All Stories

  1. Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc1 sub-unit

    Article • PLoS Pathogens, August 2021, PLOS

    Professor Paul Williams

  2. Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections

    Article • Biomaterials Science, January 2020, Royal Society of Chemistry

    Professor Paul Williams

  3. Simultaneous Tracking of Pseudomonas aeruginosa Motility in Liquid and at the Solid-Liquid Interface Reveals Differential Roles for the Flagellar Stators

    Article • mSystems, September 2019, ASM Journals

    Professor Paul Williams

  4. Timing Is Everything: Impact of Naturally Occurring Staphylococcus aureus AgrC Cytoplasmic Domain Adaptive Mutations on Autoinduction

    Article • Journal of Bacteriology, July 2019, ASM Journals

    Professor Paul Williams

  5. Dual bioresponsive antibiotic and quorum sensing inhibitor combination nanoparticles for treatment of Pseudomonas aeruginosa biofilms in vitro and ex vivo

    Article • Biomaterials Science, January 2019, Royal Society of Chemistry

    Professor Paul Williams

  6. Genome-wide mapping of the RNA targets of the Pseudomonas aeruginosa riboregulatory protein RsmN

    Article • Nucleic Acids Research, April 2018, Oxford University Press (OUP)

    Professor Paul Williams

  7. To Boil an Egg: Substrate Binding Affects Critical Stability in Thermal Unfolding of Proteins

    Article • The Journal of Physical Chemistry B, February 2018, American Chemical Society (ACS)

    Professor Paul Williams

  8. In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa

    Article • Molecules, January 2018, MDPI AG

    Professor Paul Williams

  9. Prediction of Broad-Spectrum Pathogen Attachment to Coating Materials for Biomedical Devices

    Article • ACS Applied Materials & Interfaces, January 2018, American Chemical Society (ACS)

    Professor Paul Williams, Professor Dave A Winkler

  10. Effect of surfactant on Pseudomonas aeruginosa colonization of polymer microparticles and flat films

    Article • RSC Advances, January 2018, Royal Society of Chemistry

    Professor Paul Williams

  11. Detection of 2-Alkyl-4-Quinolones Using Biosensors

    Article • November 2017, Springer Science + Business Media

    Professor Paul Williams

  12. Detection of Agr-Type Autoinducing Peptides Produced by Staphylococcus aureus

    Article • November 2017, Springer Science + Business Media

    Professor Paul Williams

  13. Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: A longitudinal study; response to comments

    Article • Journal of Cystic Fibrosis, November 2017, Elsevier

    Professor Paul Williams

  14. Professor Dieter Haas (1945–2017)

    Article • FEMS Microbiology Reviews, August 2017, Oxford University Press (OUP)

    Professor Paul Williams

  15. Weight gain during acute treatment of an initial pulmonary exacerbation is associated with a longer interval to the next exacerbation in adults with cystic fibrosis

    Article • ERJ Open Research, July 2017, European Respiratory Society (ERS)

    Professor Paul Williams

  16. Water contact angle is not a good predictor of biological responses to materials

    Article • Biointerphases, June 2017, American Vacuum Society

    Professor Paul Williams

  17. Development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating

    Article • Biointerphases, June 2017, American Vacuum Society

    Professor Paul Williams

  18. Particulate air pollution impacts directly on bacterial pathogen behaviour and infection

    Article • Environmental Microbiology, May 2017, Wiley

    Professor Paul Williams

  19. Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production

    Article • Proceedings of the Royal Society B Biological Sciences, April 2017, Royal Society Publishing

    Professor Paul Williams

  20. Negative Regulation of Violacein Biosynthesis in Chromobacterium violaceum

    Article • Frontiers in Microbiology, March 2017, Frontiers

    PhD Milan Kojic, Professor Paul Williams

  21. Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: A longitudinal study

    Article • Journal of Cystic Fibrosis, March 2017, Elsevier

    Professor Paul Williams

  22. 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due toStaphylococcus aureus

    Article • Journal of Antimicrobial Chemotherapy, December 2016, Oxford University Press (OUP)

    Professor Paul Williams

  23. Making Silicone Rubber Highly Resistant to Bacterial Attachment Using Thiol-ene Grafting

    Article • ACS Applied Materials & Interfaces, November 2016, American Chemical Society (ACS)

    Professor Paul Williams

  24. Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa

    Article • PLoS Pathogens, November 2016, PLOS

    Professor Paul Williams

  25. The fitness burden imposed by synthesising quorum sensing signals

    Article • Scientific Reports, September 2016, Springer Science + Business Media

    Professor Paul Williams

  26. Genome sequencing-assisted identification and the first functional validation ofN-acyl-homoserine-lactone synthases from the Sphingomonadaceae family

    Article • PeerJ, August 2016, PeerJ

    Professor Paul Williams

  27. Cystic Fibrosis Isolates of Pseudomonas aeruginosa Retain Iron-Regulated Antimicrobial Activity against Staphylococcus aureus through the Action of Multiple Alkylquinolones

    Article • Frontiers in Microbiology, July 2016, Frontiers

    Amanda Oglesby-Sherrouse, Professor Paul Williams

  28. Yersinia virulence factors - a sophisticated arsenal for combating host defences

    Article • F1000Research, June 2016, Faculty of 1000, Ltd.

