Professor Paul Peter Tak

All Stories

1. 
   Interview with Paul-Peter Tak: Stimulating the vagus nerve to treat rheumatoid arthritis

   Article • Bioelectronics in Medicine, January 2018, Future Medicine

   Professor Paul Peter Tak

2. 
   Balancing the autonomic nervous system to reduce inflammation in rheumatoid arthritis

   Article • Journal of Internal Medicine, May 2017, Wiley

   Professor Paul Peter Tak

3. 
   Cholinergic anti-inflammatory pathway in the non-obese diabetic mouse model

   Article • Oral Diseases, July 2015, Wiley

   Professor Paul Peter Tak

4. 
   DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis

   Article • Arthritis & Rheumatology, June 2015, Wiley

   Professor Paul Peter Tak

5. 
   Effect of Anti-ApoA-I Antibody-Coating of Stents on Neointima Formation in a Rabbit Balloon-Injury Model

   Article • PLoS ONE, March 2015, PLOS

   Professor Paul Peter Tak

6. 
   Faculty Opinions recommendation of Lymphocyte-derived ACh regulates local innate but not adaptive immunity.

   Article • February 2015, F1000Research

   Professor Paul Peter Tak

7. 
   Faculty Opinions recommendation of Leptin induces IL-6 expression through OBRl receptor signaling pathway in human synovial fibroblasts.

   Article • February 2015, F1000Research

   Professor Paul Peter Tak

8. 
   Histological characteristics of ligament healing after bio-enhanced repair of the transected goat ACL

   Article • Journal of Experimental Orthopaedics, February 2015, Springer Science + Business Media

   Professor Paul Peter Tak

9. 
   Two Novel α7 Nicotinic Acetylcholine Receptor Ligands: In Vitro Properties and Their Efficacy in Collagen-Induced Arthritis in Mice

   Article • PLoS ONE, January 2015, PLOS

   Professor Paul Peter Tak

10. 
    Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde?

    Article • Arthritis Research & Therapy, January 2015, Springer Science + Business Media

    Professor Paul Peter Tak

11. 
    CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis

    Article • Arthritis Research & Therapy, January 2015, Springer Science + Business Media

    Professor Paul Peter Tak

12. 
    Citrullination of Epithelial Neutrophil-Activating Peptide 78/CXCL5 Results in Conversion From a Non-Monocyte-Recruiting Chemokine to a Monocyte-Recruiting Chemokine

    Article • Arthritis & Rheumatology, September 2014, Wiley

    Professor Paul Peter Tak

13. 
    From Synovial Tissue to Peripheral Blood: Myeloid Related Protein 8/14 Is a Sensitive Biomarker for Effective Treatment in Early Drug Development in Patients with Rheumatoid Arthritis

    Article • PLoS ONE, August 2014, PLOS

    Professor Paul Peter Tak

14. 
    NF‐κB ‐inducing kinase is a key regulator of inflammation‐induced and tumour‐associated angiogenesis

    Article • The Journal of Pathology, August 2014, Wiley

    Professor Paul Peter Tak

15. 
    Neurostimulation of the Cholinergic Anti-Inflammatory Pathway Ameliorates Disease in Rat Collagen-Induced Arthritis

    Article • PLoS ONE, August 2014, PLOS

    Professor Paul Peter Tak

16. 
    Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?

    Article • Arthritis Research & Therapy, August 2014, Springer Science + Business Media

    Professor Paul Peter Tak

17. 
    Reply

    Article • Arthritis & Rheumatology, May 2014, Wiley

    Professor Paul Peter Tak

18. 
    Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population Identifies PLB1 as a Candidate Rheumatoid Arthritis Risk Gene

    Article • PLoS ONE, February 2014, PLOS

    Professor Paul Peter Tak

19. 
    Early start and stop of biologics: has the time come?

    Article • BMC Medicine, February 2014, Springer Science + Business Media

    Professor Paul Peter Tak

20. 
    Safety with Ocrelizumab in Rheumatoid Arthritis: Results from the Ocrelizumab Phase III Program

    Article • PLoS ONE, February 2014, PLOS

    Professor Paul Peter Tak

21. 
    Tie2 Signaling Cooperates with TNF to Promote the Pro-Inflammatory Activation of Human Macrophages Independently of Macrophage Functional Phenotype

    Article • PLoS ONE, January 2014, PLOS

    Professor Paul Peter Tak

22. 
    14-3-3η is a novel mediator associated with the pathogenesis of rheumatoid arthritis and joint damage

    Article • Arthritis Research & Therapy, January 2014, Springer Science + Business Media

    Professor Paul Peter Tak

23. 
    Local Synovial Engagement of Angiogenic TIE-2 Is Associated With the Development of Persistent Erosive Rheumatoid Arthritis in Patients With Early Arthritis

    Article • Arthritis & Rheumatism, November 2013, Wiley

    Professor Paul Peter Tak

24. 
    Tumor Necrosis Factor Inhibition Modulates Thrombospondin-1 Expression in Human Inflammatory Joint Disease through Altered NR4A2 Activity

    Article • American Journal Of Pathology, October 2013, Elsevier

    Professor Paul Peter Tak

25. 
    Pro-atherogenic lipid changes and decreased hepatic LDL receptor expression by tocilizumab in rheumatoid arthritis

    Article • Atherosclerosis, July 2013, Elsevier

    Professor Paul Peter Tak

26. 
    Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis

    Article • Hepatology, May 2013, Wiley

    Professor Paul Peter Tak

27. 
    How to perform and analyse synovial biopsies

    Article • Best Practice & Research Clinical Rheumatology, April 2013, Elsevier

    Professor Paul Peter Tak

28. 
    Presence and Role of Anti-Citrullinated Protein Antibodies in Experimental Arthritis Models

    Article • Arthritis & Rheumatism, March 2013, Wiley

    Professor Paul Peter Tak

29. 
    Reumachip

    Article • Mednet, March 2013, Springer Science + Business Media

    Professor Paul Peter Tak

30. 
    Anti-TNF Therapy Reduces Serum Levels of Chemerin in Rheumatoid Arthritis: A New Mechanism by Which Anti-TNF Might Reduce Inflammation

    Article • PLoS ONE, February 2013, PLOS

    Professor Paul Peter Tak

31. 
    Evaluating the safety and efficacy of CCX354-C in subjects with rheumatoid arthritis partially responsive to methotrexate therapy

    Article • January 2013, Springer Science + Business Media

    Professor Paul Peter Tak

32. 
    Biologic Markers

    Article • January 2013, Elsevier

    Professor Paul Peter Tak

33. 
    The role of B lymphocytes in the progression from autoimmunity to autoimmune disease

    Article • Clinical Immunology, January 2013, Elsevier

    Professor Paul Peter Tak

34. 
    FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis in rheumatoid arthritis

    Article • Arthritis Research & Therapy, January 2013, Springer Science + Business Media

    Professor Paul Peter Tak

35. 
    Experience of Patients Undergoing Mini-Arthroscopy Compared to MRI in the Earliest Phases of Arthritis

    Article • International Journal of Clinical Medicine, January 2013, Scientific Research Publishing, Inc,

    Professor Paul Peter Tak

36. 
    Disease-specific and inflammation-independent stromal alterations in spondylarthritis synovitis

    Article • Arthritis & Rheumatism, December 2012, Wiley

    Professor Paul Peter Tak

37. 
    Local Administration of Soluble CD40:Fc to the Salivary Glands of Non-Obese Diabetic Mice Does Not Ameliorate Autoimmune Inflammation

    Article • PLoS ONE, December 2012, PLOS

    Professor Paul Peter Tak

38. 
    The resolution of inflammation

    Article • Nature Reviews Immunology, November 2012, Springer Science + Business Media

