All Stories

  1. Analysis of microRNA transcription and post-transcriptional processing by Dicer in the context of CHO cell proliferation

    Article • Journal of Biotechnology, November 2014, Elsevier

    Professor Nicole Borth, Dr Vaibhav Jadhav

  2. Reducing Recon 2 for steady-state flux analysis of HEK cell culture

    Article • Journal of Biotechnology, August 2014, Elsevier

    Lars K Nielsen, Professor Nicole Borth

  3. Identification of microRNAs specific for high producer CHO cell lines using steady-state cultivation

    Article • Applied Microbiology and Biotechnology, July 2014, Springer Science + Business Media

    Professor Nicole Borth

  4. Utilization of recombinase mediated cassette exchange (RMCE) for the generation of recombinant CHO cell lines with defined expression properties

    Article • New Biotechnology, July 2014, Elsevier

    Professor Nicole Borth

  5. Development of a method to quantify genomic rearrangements in Chinese Hamster Ovary cells

    Article • New Biotechnology, July 2014, Elsevier

    Professor Nicole Borth, Dr Vaibhav Jadhav

  6. Integrative ‘-omic’ approach to explore molecular mechanism of miRNA engineered Chinese hamster ovary cell

    Article • New Biotechnology, July 2014, Elsevier

    Professor Nicole Borth

  7. Effective Fast Filtration Method for Metabolomics Studies of Mammalian Cells

    Article • New Biotechnology, July 2014, Elsevier

    Professor Nicole Borth

  8. A method to stably integrate multiple genetic elements into Chinese hamster ovary (CHO) cells

    Article • New Biotechnology, July 2014, Elsevier

    Professor Nicole Borth

  9. Reduced quenching and extraction time for mammalian cells using filtration and syringe extraction

    Article • Journal of Biotechnology, July 2014, Elsevier

    Professor Nicole Borth

  10. Characterization of a novel cell penetrating peptide derived from human Oct4

    Article • New Biotechnology, July 2014, Elsevier

    Professor Nicole Borth

  11. One plus one makes three: adding value by co‐transfection of anti‐apoptotic genes during transient gene expression

    Article • Biotechnology Journal, May 2014, Wiley

    Professor Nicole Borth

  12. Stable overexpression of miR-17 enhances recombinant protein production of CHO cells

    Article • Journal of Biotechnology, April 2014, Elsevier

    Professor Nicole Borth, Dr Vaibhav Jadhav

  13. Endogenous microRNA clusters outperform chimeric sequence clusters in Chinese hamster ovary cells

    Article • Biotechnology Journal, February 2014, Wiley

    Professor Nicole Borth, Dr Vaibhav Jadhav

  14. Construction of a Public CHO Cell Line Transcript Database Using Versatile Bioinformatics Analysis Pipelines

    Article • PLoS ONE, January 2014, PLOS

    Professor Nicole Borth

  15. Characterization of a novel cell penetrating peptide derived from human Oct4

    Article • Cell Regeneration, January 2014, Springer Science + Business Media

    Professor Nicole Borth

  16. CHO microRNA engineering is growing up: Recent successes and future challenges

    Article • Biotechnology Advances, December 2013, Elsevier

    Professor Nicole Borth, Dr Vaibhav Jadhav

  17. Chinese hamster genome sequenced from sorted chromosomes

    Article • Nature Biotechnology, August 2013, Springer Science + Business Media

    Professor Nicole Borth

  18. Prediction of transcribed PIWI-interacting RNAs from CHO RNAseq data

    Article • Journal of Biotechnology, June 2013, Elsevier

    Professor Nicole Borth

  19. Construction of a Stability Landscape of the CH3 Domain of Human IgG1 by Combining Directed Evolution with High Throughput Sequencing

    Article • Journal of Molecular Biology, October 2012, Elsevier

    Professor Nicole Borth

  20. miRNAs – pathway engineering of CHO cell factories that avoids translational burdening