    Professor Paul Williams

  29. Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment

    Article • Acta Biomaterialia, April 2016, Elsevier

    Professor Paul Williams

  30. Burkholderia pseudomallei kynB plays a role in AQ production, biofilm formation, bacterial swarming and persistence

    Article • Research in Microbiology, April 2016, Elsevier

    Professor Paul Williams

  31. PqsBC, a Condensing Enzyme in the Biosynthesis of thePseudomonas aeruginosaQuinolone Signal

    Article • Journal of Biological Chemistry, January 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Paul Williams

  32. Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium

    Article • Frontiers in Microbiology, September 2015, Frontiers

    Prof Eric Déziel, Professor Paul Williams

  33. Conflict of interest and signal interference lead to the breakdown of honest signaling

    Article • Evolution, September 2015, Wiley

    Professor Paul Williams

  34. Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis

    Article • European Respiratory Journal, May 2015, European Respiratory Society (ERS)

    Professor Paul Williams

  35. Integrated whole-genome screening forPseudomonas aeruginosavirulence genes using multiple disease models reveals that pathogenicity is host specific

    Article • Environmental Microbiology, May 2015, Wiley

    Professor Paul Williams

  36. Biotic inactivation of thePseudomonas aeruginosaquinolone signal molecule

    Article • Environmental Microbiology, April 2015, Wiley

    Professor Paul Williams

  37. [18F]FDG-6-P as a novel in vivo tool for imaging staphylococcal infections

    Article • EJNMMI Research, March 2015, Springer Science + Business Media

    Professor Paul Williams

  38. Granulocyte-Macrophage Colony Stimulatory Factor Enhances the Pro-Inflammatory Response of Interferon-γ-Treated Macrophages to Pseudomonas aeruginosa Infection

    Article • PLoS ONE, February 2015, PLOS

    Professor Paul Williams

  39. Genome Sequences of Two Pandoraea pnomenusa Isolates Recovered 11 Months Apart from a Cystic Fibrosis Patient

    Article • Genome Announcements, February 2015, ASM Journals

    Dr Louise Frances Roddam, Professor Paul Williams

  40. Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity

    Article • Advanced Healthcare Materials, December 2014, Wiley

    Professor Paul Williams

  41. Genome-Wide Evaluation of the Interplay between Caenorhabditis elegans and Yersinia pseudotuberculosis duringIn VivoBiofilm Formation

    Article • Infection and Immunity, October 2014, ASM Journals

    Professor Paul Williams

  42. The art of antibacterial warfare: Deception through interference with quorum sensing–mediated communication

    Article • Bioorganic Chemistry, August 2014, Elsevier

    Professor Paul Williams

  43. Predicting the virulence of MRSA from its genome sequence

    Article • Genome Research, April 2014, Cold Spring Harbor Laboratory Press

    Professor Paul Williams

  44. Targeting Staphylococcus aureus Quorum Sensing with Nonpeptidic Small Molecule Inhibitors

    Article • Journal of Medicinal Chemistry, March 2014, American Chemical Society (ACS)

    Professor Paul Williams

  45. Thermally Switchable Polymers Achieve ControlledEscherichia coliDetachment

    Article • Advanced Healthcare Materials, February 2014, Wiley

    Professor Paul Williams

  46. Biosensors for Qualitative and Semiquantitative Analysis of Quorum Sensing Signal Molecules

    Article • January 2014, Springer Science + Business Media

    Professor Paul Williams

  47. LC-MS/MS Quantitative Analysis of Quorum Sensing Signal Molecules

    Article • January 2014, Springer Science + Business Media

    Professor Paul Williams

  48. Structural Rearrangement in an RsmA/CsrA Ortholog of Pseudomonas aeruginosa Creates a Dimeric RNA-Binding Protein, RsmN

    Article • Structure, September 2013, Elsevier

    Professor Paul Williams

  49. Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR)

    Article • PLoS Pathogens, July 2013, PLOS

    Professor Paul Williams

  50. Interference with the germination and growth of U lva zoospores by quorum‐sensing molecules from U lva ...

    Article • Environmental Microbiology, July 2013, Wiley

    Professor Paul Williams

  51. Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays

    Article • Advanced Materials, February 2013, Wiley

    Professor Paul Williams

  52. Attenuating Staphylococcus aureus Virulence Gene Regulation: A Medicinal Chemistry Perspective

    Article • Journal of Medicinal Chemistry, January 2013, American Chemical Society (ACS)

    Christopher Gordon, Professor Paul Williams

  53. Quorum-sensing and cheating in bacterial biofilms

    Article • Proceedings of the Royal Society B Biological Sciences, October 2012, Royal Society Publishing

    Professor Paul Williams

  54. Combinatorial discovery of polymers resistant to bacterial attachment

    Article • Nature Biotechnology, August 2012, Springer Science + Business Media

    Professor Paul Williams

  55. Bursting the bubble on bacterial biofilms: a flow cell methodology

    Article • Biofouling, August 2012, Taylor & Francis

    Professor Paul Williams

  56. 86 Genome wide random screening strategy for the discovery of novel antimicrobial targets in Pseudomonas aeruginosa

    Article • Journal of Cystic Fibrosis, June 2012, Elsevier

    Professor Paul Williams

  57. High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry

    Article • Surface and Interface Analysis, March 2012, Wiley

    Professor Paul Williams

  58. Methicillin Resistance Reduces the Virulence of Healthcare-Associated Methicillin-Resistant Staphylococcus aureus by Interfering With the agr Quorum Sensing System

    Article • The Journal of Infectious Diseases, February 2012, Oxford University Press (OUP)

    Professor James P. O'Gara, Professor Paul Williams

  59. Polymer Microarrays for High Throughput Discovery of Biomaterials

    Article • Journal of Visualized Experiments, January 2012, MyJove Corporation

    Professor Paul Williams

  60. Phenotypic and Genome-Wide Analysis of an Antibiotic-Resistant Small Colony Variant (SCV) of Pseudomonas aeruginosa

    Article • PLoS ONE, December 2011, PLOS

    Professor Paul Williams, Professor Ronnie Guy Willaert, Jan Michiels

  61. Cross-Strain Quorum Sensing Inhibition by Staphylococcus aureus. Part 1: A Spatially Homogeneous Model

    Article • Bulletin of Mathematical Biology, November 2011, Springer Science + Business Media

    Professor Paul Williams

  62. Cross-Strain Quorum Sensing Inhibition by Staphylococcus Aureus. Part 2: A Spatially Inhomogeneous Model

    Article • Bulletin of Mathematical Biology, November 2011, Springer Science + Business Media