    Professor Paul Peter Tak

39. 
    The role of Bob1 in rheumatoid arthritis: potential implications for autoimmunity

    Article • Journal of Translational Medicine, November 2012, Springer Science + Business Media

    Professor Paul Peter Tak

40. 
    MicroRNAs—novel regulators of systemic lupus erythematosus pathogenesis

    Article • Nature Reviews Rheumatology, October 2012, Springer Science + Business Media

    Professor Paul Peter Tak

41. 
    Relationship between inflammation, bone destruction, and osteoproliferation in the HLA-B27/human β2-microglobulin-transgenic rat model of spondylarthritis

    Article • Arthritis & Rheumatism, September 2012, Wiley

    Professor Paul Peter Tak

42. 
    Sustained Rap1 activation in autoantigen-specific T lymphocytes attenuates experimental autoimmune encephalomyelitis

    Article • Journal of Neuroimmunology, September 2012, Elsevier

    Professor Paul Peter Tak

43. 
    Pathogenesis of spondyloarthritis

    Article • Current Opinion in Rheumatology, July 2012, Wolters Kluwer Health

    Professor Paul Peter Tak

44. 
    Increased numbers of CD5+ B lymphocytes with a regulatory phenotype in spondylarthritis

    Article • Arthritis & Rheumatism, May 2012, Wiley

    Professor Paul Peter Tak

45. 
    Brief Report: A phase IIa, randomized, double-blind, placebo-controlled trial of apilimod mesylate, an interleukin-12/interleukin-23 inhibitor, in patients with rheumatoid arthritis

    Article • Arthritis & Rheumatism, May 2012, Wiley

    Professor Paul Peter Tak

46. 
    Triggering of the dsRNA Sensors TLR3, MDA5, and RIG-I Induces CD55 Expression in Synovial Fibroblasts

    Article • PLoS ONE, May 2012, PLOS

    Professor Paul Peter Tak

47. 
    The Features of the Synovium in Early Rheumatoid Arthritis According to the 2010 ACR/EULAR Classification Criteria

    Article • PLoS ONE, May 2012, PLOS

    Professor Paul Peter Tak

48. 
    Soluble Immune Complexes Shift the TLR-Induced Cytokine Production of Distinct Polarized Human Macrophage Subsets towards IL-10

    Article • PLoS ONE, April 2012, PLOS

    Professor Paul Peter Tak

49. 
    Taking advances from bench to bedside during the last decade

    Article • Best Practice & Research Clinical Rheumatology, April 2012, Elsevier

    Professor Paul Peter Tak

50. 
    Reumatologie in beeld

    Article • January 2012, Springer Science + Business Media

    Professor Paul Peter Tak

51. 
    Extrathymic Autoimmune Regulator (AIRE) expression in rheumatoid arthritis

    Article • Journal of Translational Medicine, January 2012, Springer Science + Business Media

    Professor Paul Peter Tak

52. 
    Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis

    Article • Arthritis Research & Therapy, January 2012, Springer Science + Business Media

    Professor Paul Peter Tak

53. 
    A Prospective, Randomized, Placebo-Controlled Study to Identify Biomarkers Associated with Active Treatment in Psoriatic Arthritis: Effects of Adalimumab Treatment on Lesional and Nonlesional Skin

    Article • Dermatology, January 2012, Karger Publishers

    Professor Paul Peter Tak

54. 
    Expression of IL-20 in synovium and lesional skin of patients with psoriatic arthritis: differential response to alefacept treatment

    Article • Arthritis Research & Therapy, January 2012, Springer Science + Business Media

    Professor Paul Peter Tak

55. 
    NF-kappaB inducing kinase (NIK) is a key regulator of inflammation-induced angiogenesis

    Article • Journal of Translational Medicine, January 2012, Springer Science + Business Media

    Professor Paul Peter Tak

56. 
    Relative overexpression of membrane-bound versus soluble TNF in spondyloarthritis

    Article • Journal of Translational Medicine, January 2012, Springer Science + Business Media

    Professor Paul Peter Tak

57. 
    Editorial - Lessons Learned from Synovial Tissue Analysis

    Article • The Open Rheumatology Journal, December 2011, Bentham Science Publishers

    Professor Paul Peter Tak

58. 
    Synovial Tissue Response to Treatment in Rheumatoid Arthritis

    Article • The Open Rheumatology Journal, December 2011, Bentham Science Publishers

    Professor Paul Peter Tak

59. 
    Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis

    Article • Arthritis & Rheumatism, December 2011, Wiley

    Professor Paul Peter Tak

60. 
    Reply

    Article • Arthritis & Rheumatism, November 2011, Wiley

    Professor Paul Peter Tak

61. 
    Triggering of viral RNA sensors induces CD55 expression on synovial fibroblasts

    Article • Journal of Translational Medicine, November 2011, Springer Science + Business Media

    Professor Paul Peter Tak

62. 
    Flt3 inhibition leads to decreased production of IL-6 by synovial biopsies and fibroblast-like synoviocytes by reducing NFKb activity

    Article • Journal of Translational Medicine, November 2011, Springer Science + Business Media

    Professor Paul Peter Tak

63. 
    IL-17 producing mast cells contribute to synovial inflammation in non-psoriatic and psoriatic spondyloarthritis

    Article • Journal of Translational Medicine, November 2011, Springer Science + Business Media

    Professor Paul Peter Tak

64. 
    Immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10

    Article • Journal of Translational Medicine, November 2011, Springer Science + Business Media

    Professor Paul Peter Tak

65. 
    Serum biomarkers to predict clinical response in proof-of-concept trials in spondyloarthritis

    Article • Journal of Translational Medicine, November 2011, Springer Science + Business Media

    Professor Paul Peter Tak

66. 
    Identification of robust and disease-specific stromal alterations in spondyloarthritis synovitis

    Article • Journal of Translational Medicine, November 2011, Springer Science + Business Media

    Professor Paul Peter Tak

67. 
    Response to rituximab in patients with rheumatoid arthritis in different compartments of the immune system

    Article • Arthritis & Rheumatism, October 2011, Wiley

    Professor Paul Peter Tak

68. 
    Advancements in adeno-associated viral gene therapy approaches: exploring a new horizon

    Article • F1000 Medicine Reports, September 2011, Faculty of 1000, Ltd.

    Professor Paul Peter Tak

69. 
    Reply

    Article • Arthritis & Rheumatism, August 2011, Wiley

    Professor Paul Peter Tak

70. 
    Persistent Activation of Dendritic Cells after Resolution of Allergic Airway Inflammation Breaks Tolerance to Inhaled Allergens in Mice

    Article • American Journal of Respiratory and Critical Care Medicine, August 2011, American Thoracic Society

    Professor Paul Peter Tak

71. 
    Inflammatory memories: Is epigenetics the missing link to persistent stromal cell activation in rheumatoid arthritis?

