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- Precision Vaccinology Approaches for the Development of Adjuvanted Vaccines Targeted to Distinct Vulnerable Populations
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- Reduced Steroid Metabolites Identify Infection-Prone Children in Two Independent Pre-Birth Cohorts
- OMIC Technologies and Vaccine Development: From the Identification of Vulnerable Individuals to the Formulation of Invulnerable Vaccines
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- Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro
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- Microphysiologic Human Tissue Constructs Reproduce Autologous Age-Specific BCG and HBV Primary Immunization in vitro
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- Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes In Vitro
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- Early Life HIV-1 Immunization: Providing a Window for Protection Before Sexual Debut
- First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
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- Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future
- Anti-infective proteins and peptides differ in their activities in human newborn blood.
- Correction: Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis
- Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro
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- A Cost-Effective High-Throughput Plasma and Serum Proteomics Workflow Enables Mapping of the Molecular Impact of Total Pancreatectomy with Islet Autotransplantation
- Neonatal Immunization: Rationale, Current State, and Future Prospects
- Hepatic Legionella pneumophila Infection in an Infant With Severe Combined Immunodeficiency
- Adjuvant Effect of Bacille Calmette–Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn
- Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization
- Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses
- Waning Immunity and Microbial Vaccines—Workshop of the National Institute of Allergy and Infectious Diseases
- Human newborn B cells mount an interferon-α/β receptor-dependent humoral response to respiratory syncytial virus
- Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis
Article
- Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny
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- Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns
- Mononuclear Phagocyte System
- Use of cidofovir in pediatric patients with adenovirus infection
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- A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity
- Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization
- Antimicrobial Proteins and Peptides in Early Life: Ontogeny and Translational Opportunities
- Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells
- Heterologous vaccine effects
- In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant
- Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures
- Harnessing the beneficial heterologous effects of vaccination
- Use of cidofovir in pediatric patients with adenovirus infection
- Circulating Human Neonatal Naïve B Cells are Deficient in CD73 Impairing Purine Salvage
- Changing oral vaccine to inactivated polio vaccine might increase mortality
- Pilot experience with opebacan/rBPI21 in myeloablative hematopoietic cell transplantation
- Pediatric Vaccine Adjuvants
- Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs
- The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes
- Systems vaccinology: a promise for the young and the poor
- Staphylococcus epidermidisBacteremia Induces Brain Injury in Neonatal Mice via Toll-like Receptor 2-Dependent and -Independent Pathways
- Ready to benefit from training: heterologous effects of early life immunization
- The effect of stable macromolecular complexes of ionic polyphosphazene on HIV Gag antigen and on activation of human dendritic cells and presentation to T-cells
- Soluble Mediators Regulating Immunity in Early Life
- Infection-induced inflammation and cerebral injury in preterm infants
- Ontogeny of early life immunity
- A Prime Time for Trained Immunity: Innate Immune Memory in Newborns and Infants
- Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity
- Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines
- Identification of single nucleotide polymorphisms in hematopoietic cell transplant patients affecting early recognition of, and response to, endotoxin
- Soluble Ecto-5′-nucleotidase (5′-NT), Alkaline Phosphatase, and Adenosine Deaminase (ADA1) Activities in Neonatal Blood Favor Elevated Extracellular Adenosine
- Vaccine-induced immunity in early life
- Immune response to vaccine adjuvants during the first year of life
- Heterologous ("Nonspecific") and Sex-Differential Effects of Vaccines: Epidemiology, Clinical Trials, and Emerging Immunologic Mechanisms
- The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes
- Role of Innate Immunity in Neonatal Infection
- Neonatal Host Defense against Staphylococcal Infections
- Plasma‐mediated immune suppression: a neonatal perspective
- Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly
- A Neonatal Model of Intravenous Staphylococcus epidermidis Infection in Mice <24 h Old Enables Characterization of Early Innate Immune Responses
- Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways
- Innate immune activation in neonatal tracheal aspirates suggests endotoxin-driven inflammation
- Responsiveness of human monocytes to the commensal bacterium Staphylococcus epidermidis develops late in gestation