    Professor Paul Williams

  63. A Glycopeptide Dendrimer Inhibitor of the Galactose-Specific Lectin LecA and of Pseudomonas aeruginosa Biofilms

    Article • Angewandte Chemie, September 2011, Wiley

    Professor Paul Williams

  64. A Glycopeptide Dendrimer Inhibitor of the Galactose-Specific Lectin LecA and of Pseudomonas aeruginosa Biofilms

    Article • Angewandte Chemie International Edition, September 2011, Wiley

    Professor Paul Williams

  65. Interkingdom crosstalk

    Article • Virulence, July 2011, Taylor & Francis

    Professor Paul Williams

  66. 94* A commercial garlic preparation exerts global inhibition of the quorum sensing (QS) system and virulence factor production of laboratory and clinical strains of Pseudomonas aeruginosa

    Article • Journal of Cystic Fibrosis, June 2011, Elsevier

    Professor Paul Williams

  67. Immunosuppressive but Non-LasR-Inducing Analogues of thePseudomonas aeruginosaQuorum-Sensing MoleculeN-(3-Oxododecanoyl)-l-homoserine Lactone

    Article • Journal of Medicinal Chemistry, May 2011, American Chemical Society (ACS)

    Professor Paul Williams

  68. Quinolones: from antibiotics to autoinducers

    Article • FEMS Microbiology Reviews, March 2011, Oxford University Press (OUP)

    Professor Paul Williams

  69. Salmonella Typhi sense host neuroendocrine stress hormones and release the toxin haemolysin E

    Article • EMBO Reports, February 2011, Wiley

    Professor Paul Williams

  70. Inactivation of AHLs by Ochrobactrum sp. A44 depends on the activity of a novel class of AHL acylase

    Article • Environmental Microbiology Reports, February 2011, Wiley

    Professor Robert Czajkowski, Professor Paul Williams

  71. Biofilm Development on Caenorhabditis elegans by Yersinia Is Facilitated by Quorum Sensing-Dependent Repression of Type III Secretion

    Article • PLoS Pathogens, January 2011, PLOS

    Professor Paul Williams

  72. Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids

    Article • MedChemComm, January 2011, Royal Society of Chemistry

    Professor Paul Williams

  73. Characterization of N-acylhomoserine lactone-degrading bacteria associated with the Zingiber officinale (ginger) rhizosphere: Co-existence of quorum quenching and quorum sensing in Acinetobacter and Burkholderia

    Article • BMC Microbiology, January 2011, Springer Science + Business Media

    Professor Paul Williams, Dr Chong Lek Koh

  74. Simultaneous quantitative profiling of N-acyl-l-homoserine lactone and 2-alkyl-4(1H)-quinolone families of quorum-sensing signaling molecules using LC-MS/MS

    Article • Analytical and Bioanalytical Chemistry, October 2010, Springer Science + Business Media

    Professor Paul Williams

  75. The Interaction of N-Acylhomoserine Lactone Quorum Sensing Signaling Molecules with Biological Membranes: Implications for Inter-Kingdom Signaling

    Article • PLoS ONE, October 2010, PLOS

    Professor Paul Williams

  76. Detection of 2-Alkyl-4-Quinolones Using Biosensors

    Article • October 2010, Springer Science + Business Media

    Professor Paul Williams

  77. Quantitative liquid chromatography–tandem mass spectrometry profiling of activated methyl cycle metabolites involved in LuxS-dependent quorum sensing in Escherichia coli

    Article • Analytical Biochemistry, August 2010, Elsevier

    Professor Paul Williams

  78. Commercial garlic preparations inhibit quorum sensing lasB and pqsA gene expression in Pseudomonas aeruginosa clinical strains

    Article • Journal of Cystic Fibrosis, June 2010, Elsevier

    Professor Paul Williams

  79. A mathematical investigation of the effects of inhibitor therapy on three putative phosphorylation cascades governing the two-component system of the agr operon

    Article • Mathematical Biosciences, June 2010, Elsevier

    Professor Paul Williams

  80. Transcriptomic analysis reveals a global alkyl-quinolone-independent regulatory role for PqsE in facilitating the environmental adaptation ofPseudomonas aeruginosato plant and animal hosts

    Article • Environmental Microbiology, May 2010, Wiley

    Professor Paul Williams

  81. The acylase PvdQ has a conserved function among fluorescent Pseudomonas spp.

    Article • Environmental Microbiology Reports, March 2010, Wiley

    Professor Paul Williams

  82. Garlic as an inhibitor ofPseudomonas aeruginosaquorum sensing in cystic fibrosis-a pilot randomized controlled trial

    Article • Pediatric Pulmonology, March 2010, Wiley

    Professor Paul Williams

  83. 2-Alkyl-4(1H)-Quinolone Signalling in Pseudomonas aeruginosa

    Article • January 2010, Springer Science + Business Media

    Professor Paul Williams

  84. High throughput methods applied in biomaterial development and discovery

    Article • Biomaterials, January 2010, Elsevier

    Professor Paul Williams

  85. Dioxygenase-Mediated Quenching of Quinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa

    Article • Chemistry & Biology, December 2009, Elsevier

    Professor Paul Williams

  86. Genome-Wide Transposon Mutagenesis Identifies a Role for Host Neuroendocrine Stress Hormones in Regulating the Expression of Virulence Genes in Salmonella

    Article • Journal of Bacteriology, November 2009, ASM Journals

    Professor Paul Williams

  87. Quorum sensing and social networking in the microbial world

    Article • Journal of The Royal Society Interface, November 2009, Royal Society Publishing

    Professor Paul Williams

  88. LuxS-Based Quorum Sensing Does Not Affect the Ability of Salmonella enterica Serovar Typhimurium To Express the SPI-1 Type 3 Secretion System, Induce Membrane Ruffles, or Invade Epithelial Cells

    Article • Journal of Bacteriology, September 2009, ASM Journals

    Professor Paul Williams

  89. Mathematical modelling of the agr operon in Staphylococcus aureus

    Article • Journal of Mathematical Biology, August 2009, Springer Science + Business Media

    Professor Paul Williams

  90. Turnover of quorum sensing signal molecules modulates cross-kingdom signalling

    Article • Environmental Microbiology, July 2009, Wiley

    Professor Paul Williams

  91. Is quorum sensing related to strain type in Pseudomonas aeruginosa

    Article • Journal of Cystic Fibrosis, June 2009, Elsevier

    Professor Paul Williams

  92. Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules

    Article • Current Opinion in Microbiology, April 2009, Elsevier

    Professor Paul Williams

  93. Significant immunomodulatory effects of Pseudomonas aeruginosa quorum-sensing signal molecules: possible link in human sepsis

    Article • Clinical Science, December 2008, Portland Press Ltd.

