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  1. Control of cellular cortical tension and shape by RhoGTPase signalling

    Article • December 2025, openRxiv

    Dr Philippe P Roux

  2. CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability

    Article • Cell Reports, November 2025, Elsevier

    Dr Philippe P Roux

  3. mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport

    Article • Molecular Cell, September 2025, Elsevier

    Dr Philippe P Roux

  4. A platform for the systematic interrogation of genetic interactions in human cells: 26 gene by genome-wide double knockout screens as a proof of concept

    Article • August 2025, Cold Spring Harbor Laboratory Press

    Dr Philippe P Roux

  5. 14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation

    Article • Molecular Metabolism, July 2025, Elsevier

    Dr Philippe P Roux

  6. IL1RAP is an immunotherapeutic target for normal karyotype triple-mutated acute myeloid leukemia

    Article • Biomarker Research, April 2025, Springer Science + Business Media

    Dr Philippe P Roux

  7. The expanding landscape of canonical and non-canonical protein phosphorylation

    Article • Trends in Biochemical Sciences, September 2024, Elsevier

    Dr Philippe P Roux

  8. Immunotherapeutic targeting of surfaceome heterogeneity in AML

    Article • Cell Reports, June 2024, Elsevier

    Dr Philippe P Roux

  9. Plakoglobin regulates adipocyte differentiation independently of the Wnt/β-catenin signaling pathway

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, April 2024, Elsevier

    Dr Philippe P Roux

  10. 14-3-3ζ regulates adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation

    Article • March 2024, Cold Spring Harbor Laboratory Press

    Dr Philippe P Roux

  11. Identification of RSK substrates using an analog-sensitive kinase approach

    Article • Journal of Biological Chemistry, March 2024, Elsevier

    Dr Philippe P Roux, Thomas Michiels

  12. The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma

    Article • Cell Death Discovery, December 2023, Springer Science + Business Media

    Dr Philippe P Roux

  13. The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression

    Article • Cell Reports, December 2023, Elsevier

    Dr Philippe P Roux

  14. CBFA2T3::GLIS2 Pediatric Acute Megakaryoblastic Leukemia is Sensitive to BCL-XL Inhibition by Navitoclax and DT2216

    Article • Blood Advances, September 2023, American Society of Hematology

    Dr Philippe P Roux

  15. Synergistic action of actin binding proteins regulate actin network organization and cell shape

    Article • September 2023, Cold Spring Harbor Laboratory Press

    Dr Philippe P Roux

  16. Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

    Article • Nature Communications, September 2023, Springer Science + Business Media

    Dr Philippe P Roux

  17. SPAT: Surface Protein Annotation Tool

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Dr Philippe P Roux

  18. HER2Δ16 Engages ENPP1 to Promote an Immune-Cold Microenvironment in Breast Cancer

    Article • Cancer Immunology Research, June 2023, American Association for Cancer Research (AACR)

    Dr Philippe P Roux

  19. The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma

    Article • May 2023, Cold Spring Harbor Laboratory Press

    Dr Philippe P Roux

  20. In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

    Article • Nature Communications, May 2023, Springer Science + Business Media

    Dr Philippe P Roux

  21. Identification of Novel Antigens for Normal Karyotype Triple Mutated Acute Myeloid Leukemia

    Article • Blood, November 2022, American Society of Hematology

    Dr Philippe P Roux

  22. Identification of Novel Cell Surface Therapeutic Targets for KMT2A-Rearranged Acute Myeloid Leukemia

    Article • Blood, November 2022, American Society of Hematology

    Dr Philippe P Roux

  23. CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma

    Article • Nature Communications, October 2022, Springer Science + Business Media

    Dr Philippe P Roux

  24. Proteomic analysis of the actin cortex in interphase and mitosis

    Article • Journal of Cell Science, August 2022, The Company of Biologists

    Dr Philippe P Roux

  25. CEACAM1 is a novel culture-compatible surface marker of expanded long-term reconstituting hematopoietic stem cells

    Article • Blood Advances, June 2022, American Society of Hematology

    Dr Philippe P Roux

  26. 1396-P: Critical Cellular Functions That Mediate the Early Stages of Adipogenesis Are Directly Influenced by 14-3-3zeta and Its Interactome

