All Stories

  1. A composite reference standard is needed for bedaquiline antimicrobial susceptibility testing forMycobacterium tuberculosiscomplex

    Article • European Respiratory Journal, July 2024, European Respiratory Society (ERS)

    Paolo Miotto

  2. Careful classification of potential bedaquiline resistance mutations is critical when analysing their clinical impact

    Article • The International Journal of Tuberculosis and Lung Disease, June 2024, International Union Against Tuberculosis and Lung Disease

    Paolo Miotto

  3. Transcriptomic responses to antibiotic exposure in Mycobacterium tuberculosis

    Article • Antimicrobial Agents and Chemotherapy, May 2024, ASM Journals

    Paolo Miotto

  4. The exceptions that prove the rule—a historical view of bedaquiline susceptibility

    Article • Genome Medicine, March 2024, Springer Science + Business Media

    Paolo Miotto

  5. Prison as a driver of recent transmissions of multidrug-resistant tuberculosis in Callao, Peru: a cross-sectional study

    Article • The Lancet Regional Health - Americas, March 2024, Elsevier

    Paolo Miotto

  6. Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach

    Article • Nature Communications, January 2024, Springer Science + Business Media

    Paolo Miotto

  7. Loss-of-function mutations in ndh do not confer delamanid, ethionamide, isoniazid, or pretomanid resistance in Mycobacterium tuberculosis

    Article • Antimicrobial Agents and Chemotherapy, December 2023, ASM Journals

    Paolo Miotto

  8. The small non-coding RNA B11 regulates multiple facets of Mycobacterium abscessus virulence

    Article • PLoS Pathogens, August 2023, PLOS

    Paolo Miotto

  9. Reply: Epidemiological cut-off values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing ofM. tuberculosis

    Article • European Respiratory Journal, May 2023, European Respiratory Society (ERS)

    Paolo Miotto

  10. Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis

    Article • The Lancet Microbe, May 2023, Elsevier

    Paolo Miotto

  11. Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a 2023 TBnet/RESIST-TB consensus statement

    Article • The Lancet Infectious Diseases, April 2023, Elsevier

    Paolo Miotto

  12. Updating the WHO target product profile for next-generation Mycobacterium tuberculosis drug susceptibility testing at peripheral centres

    Article • PLOS Global Public Health, March 2023, PLOS

    Paolo Miotto

  13. Designing molecular diagnostics for current tuberculosis drug regimens

    Article • Emerging Microbes & Infections, February 2023, Taylor & Francis

    Paolo Miotto

  14. Transcriptional regulation and drug resistance in Mycobacterium tuberculosis

    Article • Frontiers in Cellular and Infection Microbiology, September 2022, Frontiers

    Paolo Miotto

  15. A crowd of BashTheBug volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates

    Article • eLife, May 2022, eLife

    Paolo Miotto

  16. Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment

    Article • European Respiratory Journal, April 2022, European Respiratory Society (ERS)

    Paolo Miotto, Dr. Jaime Robledo

  17. The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis

    Article • The Lancet Microbe, April 2022, Elsevier

    Paolo Miotto, Dr. Jaime Robledo

  18. Role of Epistasis in Amikacin, Kanamycin, Bedaquiline, and Clofazimine Resistance in Mycobacterium tuberculosis Complex

    Article • Antimicrobial Agents and Chemotherapy, October 2021, ASM Journals

    Paolo Miotto

  19. Making IGRA testing easier: First performance report of QIAreach QFT for tuberculosis infection diagnosis

    Article • Pulmonology, October 2021, Elsevier

    Paolo Miotto

  20. Is the new WHO definition of extensively drug-resistant tuberculosis easy to apply in practice?

    Article • European Respiratory Journal, July 2021, European Respiratory Society (ERS)

    Paolo Miotto

  21. A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression

    Article • Immunity, June 2021, Elsevier

    Paolo Miotto

  22. A New Model of Chronic Mycobacterium abscessus Lung Infection in Immunocompetent Mice

    Article • International Journal of Molecular Sciences, September 2020, MDPI AG

    Dr Enrico Tortoli, Paolo Miotto

  23. How To Optimally Combine Genotypic and Phenotypic Drug Susceptibility Testing Methods for Pyrazinamide

    Article • Antimicrobial Agents and Chemotherapy, June 2020, ASM Journals

    Paolo Miotto

  24. Guidance for Studies Evaluating the Accuracy of Rapid Tuberculosis Drug-Susceptibility Tests

    Article • The Journal of Infectious Diseases, October 2019, Oxford University Press (OUP)