    Professor Paul Williams

  94. Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms by Glycopeptide Dendrimers Targeting the Fucose-Specific Lectin LecB

    Article • Chemistry & Biology, December 2008, Elsevier

    Professor Paul Williams

  95. The PA4204 gene encodes a periplasmic gluconolactonase (PpgL) which is important for fitness of Pseudomonas aeruginosa

    Article • Microbiology, October 2008, Society for General Microbiology

    Professor Paul Williams

  96. Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC

    Article • Journal of Molecular Biology, August 2008, Elsevier

    Professor Paul Williams

  97. Functional interplay between theYersinia pseudotuberculosisYpsRI and YtbRI quorum sensing systems modulates swimming motility by controlling expression offlhDCandfliA

    Article • Molecular Microbiology, July 2008, Wiley

    Professor Paul Williams

  98. An RCT of macerated garlic oil in patients with CF & chronic Pseudomonas aeruginosa

    Article • Journal of Cystic Fibrosis, June 2008, Elsevier

    Professor Paul Williams

  99. Adrenaline modulates the global transcriptional profile of Salmonella revealing a role in the antimicrobial peptide and oxidative stress resistance responses

    Article • BMC Genomics, January 2008, Springer Science + Business Media

    Professor Paul Williams

  100. Quorum sensing, communication and cross-kingdom signalling in the bacterial world

    Article • Microbiology, December 2007, Society for General Microbiology

    Professor Paul Williams

  101. LuxS Affects Flagellar Phase Variation Independently of Quorum Sensing in Salmonella enterica Serovar Typhimurium

    Article • Journal of Bacteriology, November 2007, ASM Journals

    Professor Paul Williams

  102. A dual biosensor for 2-alkyl-4-quinolone quorum-sensing signal molecules

    Article • Environmental Microbiology, November 2007, Wiley

    Professor Paul Williams

  103. Look who's talking: communication and quorum sensing in the bacterial world

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, July 2007, Royal Society Publishing

    Professor Paul Williams

  104. Bacterial conversations: talking, listening and eavesdropping. An introduction

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, July 2007, Royal Society Publishing

    Professor Paul Williams

  105. Bacillus subtilis: A Shocking Message from a Probiotic

    Article • Cell Host & Microbe, June 2007, Elsevier

    Professor Paul Williams

  106. Biosensor-based assays for PQS, HHQ and related 2-alkyl-4-quinolone quorum sensing signal molecules

    Article • Nature Protocols, May 2007, Springer Science + Business Media

    Professor Paul Williams

  107. The Pseudomonas aeruginosa 4-Quinolone Signal Molecules HHQ and PQS Play Multifunctional Roles in Quorum Sensing and Iron Entrapment

    Article • Chemistry & Biology, January 2007, Elsevier

    Professor Paul Williams, Pierre Cornelis

  108. Quorum sensing regulates dpsA and the oxidative stress response in Burkholderia pseudomallei

    Article • Microbiology, December 2006, Society for General Microbiology

    Professor Paul Williams

  109. N-acyl homoserine lactones are degraded via an amidolytic activity in Comamonas sp. strain D1

    Article • Archives of Microbiology, November 2006, Springer Science + Business Media

    Professor Paul Williams, Dr Phil M Oger

  110. Comprehensive profiling of N-acylhomoserine lactones produced by Yersinia pseudotuberculosis using liquid chromatography coupled to hybrid quadrupole–linear ion trap mass spectrometry

    Article • Analytical and Bioanalytical Chemistry, September 2006, Springer Science + Business Media

    Professor Paul Williams

  111. Functional Genetic Analysis Reveals a 2-Alkyl-4-Quinolone Signaling System in the Human Pathogen Burkholderia pseudomallei and Related Bacteria

    Article • Chemistry & Biology, July 2006, Elsevier

    Professor Paul Williams

  112. The galactophilic lectin, LecA, contributes to biofilm development in Pseudomonas aeruginosa

    Article • Environmental Microbiology, June 2006, Wiley

    Professor Paul Williams

  113. RETRACTED: Cell–cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover

    Article • Proceedings of the National Academy of Sciences, April 2006, Proceedings of the National Academy of Sciences

    Professor Paul Williams

  114. Functional Analysis of luxS in Staphylococcus aureus Reveals a Role in Metabolism but Not Quorum Sensing

    Article • Journal of Bacteriology, April 2006, ASM Journals

    Professor Paul Williams

  115. 4-Quinolone signalling in Pseudomonas aeruginosa: Old molecules, new perspectives