    Article • Diabetes, June 2022, American Diabetes Association

    Dr Philippe P Roux

  27. Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation

    Article • JCI Insight, March 2022, American Society for Clinical Investigation

    Dr Philippe P Roux

  28. In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

    Article • March 2022, Cold Spring Harbor Laboratory Press

    Dr Philippe P Roux

  29. Proteomic analysis of the actin cortex in interphase and mitosis

    Article • February 2022, Cold Spring Harbor Laboratory Press

    Dr Philippe P Roux

  30. Plakoglobin regulates adipocyte differentiation independently of the Wnt/β-catenin signalling pathway

    Article • February 2022, Cold Spring Harbor Laboratory Press

    Dr Philippe P Roux

  31. Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

    Article • Current Biology, February 2022, Elsevier

    Dr Philippe P Roux

  32. RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit

    Article • PLoS Genetics, June 2021, PLOS

    Dr Philippe P Roux

  33. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation

    Article • Cell, April 2021, Elsevier

    Dr Philippe P Roux

  34. Correction: RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation

    Article • Biochemical Journal, March 2021, Portland Press Ltd.

    Dr. Rima Saha, Dr Philippe P Roux

  35. Sustained ERK1/2 signaling is necessary for follicular rupture during ovulation in mice

    Article • Reproduction, February 2021, Bioscientifica

    Dr Philippe P Roux

  36. RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit

    Article • October 2020, Cold Spring Harbor Laboratory Press

    Dr Philippe P Roux

  37. Targeting copper metabolism to defeat KRAS-driven colorectal cancer

    Article • Molecular & Cellular Oncology, October 2020, Taylor & Francis

    Dr Philippe P Roux

  38. STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity

    Article • Journal of Cell Biology, September 2020, Rockefeller University Press

    Dr Philippe P Roux

  39. An ErbB2 splice variant lacking exon 16 drives lung carcinoma

    Article • Proceedings of the National Academy of Sciences, July 2020, Proceedings of the National Academy of Sciences

    William Muller, Dr Philippe P Roux

  40. Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

    Article • Nature Communications, July 2020, Springer Science + Business Media

    Dr Philippe P Roux

  41. SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization

    Article • Nature Cell Biology, June 2020, Springer Science + Business Media

    Dr Philippe P Roux

  42. Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling

    Article • American Review of Respiratory Disease, May 2020, American Thoracic Society

    Dr Philippe P Roux

  43. NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay

    Article • Cell Reports, May 2020, Elsevier

    Dr Philippe P Roux

  44. Controversies around the function of LARP1

    Article • RNA Biology, April 2020, Taylor & Francis

    Dr Philippe P Roux

  45. Publisher Correction: Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1

    Article • Scientific Reports, February 2020, Springer Science + Business Media

    Dr Philippe P Roux

  46. F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis

    Article • Developmental Cell, January 2020, Elsevier

    Dr Philippe P Roux

  47. Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion

    Article • Molecular & Cellular Proteomics, January 2020, Elsevier

    Dr Philippe P Roux

  48. Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1

    Article • Scientific Reports, November 2019, Springer Science + Business Media

    Dr Philippe P Roux

  49. Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities

    Article • Blood Advances, November 2019, American Society of Hematology

    Dr Philippe P Roux

  50. Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration

    Article • Nature Communications, September 2019, Springer Science + Business Media

    Dr Philippe P Roux

  51. Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

    Article • Cancer Cell, July 2019, Elsevier

    Dr Philippe P Roux

  52. Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children

    Article • Genes Chromosomes and Cancer, May 2019, Wiley

    Dr Philippe P Roux

  53. ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation

    Article • Proceedings of the National Academy of Sciences, February 2019, Proceedings of the National Academy of Sciences

    Dr Philippe P Roux

  54. Nckipsd Coordinates Arp2/3 and Formin Nucleation of Actin Filaments in the Cell Cortex

    Article • Biophysical Journal, February 2019, Elsevier

    Dr Philippe P Roux

  55. Genetic Landscape of Electron Transport Chain Complex I Dependency in Acute Myeloid Leukemia

    Article • January 2019, Cold Spring Harbor Laboratory Press

    Dr Philippe P Roux

  56. Coordination of Pro- and Anti-Inflammatory Signals Determine Human Hematopoietic Stem and Progenitor Cell Expansion

    Article • Blood, November 2018, American Society of Hematology

    Dr Philippe P Roux

  57. Germline GAB2 Mutations in Childhood Acute Lymphoblastic Leukemia

    Article • Blood, November 2018, American Society of Hematology

    Dr Philippe P Roux

  58. Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of Mitochondrial Vulnerability in Acute Myeloid Leukemia

    Article • Blood, November 2018, American Society of Hematology

    Dr Philippe P Roux

  59. Abstract 3502: Chemoproteomics provide insights into cell surface reprogramming during KRAS-mediated transformation

    Article • Cancer Research, July 2018, American Association for Cancer Research (AACR)