    Article • Autoimmunity Reviews, July 2011, Elsevier

    Professor Paul Peter Tak, Professor Steffen Gay

72. 
    The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants

    Article • Immunity, July 2011, Elsevier

    Professor Paul Peter Tak

73. 
    Why CCR2 and CCR5 Blockade Failed and Why CCR1 Blockade Might Still Be Effective in the Treatment of Rheumatoid Arthritis

    Article • PLoS ONE, July 2011, PLOS

    Professor Paul Peter Tak

74. 
    A Functional Variant in MicroRNA-146a Promoter Modulates Its Expression and Confers Disease Risk for Systemic Lupus Erythematosus

    Article • PLoS Genetics, June 2011, PLOS

    Professor Paul Peter Tak

75. 
    Effect of Soluble ICAM-1 on a Sjögren's Syndrome-like Phenotype in NOD Mice Is Disease Stage Dependent

    Article • PLoS ONE, May 2011, PLOS

    Professor Paul Peter Tak

76. 
    Synovitis in Psoriatic Arthritis: Immunohistochemistry, Comparisons With Rheumatoid Arthritis, and Effects of Therapy

    Article • Current Rheumatology Reports, April 2011, Springer Science + Business Media

    Professor Paul Peter Tak

77. 
    Abatacept in the treatment of patients with psoriatic arthritis: Results of a six-month, multicenter, randomized, double-blind, placebo-controlled, phase II trial

    Article • Arthritis & Rheumatism, March 2011, Wiley

    Professor Paul Peter Tak

78. 
    Introduction

    Article • Annals of the Rheumatic Diseases, February 2011, BMJ

    Professor Paul Peter Tak

79. 
    Body mass index and clinical response to infliximab in rheumatoid arthritis

    Article • Arthritis & Rheumatism, January 2011, Wiley

    Professor Paul Peter Tak

80. 
    Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation

    Article • Arthritis & Rheumatism, January 2011, Wiley

    Professor Paul Peter Tak, Professor Steffen Gay

81. 
    Prostaglandin E2 Synthesizing Enzymes in Rheumatoid Arthritis B Cells and the Effects of B Cell Depleting Therapy on Enzyme Expression

    Article • PLoS ONE, January 2011, PLOS

    Professor Paul Peter Tak

82. 
    Experiences and needs for work participation in employees with rheumatoid arthritis treated with anti-tumour necrosis factor therapy

    Article • Disability and Rehabilitation, January 2011, Taylor & Francis

    Dr Jan L Hoving, Professor Paul Peter Tak

83. 
    Minimally invasive procedures

    Article • January 2011, Elsevier

    Professor Paul Peter Tak

84. 
    Function of Histone Deacetylase Inhibitors in Inflammation

    Article • Critical Reviews™ in Immunology, January 2011, Begell House

    Professor Paul Peter Tak

85. 
    Epigenetics of Rheumatoid Arthritis

    Article • January 2011, Springer Science + Business Media

    Professor Paul Peter Tak

86. 
    Non-canonical NF-κB signaling in endothelial cells may enhance synovial inflammation by stimulating angiogenesis

    Article • Journal of Translational Medicine, January 2011, Springer Science + Business Media

    Professor Paul Peter Tak

87. 
    Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy - a single centre, open-label study

    Article • Arthritis Research & Therapy, January 2011, Springer Science + Business Media

    Professor Paul Peter Tak

88. 
    Silencing the Expression of Ras Family GTPase Homologues Decreases Inflammation and Joint Destruction in Experimental Arthritis

    Article • American Journal Of Pathology, December 2010, Elsevier

    Professor Paul Peter Tak, PhD Kees Fluiter

89. 
    Relationship between the type I interferon signature and the response to rituximab in rheumatoid arthritis patients

    Article • Arthritis & Rheumatism, November 2010, Wiley

    Professor Paul Peter Tak

90. 
    'MRI-tis' in the early diagnosis of axial SpA: issues and limitations

    Article • Nature Reviews Rheumatology, October 2010, Springer Science + Business Media

    Professor Paul Peter Tak

91. 
    Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance

    Article • October 2010, Springer Science + Business Media

    Professor Paul Peter Tak

92. 
    Soluble Biomarkers of Cartilage and Bone Metabolism in Early Proof of Concept Trials in Psoriatic Arthritis: Effects of Adalimumab Versus Placebo

    Article • PLoS ONE, September 2010, PLOS

    Professor Paul Peter Tak

93. 
    Human T-cell memory consists mainly of unexpanded clones

    Article • Immunology Letters, September 2010, Elsevier

    Professor Paul Peter Tak

94. 
    2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

    Article • Arthritis & Rheumatism, August 2010, Wiley

    Professor Paul Peter Tak

95. 
    The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: Phase 2 methodological report

    Article • Arthritis & Rheumatism, August 2010, Wiley

    Professor Paul Peter Tak

96. 
    Sustained T cell Rap1 signaling is protective in the collagen-induced arthritis model of rheumatoid arthritis

    Article • Arthritis & Rheumatism, July 2010, Wiley

    Professor Paul Peter Tak

97. 
    Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate

    Article • Arthritis & Rheumatism, July 2010, Wiley

    Professor Paul Peter Tak

98. 
    Mycophenolate mofetil attenuates plaque inflammation in patients with symptomatic carotid artery stenosis

    Article • Atherosclerosis, July 2010, Elsevier

    Professor Paul Peter Tak

99. 
    The Gene Expression Profile in the Synovium as a Predictor of the Clinical Response to Infliximab Treatment in Rheumatoid Arthritis

    Article • PLoS ONE, June 2010, PLOS

    Professor Paul Peter Tak

100. 
     The Prothrombotic State in Rheumatoid Arthritis: An Additive Risk Factor for Adverse Cardiovascular Events

     Article • Seminars in Thrombosis and Hemostasis, June 2010, Thieme Publishing Group

     Professor Paul Peter Tak

101. 
     Improvement of Work Ability, Quality of Life, and Fatigue in Patients With Rheumatoid Arthritis Treated With Adalimumab

     Article • Journal of Occupational and Environmental Medicine, June 2010, Wolters Kluwer Health

     Professor Paul Peter Tak

102. 
     Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

     Article • Nature Genetics, May 2010, Springer Science + Business Media

     Professor Paul Peter Tak

103. 
     Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

     Article • Arthritis & Rheumatism, April 2010, Wiley

     Professor Paul Peter Tak

104. 
     Reply to the letter to the editor by di carlo, airoldi, and pistoia, commenting on the enigmatic role of IL-12 in the pathogenesis of Sjögren's syndrome

     Article • Arthritis & Rheumatism, March 2010, Wiley

     Professor Paul Peter Tak

105. 
     Paul-Peter Tak, Academic Medical Center, University of Amsterdam, The Netherlands (ed): New Therapeutic Targets in Rheumatoid Arthritis. (PIR: Progress in Inflammation Research Series)

     Article • Inflammation Research, March 2010, Springer Science + Business Media

     Professor Paul Peter Tak

106. 
     Targeting B cells in immune-mediated inflammatory disease: A comprehensive review of mechanisms of action and identification of biomarkers

     Article • Pharmacology & Therapeutics, March 2010, Elsevier

     Professor Paul Peter Tak

107. 
     Adeno-associated virus type 5-mediated intraarticular administration of tumor necrosis factor small interfering RNA improves collagen-induced arthritis

     Article • Arthritis & Rheumatism, February 2010, Wiley

     Professor Paul Peter Tak

108. 
     Synovial tissue heterogeneity in rheumatoid arthritis in relation to disease activity and biomarkers in peripheral blood

     Article • Arthritis & Rheumatism, February 2010, Wiley

     Professor Paul Peter Tak

109. 
     Targeting cardiovascular risk in rheumatoid arthritis: a dual role for statins

     Article • Nature Reviews Rheumatology, February 2010, Springer Science + Business Media

     Professor Paul Peter Tak

110. 
     Deletion of either CD55 or CD97 ameliorates arthritis in mouse models

     Article • Arthritis & Rheumatism, January 2010, Wiley

     Professor Paul Peter Tak

111. 
     Macrophage Subsets in Immune-Mediated Inflammatory Disease: Lessons from Rheumatoid Arthritis, Spondyloarthritis, Osteoarthitis, Behcet`s Disease and Gout

     Article • The Open Arthritis Journal, January 2010, Bentham Science Publishers

     Professor Paul Peter Tak

112. 
     Macrophage Subsets in Immune-Mediated Inflammatory Disease: Lessons from Rheumatoid Arthritis, Spondyloarthritis, Osteoarthitis, Behets Disease and Gout

     Article • The Open Arthritis Journal, January 2010, Bentham Science Publishers

     Professor Paul Peter Tak

113. 
     Chapter 12 Future treatments in rheumatoid arthritis

     Article • January 2010, Oxford University Press (OUP)