    Article • International Journal of Medical Microbiology, April 2006, Elsevier

    Professor Paul Williams, Pierre Cornelis

  116. Quorum Quenching by an N-Acyl-Homoserine Lactone Acylase from Pseudomonas aeruginosa PAO1

    Article • Infection and Immunity, March 2006, ASM Journals

    Professor Paul Williams

  117. Quorum Sensing in Yersinia enterocolitica Controls Swimming and Swarming Motility

    Article • Journal of Bacteriology, February 2006, ASM Journals

    Professor Paul Williams

  118. A Mobile Quorum-Sensing System in Serratia marcescens

    Article • Journal of Bacteriology, February 2006, ASM Journals

    Professor Paul Williams

  119. N-Acylhomoserine Lactones Antagonize Virulence Gene Expression and Quorum Sensing in Staphylococcus aureus

    Article • Infection and Immunity, February 2006, ASM Journals

    Professor Paul Williams

  120. Functional Analysis of the Post-transcriptional Regulator RsmA Reveals a Novel RNA-binding Site

    Article • Journal of Molecular Biology, February 2006, Elsevier

    Professor Paul Williams

  121. Alleviation of insulitis and moderation of diabetes in NOD mice following treatment with a synthetic Pseudomonas aeruginosasignal molecule, N-(3-oxododecanoyl)-L-homoserine lactone

    Article • Acta Diabetologica, October 2005, Springer Science + Business Media

    Professor Paul Williams

  122. All subtypes of the cytotoxin VacA adsorb to the surface of Helicobacter pylori post-secretion

    Article • Journal of Medical Microbiology, July 2005, Society for General Microbiology

    Professor Paul Williams

  123. The RssAB Two-Component Signal Transduction System in Serratia marcescens Regulates Swarming Motility and Cell Envelope Architecture in Response to Exogenous Saturated Fatty Acids

    Article • Journal of Bacteriology, May 2005, ASM Journals

    Professor Paul Williams

  124. HosA, a Member of the SlyA Family, Regulates Motility in Enteropathogenic Escherichia coli

    Article • Infection and Immunity, March 2005, ASM Journals

    Professor Paul Williams

  125. Disruption of quorum sensing in seawater abolishes attraction of zoospores of the green alga Ulva to bacterial biofilms

    Article • Environmental Microbiology, February 2005, Wiley

    Professor Paul Williams

  126. Quorum sensing in Clostridium difficile: analysis of a luxS-type signalling system

    Article • Journal of Medical Microbiology, February 2005, Society for General Microbiology

    Professor Paul Williams

  127. TheAeromonas hydrophilaLuxR homologue AhyR regulates theN-acyl homoserine lactone synthase, AhyI positively and negatively in a growth phase-dependent manner

    Article • FEMS Microbiology Letters, December 2004, Oxford University Press (OUP)

    Professor Paul Williams

  128. Deterministic and stochastic modelling of endosome escape by Staphylococcus aureus: ?quorum? sensing by a single bacterium

    Article • Journal of Mathematical Biology, November 2004, Springer Science + Business Media

    Professor Paul Williams

  129. Differential Immune Modulatory Activity of Pseudomonas aeruginosa Quorum-Sensing Signal Molecules

    Article • Infection and Immunity, November 2004, ASM Journals

    Professor Paul Williams

  130. Mathematical modelling of therapies targeted at bacterial quorum sensing

    Article • Mathematical Biosciences, November 2004, Elsevier

    Professor Paul Williams

  131. Virulence Regulation and Quorum Sensing in Staphylococcal Infections:  Competitive AgrC Antagonists as Quorum Sensing Inhibitors§

    Article • Journal of Medicinal Chemistry, September 2004, American Chemical Society (ACS)

    Professor Paul Williams

  132. Potato Plants Genetically Modified to ProduceN-Acylhomoserine Lactones Increase Susceptibility to Soft Rot Erwiniae

    Article • Molecular Plant-Microbe Interactions, August 2004, Scientific Societies

    Professor Paul Williams

  133. Positive Control of Swarming, Rhamnolipid Synthesis, and Lipase Production by the Posttranscriptional RsmA/RsmZ System in Pseudomonas aeruginosa PAO1

    Article • Journal of Bacteriology, May 2004, ASM Journals

    Professor Paul Williams

  134. A distinctive dual-channel quorum-sensing system operates in Vibrio anguillarum

    Article • Molecular Microbiology, May 2004, Wiley

    Professor Paul Williams

  135. Biofilm Formation in Pseudomonas aeruginosa: Fimbrial cup Gene Clusters Are Controlled by the Transcriptional Regulator MvaT

    Article • Journal of Bacteriology, May 2004, ASM Journals

    Professor Paul Williams

  136. Real-Time Monitoring of Intracellular Staphylococcus aureus Replication

    Article • Journal of Bacteriology, February 2004, ASM Journals

    Professor Paul Williams

  137. The Staphylococcal Ferritins Are Differentially Regulated in Response to Iron and Manganese and via PerR and Fur

    Article • Infection and Immunity, February 2004, ASM Journals

    Professor Paul Williams

  138. Post-Transcriptional Regulation in Pseudomonas SPP. Via the Gac/Rsm Regulatory Network

    Article • January 2004, Springer Science + Business Media

    Professor Paul Williams

  139. Functional complementation ofE. coli secDandsecGmutants byHelicobacter pylorihomologues

    Article • FEMS Microbiology Letters, December 2003, Oxford University Press (OUP)

    Professor Paul Williams

  140. Global regulation of virulence and the stress response by CsrA in the highly adapted human gastric pathogen Helicobacter pylori

    Article • Molecular Microbiology, November 2003, Wiley

    Professor Paul Williams

  141. Electrostatic sensor for identifying interactions between peptides and bacterial membranes

    Article • Molecular Immunology, November 2003, Elsevier

    Professor Paul Williams

  142. Modelling host tissue degradation by extracellular bacterial pathogens

    Article • Mathematical Medicine and Biology A Journal of the IMA, September 2003, Oxford University Press (OUP)

    Professor Paul Williams

  143. The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR

    Article • Molecular Microbiology, August 2003, Wiley

    Professor Paul Williams

  144. Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system

    Article • Bioorganic & Medicinal Chemistry Letters, August 2003, Elsevier

    Professor Paul Williams

  145. Preliminary findings of quorum signal molecules in clinically stable lung allograft recipients

    Article • Thorax, May 2003, BMJ

    Professor Paul Williams

  146. Bacterial quorum sensing signalling molecules as immune modulators

    Article • April 2003, Cambridge University Press

    Professor Paul Williams

  147. Synthetic Analogues of the Bacterial Signal (Quorum Sensing) MoleculeN-(3-Oxododecanoyl)-l-homoserine Lactone as Immune Modulators

