All Stories

  1. A disturbance of lipid synthesis causes demyelinating disease

    Article • Brain, May 2024, Oxford University Press (OUP)

    PhD Kees Fluiter

  2. Ldlr-/-.Leiden mice develop neurodegeneration, age-dependent astrogliosis and obesity-induced changes in microglia immunophenotype which are partly reversed by complement component 5 neutralizing antibody

    Article • Frontiers in Cellular Neuroscience, June 2023, Frontiers

    PhD Kees Fluiter

  3. The systemic inhibition of the terminal complement system reduces neuroinflammation but does not improve motor function in mouse models of CMT1A with overexpressed PMP22

    Article • Current Research in Neurobiology, January 2023, Elsevier

    PhD Kees Fluiter

  4. Tackling Neuroinflammation After Traumatic Brain Injury: Complement Inhibition as a Therapy for Secondary Injury

    Article • Neurotherapeutics, October 2022, Springer Science + Business Media

    PhD Kees Fluiter

  5. Therapeutic Intervention with Anti-Complement Component 5 Antibody Does Not Reduce NASH but Does Attenuate Atherosclerosis and MIF Concentrations in Ldlr-/-.Leiden Mice

    Article • International Journal of Molecular Sciences, September 2022, MDPI AG

    PhD Kees Fluiter

  6. The development and properties of a new antibody that blocks the terminal complement system.

    Article • Journal of Innate Immunity, May 2022, Karger Publishers

    PhD Kees Fluiter

  7. Safety and efficacy of C1-inhibitor in traumatic brain injury (CIAO@TBI): study protocol for a randomized, placebo-controlled, multi-center trial

    Article • Trials, December 2021, Springer Science + Business Media

    PhD Kees Fluiter

  8. Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis

    Article • Acta Neuropathologica Communications, May 2018, Springer Science + Business Media

    PhD Kees Fluiter

  9. Inhibition of miR-142-5P ameliorates disease in mouse models of experimental colitis

    Article • PLoS ONE, October 2017, PLOS

    PhD Kees Fluiter

  10. TUB gene expression in hypothalamus and adipose tissue and its association with obesity in humans

    Article • International Journal of Obesity, August 2017, Springer Science + Business Media

    PhD Kees Fluiter

  11. Deregulated expression ofEZH2in congenital brainstem disconnection

    Article • Neuropathology and Applied Neurobiology, May 2017, Wiley

    PhD Kees Fluiter

  12. M. leprae components induce nerve damage by complement activation: identification of lipoarabinomannan as the dominant complement activator

    Article • Acta Neuropathologica, March 2015, Springer Science + Business Media

    PhD Kees Fluiter

  13. Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-Convergence on axonal guidance

    Article • Epilepsia, November 2014, Wiley

    PhD Kees Fluiter

  14. The microRNA-15 family inhibits the TGFβ-pathway in the heart

    Article • Cardiovascular Research, August 2014, European Society of Cardiology

    PhD Kees Fluiter

  15. Inhibition of the Membrane Attack Complex of the Complement System Reduces Secondary Neuroaxonal Loss and Promotes Neurologic Recovery after Traumatic Brain Injury in Mice

    Article • The Journal of Immunology, January 2014, The American Association of Immunologists

    PhD Kees Fluiter

  16. Traumatic Brain Injury in Rats Induces Lung Injury and Systemic Immune Suppression

    Article • Journal of Neurotrauma, December 2013, Mary Ann Liebert Inc

    PhD Kees Fluiter

  17. Toll-like receptor 4 activation in Barrett’s esophagus results in a strong increase in COX-2 expression

    Article • Journal of Gastroenterology, August 2013, Springer Science + Business Media

    Dr Frank P Vleggaar, PhD Kees Fluiter

  18. Glucocorticoid-induced Changes in Gene Expression of Airway Smooth Muscle in Patients with Asthma

    Article • American Journal of Respiratory and Critical Care Medicine, May 2013, American Thoracic Society

    PhD Kees Fluiter

  19. MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response

    Article • PLoS ONE, September 2012, PLOS

    PhD Kees Fluiter

  20. Ultrastructural Localization and Expression of TRPM1 in the Human Retina

    Article • Investigative Ophthalmology & Visual Science, October 2011, Association for Research in Vision and Ophthalmology (ARVO)

    PhD Kees Fluiter

  21. A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy

    Article • Human Molecular Genetics, October 2011, Oxford University Press (OUP)

    PhD Kees Fluiter

  22. Activation of toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development

    Article • Brain, March 2011, Oxford University Press (OUP)

    PhD Kees Fluiter

  23. Impairment of the tRNA-splicing endonuclease subunit 54 (tsen54) gene causes neurological abnormalities and larval death in zebrafish models of pontocerebellar hypoplasia

    Article • Human Molecular Genetics, January 2011, Oxford University Press (OUP)

    PhD Kees Fluiter

  24. Silencing the Expression of Ras Family GTPase Homologues Decreases Inflammation and Joint Destruction in Experimental Arthritis

