All Stories

  1. Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages

    Article • Antimicrobial Agents and Chemotherapy, June 2018, ASM Journals

    Professor Lyn-Marie Birkholtz

  2. Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites

    Article • Bioorganic & Medicinal Chemistry, August 2015, Elsevier

    Professor Lyn-Marie Birkholtz, Prof. Patrick M. Woster

  3. Synthesis and in vitro biological evaluation of dihydroartemisinyl-chalcone esters

    Article • European Journal of Medicinal Chemistry, January 2015, Elsevier

    Professor Lyn-Marie Birkholtz

  4. A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail

    Article • Malaria Journal, January 2015, Springer Science + Business Media

    Professor Lyn-Marie Birkholtz

  5. Differential activity of novel gametocytocidal compounds: drug mode-of-action and ex vivo efficacy

    Article • Malaria Journal, September 2014, Springer Science + Business Media

    Professor Lyn-Marie Birkholtz

  6. Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites

    Article • International Journal for Parasitology Drugs and Drug Resistance, April 2014, Elsevier

    Professor Lyn-Marie Birkholtz

  7. Discovery of Compounds Blocking the Proliferation of Toxoplasma gondii and Plasmodium falciparum in a Chemical Space Based on Piperidinyl-Benzimidazolone Analogs

    Article • Antimicrobial Agents and Chemotherapy, February 2014, ASM Journals

    Professor Lyn-Marie Birkholtz

  8. 17-beta-estradiol analog inhibits cell proliferation by induction of apoptosis in breast cell lines

    Article • Microscopy Research and Technique, January 2014, Wiley

    Professor Lyn-Marie Birkholtz

  9. Anthracene-Polyamine Conjugates InhibitIn VitroProliferation of Intraerythrocytic Plasmodium falciparum Parasites

    Article • Antimicrobial Agents and Chemotherapy, April 2013, ASM Journals

    Professor Lyn-Marie Birkholtz

  10. Polyamine Metabolism

    Article • January 2013, Springer Science + Business Media

    Professor Lyn-Marie Birkholtz

  11. Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum

    Article • Biochemical Journal, January 2013, Portland Press Ltd.

    Professor Lyn-Marie Birkholtz

  12. Sustainable malaria control: transdisciplinary approaches for translational applications

    Article • Malaria Journal, December 2012, Springer Science + Business Media

    Riana (MS) Bornman, Professor Lyn-Marie Birkholtz

  13. Polyamine uptake by the intraerythrocytic malaria parasite, Plasmodium falciparum

    Article • International Journal for Parasitology, September 2012, Elsevier

    Professor Lyn-Marie Birkholtz

  14. Inhibition of p-Aminobenzoate and Folate Syntheses in Plants and Apicomplexan Parasites by Natural Product Rubreserine

    Article • Journal of Biological Chemistry, May 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Lyn-Marie Birkholtz, Christophe Stove

  15. The structure of Plasmodium falciparum spermidine synthase in complex with 5'-methylthioadenosine and N-(3-aminopropyl)-trans-cyclohexane-1,4-diamine

    Article • April 2012, Protein Data Bank, Rutgers University

    Professor Lyn-Marie Birkholtz

  16. Thermo‐responsive non‐woven scaffolds for “smart” 3D cell culture

    Article • Biotechnology and Bioengineering, February 2012, Wiley

    Professor Lyn-Marie Birkholtz

  17. Biochemical characterisation and novel classification of monofunctional S-adenosylmethionine decarboxylase of Plasmodium falciparum

    Article • Molecular and Biochemical Parasitology, November 2011, Elsevier

    Professor Lyn-Marie Birkholtz

  18. Discovery of Novel Alkylated (bis)Urea and (bis)Thiourea Polyamine Analogues with Potent Antimalarial Activities

    Article • Journal of Medicinal Chemistry, October 2011, American Chemical Society (ACS)

    Professor Lyn-Marie Birkholtz, Prof. Patrick M. Woster

  19. Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities

    Article • Biochemical Journal, September 2011, Portland Press Ltd.

    Professor Lyn-Marie Birkholtz

  20. Polyamine uptake in the malaria parasite, Plasmodium falciparum, is dependent on the parasite's membrane potential

    Article • Malaria Journal, October 2010, Springer Science + Business Media

    Professor Lyn-Marie Birkholtz

  21. Polyamine uptake in the malaria parasite, Plasmodium falciparum, is dependent on the parasite's membrane potential

    Article • Malaria Journal, October 2010, Springer Science + Business Media

    Professor Lyn-Marie Birkholtz

  22. Proteomic Profiling of Plasmodium falciparum through Improved, Semiquantitative Two-Dimensional Gel Electrophoresis

    Article • Journal of Proteome Research, May 2010, American Chemical Society (ACS)

    Professor Lyn-Marie Birkholtz

  23. Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels

    Article • BMC Genomics, January 2010, Springer Science + Business Media

    Professor Lyn-Marie Birkholtz

  24. Functional consequences of perturbing polyamine metabolism in the malaria parasite, Plasmodium falciparum

    Article • Amino Acids, December 2009, Springer Science + Business Media

    Professor Lyn-Marie Birkholtz

  25. In silico Discovery of Chemotherapeutic Agents

    Article • October 2009, Springer Science + Business Media

    Professor Lyn-Marie Birkholtz

  26. Antimalarial Drug Discovery: In Silico Structural Biology and Rational Drug Design

    Article • Infectious Disorders - Drug Targets, June 2009, Bentham Science Publishers

    Professor Lyn-Marie Birkholtz

  27. Co-inhibition of Plasmodium falciparum S-Adenosylmethionine Decarboxylase/Ornithine Decarboxylase Reveals Perturbation-specific Compensatory Mechanisms by Transcriptome, Proteome, and Metabolome Analyses

    Article • Journal of Biological Chemistry, December 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Lyn-Marie Birkholtz

  28. Transcriptional responses of Plasmodium falciparum to α-difluoromethylornithine-induced polyamine depletion

    Article • Biological Chemistry, February 2008, De Gruyter

    Professor Lyn-Marie Birkholtz

  29. Exploring functional genomics for drug target and therapeutics discovery in Plasmodia

    Article • Acta Tropica, February 2008, Elsevier

    Professor Lyn-Marie Birkholtz

  30. Heterologous expression of plasmodial proteins for structural studies and functional annotation

    Article • Malaria Journal, January 2008, Springer Science + Business Media

    Professor Lyn-Marie Birkholtz

  31. Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase

    Article • Bioorganic & Medicinal Chemistry, February 2007, Elsevier

    Professor Lyn-Marie Birkholtz

  32. Deletion mutagenesis of large areas in Plasmodium falciparum genes: a comparative study

    Article • Malaria Journal, January 2007, Springer Science + Business Media

    Professor Lyn-Marie Birkholtz

  33. Novel properties of malarial S-adenosylmethionine decarboxylase as revealed by structural modelling

    Article • Journal of Molecular Graphics and Modelling, January 2006, Elsevier

    Professor Lyn-Marie Birkholtz

  34. Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions

    Article • Biochemical Journal, January 2004, Portland Press Ltd.

    Professor Lyn-Marie Birkholtz

  35. Comparative properties of a three-dimensional model of Plasmodium falciparum ornithine decarboxylase

    Article • Proteins Structure Function and Bioinformatics, January 2003, Wiley

    Professor Lyn-Marie Birkholtz