    Article • Journal of Medicinal Chemistry, January 2003, American Chemical Society (ACS)

    Professor Paul Williams

  148. Controlling infection by tuning in and turning down the volume of bacterial small-talk

    Article • The Lancet Infectious Diseases, November 2002, Elsevier

    Professor Paul Williams

  149. The Growth Response of Escherichia coli to Neurotransmitters and Related Catecholamine Drugs Requires a Functional Enterobactin Biosynthesis and Uptake System

    Article • Infection and Immunity, November 2002, ASM Journals

    Professor Paul Williams

  150. N-Acylhomoserine Lactones Undergo Lactonolysis in a pH-, Temperature-, and Acyl Chain Length-Dependent Manner during Growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa

    Article • Infection and Immunity, October 2002, ASM Journals

    Professor Paul Williams

  151. Quorum sensing in Vibrio cholerae

    Article • Nature Genetics, October 2002, Springer Science + Business Media

    Professor Paul Williams

  152. Identification of a Quorum-Sensing Signal Molecule in the Facultative Intracellular Pathogen Brucella melitensis

    Article • Infection and Immunity, June 2002, ASM Journals

    Professor Paul Williams

  153. Quorum sensing: an emerging target for antibacterial chemotherapy?

    Article • Expert Opinion on Therapeutic Targets, June 2002, Informa Healthcare

    Professor Paul Williams

  154. Advancing the Quorum in Pseudomonas aeruginosa: MvaT and the Regulation of N-Acylhomoserine Lactone Production and Virulence Gene Expression

    Article • Journal of Bacteriology, May 2002, ASM Journals

    Professor Paul Williams

  155. In vitro biosynthesis of the Pseudomonas aeruginosa quorum-sensing signal molecule N-butanoyl-L-homoserine lactone

    Article • Molecular Microbiology, May 2002, Wiley

    Professor Paul Williams

  156. Conservation, Surface Exposure, and In Vivo Expression of the Frp Family of Iron-Regulated Cell Wall Proteins in Staphylococcus aureus

    Article • Infection and Immunity, May 2002, ASM Journals

    Professor Paul Williams

  157. Bacterial cell-to-cell communication: sorry, can't talk now — gone to lunch!

    Article • Current Opinion in Microbiology, April 2002, Elsevier

    Professor Paul Williams

  158. LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)-furanone

    Article • Microbiology, April 2002, Society for General Microbiology

    Professor Paul Williams

  159. VanT, a Homologue of Vibrio harveyi LuxR, Regulates Serine, Metalloprotease, Pigment, and Biofilm Production in Vibrio anguillarum

    Article • Journal of Bacteriology, March 2002, ASM Journals

    Professor Paul Williams

  160. A Mathematical Model of Partial-thickness Burn-wound Infection by Pseudomonas aeruginosa: Quorum Sensing and the Build-up to Invasion

    Article • Bulletin of Mathematical Biology, March 2002, Springer Science + Business Media

    Professor Paul Williams

  161. LuxS-dependent quorum sensing in Porphyromonas gingivalis modulates protease and haemagglutinin activities but is not essential for virulence

    Article • Microbiology, March 2002, Society for General Microbiology

    Professor Paul Williams

  162. A hierarchical quorum-sensing system in Yersinia pseudotuberculosis is involved in the regulation of motility and clumping

    Article • Molecular Microbiology, March 2002, Wiley

    Professor Paul Williams

  163. Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other Gram-negative bacteria

    Article • Molecular Microbiology, March 2002, Wiley

    Professor Paul Williams

  164. The Global Posttranscriptional Regulator RsmA Modulates Production of Virulence Determinants and N-Acylhomoserine Lactones in Pseudomonas aeruginosa

    Article • Journal of Bacteriology, January 2002, ASM Journals

    Professor Paul Williams

  165. Direct detection ofN-acylhomoserine lactones in cystic fibrosis sputum

    Article • FEMS Microbiology Letters, January 2002, Oxford University Press (OUP)

    Professor Paul Williams

  166. The regulation of biofilm development by quorum sensing in Aeromonas hydrophila

    Article • Environmental Microbiology, January 2002, Wiley

    Professor Paul Williams

  167. Structure, activity and evolution of the group I thiolactone peptide quorum-sensing system of Staphylococcus aureus

    Article • Molecular Microbiology, December 2001, Wiley

    Professor Paul Williams

  168. QUORUM SENSING AND THE POPULATION-DEPENDENT CONTROL OF VIRULENCE

    Article • December 2001, World Scientific Pub Co Pte Lt

    Professor Paul Williams

  169. The Global Posttranscriptional Regulator RsmA Modulates Production of Virulence Determinants andN-Acylhomoserine Lactones in Pseudomonas aeruginosa

    Article • Journal of Bacteriology, November 2001, ASM Journals

    Professor Paul Williams

  170. agr Expression Precedes Escape of InternalizedStaphylococcus aureus from the Host Endosome

    Article • Infection and Immunity, November 2001, ASM Journals

    Professor Paul Williams

  171. Haemodynamic effects of the bacterial quorum sensing signal molecule,N-(3-oxododecanoyl)-L-homoserine lactone, in conscious, normal and endotoxaemic rats

    Article • British Journal of Pharmacology, August 2001, Wiley

    Professor Paul Williams

  172. The LuxM Homologue VanM from Vibrio anguillarumDirects the Synthesis of N-(3-Hydroxyhexanoyl)homoserine Lactone and N-Hexanoylhomoserine Lactone

    Article • Journal of Bacteriology, June 2001, ASM Journals

    Professor Paul Williams

  173. Quorum sensing as an integral component of gene regulatory networks in Gram-negative bacteria

    Article • Current Opinion in Microbiology, April 2001, Elsevier

    Professor Paul Williams

  174. Synthesis of Multiple N-Acylhomoserine Lactones is Wide-spread Among the Members of the Burkholderia cepacia Complex