     Professor Paul Peter Tak

114. 
     Gene therapy for arthritis

     Article • January 2010, Springer Science + Business Media

     Professor Paul Peter Tak

115. 
     Gene therapy: Sjögren’s syndrome

     Article • January 2010, Springer Science + Business Media

     Professor Paul Peter Tak

116. 
     Mast Cells Contribute to Synovial Inflammation in Non-psoriatic and Psoriatic Spondyloarthritis

     Article • Clinical Immunology, January 2010, Elsevier

     Professor Paul Peter Tak

117. 
     Elevated Levels of CD5+ B Cells in Spondyloarthritis Patients

     Article • Clinical Immunology, January 2010, Elsevier

     Professor Paul Peter Tak

118. 
     Decreased Soluble TNF-α in Spondyloarthritis Versus Rheumatoid Arthritis Synovitis

     Article • Clinical Immunology, January 2010, Elsevier

     Professor Paul Peter Tak

119. 
     Specific Phenotypical Markers for Human Polarized Macrophages

     Article • Clinical Immunology, January 2010, Elsevier

     Professor Paul Peter Tak

120. 
     CD97 in Leukocyte Trafficking

     Article • January 2010, Springer Science + Business Media

     Professor Paul Peter Tak

121. 
     TNFα Blockade Impairs T Cell Dependent Antibody Responses

     Article • Clinical Immunology, January 2010, Elsevier

     Professor Paul Peter Tak

122. 
     Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment

     Article • Arthritis Research & Therapy, January 2010, Springer Science + Business Media

     Professor Paul Peter Tak

123. 
     Detection of Genuine Anti-citrullinated Protein Antibodies in Mice Reveals Their Presence in BALB/c but not DBA/1 and SJL Mice Hyperimmunized with Citrullinated Collagen

     Article • Clinical Immunology, January 2010, Elsevier

     Professor Paul Peter Tak

124. 
     Surprising negative association between IgG1 allotype disparity and anti-adalimumab formation: a cohort study

     Article • Arthritis Research & Therapy, January 2010, Springer Science + Business Media

     Professor Paul Peter Tak

125. 
     A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis

     Article • Arthritis Research & Therapy, January 2010, Springer Science + Business Media

     Professor Paul Peter Tak

126. 
     A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis

     Article • Arthritis Research & Therapy, January 2010, Springer Science + Business Media

     Professor Paul Peter Tak

127. 
     Reumatoïde artritis

     Article • January 2010, Springer Science + Business Media

     Professor Paul Peter Tak

128. 
     PTPRCrheumatoid arthritis risk allele is also associated with response to anti-TNF therapy

     Article • Arthritis & Rheumatism, January 2010, Wiley

     Professor Paul Peter Tak

129. 
     Mediators of structural remodeling in peripheral spondylarthritis

     Article • Arthritis & Rheumatism, December 2009, Wiley

     Professor Paul Peter Tak

130. 
     MLN3897 plus methotrexate in patients with rheumatoid arthritis: Safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study

     Article • Arthritis & Rheumatism, December 2009, Wiley

     Professor Paul Peter Tak

131. 
     Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome

     Article • Arthritis & Rheumatism, December 2009, Wiley

     Professor Paul Peter Tak

132. 
     Monocyte Scintigraphy in Rheumatoid Arthritis: The Dynamics of Monocyte Migration in Immune-Mediated Inflammatory Disease

     Article • PLoS ONE, November 2009, PLOS

     Professor Paul Peter Tak

133. 
     Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

     Article • Nature Genetics, November 2009, Springer Science + Business Media

     Professor Paul Peter Tak

134. 
     Collagen-Induced Arthritis in Mice

     Article • November 2009, Springer Science + Business Media

     Professor Paul Peter Tak

135. 
     The relationship between synovial lymphocyte aggregates and the clinical response to infliximab in rheumatoid arthritis: A prospective study

     Article • Arthritis & Rheumatism, November 2009, Wiley

     Professor Paul Peter Tak

136. 
     Rheumatoid Synovial Inflammation: Pixel-by-Pixel Dynamic Contrast-enhanced MR Imaging Time-Intensity Curve Shape Analysis—A Feasibility Study 1

     Article • Radiology, October 2009, Radiological Society of North America (RSNA)

     Professor Paul Peter Tak

137. 
     Statin therapy for targeting cardiovascular risk in rheumatoid arthritis

     Article • International Journal of Clinical Rheumatology, August 2009, OMICS Publishing Group

     Professor Paul Peter Tak

138. 
     Alterations of the synovial T cell repertoire in anti-citrullinated protein antibody-positive rheumatoid arthritis

     Article • Arthritis & Rheumatism, July 2009, Wiley

     Professor Paul Peter Tak

139. 
     Identification of candidate genes for susceptibility to reactive arthritis

     Article • Rheumatology International, June 2009, Springer Science + Business Media

     Professor Paul Peter Tak

140. 
     Gene Therapy Targeting Nuclear Factor-κB: Towards Clinical Application in Inflammatory Diseases and Cancer

     Article • Current Gene Therapy, June 2009, Bentham Science Publishers

     Professor Paul Peter Tak

141. 
     The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases

     Article • Arthritis & Rheumatism, May 2009, Wiley

     Professor Paul Peter Tak

142. 
     Dendritic cells in rheumatoid arthritis: Which subset should be used as a tool to induce tolerance?

     Article • Human Immunology, May 2009, Elsevier

     Professor Paul Peter Tak

143. 
     The α7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: A possible role for a key neurotransmitter in synovial inflammation

     Article • Arthritis & Rheumatism, May 2009, Wiley

     Professor Paul Peter Tak

144. 
     In vitro spontaneous osteoclastogenesis of human peripheral blood mononuclear cells is not crucially dependent on T lymphocytes

     Article • Arthritis & Rheumatism, April 2009, Wiley

     Professor Paul Peter Tak

145. 
     How to perform and analyse synovial biopsies

     Article • Best Practice & Research Clinical Rheumatology, April 2009, Elsevier

     Professor Paul Peter Tak

146. 
     The cholinergic anti-inflammatory pathway: towards innovative treatment of rheumatoid arthritis

     Article • Nature Reviews Rheumatology, April 2009, Springer Science + Business Media

     Professor Paul Peter Tak

147. 
     Absence of a classically activated macrophage cytokine signature in peripheral spondylarthritis, including psoriatic arthritis

     Article • Arthritis & Rheumatism, April 2009, Wiley

     Professor Paul Peter Tak

148. 
     MicroRNA-146a contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins

     Article • Arthritis & Rheumatism, April 2009, Wiley

     Professor Paul Peter Tak

149. 
     Differential expression of CD97 on human lymphocyte subsets and limited effect of CD97 antibodies on allogeneic T-cell stimulation

     Article • Immunology Letters, April 2009, Elsevier

     Professor Paul Peter Tak

150. 
     Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide

     Article • Arthritis & Rheumatism, March 2009, Wiley

     Professor Paul Peter Tak

151. 
     Zebrafish development and regeneration: new tools for biomedical research

     Article • The International Journal of Developmental Biology, January 2009, UBC Press

     alexander kros, Professor Paul Peter Tak

152. 
     Biologic Markers

     Article • January 2009, Elsevier

     Professor Paul Peter Tak

153. 
     Synovial Biomarkers

     Article • January 2009, Elsevier

     Professor Paul Peter Tak

154. 
     New Therapeutic Targets in Rheumatoid Arthritis

     Article • January 2009, Springer Science + Business Media

     Professor Paul Peter Tak

155. 
     Synovial and Mucosal Immunopathology in Spondyloarthritis

     Article • January 2009, Springer Science + Business Media

     Professor Paul Peter Tak

156. 
     F.131. DKK-1, a Master Regulator of Bone Remodelling, is Abundantly Expressed in Peripheral Inflammatory Arthritis