    Article • Trends in Biotechnology, August 2012, Elsevier

    Professor Nicole Borth

  21. Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell lines

    Article • Journal of Biotechnology, April 2012, Elsevier

    Professor Nicole Borth, Dr Vaibhav Jadhav

  22. A screening method to assess biological effects of microRNA overexpression in Chinese hamster ovary cells

    Article • Biotechnology and Bioengineering, March 2012, Wiley

    Professor Nicole Borth, Dr Vaibhav Jadhav

  23. Utilization and evaluation of CHO‐specific sequence databases for mass spectrometry based proteomics

    Article • Biotechnology and Bioengineering, March 2012, Wiley

    Professor Nicole Borth

  24. Flow-cytometry and cell sorting: An efficient approach to investigate productivity and cell physiology in mammalian cell factories

    Article • Methods, March 2012, Elsevier

    Professor Nicole Borth

  25. The CHO miRNA Transcriptome

    Article • January 2012, Springer Science + Business Media

    Professor Nicole Borth

  26. Growth, productivity and protein glycosylation in a CHO EpoFc producer cell line adapted to glutamine-free growth

    Article • Journal of Biotechnology, January 2012, Elsevier

    Professor Nicole Borth

  27. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing

    Article • Journal of Biotechnology, December 2011, Elsevier

    Professor Nicole Borth

  28. Chinese hamster genome database: An online resource for the CHO community at www.CHOgenome.org

    Article • Biotechnology and Bioengineering, November 2011, Wiley

    Professor Nicole Borth

  29. Next-generation sequencing of the CHO cell transcriptome

    Article • BMC Proceedings, November 2011, Springer Science + Business Media

    Professor Nicole Borth

  30. Exo70, a subunit of the exocyst complex, interacts with SNEV hPrp19/hPso4 and is involved in pre-mRNA splicing

    Article • Biochemical Journal, August 2011, Portland Press Ltd.

    Professor Nicole Borth

  31. Dynamic mRNA and miRNA profiling of CHO‐K1 suspension cell cultures

    Article • Biotechnology Journal, August 2011, Wiley

    Professor Nicole Borth, Dr Vaibhav Jadhav

  32. Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: Identification, annotation and profiling of microRNAs as targets for cellular engineering

    Article • Journal of Biotechnology, April 2011, Elsevier

    Professor Nicole Borth

  33. Nucleotide and Nucleotide Sugar Analysis by Liquid Chromatography-Electrospray Ionization-Mass Spectrometry on Surface-Conditioned Porous Graphitic Carbon

    Article • Analytical Chemistry, November 2010, American Chemical Society (ACS)

    Professor Nicole Borth

  34. Selection of CHO host cell subclones with increased specific antibody production rates by repeated cycles of transient transfection and cell sorting

    Article • Biotechnology and Bioengineering, October 2010, Wiley

    Professor Nicole Borth

  35. CHO‐K1 host cells adapted to growth in glutamine‐free medium by FACS‐assisted evolution

    Article • Biotechnology Journal, October 2010, Wiley

    Professor Nicole Borth

  36. A study on the temperature dependency and time course of the cold capture antibody secretion assay

    Article • Journal of Biotechnology, April 2009, Elsevier

    Professor Nicole Borth

  37. Effect of Increased Expression of Protein Disulfide Isomerase and Heavy Chain Binding Protein on Antibody Secretion in a Recombinant CHO Cell Line

    Article • Biotechnology Progress, September 2008, Wiley

    Professor Nicole Borth

  38. Genetically different wine yeasts isolated from Austrian vine-growing regions influence wine aroma differently and contain putative hybrids between Saccharomyces cerevisiae and Saccharomyces kudriavzevii

    Article • FEMS Yeast Research, September 2007, Oxford University Press (OUP)

    Professor Nicole Borth

  39. Improvement of the energy metabolism of recombinant CHO cells by cell sorting for reduced mitochondrial membrane potential

    Article • Journal of Biotechnology, May 2007, Elsevier

    Professor Nicole Borth

  40. Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo‐Fc expressing CHO cells cultivated in controlled batch bioreactors

    Article • Biotechnology and Bioengineering, May 2006, Wiley

    Professor Nicole Borth

  41. Process parameter shifting: Part II. Biphasic cultivation—A tool for enhancing the volumetric productivity of batch processes using Epo‐Fc expressing CHO cells

    Article • Biotechnology and Bioengineering, May 2006, Wiley

    Professor Nicole Borth

  42. Nuclear Flow FISH: Isolation of cell nuclei improves the determination of telomere lengths

    Article • Experimental Gerontology, February 2006, Elsevier

    Professor Nicole Borth

  43. Establishment of a strategy for the rapid generation of a monoclonal antibody against the human protein SNEV (hNMP200) by flow-cytometric cell sorting