    Dr Philippe P Roux

  60. The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression

    Article • Cell Reports, May 2018, Elsevier

    Dr Philippe P Roux

  61. RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma

    Article • Cancer Research, April 2018, American Association for Cancer Research (AACR)

    Dr Philippe P Roux

  62. Signaling Pathways Involved in the Regulation of mRNA Translation

    Article • Molecular and Cellular Biology, April 2018, ASM Journals

    Dr Philippe P Roux

  63. Defining the role of the RSK isoforms in cancer

    Article • Seminars in Cancer Biology, February 2018, Elsevier

    Dr Philippe P Roux

  64. CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein

    Article • Oncotarget, January 2018, Impact Journals, LLC

    Dr Philippe P Roux

  65. RSK (p90 Ribosomal S6 Kinase)

    Article • January 2018, Springer Science + Business Media

    Dr Philippe P Roux

  66. The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade During HER2-Positive Breast Cancer Progression

    Article • SSRN Electronic Journal, January 2018, Elsevier

    Dr Philippe P Roux

  67. Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

    Article • Molecular Cell, August 2017, Elsevier

    Dr Philippe P Roux

  68. EPCR expression marks UM171-expanded CD34+ cord blood stem cells

    Article • Blood, June 2017, American Society of Hematology

    Dr Philippe P Roux

  69. Actin cortex architecture regulates cell surface tension

    Article • Nature Cell Biology, May 2017, Springer Science + Business Media

    Dr Philippe P Roux

  70. A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

    Article • Nature Communications, April 2017, Springer Science + Business Media

    Dr Philippe P Roux

  71. Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling

    Article • Molecular and Cellular Biology, January 2017, ASM Journals

    Dr Philippe P Roux

  72. Targeting Pre-Leukemic Stem Cells in T-Acute Lymphoblastic Leukemia

    Article • Blood, December 2016, American Society of Hematology

    Dr Philippe P Roux

  73. Proteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis

    Article • Molecular and Cellular Biology, November 2016, ASM Journals

    Dr Philippe P Roux

  74. High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells

    Article • Journal of Clinical Investigation, October 2016, American Society for Clinical Investigation

    Dr Philippe P Roux

  75. RSK (p90 Ribosomal S6 Kinase)

    Article • January 2016, Springer Science + Business Media

    Dr Philippe P Roux

  76. ISDN2014_0400: Mutations in DOCK7 in individuals with epileptic encephalopathy and cortical blindness

    Article • International Journal of Developmental Neuroscience, November 2015, Wiley

    Dr Philippe P Roux

  77. Targeting pre-leukemic stem cells in T-acute lymphoblastic leukemia

    Article • Experimental Hematology, September 2015, Elsevier

    Dr Philippe P Roux

  78. Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression

    Article • Proceedings of the National Academy of Sciences, August 2015, Proceedings of the National Academy of Sciences

    Dr Philippe P Roux

  79. Translational control by oncogenic signaling pathways

    Article • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, July 2015, Elsevier

    Dr Philippe P Roux

  80. Effect of the Transient Pharmacological Inhibition of Mapk3/1 Pathway on Ovulation in Mice

    Article • PLOS One, March 2015, PLOS

    Dr Philippe P Roux

  81. The expanding role of mTOR in cancer cell growth and proliferation

    Article • Mutagenesis, February 2015, Oxford University Press (OUP)

    Dr Philippe P Roux

  82. Regulation of global and specific mRNA translation by the mTOR signaling pathway

    Article • Translation, January 2015, Taylor & Francis

    Dr Philippe P Roux

  83. A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells

    Article • Nature Communications, July 2014, Springer Science + Business Media

    Dr Philippe P Roux

  84. Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3

    Article • Proceedings of the National Academy of Sciences, July 2014, Proceedings of the National Academy of Sciences

    Dr Philippe P Roux

  85. Cellular Control of Cortical Actin Nucleation

    Article • Current Biology, July 2014, Elsevier

    Dr Philippe P Roux

  86. Mechanistic target of rapamycin (MTOR) signaling during ovulation in mice

    Article • Molecular Reproduction and Development, June 2014, Wiley

    Dr Philippe P Roux

  87. Mutations in DOCK7 in Individuals with Epileptic Encephalopathy and Cortical Blindness

    Article • The American Journal of Human Genetics, June 2014, Elsevier

    Dr Philippe P Roux

  88. The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation

    Article • Molecular Systems Biology, April 2014, EMBO

    Dr Philippe P Roux

  89. Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5′TOP mRNA translation

    Article • Genes & Development, February 2014, Cold Spring Harbor Laboratory Press