     Article • Clinical Immunology, January 2009, Elsevier

     Professor Paul Peter Tak

157. 
     T.10. The Cartilage-specific Molecule, Melanoma Inhibitory Activity, Contributes to Collagen-induced Arthritis

     Article • Clinical Immunology, January 2009, Elsevier

     Professor Paul Peter Tak

158. 
     T.21. TNF Alpha Blockade Impairs T Cell Dependent Antibody Responses

     Article • Clinical Immunology, January 2009, Elsevier

     Professor Paul Peter Tak

159. 
     Rituximab treatment in rheumatoid arthritis: how does it work?

     Article • Arthritis Research & Therapy, January 2009, Springer Science + Business Media

     Professor Paul Peter Tak

160. 
     Distinct synovial immunopathology in Behçet disease and psoriatic arthritis

     Article • Arthritis Research & Therapy, January 2009, Springer Science + Business Media

     Professor Paul Peter Tak

161. 
     The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue

     Article • Arthritis Research & Therapy, January 2009, Springer Science + Business Media

     Professor Paul Peter Tak

162. 
     Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice

     Article • Arthritis & Rheumatism, January 2009, Wiley

     Professor Paul Peter Tak

163. 
     Local expression of tumor necrosis factor-receptor 1:immunoglobulin G can induce salivary gland dysfunction in a murine model of Sjögren's syndrome

     Article • Arthritis Research & Therapy, January 2009, Springer Science + Business Media

     Professor Paul Peter Tak

164. 
     OR.42. Constitutive Expression of the Costimulatory Molecule CD70 by Non-antigen Specific B Cells is Sufficient to Drive T Cell-driven Autoimmune Disease

     Article • Clinical Immunology, January 2009, Elsevier

     Professor Paul Peter Tak

165. 
     Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis

     Article • Arthritis Research & Therapy, January 2009, Springer Science + Business Media

     Professor Paul Peter Tak

166. 
     Folate receptor β as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients

     Article • Arthritis & Rheumatism, January 2009, Wiley

     Professor Paul Peter Tak

167. 
     Remission of active diabetic hepatitis after correction of hyperglycemia

     Article • Liver International, December 2008, Wiley

     Professor Paul Peter Tak

168. 
     Disease activity-guided rituximab therapy in rheumatoid arthritis: The effects of re-treatment in initial nonresponders versus initial responders

     Article • Arthritis & Rheumatism, December 2008, Wiley

     Professor Paul Peter Tak

169. 
     Construct Validity and Reliability of the Disability of Arm, Shoulder and Hand Questionnaire for Upper Extremity Complaints in Rheumatoid Arthritis

     Article • The Journal of Rheumatology, December 2008, The Journal of Rheumatology

     Professor Paul Peter Tak, MD Eric E Raven

170. 
     Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis

     Article • Arthritis & Rheumatism, December 2008, Wiley

     Professor Paul Peter Tak, Professor Steffen Gay

171. 
     Targeting Complement in Rheumatoid Arthritis

     Article • Current Rheumatology Reviews, November 2008, Bentham Science Publishers

     Professor Paul Peter Tak

172. 
     Identification of interleukin-7 as a candidate disease mediator in spondylarthritis

     Article • Arthritis & Rheumatism, November 2008, Wiley

     Professor Paul Peter Tak

173. 
     Analysis of apoptosis in peripheral blood and synovial tissue very early after initiation of infliximab treatment in rheumatoid arthritis patients

     Article • Arthritis & Rheumatism, November 2008, Wiley

     Professor Paul Peter Tak

174. 
     Tumor necrosis factor α drives cadherin 11 expression in rheumatoid inflammation

     Article • Arthritis & Rheumatism, October 2008, Wiley

     Professor Paul Peter Tak

175. 
     Common variants at CD40 and other loci confer risk of rheumatoid arthritis

     Article • Nature Genetics, September 2008, Springer Science + Business Media

     Professor Paul Peter Tak

176. 
     Advances in local targeted gene therapy for arthritis: towards clinical reality

     Article • Future Rheumatology, August 2008, Future Medicine

     Professor Paul Peter Tak

177. 
     Modulation of CCR2 in rheumatoid arthritis: A double‐blind, randomized, placebo‐controlled clinical trial

     Article • Arthritis & Rheumatism, July 2008, Wiley

     Professor Paul Peter Tak

178. 
     Faculty Opinions recommendation of Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice.

     Article • May 2008, F1000Research

     Professor Paul Peter Tak

179. 
     Novel approaches for the treatment of rheumatoid arthritis: lessons from the evaluation of synovial biomarkers in clinical trials

     Article • Best Practice & Research Clinical Rheumatology, April 2008, Elsevier

     Professor Paul Peter Tak

180. 
     Rheumatoid Arthritis Synovium Contains Two Subsets of CD83−DC-LAMP− Dendritic Cells with Distinct Cytokine Profiles

     Article • American Journal Of Pathology, April 2008, Elsevier

     Professor Paul Peter Tak

181. 
     Increased cortisol relative to adrenocorticotropic hormone predicts improvement during anti-tumor necrosis factor therapy in rheumatoid arthritis

     Article • Arthritis & Rheumatism, March 2008, Wiley

     Professor Paul Peter Tak

182. 
     Can Islamic prayers benefit spondyloarthritides? Case report of a patient with ankylosing spondylitis and increased spinal mobility after an intensive regimen of Islamic prayer

     Article • Rheumatology International, March 2008, Springer Science + Business Media

     Professor Paul Peter Tak

183. 
     Tumor necrosis factor antagonist mechanisms of action: A comprehensive review

     Article • Pharmacology & Therapeutics, February 2008, Elsevier

     Professor Paul Peter Tak

184. 
     Faculty Opinions recommendation of Magnetic resonance imaging findings in 84 patients with early rheumatoid arthritis: bone marrow oedema predicts erosive progression.

     Article • January 2008, F1000Research

     Professor Paul Peter Tak

185. 
     Sa.18. The Type I IFN Signature Determines the Sustained Anti-citrullinated Protein Antibody Levels During TNFα Blockade in Rheumatoid Arthritis

     Article • Clinical Immunology, January 2008, Elsevier

     Dr Clio P Mavragani, Professor Paul Peter Tak

186. 
     Sa.23. Nucleosomes, but Not Type I Interferons, Contribute to the Induction of Anti-nuclear Antibodies by TNF Alpha Blockade in Spondyloarthritis

     Article • Clinical Immunology, January 2008, Elsevier

     Dr Clio P Mavragani, Professor Paul Peter Tak

187. 
     Spondylarthritis in the absence of B lymphocytes

     Article • Arthritis & Rheumatism, January 2008, Wiley

     Professor Paul Peter Tak

188. 
     Sa.16. T Lymphocyte Clonal Alterations in Anti-citrullinated Protein Antibody Positive Synovitis

     Article • Clinical Immunology, January 2008, Elsevier

     Professor Paul Peter Tak

189. 
     The abundant synovial expression of the RANK/RANKL/Osteoprotegerin system in peripheral spondylarthritis is partially disconnected from inflammation

     Article • Arthritis & Rheumatism, January 2008, Wiley

     Professor Paul Peter Tak

190. 
     Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study

     Article • Arthritis Research & Therapy, January 2008, Springer Science + Business Media

     Professor Paul Peter Tak

191. 
     Sa.17. A Functional Variant of TIR-domain-containing Adaptor Protein (TIRAP) is Not Associated with Spondyloarthritis

     Article • Clinical Immunology, January 2008, Elsevier

     Professor Paul Peter Tak

192. 
     Synovial lymphoid neogenesis does not define a specific clinical rheumatoid arthritis phenotype

     Article • Arthritis & Rheumatism, January 2008, Wiley

     Professor Paul Peter Tak

193. 
     Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on?