    Article • Systematic and Applied Microbiology, January 2001, Elsevier

    Professor Paul Williams, Professor Leo Eberl, Professor Peter A Vandamme

  175. Quorum sensing and the regulation of virulence gene expression in pathogenic bacteria

    Article • International Journal of Medical Microbiology, January 2001, Elsevier

    Professor Paul Williams

  176. Quorum sensing as a population-density-dependent determinant of bacterial physiology

    Article • January 2001, Elsevier

    Professor Paul Williams

  177. The Pseudomonas aeruginosa Lectins PA-IL and PA-IIL Are Controlled by Quorum Sensing and by RpoS

    Article • Journal of Bacteriology, November 2000, ASM Journals

    Professor Paul Williams

  178. Molecular Cloning and Analysis of a Putative Siderophore ABC Transporter from Staphylococcus aureus

    Article • Infection and Immunity, November 2000, ASM Journals

    Professor Paul Williams

  179. The biocontrol strain Pseudomonas fluorescens F113 produces the Rhizobium small bacteriocin, N-(3-hydroxy-7-cis-tetradecenoyl)homoserine lactone, via HdtS, a putative novel N-acylhomoserine lactone synthase

    Article • Microbiology, October 2000, Society for General Microbiology

    Professor Paul Williams

  180. The regulatory locus cinRI in Rhizobium leguminosarum controls a network of quorum-sensing loci

    Article • Molecular Microbiology, July 2000, Wiley

    Professor Paul Williams

  181. Quorum sensing and the population-dependent control of virulence

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, May 2000, Royal Society Publishing

    Professor Paul Williams

  182. The staphylococcal transferrin receptor: a glycolytic enzyme with novel functions

    Article • Trends in Microbiology, May 2000, Elsevier

    Professor Paul Williams

  183. The Pseudomonas aeruginosa quorum-sensing signal molecule, N-(3-oxododecanoyl)-L -homoserine lactone, inhibits porcine arterial smooth muscle contraction

    Article • British Journal of Pharmacology, October 1999, Wiley

    Professor Paul Williams

  184. Plants genetically modified to produce N-acylhomoserine lactones communicate with bacteria

    Article • Nature Biotechnology, October 1999, Springer Science + Business Media

    Professor Paul Williams

  185. Obituary for Professor Gordon S. A. B. Stewart

    Article • Molecular Microbiology, May 1999, Wiley

    Professor Paul Williams

  186. RpoS-dependent stress tolerance in Pseudomonas aeruginosa

    Article • Microbiology, April 1999, Society for General Microbiology

    Professor Paul Williams

  187. Quorum sensing: a novel target for anti-infective therapy

    Article • Journal of Antimicrobial Chemotherapy, November 1998, Oxford University Press (OUP)

    Professor Paul Williams

  188. Construction and analysis ofluxCDABE-based plasmid sensors for investigatingN-acyl homoserine lactone-mediated quorum sensing

    Article • FEMS Microbiology Letters, June 1998, Oxford University Press (OUP)

    Professor Paul Williams

  189. Engineering theluxCDABEgenes fromPhotorhabdus luminescensto provide a bioluminescent reporter for constitutive and promoter probe plasmids and mini-Tn5constructs

    Article • FEMS Microbiology Letters, June 1998, Oxford University Press (OUP)

    Professor Paul Williams

  190. The Staphylococcus aureus and Staphylococcus epidermidis transferrin-binding proteins are expressed in vivo during infection

    Article • Microbiology, April 1998, Society for General Microbiology

    Professor Paul Williams

  191. Article • Antonie van Leeuwenhoek, January 1998, Springer Science + Business Media

    Professor Paul Williams

  192. Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones

    Article • Microbiology, December 1997, Society for General Microbiology

    Professor Paul Williams

  193. Elemental iron does repress transferrin, haemopexin and haemoglobin receptor expression in

    Article • FEMS Microbiology Letters, May 1997, Oxford University Press (OUP)

    Professor Paul Williams

  194. Quorum sensing in Aeromonas hydrophila and Aeromonas salmonicida: identification of the LuxRI homologs AhyRI and AsaRI and their cognate N-acylhomoserine lactone signal molecules.

    Article • Journal of Bacteriology, January 1997, ASM Journals

    Professor Paul Williams

  195. Quorum sensing in Vibrio anguillarum: characterization of the vanI/vanR locus and identification of the autoinducer N-(3-oxodecanoyl)-L-homoserine lactone.

    Article • Journal of Bacteriology, January 1997, ASM Journals

    Professor Paul Williams

  196. N-acyl-homoserine lactone-mediated regulation of phenazine gene expression by Pseudomonas aureofaciens 30-84 in the wheat rhizosphere.

    Article • Journal of Bacteriology, January 1997, ASM Journals

    Professor Paul Williams

  197. Conservation and antigenic cross-reactivity of the transferrin-binding proteins of Haemophilus influenzae, Actinobacillus pleuropneumoniae and Neisseria meningitidis

    Article • Microbiology, December 1996, Society for General Microbiology

    Professor Paul Williams

  198. The inner workings of a quorum sensing signal generator

    Article • Trends in Microbiology, December 1996, Elsevier

    Professor Paul Williams

  199. Analysis of bacterial carbapenem antibiotic production genes reveals a novel β-lactam biosynthesis pathway

    Article • Molecular Microbiology, November 1996, Wiley

    Professor Paul Williams

  200. Quorum sensing: a population-density component in the determination of bacterial phenotype

    Article • Trends in Biochemical Sciences, June 1996, Elsevier

    Professor Paul Williams

  201. Characterisation of the yenI/yenR locus from Yersinia enterocolitica mediating the synthesis of two N-acylhomoserine lactone signal molecules

    Article • Molecular Microbiology, July 1995, Wiley

    Professor Paul Williams

  202. Continuous ambulatory peritoneal dialysis-associated peritonitis as a model device-related infection: phenotypic adaptation, the staphylococcal cell envelope and infection

    Article • Journal of Hospital Infection, June 1995, Elsevier

    Professor Paul Williams

  203. Small molecule mediated autoinduction of antibiotic biosynthesis in the plant pathogenErwinia carotovora

    Article • Biochemical Society Transactions, February 1995, Portland Press Ltd.