    Article • Journal of Immunological Methods, December 2005, Elsevier

    Professor Nicole Borth

  44. Screening for improved cell performance: Selection of subclones with altered production kinetics or improved stability by cell sorting

    Article • Biotechnology and Bioengineering, November 2004, Wiley

    Professor Nicole Borth

  45. Effects of gene dosage, promoters, and substrates on unfolded protein stress of recombinant Pichia pastoris

    Article • Biotechnology and Bioengineering, December 2003, Wiley

    Professor Nicole Borth

  46. Assessing viability and cell-associated product of recombinant protein producing Pichia pastoris with flow cytometry

    Article • Journal of Biotechnology, May 2003, Elsevier

    Professor Nicole Borth

  47. Optimization of recombinant protein expression level in Escherichia coli by flow cytometry and cell sorting

    Article • Biotechnology and Bioengineering, August 2002, Wiley

    Professor Nicole Borth

  48. Efficient selection of high-producing subclones during gene amplification of recombinant Chinese hamster ovary cells by flow cytometry and cell sorting

    Article • Biotechnology and Bioengineering, January 2002, Wiley

    Professor Nicole Borth

  49. Efficient selection of high‐producing subclones during gene amplification of recombinant Chinese hamster ovary cells by flow cytometry and cell sorting

    Article • Biotechnology and Bioengineering, December 2001, Wiley

    Professor Nicole Borth

  50. Determination of liposome size distribution by flow cytometry

    Article • Cytometry, February 2000, Wiley

    Professor Nicole Borth

  51. Determination of liposome size distribution by flow cytometry

    Article • Cytometry, February 2000, Wiley

    Professor Nicole Borth

  52. Efficient selection of high-producing subclones during gene amplification of recombinant Chinese hamster ovary cells by flow cytometry and cell sorting

    Article • Biotechnology and Bioengineering, January 2000, Wiley

    Professor Nicole Borth

  53. Flow Cytometric Analysis of Metabolic Stress Effects Due to Recombinant Plasmids and Proteins in Escherichia coli Production Strains

    Article • Metabolic Engineering, July 1999, Elsevier

    Professor Nicole Borth

  54. Changes during subclone development and ageing of human antibody-producing recombinant CHO cells

    Article • Journal of Biotechnology, April 1999, Elsevier

    Professor Nicole Borth

  55. Analysis of changes during subclone development and ageing of human antibody-producing heterohybridoma cells by Northern blot and flow cytometry1This paper was presented at the American Chemical Society Spring National Meeting in San Francisco, April 1...

    Article • Journal of Biotechnology, January 1999, Elsevier

    Professor Nicole Borth

  56. INTERFERON-α PRIMES EARLY PROLIFERATIVE RESPONSE OF BONE MARROW CELLS IN VIVO

    Article • Cytokine, March 1998, Elsevier

    Professor Nicole Borth

  57. Comparison of the production of a human monoclonal antibody against HIV-1 by heterohybridoma cells and recombinant CHO cells: A flow cytometric study

    Article • Cytotechnology, January 1996, Springer Science + Business Media

    Professor Nicole Borth

  58. Rhodamine 123 fluorescence of immortal hybridoma cell lines as a function of glucose concentration

    Article • Cytometry, January 1993, Wiley

    Professor Nicole Borth

  59. Determination of division rates of rCHO cells in high density and immobilized fermentation systems by flow cytometry

    Article • Cytotechnology, October 1992, Springer Science + Business Media

    Professor Nicole Borth

  60. Growth and production kinetics of human × mouse and mouse hybridoma cells at reduced temperature and serum content

    Article • Journal of Biotechnology, September 1992, Elsevier

    Professor Nicole Borth

  61. ADAPTATION OF rCHO CELLS TO GROWTH IN SERUM FREE MEDIUM: A FLOW CYTOMETRIC STUDY

    Article • January 1992, Elsevier

    Professor Nicole Borth

  62. A continuous multistage roller reactor for animal cell culture: 1. Patterns of growth, production and catabolism of a murine hybridoma

    Article • Cytotechnology, May 1990, Springer Science + Business Media

    Professor Nicole Borth