     Article • Arthritis Research & Therapy, January 2008, Springer Science + Business Media

     Professor Paul Peter Tak

194. 
     Reply

     Article • Arthritis & Rheumatism, January 2008, Wiley

     Professor Paul Peter Tak

195. 
     Rheumatoid arthritis in the United Arab Emirates

     Article • Clinical Rheumatology, November 2007, Springer Science + Business Media

     Professor Paul Peter Tak

196. 
     Labeling of autologous monocytes with 99mTc–HMPAO at very high specific radioactivity

     Article • Nuclear Medicine and Biology, November 2007, Elsevier

     Professor Paul Peter Tak

197. 
     Pixel-by-pixel analysis of DCE MRI curve patterns and an illustration of its application to the imaging of the musculoskeletal system

     Article • Magnetic Resonance Imaging, June 2007, Elsevier

     Professor Paul Peter Tak

198. 
     Faculty Opinions recommendation of Ectopic lymphoid neogenesis in psoriatic arthritis.

     Article • May 2007, F1000Research

     Professor Paul Peter Tak

199. 
     Gene Therapy for Rheumatoid Arthritis

     Article • Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, May 2007, Bentham Science Publishers

     Professor Paul Peter Tak

200. 
     How useful are synovial biopsies for the diagnosis of rheumatic diseases?

     Article • Nature Clinical Practice Rheumatology, May 2007, Springer Science + Business Media

     Professor Paul Peter Tak

201. 
     Preclinical models of arthritic disease in non-human primates

     Article • Drug Discovery Today, April 2007, Elsevier

     Professor Paul Peter Tak

202. 
     Quantitative Image Analysis of Synovial Tissue

     Article • January 2007, Springer Science + Business Media

     Professor Paul Peter Tak

203. 
     T Lymphocyte Clonal Alterations in Anti-Citrullinated Protein Antibody Positive Synovitis

     Article • Clinical Immunology, January 2007, Elsevier

     Professor Paul Peter Tak

204. 
     Early effects of rituximab on the synovial cell infiltrate in patients with rheumatoid arthritis

     Article • Arthritis & Rheumatism, January 2007, Wiley

     Professor Paul Peter Tak

205. 
     Absence of changes in the number of synovial sublining macrophages after ineffective treatment for rheumatoid arthritis: Implications for use of synovial sublining macrophages as a biomarker

     Article • Arthritis & Rheumatism, January 2007, Wiley

     Professor Paul Peter Tak

206. 
     Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: Identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis

     Article • Arthritis & Rheumatism, January 2007, Wiley

     Professor Paul Peter Tak

207. 
     Synovial T/B Cell Lymphoid Aggregates Regulate the Production of Rheumatoid Arthritis-specific Autoantibodies

     Article • Clinical Immunology, January 2007, Elsevier

     Professor Paul Peter Tak

208. 
     Non-pathogenic antinuclear antibodies contribute to the clearance of apoptotic antigens released during TNFα blockade in spondyloarthritis (SpA)

     Article • Clinical Immunology, January 2007, Elsevier

     Professor Paul Peter Tak

209. 
     Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: A potential marker of erosive joint destruction

     Article • Arthritis & Rheumatism, January 2007, Wiley

     Professor Paul Peter Tak

210. 
     Monitoring the T-Cell Receptor Repertoire at Single-Clone Resolution

     Article • PLoS ONE, December 2006, PLOS

     Dr Ester B.M. Remmerswaal, Professor Paul Peter Tak

211. 
     Faculty Opinions recommendation of Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: a double-blind randomised trial.

     Article • November 2006, F1000Research

     Professor Paul Peter Tak

212. 
     Chemokine inhibition in inflammatory arthritis

     Article • Best Practice & Research Clinical Rheumatology, October 2006, Elsevier

     Professor Paul Peter Tak

213. 
     Developing a gene therapy for Sjögren’s syndrome

     Article • Future Rheumatology, August 2006, Future Medicine

     Professor Paul Peter Tak

214. 
     Amelioration of Arthritis by Intraarticular Dominant Negative IKK β Gene Therapy Using Adeno-Associated Virus Type 5

     Article • Human Gene Therapy, August 2006, Mary Ann Liebert Inc

     Professor Paul Peter Tak

215. 
     Amelioration of Arthritis by Intraarticular Dominant Negative IKK Gene Therapy Using Adeno-Associated Virus Type 5

     Article • Human Gene Therapy, July 2006, Mary Ann Liebert Inc

     Professor Paul Peter Tak

216. 
     Pathogenesis of spondyloarthritis: Insights from synovial membrane studies

     Article • Current Rheumatology Reports, July 2006, Springer Science + Business Media

     Professor Paul Peter Tak

217. 
     Pharmacokinetics of IL-18 binding protein in healthy volunteers and subjects with rheumatoid arthritis or plaque psoriasis

     Article • European Journal of Drug Metabolism and Pharmacokinetics, June 2006, Springer Science + Business Media

     Professor Paul Peter Tak

218. 
     Citrullinated proteins in rheumatoid arthritis: Crucial … but not sufficient!

     Article • Arthritis & Rheumatism, January 2006, Wiley

     Professor Paul Peter Tak

219. 
     Distinct synovial immunopathologic characteristics of juvenile-onset spondylarthritis and other forms of juvenile idiopathic arthritis

     Article • Arthritis & Rheumatism, January 2006, Wiley

     Professor Paul Peter Tak

220. 
     1067. Amelioration of Arthritis after Local Delivery of an Adeno-Associated Virus Type 6 Expressing a TNF-Blocking Agent under a Disease-Inducible Promoter

     Article • Molecular Therapy, January 2006, Elsevier

     Professor Paul Peter Tak

221. 
     Identification of synovial biomarkers of response to experimental treatment in early-phase clinical trials in spondylarthritis

     Article • Arthritis & Rheumatism, January 2006, Wiley

     Professor Paul Peter Tak

222. 
     Development of antiinfliximab antibodies and relationship to clinical response in patients with rheumatoid arthritis

     Article • Arthritis & Rheumatism, January 2006, Wiley

     Professor Paul Peter Tak

223. 
     Reduction of proinflammatory cytokine expression in the synovium by targeting IKKβ in vivo in a rat model

     Article • Arthritis & Rheumatism, January 2006, Wiley

     Professor Paul Peter Tak

224. 
     OR.55. Synovial Follicular Microarchitecture Is Not Related to Antigen-Specific Humoral Responses in Chronic Inflammatory Arthritis

     Article • Clinical Immunology, January 2006, Elsevier

     Professor Paul Peter Tak

225. 
     F.72. Identification of Synovial Biomarkers of Response to Treatment in Spondyloarthropathy

     Article • Clinical Immunology, January 2006, Elsevier

     Professor Paul Peter Tak

226. 
     A randomized controlled trial with an anti-CCL2 (anti–monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis

     Article • Arthritis & Rheumatism, January 2006, Wiley

     Professor Paul Peter Tak

227. 
     Kan men hydroxocobalamine (vitamine B12) overdoseren?

     Article • January 2006, Springer Science + Business Media

     Professor Paul Peter Tak

228. 
     Chemokines: Their role in rheumatoid arthritis

     Article • Current Rheumatology Reports, September 2005, Springer Science + Business Media

     Professor Paul Peter Tak

229. 
     Digital image analysis for the evaluation of the inflammatory infiltrate in psoriasis

     Article • Archives of Dermatological Research, July 2005, Springer Science + Business Media

     Professor Paul Peter Tak

230. 
     Synovial biopsy

     Article • Best Practice & Research Clinical Rheumatology, June 2005, Elsevier

     Professor Paul Peter Tak

231. 
     Targeting cellular adhesion molecules, chemokines and chemokine receptors in rheumatoid arthritis

     Article • Expert Opinion on Emerging Drugs, May 2005, Informa Healthcare

     Professor Paul Peter Tak

232. 
     Selective inhibition of NF-?B in dendritic cells by the NEMO-binding domain peptide blocks maturation and prevents T cell proliferation and polarization