    Dr Philippe P Roux

  90. Casein Kinase 1ϵ Promotes Cell Proliferation by Regulating mRNA Translation

    Article • Cancer Research, January 2014, American Association for Cancer Research (AACR)

    Dr Philippe P Roux

  91. The Coming of Age of Phosphoproteomics—from Large Data Sets to Inference of Protein Functions

    Article • Molecular & Cellular Proteomics, December 2013, Elsevier

    Dr Philippe P Roux

  92. Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging

    Article • Cytoskeleton, October 2013, Wiley

    Dr Philippe P Roux

  93. Rapamycin Resistance: mTORC1 Substrates Hold Some of the Answers

    Article • Current Biology, October 2013, Elsevier

    Dr Philippe P Roux

  94. Insulin Activates RSK (p90 Ribosomal S6 Kinase) to Trigger a New Negative Feedback Loop That Regulates Insulin Signaling for Glucose Metabolism

    Article • Journal of Biological Chemistry, September 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Philippe P Roux

  95. Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression

    Article • Journal of Cell Biology, July 2013, Rockefeller University Press

    Dr Philippe P Roux

  96. Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly

    Article • Journal of Medical Genetics, May 2013, BMJ

    Dr Philippe P Roux

  97. Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1

    Article • Oncogene, April 2013, Springer Science + Business Media

    Dr Philippe P Roux

  98. Abstract 5191: Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility.

    Article • Cancer Research, April 2013, American Association for Cancer Research (AACR)

    Dr Philippe P Roux

  99. Gab2 Phosphorylation by RSK Inhibits Shp2 Recruitment and Cell Motility

    Article • Molecular and Cellular Biology, February 2013, ASM Journals

    Dr Philippe P Roux

  100. RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance

    Article • Oncogene, October 2012, Springer Science + Business Media

    Dr Philippe P Roux

  101. RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation

    Article • Biochemical Journal, October 2012, Portland Press Ltd.

    Dr Philippe P Roux, Dr. Rima Saha

  102. Phosphorylation of the Eukaryotic Translation Initiation Factor 4E-Transporter (4E-T) by c-Jun N-Terminal Kinase Promotes Stress-Dependent P-Body Assembly

    Article • Molecular and Cellular Biology, September 2012, ASM Journals

    Dr Philippe P Roux

  103. Regulation of mRNA Translation by Signaling Pathways

    Article • Cold Spring Harbor Perspectives in Biology, August 2012, Cold Spring Harbor Laboratory Press

    Dr Philippe P Roux

  104. RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth

    Article • Oncogene, July 2012, Springer Science + Business Media

    Dr Philippe P Roux

  105. F-Box Proteins Elongate Translation During Stress Recovery

    Article • Science Signaling, June 2012, American Association for the Advancement of Science

    Dr Philippe P Roux

  106. Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

    Article • Microbiology and Molecular Biology Reviews, June 2012, ASM Journals

    Dr Philippe P Roux

  107. Regulation of Karyopherin α1 and Nuclear Import by Mammalian Target of Rapamycin

    Article • Journal of Biological Chemistry, April 2012, Elsevier

    Dr Philippe P Roux

  108. Regulation and function of the RSK family of protein kinases

    Article • Biochemical Journal, January 2012, Portland Press Ltd.

    Dr Philippe P Roux

  109. RSK (p90 Ribosomal S6 Kinase)

    Article • January 2012, Springer Science + Business Media

    Dr Philippe P Roux

  110. Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

    Article • Microbiology and Molecular Biology Reviews, March 2011, ASM Journals

    Dr Philippe P Roux

  111. A comprehensive map of the mTOR signaling network

    Article • Molecular Systems Biology, December 2010, EMBO

    Dr Philippe P Roux

  112. mTOR, la cible fonctionnelle de la rapamycine

    Article • médecine/sciences, December 2010, EDP Sciences

    Dr Philippe P Roux

  113. ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)

    Article • Journal of Biological Chemistry, November 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Philippe P Roux

  114. mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

    Article • The EMBO Journal, November 2010, Wiley

    Dr Philippe P Roux

  115. Paving the way for targeting RSK in cancer

    Article • Expert Opinion on Therapeutic Targets, October 2010, Informa Healthcare

    Dr Philippe P Roux

  116. Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation

    Article • Cell, May 2010, Elsevier

    Dr Philippe P Roux

  117. mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

    Article • Molecular and Cellular Biology, December 2009, ASM Journals

    Dr Philippe P Roux

  118. Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser 863 and Multisite Phosphorylation

    Article • Journal of Biological Chemistry, October 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Philippe P Roux

  119. Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells

    Article • November 2008, Springer Science + Business Media

    Dr Philippe P Roux

  120. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

    Article • Proceedings of the National Academy of Sciences, November 2008, Proceedings of the National Academy of Sciences