    Professor Paul Williams

  204. Compromising Bacterial Communication Skills*

    Article • Journal of Pharmacy and Pharmacology, April 1994, Wiley

    Professor Paul Williams

  205. In vivo evaluation of protein adsorption to sterically stabilised colloidal carriers

    Article • Journal of Biomedical Materials Research, July 1993, Wiley

    Professor Paul Williams

  206. A method for the enumeration of bacterial adhesion to epithelial cells using image analysis

    Article • FEMS Microbiology Letters, February 1993, Oxford University Press (OUP)

    Professor Paul Williams

  207. Influence of block copolymers on the adsorption of plasma proteins to microspheres

    Article • Biomaterials, January 1993, Elsevier

    Professor Paul Williams

  208. N-(3-oxohexanoyl)-l-homoserine lactone regulates carbapenem antibiotic production inErwinia carotovora

    Article • Biochemical Journal, December 1992, Portland Press Ltd.

    Professor Paul Williams

  209. Small molecule-mediated density-dependent control of gene expression in prokaryotes: Bioluminescence and the biosynthesis of carbapenem antibiotics

    Article • FEMS Microbiology Letters, December 1992, Oxford University Press (OUP)

    Professor Paul Williams

  210. Bacterial transferrin receptors ? structure, function and contribution to virulence

    Article • Medical Microbiology and Immunology, December 1992, Springer Science + Business Media

    Professor Paul Williams

  211. lux genes and the applications of bacterial bioluminescence

    Article • Journal of General Microbiology, July 1992, Society for General Microbiology

    Professor Paul Williams

  212. Tn916 insertion mutagenesis in Escherichia coli and Haemophilus influenzae type b following conjugative transfer

    Article • Journal of General Microbiology, March 1992, Society for General Microbiology

    Professor Paul Williams

  213. Human serum albumin as a probe for surface conditioning (opsonization) of block copolymer-coated microspheres

    Article • Biomaterials, January 1992, Elsevier

    Professor Paul Williams

  214. Variation in the expression of cell envelope proteins of coagulase-negative staphylococci cultured under iron-restricted conditions in human peritoneal dialysate

    Article • Journal of General Microbiology, November 1991, Society for General Microbiology

    Professor Paul Williams

  215. Irreversible inactivation ofβ-lactamase I fromBacillus cereusby chlorinated 6-spiroepoxypenicillins

    Article • Biochemical Journal, June 1991, Portland Press Ltd.

    Professor Paul Williams

  216. Isolation and characterisation of Haemophilus influenzae type b mutants defective in transferrin-binding and iron assimilation

    Article • FEMS Microbiology Letters, January 1991, Oxford University Press (OUP)

    Professor Paul Williams

  217. Effects of carbon dioxide and sub-lethal levels of antibiotics on adherence of coagulase-negativestaphylococci to polystyrene and silicone rubber

    Article • Journal of Antimicrobial Chemotherapy, January 1991, Oxford University Press (OUP)

    Professor Paul Williams

  218. Utilization of enterobactin and other exogenous iron sources by Haemophilus influenzae, H. parainfluenzae and H. paraphrophilus

    Article • Journal of General Microbiology, December 1990, Society for General Microbiology

    Professor Paul Williams

  219. Influence of lipopolysaccharide chemotype on the interaction between Klebsiella pneumoniae and human polymorphonuclear leucocytes

    Article • FEMS Microbiology Letters, June 1990, Oxford University Press (OUP)

    Professor Paul Williams

  220. Siderophore-independent acquisition of transferrin-bound iron by Haemophilus influenzae type b

    Article • Journal of General Microbiology, May 1990, Society for General Microbiology

    Professor Paul Williams

  221. Novel Aerobactin Receptor in Klebsiella pneumoniae

    Article • Microbiology, December 1989, Society for General Microbiology

    Professor Paul Williams

  222. Utilization of transferrin-bound iron by Haemophilus species of human and porcine origins

    Article • FEMS Microbiology Letters, November 1989, Oxford University Press (OUP)

    Professor Paul Williams

  223. Antibacterial and immunostimulatory properties of chemotactic N-formyl peptide conjugates of ampicillin and amoxicillin.

    Article • Antimicrobial Agents and Chemotherapy, September 1989, ASM Journals

    Professor Paul Williams

  224. Topoisomerase II: A potential target for novel antifungal agents

    Article • Biochemical and Biophysical Research Communications, April 1989, Elsevier

    Professor Paul Williams

  225. Characterization of the Outer-membrane Proteins of Haemophilus parainfluenzae Expressed under Iron-sufficient and Iron-restricted Conditions

    Article • Microbiology, February 1989, Society for General Microbiology

    Professor Paul Williams

  226. Role of the cell envelope in bacterial adaptation to growth in vivo in infections

    Article • Biochimie, August 1988, Elsevier

    Professor Paul Williams

  227. Penetration of immunoglobulins through the Klebsiella capsule and their effect on cell-surface hydrophobicity

    Article • Journal of Medical Microbiology, May 1988, Society for General Microbiology

    Professor Paul Williams

  228. Sub-MICs of cefuroxime and ciprofloxacin influence interaction of complement and immunoglobulins with Klebsiella pneumoniae.

    Article • Antimicrobial Agents and Chemotherapy, May 1987, ASM Journals

    Professor Paul Williams

  229. Influence of growth rate and iron limitation on the expression of outer membrane proteins and enterobactin by Klebsiella pneumoniae grown in continuous culture.

    Article • Journal of Bacteriology, January 1986, ASM Journals

    Professor Paul Williams