All Stories

  1. The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)-α via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK)–mediated induction of suppressor of...

    Article • The FASEB Journal, June 2019, Federation of American Societies For Experimental Biology (FASEB)

    Dr Nigel J Stevenson, Orla Convery, Cliona O'Farrelly

  2. HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction

    Article • EBioMedicine, March 2018, Elsevier

    Dr Nigel J Stevenson

  3. Control of HIV infection by IFN-α: implications for latency and a cure

    Article • Cellular and Molecular Life Sciences, October 2017, Springer Science + Business Media

    Dr Nigel J Stevenson

  4. Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway

    Article • Cellular and Molecular Life Sciences, April 2017, Springer Science + Business Media

    Dr Nigel J Stevenson

  5. A novel anti-viral role for STAT3 in IFN-α signalling responses

    Article • Cellular and Molecular Life Sciences, December 2016, Springer Science + Business Media

    Dr Nigel J Stevenson

  6. SOCS3 revisited: a broad regulator of disease, now ready for therapeutic use?

    Article • Cellular and Molecular Life Sciences, May 2016, Springer Science + Business Media

    Dr Nigel J Stevenson

  7. Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C

    Article • Brain Behavior and Immunity, August 2015, Elsevier

    Dr Nigel J Stevenson

  8. The role of microRNA in regulating signalling pathway cascades

    Article • Cellular and Molecular Life Sciences, June 2015, Springer Science + Business Media

    Dr Nigel J Stevenson

  9. Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-  responses

    Article • Journal of Leukocyte Biology, March 2014, Society for Leukocyte Biology

    Dr Nigel J Stevenson

  10. In vitro blood cell responsiveness to IFN-α predicts clinical response independently of IL28B in hepatitis C virus genotype 1 infected patients

    Article • Journal of Translational Medicine, January 2014, Springer Science + Business Media

    Dr Nigel J Stevenson

  11. miR-19a: An Effective Regulator of SOCS3 and Enhancer of JAK-STAT Signalling

    Article • PLoS ONE, July 2013, PLOS

    Dr Nigel J Stevenson

  12. Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes

    Article • FEBS Letters, April 2013, Wiley

    Dr Nigel J Stevenson

  13. Ribavirin Enhances IFN-α Signalling and MxA Expression: A Novel Immune Modulation Mechanism during Treatment of HCV

    Article • PLoS ONE, November 2011, PLOS

    Dr Nigel J Stevenson

  14. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility

    Article • Nature Communications, March 2011, Nature

    Dr Nigel J Stevenson

  15. Chronic hepatitis C infection blocks the ability of dendritic cells to secrete IFN-α and stimulate T-cell proliferation

    Article • Journal of Viral Hepatitis, March 2011, Wiley

    Dr Nigel J Stevenson

  16. Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11

    Article • FEBS Letters, October 2010, Wiley

    Dr Nigel J Stevenson

  17. Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection

    Article • Human Immunology, August 2010, Elsevier

    Dr Nigel J Stevenson

  18. CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression

    Article • Journal of Leukocyte Biology, October 2008, Society for Leukocyte Biology

    Dr Nigel J Stevenson

  19. Respiratory Syncytial Virus NS1 Protein Degrades STAT2 by Using the Elongin-Cullin E3 Ligase

    Article • Journal of Virology, January 2007, ASM Journals

    Prof. Ultan F Power, Dr Nigel J Stevenson

  20. Mechanisms of SOCS3 Phosphorylation upon Interleukin-6 Stimulation: CONTRIBUTIONS OF Src- AND RECEPTOR-TYROSINE KINASES

    Article • Journal of Biological Chemistry, July 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Nigel J Stevenson

  21. The Chemoattractants, IL-8 and Formyl-Methionyl-Leucyl-Phenylalanine, Regulate Granulocyte Colony-Stimulating Factor Signaling by Inducing Suppressor of Cytokine Signaling-1 Expression

    Article • The Journal of Immunology, August 2004, The American Association of Immunologists

    Dr Nigel J Stevenson