    Dr Philippe P Roux

  121. Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation

    Article • Current Biology, September 2008, Elsevier

    Dr Philippe P Roux

  122. The RSK factors of activating the Ras/MAPK signaling cascade

    Article • Frontiers in Bioscience, January 2008, Frontiers in Bioscience

    Dr Philippe P Roux

  123. Rsk4

    Article • AfCS-Nature Molecule Pages, July 2007, Springer Science + Business Media

    Dr Philippe P Roux

  124. Rsk3

    Article • AfCS-Nature Molecule Pages, July 2007, Springer Science + Business Media

    Dr Philippe P Roux

  125. Rsk1

    Article • AfCS-Nature Molecule Pages, April 2007, Springer Science + Business Media

    Dr Philippe P Roux

  126. RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation

    Article • Journal of Biological Chemistry, March 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Philippe P Roux

  127. Mind the GAP: Wnt Steps onto the mTORC1 Train

    Article • Cell, September 2006, Elsevier

    Dr Philippe P Roux

  128. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

    Article • The EMBO Journal, June 2006, Springer Science + Business Media

    Dr Philippe P Roux

  129. The Tumor Suppressor DAP Kinase Is a Target of RSK-Mediated Survival Signaling

    Article • Current Biology, October 2005, Elsevier

    Dr Philippe P Roux

  130. Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors

    Article • Proceedings of the National Academy of Sciences, January 2005, Proceedings of the National Academy of Sciences

    Dr Philippe P Roux

  131. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

    Article • Proceedings of the National Academy of Sciences, September 2004, Proceedings of the National Academy of Sciences

    Dr Philippe P Roux

  132. ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions

    Article • Microbiology and Molecular Biology Reviews, June 2004, ASM Journals

    Dr Philippe P Roux

  133. Protein Kinase A Activation Promotes Plasma Membrane Insertion of DCC from an Intracellular Pool: A Novel Mechanism Regulating Commissural Axon Extension

    Article • Journal of Neuroscience, March 2004, Society for Neuroscience

    Dr Philippe P Roux

  134. Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

    Article • Current Biology, August 2003, Elsevier

    Dr Philippe P Roux

  135. Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity

    Article • Molecular and Cellular Biology, July 2003, ASM Journals

    Dr Philippe P Roux

  136. K252a and CEP1347 Are Neuroprotective Compounds That Inhibit Mixed-lineage Kinase-3 and Induce Activation of Akt and ERK

    Article • Journal of Biological Chemistry, October 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Alexandre Angers-Loustau, Dr Philippe P Roux

  137. Neurotrophin signaling through the p75 neurotrophin receptor

    Article • Progress in Neurobiology, June 2002, Elsevier

    Dr Philippe P Roux

  138. The p75 Neurotrophin Receptor Activates Akt (Protein Kinase B) through a Phosphatidylinositol 3-Kinase-dependent Pathway

    Article • Journal of Biological Chemistry, April 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Philippe P Roux

  139. NRAGE, A Novel MAGE Protein, Interacts with the p75 Neurotrophin Receptor and Facilitates Nerve Growth Factor–Dependent Apoptosis

    Article • Neuron, August 2000, Elsevier

    Dr Philippe P Roux

  140. Activation of Transcription Factors NF-κB and NF-IL-6 by Human Immunodeficiency Virus Type 1 Protein R (Vpr) Induces Interleukin-8 Expression

    Article • Journal of Virology, May 2000, ASM Journals

    Dr Philippe P Roux

  141. p75 Neurotrophin Receptor Expression Is Induced in Apoptotic Neurons After Seizure

    Article • Journal of Neuroscience, August 1999, Society for Neuroscience

    Dr Philippe P Roux

  142. The p75 Neurotrophin Receptor (p75NTR) Alters Tumor Necrosis Factor-mediated NF- B Activity under Physiological Conditions, but Direct p75NTR-mediated NF- B Activation Requires Cell Stress

    Article • Journal of Biological Chemistry, July 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Philippe P Roux

  143. INCREASED APOPTOSIS, CHANGES IN INTRACELLULAR Ca2+, AND FUNCTIONAL ALTERATIONS IN LYMPHOCYTES AND MACROPHAGES AFTER IN VITRO EXPOSURE TO STATIC MAGNETIC FIELD

    Article • Journal of Toxicology and Environmental Health Part A, May 1998, Taylor & Francis

    Dr Philippe P Roux

  144. MAPK Signaling in Human Diseases

    Article • Springer Science + Business Media

    Dr Philippe P Roux