- Neonatal Plasma Polarizes TLR4-Mediated Cytokine Responses towards Low IL-12p70 and High IL-10 Production via Distinct Factors
- Potential Role of Coagulase-negative Staphylococcus Infection in Preterm Brain Injury
- Bactericidal/Permeability-Increasing Protein (rBPI 21 ) and Fluoroquinolone Mitigate Radiation-Induced Bone Marrow Aplasia and Death
- Toll2011 at Lago di Garda: studying danger sensors by the guard towers at the lake
- Deficient expression of bactericidal/permeability-increasing protein in immunocompromised hosts: translational potential of replacement therapy
- Development of Newborn and Infant Vaccines
- 17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and liveE. coli
- Systemic Stimulation of TLR2 Impairs Neonatal Mouse Brain Development
- Age-Dependent Maturation of Toll-Like Receptor-Mediated Cytokine Responses in Gambian Infants
- Challenges in infant immunity: implications for responses to infection and vaccines
- Adenosine modulates Toll-like receptor function: basic mechanisms and translational opportunities
- Human Neonatal Peripheral Blood Leukocytes Demonstrate Pathogen-Specific Coordinate Expression of TLR2, TLR4/MD2, and MyD88 During Bacterial Infection In Vivo
- Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency
- Method of bacterial killing differentially affects the human innate immune response to Staphylococcus epidermidis
- Role of Innate Host Defenses in Susceptibility to Early-Onset Neonatal Sepsis
- TLR2 Mediates Recognition of Live Staphylococcus epidermidis and Clearance of Bacteremia
- Neonatal innate immunity in allergy development
- Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: Low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life
- Neonatal Vaccination
- Endotoxin-Directed Innate Immunity in Tracheal Aspirates of Mechanically Ventilated Human Neonates
- Developmental Biology of the Innate Immune Response: Implications for Neonatal and Infant Vaccine Development
- Antibiotic proteins of polymorphonuclear leukocytes
- Reduced levels of antimicrobial proteins and peptides in human cord blood plasma: Table 1
- Safety and efficacy of neonatal vaccination
- Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-κB essential modulator deficiency
- Bactericidal/permeability-increasing protein (BPI) and BPI homologs at mucosal sites
- Novel Vaccines: Bridging Research, Development and Production
- Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis
- Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists
- Immunostimulatory activity of Toll-like receptor 8 agonists towards human leucocytes: basic mechanisms and translational opportunities
- Evidence of a bactericidal permeability increasing protein in an invertebrate, theCrassostrea gigas Cg-BPI
- Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity
- Neonatal immune responses to coagulase-negative staphylococci
- Innate immunity of the newborn: basic mechanisms and clinical correlates
- Bruton tyrosine kinase (Btk): key for signaling via Toll-like receptor 8
- Recombinant Bactericidal/Permeability-Increasing Protein rBPI21 Protects against Pneumococcal Disease
- Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells
- Functional and biochemical characterization of epithelial bactericidal/permeability-increasing protein
- Neonatal Babesiosis
- Innate immunity of the human newborn: distinct cytokine responses to LPS and other Toll-like receptor agonists
- Human disease resulting from gene mutations that interfere with appropriate nuclear factor‐κB activation
- Human nuclear factor κB essential modulator mutation can result in immunodeficiency without ectodermal dysplasia
- Antimicrobial proteins and peptides: anti-infective molecules of mammalian leukocytes
- Genetic Screening for Susceptibility to Infection in the NICU Setting: Commentary on the article by Ahrens et al. on page 652
- Critical Role of the Complement System in Group B Streptococcus-Induced Tumor Necrosis Factor Alpha Release
- Endotoxemia and elevation of lipopolysaccharide-binding protein after hematopoietic stem cell transplantation
- Disseminated Varicella Infection Due to the Vaccine Strain of Varicella‐Zoster Virus, in a Patient with a Novel Deficiency in Natural Killer T Cells
- Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epithelia
- Impaired Innate Immunity at Birth: Deficiency of Bactericidal/Permeability-Increasing Protein (BPI) in the Neutrophils of Newborns
- Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils1
- Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia
- FATAL DISSEMINATED CANDIDA LUSITANIAE INFECTION IN AN INFANT WITH CHRONIC GRANULOMATOUS DISEASE
- Therapeutic potential of the
- A Neutrophil-Derived Anti-Infective Molecule: Bactericidal/Permeability-Increasing Protein
- Enhancement of Neonatal Innate Defense: Effects of Adding an N-Terminal Recombinant Fragment of Bactericidal/Permeability-Increasing Protein on Growth and Tumor Necrosis Factor-Inducing Activity of Gram-Negative Bacteria Tested in Neonatal Cord Blood E...
- Impaired Innate Immunity in the Newborn: Newborn Neutrophils Are Deficient in Bactericidal/Permeability-Increasing Protein
- Extracellular accumulation of potently microbicidal bactericidal/permeability-increasing protein and p15s in an evolving sterile rabbit peritoneal inflammatory exudate.
- Integration of antimicrobial host defenses: role of the bactericidal/permeability-increasing protein
- Individual and synergistic effects of rabbit granulocyte proteins on Escherichia coli.
- Structural characterization of BPI-modulating 15 kDa proteins from rabbit polymorphonuclear leukocytes: Identification of a novel family of leukocyte proteins