     Article • European Journal of Immunology, April 2005, Wiley

     Professor Paul Peter Tak

233. 
     Signal Transduction Pathways and Transcription Factors as Therapeutic Targets in Inflammatory Disease: Towards Innovative Antirheumatic Therapy

     Article • Current Pharmaceutical Design, February 2005, Bentham Science Publishers

     Professor Paul Peter Tak

234. 
     Identification of the epidermal growth factor-TM7 receptor EMR2 and its ligand dermatan sulfate in rheumatoid synovial tissue

     Article • Arthritis & Rheumatism, January 2005, Wiley

     Professor Paul Peter Tak

235. 
     Immune responses following salivary gland administration of recombinant adeno-associated virus serotype 2 vectors

     Article • The Journal of Gene Medicine, January 2005, Wiley

     Professor Paul Peter Tak

236. 
     A novel approach for gene therapy: engraftment of fibroblasts containing the artificial chromosome expression system at the site of inflammation

     Article • The Journal of Gene Medicine, January 2005, Wiley

     Professor Paul Peter Tak

237. 
     The interaction of smoking and the HLA-DRB1 shared epitope in rheumatoid factor-positive rheumatoid arthritis: Comment on the article by Padyukov et al

     Article • Arthritis & Rheumatism, January 2005, Wiley

     Professor Paul Peter Tak

238. 
     Preventing work disability among employees with rheumatoid arthritis: What medical professionals can learn from the patients' perspective

     Article • Arthritis & Rheumatism, January 2005, Wiley

     Professor Paul Peter Tak

239. 
     Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: Evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis

     Article • Arthritis & Rheumatism, January 2005, Wiley

     Professor Paul Peter Tak

240. 
     Effects of oral prednisolone on biomarkers in synovial tissue and clinical improvement in rheumatoid arthritis

     Article • Arthritis & Rheumatism, December 2004, Wiley

     Professor Paul Peter Tak

241. 
     The presence of citrullinated proteins is not specific for rheumatoid synovial tissue

     Article • Arthritis & Rheumatism, November 2004, Wiley

     Professor Paul Peter Tak

242. 
     TNF -INHIBITION IN THE TREATMENT OF RHEUMATOID ARTHRITIS. Editors: Larry W. Moreland and Paul Emery.  29.95. Martin Dunitz, Taylor & Francis, 180 pages. ISBN 1841841560.

     Article • Rheumatology, July 2004, Oxford University Press (OUP)

     Professor Paul Peter Tak

243. 
     Alefacept therapy reduces the effector T-cell population in lesional psoriatic epidermis

     Article • Archives of Dermatological Research, February 2004, Springer Science + Business Media

     Professor Paul Peter Tak

244. 
     IFN-beta in rheumatoid arthritis

     Article • Frontiers in Bioscience, January 2004, Frontiers in Bioscience

     Professor Paul Peter Tak

245. 
     Local Adeno-Associated Virus-Mediated Interleukin 10 Gene Transfer Has Disease-Modifying Effects in a Murine Model of Sjögren's Syndrome

     Article • Human Gene Therapy, November 2003, Mary Ann Liebert Inc

     Professor Paul Peter Tak

246. 
     Tumor necrosis factor ? blockade reduces the synovial cell infiltrate early after initiation of treatment, but apparently not by induction of apoptosis in synovial tissue

     Article • Arthritis & Rheumatism, August 2003, Wiley

     Professor Paul Peter Tak

247. 
     Rheumatoid arthritis is a heterogeneous disease: Evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues

     Article • Arthritis & Rheumatism, August 2003, Wiley

     Professor Paul Peter Tak

248. 
     Female sex increases risk for rheumatoid arthritis only in individuals encoding low-risk HLA-DRB1 alleles

     Article • Arthritis & Rheumatism, June 2003, Wiley

     Professor Paul Peter Tak

249. 
     Reply

     Article • Arthritis & Rheumatism, April 2003, Wiley

     Professor Paul Peter Tak

250. 
     Possible role of shared epitope status in the relationship between matrix metalloproteinase 3 genotype and radiographic progression of rheumatoid arthritis: Comment on the article by Constantin et al

     Article • Arthritis & Rheumatism, April 2003, Wiley

     Professor Paul Peter Tak

251. 
     Reply

     Article • Arthritis & Rheumatism, January 2003, Wiley

     Professor Paul Peter Tak

252. 
     Cell-derived microparticles in synovial fluid from inflamed arthritic joints support coagulation exclusively via a factor VII-dependent mechanism

     Article • Arthritis & Rheumatism, November 2002, Wiley

     Professor Paul Peter Tak

253. 
     Alefacept treatment in psoriatic arthritis: Reduction of the effector T cell population in peripheral blood and synovial tissue is associated with improvement of clinical signs of arthritis

     Article • Arthritis & Rheumatism, October 2002, Wiley

     Professor Paul Peter Tak

254. 
     Comparison of synovial tissues from the knee joints and the small joints of rheumatoid arthritis patients: Implications for pathogenesis and evaluation of treatment

     Article • Arthritis & Rheumatism, August 2002, Wiley

     Professor Paul Peter Tak

255. 
     Cytokines in rheumatoid arthritis

     Article • Current Rheumatology Reports, May 2002, Springer Science + Business Media

     Professor Paul Peter Tak

256. 
     Decrease in synovial cellularity and cytokine expression after autologous stem cell transplantation in patients with juvenile idiopathic arthritis

     Article • Arthritis & Rheumatism, April 2002, Wiley

     Professor Paul Peter Tak

257. 
     Comparative assessment of leflunomide and methotrexate for the treatment of rheumatoid arthritis, by dynamic enhanced magnetic resonance imaging

     Article • Arthritis & Rheumatism, February 2002, Wiley

     Professor Paul Peter Tak

258. 
     Alefacept selectively reduces memory-effector (CD45RO+) T cells and improves clinical outcomes in psoriasis and psoriatic arthritis

     Article • Journal of Allergy and Clinical Immunology, January 2002, Elsevier

     Professor Paul Peter Tak

259. 
     Gene therapy in rheumatic diseases

     Article • Best Practice & Research Clinical Rheumatology, December 2001, Elsevier

     Professor Paul Peter Tak

260. 
     NF-κB: a key role in inflammatory diseases

     Article • Journal of Clinical Investigation, January 2001, American Society for Clinical Investigation

     Professor Paul Peter Tak

261. 
     Inhibitor of nuclear factor ?B kinase ? is a key regulator of synovial inflammation

     Article • Arthritis & Rheumatism, January 2001, Wiley

     Professor Paul Peter Tak

262. 
     The pathogenesis and prevention of joint damage in rheumatoid arthritis: Advances from synovial biopsy and tissue analysis

     Article • Arthritis & Rheumatism, December 2000, Wiley

     Professor Paul Peter Tak

263. 
     Analysis of synovial biopsy samples: opportunities and challenges

     Article • Annals of the Rheumatic Diseases, December 2000, BMJ

     Professor Paul Peter Tak

264. 
     Antigen-presenting cells containing bacterial peptidoglycan in synovial tissues of rheumatoid arthritis patients coexpress costimulatory molecules and cytokines

     Article • Arthritis & Rheumatism, October 2000, Wiley

     Professor Paul Peter Tak

265. 
     Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis: Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-n...

