylor & Francis

    Rachelle Gaudet

  55. Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes

    Article • Molecular Cell, March 2007, Elsevier

    Rachelle Gaudet

  56. Distinct Structural and Functional Properties of the ATPase Sites in an Asymmetric ABC Transporter

    Article • Molecular Cell, October 2006, Elsevier

    Rachelle Gaudet

  57. Structural Insights into the Function of TRP Channels

    Article • September 2006, Taylor & Francis

    Rachelle Gaudet

  58. Structure of the N-terminal Ankyrin Repeat Domain of the TRPV2 Ion Channel

    Article • Journal of Biological Chemistry, June 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Rachelle Gaudet

  59. Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I

    Article • Immunology and Cell Biology, October 2005, Nature

    Rachelle Gaudet

  60. Structure of the Ubiquitin Hydrolase UCH-L3 Complexed with a Suicide Substrate

    Article • Journal of Biological Chemistry, November 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Paul J Galardy, Rachelle Gaudet

  61. Structural and Functional Analysis of Human Cytomegalovirus US3 Protein

    Article • Journal of Virology, January 2004, ASM Journals

    Rachelle Gaudet

  62. Ubiquitylation of the Transducin beta gamma Subunit Complex. REGULATION BY PHOSDUCIN

    Article • Journal of Biological Chemistry, September 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Rachelle Gaudet

  63. Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing

    Article • The EMBO Journal, September 2001, Wiley

    Rachelle Gaudet

  64. Virus subversion of immunity: a structural perspective

    Article • Current Opinion in Immunology, August 2001, Elsevier

    Rachelle Gaudet

  65. Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2

    Article • Proceedings of the National Academy of Sciences, June 2001, Proceedings of the National Academy of Sciences

    Rachelle Gaudet

  66. Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1

    Article • The EMBO Journal, January 2001, Wiley

    Rachelle Gaudet

  67. A Molecular Mechanism for the Phosphorylation-Dependent Regulation of Heterotrimeric G Proteins by Phosducin

    Article • Molecular Cell, May 1999, Elsevier

    Rachelle Gaudet

  68. Structural aspects of heterotrimeric G-protein signaling

    Article • Current Opinion in Biotechnology, August 1997, Elsevier

    Rachelle Gaudet

  69. PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX

    Article • June 1997, Protein Data Bank, Rutgers University

    Rachelle Gaudet

  70. Crystal Structure at 2.4 Å Resolution of the Complex of Transducin βγ and Its Regulator, Phosducin

    Article • Cell, November 1996, Elsevier

    Rachelle Gaudet