    Article • American Journal Of Pathology, December 2010, Elsevier

    Professor Paul Peter Tak, PhD Kees Fluiter

  25. Male Infertility

    Article • The Journal of Urology, October 2010, Wolters Kluwer Health

    PhD Kees Fluiter

  26. Induction of sodium channel Nax (SCN7A) expression in rat and human hippocampus in temporal lobe epilepsy

    Article • Epilepsia, August 2010, Wiley

    PhD Kees Fluiter

  27. In vivo efficacy and off-target effects of Locked Nucleic Acid (LNA) and Unlocked Nucleic Acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts

    Article • Artificial DNA PNA & XNA, July 2010, Taylor & Francis

    PhD Kees Fluiter

  28. Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy

    Article • European Journal of Neuroscience, March 2010, Wiley

    PhD Kees Fluiter

  29. Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

    Article • Molecular BioSystems, January 2010, Royal Society of Chemistry

    PhD Kees Fluiter

  30. Embryonic stem cell-like cells derived from adult human testis

    Article • Human Reproduction, October 2009, Oxford University Press (OUP)

    PhD Kees Fluiter

  31. Allele-specific cancer cell killing in vitro and in vivo targeting a single-nucleotide polymorphism in POLR2A

    Article • Cancer Gene Therapy, January 2009, Springer Science + Business Media

    PhD Kees Fluiter

  32. Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4′-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer

    Article • Molecular BioSystems, January 2009, Royal Society of Chemistry

    PhD Kees Fluiter

  33. The Therapeutic Potential of LNA-modified siRNAs: Reduction of Off-target Effects by Chemical Modification of the siRNA Sequence

    Article • October 2008, Springer Science + Business Media

    PhD Kees Fluiter

  34. tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia

    Article • Nature Genetics, August 2008, Springer Science + Business Media

    PhD Kees Fluiter

  35. Evaluation of locked nucleic acid–modified small interfering RNA in vitro and in vivo

    Article • Molecular Cancer Therapeutics, March 2007, American Association for Cancer Research (AACR)

    PhD Kees Fluiter

  36. Scavenger Receptor Classes A and B: Their Roles in Atherogenesis and the Metabolism of Modified LDL and HDL

    Article • Annals of the New York Academy of Sciences, January 2006, Wiley

    PhD Kees Fluiter

  37. Evaluation of LNA-Modified DNAzymes Targeting a Single Nucleotide Polymorphism in the Large Subunit of RNA Polymerase II

    Article • Oligonucleotides, December 2005, Mary Ann Liebert Inc

    PhD Kees Fluiter

  38. On the in vitro and in vivo Properties of Four Locked Nucleic Acid Nucleotides Incorporated into an Anti-H-Ras Antisense Oligonucleotide

    Article • ChemBioChem, April 2005, Wiley

    PhD Kees Fluiter

  39. Killing cancer by targeting genes that cancer cells have lost: Allele-specific inhibition, a novel approach to the treatment of genetic disorders

    Article • Cellular and Molecular Life Sciences, May 2003, Springer Science + Business Media

    PhD Kees Fluiter

  40. In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides

    Article • Nucleic Acids Research, February 2003, Oxford University Press (OUP)

    PhD Kees Fluiter

  41. Polymorphisms in the large subunit of human RNA polymerase II as target for allele-specific inhibition

    Article • Nucleic Acids Research, March 2000, Oxford University Press (OUP)

    PhD Kees Fluiter

  42. [23] Targeted delivery of antisense oligonucleotides to parenchymal liver cells in vivo

    Article • January 2000, Elsevier

    PhD Kees Fluiter

  43. Scavenger Receptor BI Mediates the Selective Uptake of Oxidized Cholesterol Esters by Rat Liver

    Article • Journal of Biological Chemistry, March 1999, Elsevier

    PhD Kees Fluiter

  44. In Vivo Regulation of Scavenger Receptor BI and the Selective Uptake of High Density Lipoprotein Cholesteryl Esters in Rat Liver Parenchymal and Kupffer Cells

    Article • Journal of Biological Chemistry, April 1998, Elsevier

    PhD Kees Fluiter

  45. Scavenger receptor B1 (SR-B1) substrates inhibit the selective uptake of high-density-lipoprotein cholesteryl esters by rat parenchymal liver cells

    Article • Biochemical Journal, September 1997, Portland Press Ltd.

    PhD Kees Fluiter

  46. Increased selective uptake in vivo and in vitro of oxidized cholesteryl esters from high-density lipoprotein by rat liver parenchymal cells

    Article • Biochemical Journal, October 1996, Portland Press Ltd.

    PhD Kees Fluiter

  47. LDL receptor-independent and -dependent uptake of lipoproteins

    Article • Atherosclerosis, December 1995, Elsevier

    PhD Kees Fluiter

  48. Interactions between the Cytosolic Components p47 and p67 of the Human Neutrophil NADPH Oxidase That Are Not Required for Activation in the Cell-free System

    Article • Journal of Biological Chemistry, May 1995, Elsevier

    PhD Kees Fluiter

  49. Production of senescent cells ofSaccharomyces cerevisiae by centrifugal elutriation

    Article • Yeast, April 1995, Wiley

    PhD Kees Fluiter