     Article • Arthritis & Rheumatism, August 2000, Wiley

     Professor Paul Peter Tak

266. 
     Lessons learnt from the synovial tissue response to anti-rheumatic treatment

     Article • Rheumatology, August 2000, Oxford University Press (OUP)

     Professor Paul Peter Tak

267. 
     Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: Findings in a prospective, randomized, double-blind clinical trial in fifteen patients

     Article • Arthritis & Rheumatism, July 2000, Wiley

     Professor Paul Peter Tak

268. 
     Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides

     Article • Arthritis & Rheumatism, March 2000, Wiley

     Professor Paul Peter Tak

269. 
     Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases

     Article • Immunology Today, February 2000, Elsevier

     Professor Paul Peter Tak

270. 
     The effects of interferon-β treatment on synovial inflammation and expression of metalloproteinases in patients with rheumatoid arthritis

     Article • Arthritis & Rheumatism, February 2000, Wiley

     Professor Paul Peter Tak

271. 
     Naar herstel van ontwricht immuunsysteem

     Article • January 2000, Amsterdam University Press

     Professor Paul Peter Tak

272. 
     Synovial tissue analysis in rheumatoid arthritis

     Article • Best Practice & Research Clinical Rheumatology, December 1999, Elsevier

     Professor Paul Peter Tak

273. 
     Expression of the thioredoxin-thioredoxin reductase system in the inflamed joints of patients with rheumatoid arthritis

     Article • Arthritis & Rheumatism, November 1999, Wiley

     Professor Paul Peter Tak

274. 
     Detection of bacterial DNA in serial synovial samples obtained during antibiotic treatment from patients with septic arthritis

     Article • Arthritis & Rheumatism, October 1999, Wiley

     Professor Paul Peter Tak

275. 
     Detection ofBorrelia burgdorferi sensu stricto by reverse line blot in the joints of Dutch patients with Lyme arthritis

     Article • Arthritis & Rheumatism, July 1999, Wiley

     Professor Paul Peter Tak

276. 
     P53 overexpression in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis

     Article • Arthritis & Rheumatism, May 1999, Wiley

     Professor Paul Peter Tak

277. 
     Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue

     Article • Arthritis & Rheumatism, April 1999, Wiley

     Professor Paul Peter Tak

278. 
     The effects of interferon beta treatment on arthritis

     Article • Rheumatology, April 1999, Oxford University Press (OUP)

     Professor Paul Peter Tak

279. 
     Apoptosis in rheumatoid arthritis

     Article • January 1999, Springer Science + Business Media

     Professor Paul Peter Tak

280. 
     Analysis of the cellular infiltrates and expression of cytokines in synovial tissue from patients with rheumatoid arthritis and reactive arthritis

     Article • The Journal of Pathology, September 1998, Wiley

     Professor Paul Peter Tak

281. 
     Asymptomatic synovitis precedes clinically manifest arthritis

     Article • Arthritis & Rheumatism, August 1998, Wiley

     Professor Paul Peter Tak

282. 
     Poor Expression of T Cell-Derived Cytokines and Activation and Proliferation Markers in Early Rheumatoid Synovial Tissue

     Article • Clinical Immunology and Immunopathology, July 1998, Elsevier

     Professor Paul Peter Tak

283. 
     Quantitative microscopic analysis of inflammation in rheumatoid arthritis synovial membrane samples selected at arthroscopy compared with samples obtained blindly by needle biopsy

     Article • Arthritis & Rheumatism, April 1998, Wiley

     Professor Paul Peter Tak

284. 
     Quantitative microscopic analysis of inflammation in rheumatoid arthritis synovial membrane samples selected at arthroscopy compared with samples obtained blindly by needle biopsy

     Article • Arthritis & Rheumatism, April 1998, Wiley

     Professor Paul Peter Tak

285. 
     Detection of bacterial dna in joint samples from patients with undifferentiated arthritis and reactive arthritis, using polymerase chain reaction with universal 16S ribosomal RNA primers

     Article • Arthritis & Rheumatism, March 1998, Wiley

     Professor Paul Peter Tak

286. 
     Detection of bacterial DNA in joint samples from patients with undifferentiated arthritis and reactive arthritis, using polymerase chain reaction with universal 16S ribosomal RNA primers

     Article • Arthritis & Rheumatism, March 1998, Wiley

     Professor Paul Peter Tak

287. 
     Is one year early, or too late? Comment on the article by Tak et al

     Article • Arthritis & Rheumatism, October 1997, Wiley

     Professor Paul Peter Tak

288. 
     Yersinia enterocolitica : A Cause of Chronic Polyarthritis

     Article • Clinical Infectious Diseases, October 1997, Oxford University Press (OUP)

     Professor Paul Peter Tak

289. 
     Analysis of Serial Synovial Biopsies as a Screening Method for Predicting the Effects of Therapeutic Interventions

     Article • JCR Journal of Clinical Rheumatology, August 1997, Wolters Kluwer Health

     Professor Paul Peter Tak

290. 
     Reply: To the editor

     Article • Arthritis & Rheumatism, April 1997, Wiley

     Professor Paul Peter Tak

291. 
     INCREASED EXPRESSION OF IL‐15 IN THE SYNOVIUM OF PATIENTS WITH RHEUMATOID ARTHRITIS COMPARED WITH PATIENTS WITH YERSINIA‐INDUCED ARTHRITIS AND OSTEOARTHRITIS

     Article • The Journal of Pathology, April 1997, Wiley

     Professor Paul Peter Tak

292. 
     INCREASED EXPRESSION OF IL-15 IN THE SYNOVIUM OF PATIENTS WITH RHEUMATOID ARTHRITIS COMPARED WITH PATIENTS WITHYERSINIA-INDUCED ARTHRITIS AND OSTEOARTHRITIS

     Article • The Journal of Pathology, April 1997, Wiley

     Professor Paul Peter Tak

293. 
     Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity

     Article • Arthritis & Rheumatism, February 1997, Wiley

     Professor Paul Peter Tak

294. 
     Expression of the Activation Antigen CD27 in Rheumatoid Arthritis

     Article • Clinical Immunology and Immunopathology, August 1996, Elsevier

     Professor Paul Peter Tak

295. 
     Decrease in cellularity and expression of adhesion molecules by anti–tumor necrosis factor α monoclonal antibody treatment in patients with rheumatoid arthritis

     Article • Arthritis & Rheumatism, July 1996, Wiley

     Professor Paul Peter Tak

296. 
     Expression of Adhesion Molecules in Early Rheumatoid Synovial Tissue

     Article • Clinical Immunology and Immunopathology, December 1995, Elsevier

     Professor Paul Peter Tak

297. 
     Reduction of synovial inflammation after anti-cd4 monoclonal antibody treatment in early rheumatoid arthritis

     Article • Arthritis & Rheumatism, October 1995, Wiley

     Professor Paul Peter Tak

298. 
     Review: Cobalamin Deficiency and Mental Impairment in Elderly People

     Article • Age and Ageing, January 1995, Oxford University Press (OUP)

     Professor Paul Peter Tak

299. 
     Granzyme-positive cytotoxic cells are specifically increased in early rheumatoid synovial tissue

     Article • Arthritis & Rheumatism, December 1994, Wiley

     Professor Paul Peter Tak

300. 
     Expression of Granzymes A and B in Synovial Tissue from Patients with Rheumatoid Arthritis and Osteoarthritis

     Article • Clinical Immunology and Immunopathology, October 1994, Elsevier

     Professor Paul Peter Tak

301. 
     Hyponatremia, Hyperkalemia and Hypercalcemia after Ileal Conduit Diversion

     Article • Scandinavian Journal of Urology and Nephrology, January 1993, Taylor & Francis

     Professor Paul Peter Tak

302. 
     Quantitative Image Analysis of Synovial Tissue

     Article • Springer Science + Business Media

     Professor Paul Peter Tak

303. 
     Modulation of the IκB Kinase/Nuclear Factor-κB Pathway by Gene Therapy

     Article • Springer Science + Business Media

     Professor Paul Peter Tak