    Paolo Miotto

  25. Whole genome sequencing in Mycobacterium tuberculosis

    Article • Annals of Translational Medicine, September 2019, AME Publishing Company

    Paolo Miotto

  26. Fluoroquinolone heteroresistance in Mycobacterium tuberculosis: detection by genotypic and phenotypic assays in experimentally mixed populations

    Article • Scientific Reports, August 2019, Springer Science + Business Media

    Paolo Miotto

  27. Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues

    Article • Nature Reviews Microbiology, June 2019, Springer Science + Business Media

    Jennifer Guthrie, Paolo Miotto

  28. Building the framework for standardized clinical laboratory reporting of next generation sequencing data for resistance-associated mutations in Mycobacterium tuberculosis complex

    Article • Clinical Infectious Diseases, March 2019, Oxford University Press (OUP)

    Paolo Miotto

  29. Evolution of programmatic definitions used in tuberculosis prevention and care

    Article • Clinical Infectious Diseases, November 2018, Oxford University Press (OUP)

    Paolo Miotto

  30. Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase

    Article • Scientific Reports, October 2018, Springer Science + Business Media

    Paolo Miotto

  31. Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, September 2018, New England Journal of Medicine (NEJM/MMS)

    Paolo Miotto, Jennifer Guthrie, Caroline Allix-Béguec

  32. Drug resistance mechanisms and drug susceptibility testing for tuberculosis

    Article • Respirology, September 2018, Wiley

    Paolo Miotto, Ying Zhang

  33. Role of Disputed Mutations in the rpoB Gene in Interpretation of Automated Liquid MGIT Culture Results for Rifampin Susceptibility Testing of Mycobacterium tuberculosis

    Article • Journal of Clinical Microbiology, March 2018, ASM Journals

    Paolo Miotto

  34. Genetic sequencing for surveillance of drug resistance in tuberculosis in highly endemic countries: a multi-country population-based surveillance study

    Article • The Lancet Infectious Diseases, March 2018, Elsevier

    Paolo Miotto

  35. A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis

    Article • European Respiratory Journal, December 2017, European Respiratory Society (ERS)

    Paolo Miotto

  36. Evaluation of a novel line probe assay to detect resistance to pyrazinamide, a key drug used for tuberculosis treatment

    Article • Clinical Microbiology and Infection, June 2017, Elsevier

    Paolo Miotto

  37. Evolution of Phenotypic and Molecular Drug Susceptibility Testing

    Article • January 2017, Springer Science + Business Media

    Paolo Miotto, Dr Enrico Tortoli

  38. Reaching consensus on drug resistance conferring mutations

    Article • International Journal of Mycobacteriology, December 2016, Medknow

    Paolo Miotto

  39. Reaching consensus on drug resistance conferring mutations

    Article • International Journal of Mycobacteriology, December 2016, Medknow

    Paolo Miotto

  40. Mycobacterium tuberculosis drug-resistance testing: challenges, recent developments and perspectives

    Article • Clinical Microbiology and Infection, November 2016, Elsevier

    Professor Miguel Viveiros, Paolo Miotto

  41. Accelerating tuberculosis elimination in low-incidence settings: the role of genomics

    Article • European Respiratory Journal, November 2015, European Respiratory Society (ERS)

    Paolo Miotto

  42. Collaborative Effort for a Centralized Worldwide Tuberculosis Relational Sequencing Data Platform: Figure 1.

    Article • Clinical Infectious Diseases, September 2015, Oxford University Press (OUP)

    Paolo Miotto

  43. Lab-on-Chip-Based Platform for Fast Molecular Diagnosis of Multidrug-Resistant Tuberculosis

    Article • Journal of Clinical Microbiology, August 2015, ASM Journals

    Dr Daniela maria Cirillo, Paolo Miotto

  44. Diagnostic Performance of the New Version (v2.0) of GenoType MTBDRslAssay for Detection of Resistance to Fluoroquinolones and Second-Line Injectable Drugs: a Multicenter Study

    Article • Journal of Clinical Microbiology, July 2015, ASM Journals

    Dr Daniela maria Cirillo, Paolo Miotto

  45. PhyResSE: a Web Tool Delineating Mycobacterium tuberculosis Antibiotic Resistance and Lineage from Whole-Genome Sequencing Data

    Article • Journal of Clinical Microbiology, April 2015, ASM Journals

    Professor Stefan Niemann, Dr Kurt Fellenberg, Paolo Miotto

  46. Drug Resistance in Mycobacterium tuberculosis

    Article • CHEST Journal, April 2015, Elsevier

    Paolo Miotto

  47. Integration of Published Information Into a Resistance-Associated Mutation Database for Mycobacterium tuberculosis

    Article • The Journal of Infectious Diseases, March 2015, Oxford University Press (OUP)

    Paolo Miotto

  48. MicroRNA induction in human macrophages associated with infection with ancient and modern TB strains

    Article • International Journal of Mycobacteriology, March 2015, Elsevier

    Dr Lucinda Furci, Paolo Miotto

  49. Utility of propidium monoazide viability assay as a biomarker for a tuberculosis disease

    Article • Tuberculosis, March 2015, Elsevier

    Paolo Miotto

  50. Use of genetic mutations for prediction of resistance to pyrazinamide in M. tuberculosis strains

    Article • International Journal of Mycobacteriology, March 2015, Medknow

    Paolo Miotto

  51. Mycobacterium tuberculosis Pyrazinamide Resistance Determinants: a Multicenter Study

    Article • mBio, October 2014, ASM Journals

    Paolo Miotto

  52. miRNA Signatures in Sera of Patients with Active Pulmonary Tuberculosis

    Article • PLoS ONE, November 2013, PLOS

    Paolo Miotto

  53. The roles of microRNAs on tuberculosis infection: Meaning or myth?

    Article • Tuberculosis, November 2013, Elsevier

    Paolo Miotto

  54. Alteration of human macrophages microRNA expression profile upon infection with Mycobacterium tuberculosis

    Article • International Journal of Mycobacteriology, September 2013, Medknow

    Dr Lucinda Furci, Paolo Miotto

  55. Mycobacterium tuberculosis Beijing Genotype Is Associated with HIV Infection in Mozambique

    Article • PLoS ONE, August 2013, PLOS

    Paolo Miotto

  56. Genome-Wide Discovery of Small RNAs in Mycobacterium tuberculosis

    Article • PLoS ONE, December 2012, PLOS

    Paolo Miotto, Gabor Balazsi

  57. Early tuberculosis treatment monitoring by Xpert® MTB/RIF: Figure 1–

    Article • European Respiratory Journal, April 2012, European Respiratory Society (ERS)

    Paolo Miotto

  58. A Genome-Wide Identification Analysis of Small Regulatory RNAs in Mycobacterium tuberculosis by RNA-Seq and Conservation Analysis

    Article • PLoS ONE, March 2012, PLOS

    Paolo Miotto

  59. GenoType MTBDRslperformance on clinical samples with diverse genetic background

    Article • European Respiratory Journal, January 2012, European Respiratory Society (ERS)

    Paolo Miotto, Dr Enrico Tortoli

  60. Is multidrug-resistant tuberculosis on the rise in Mozambique? Results of a national drug resistance survey

    Article • European Respiratory Journal, June 2011, European Respiratory Society (ERS)

    Paolo Miotto

  61. Failing a re-treatment regimen does not predict MDR/XDR tuberculosis: is "blind" treatment dangerous?

    Article • European Respiratory Journal, April 2011, European Respiratory Society (ERS)

    Paolo Miotto

  62. Molecular diversity of Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in Mozambique

    Article • BMC Microbiology, January 2010, Springer Science + Business Media

    Paolo Miotto

  63. Molecular detection of rifampin and isoniazid resistance to guide chronic TB patient management in Burkina Faso

    Article • BMC Infectious Diseases, August 2009, Springer Science + Business Media

    Paolo Miotto

  64. Identificazione molecolare di mutazioni conferenti resistenza a rifampicina ed isoniazide in M. tuberculosis in campioni clinici diretti mediante Genotype MTBDR (Hain Lifescience)

    Article • Microbiologia Medica, December 2007, PAGEPress Publications

    Paolo Miotto

  65. Genotype MTBDRplus: a Further Step toward Rapid Identification of Drug-Resistant Mycobacterium tuberculosis

    Article • Journal of Clinical Microbiology, October 2007, ASM Journals

    Paolo Miotto

  66. Use of Genotype MTBDR Assay for Molecular Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Clinical Strains Isolated in Italy

    Article • Journal of Clinical Microbiology, July 2006, ASM Journals

    Paolo Miotto