All Stories

  1. The topology of genome-scale metabolic reconstructions unravels independent modules and high network flexibility

    Article • PLoS Computational Biology, June 2022, PLOS

    Lars K Nielsen

  2. Production of the short peptide surfactant DAMP4 from glucose or sucrose in high cell density cultures of Escherichia coli BL21(DE3)

    Article • Microbial Cell Factories, August 2014, Springer Science + Business Media

    Lars K Nielsen

  3. Escherichia coli W shows fast, highly oxidative sucrose metabolism and low acetate formation

    Article • Applied Microbiology and Biotechnology, August 2014, Springer Science + Business Media

    Lars K Nielsen

  4. Reducing Recon 2 for steady-state flux analysis of HEK cell culture

    Article • Journal of Biotechnology, August 2014, Elsevier

    Lars K Nielsen, Professor Nicole Borth

  5. A depth-first search algorithm to compute elementary flux modes by linear programming

    Article • BMC Systems Biology, July 2014, Springer Science + Business Media

    Lars K Nielsen

  6. Control of chitin and N-acetylglucosamine utilization in Saccharopolyspora erythraea

    Article • Microbiology, July 2014, Society for General Microbiology

    Lars K Nielsen

  7. Absolute counting of neutrophils in whole blood using flow cytometry

    Article • Cytometry Part A, July 2014, Wiley

    Lars K Nielsen

  8. Network Thermodynamic Curation of Human and Yeast Genome-Scale Metabolic Models

    Article • Biophysical Journal, July 2014, Elsevier

    Lars K Nielsen

  9. Insight into hyaluronic acid molecular weight control

    Article • Applied Microbiology and Biotechnology, June 2014, Springer Science + Business Media

    Lars K Nielsen

  10. Targeted sequencing for gene discovery and quantification using RNA CaptureSeq

    Article • Nature Protocols, April 2014, Springer Science + Business Media

    Lars K Nielsen

  11. Temporal Dynamics of the Saccharopolyspora erythraea Phosphoproteome

    Article • Molecular & Cellular Proteomics, March 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Lars K Nielsen

  12. Concise Review: Next-Generation Cell Therapies to Prevent Infections in Neutropenic Patients

    Article • Stem Cells Translational Medicine, March 2014, Oxford University Press (OUP)

    Lars K Nielsen

  13. The Trehalose Phosphotransferase System (PTS) in E. coli W Can Transport Low Levels of Sucrose that Are Sufficient to Facilitate Induction of the csc Sucrose Catabolism Operon

    Article • PLoS ONE, February 2014, PLOS

    Lars K Nielsen

  14. Towards a Large Integrated Model of Signal Transduction and Gene Regulation Events in Mammalian Cells

    Article • January 2014, Scitepress

    Lars K Nielsen

  15. Allantoin catabolism influences the production of antibiotics in Streptomyces coelicolor

    Article • Applied Microbiology and Biotechnology, November 2013, Springer Science + Business Media

    Lars K Nielsen, Dr Eduardo Rodriguez

  16. Genome Scale Transcriptomics of Baculovirus-Insect Interactions

    Article • Viruses, November 2013, MDPI AG

    Lars K Nielsen, Dr Quan Hoang Nguyen

  17. Plant Genome-Scale Modeling and Implementation

    Article • October 2013, Springer Science + Business Media

    Lars K Nielsen

  18. Chemical inhibition of acetyl coenzyme A carboxylase as a strategy to increase polyhydroxybutyrate yields in transgenic sugarcane

    Article • Plant Biotechnology Journal, September 2013, Wiley

    Lars K Nielsen, Dr Richard Bruce McQualter

  19. Genome scale analysis of differential mRNA expression of Helicoverpa zea insect cells infected with a H. armigera baculovirus

    Article • Virology, September 2013, Elsevier

    Lars K Nielsen, Dr Quan Hoang Nguyen

  20. 2,2-Diphenyl-1-picrylhydrazyl as a screening tool for recombinant monoterpene biosynthesis

    Article • Microbial Cell Factories, August 2013, Springer Science + Business Media

    Lars K Nielsen

  21. Extracting reaction networks from databases-opening Pandora's box

    Article • Briefings in Bioinformatics, August 2013, Oxford University Press (OUP)

    Lars K Nielsen

  22. The Role of Hyaluronic Acid Precursor Concentrations in Molecular Weight Control in Streptococcus zooepidemicus

    Article • Molecular Biotechnology, August 2013, Springer Science + Business Media

    Lars K Nielsen

  23. The effect of cell line, phylogenetics and medium on baculovirus budded virus yield and quality

    Article • Archives of Virology, July 2013, Springer Science + Business Media

    Lars K Nielsen

  24. Enhanced Gametocyte Formation in Erythrocyte Progenitor Cells: A Site-Specific Adaptation by Plasmodium falciparum

    Article • The Journal of Infectious Diseases, July 2013, Oxford University Press (OUP)

    Lars K Nielsen

  25. Knock-in/Knock-out (KIKO) vectors for rapid integration of large DNA sequences, including whole metabolic pathways, onto the Escherichia coli chromosome at well-characterised loci

    Article • Microbial Cell Factories, June 2013, Springer Science + Business Media

    Lars K Nielsen, Suriana Sabri

  26. DNase I–hypersensitive exons colocalize with promoters and distal regulatory elements

    Article • Nature Genetics, June 2013, Springer Science + Business Media

    Lars K Nielsen

  27. Technoeconomic analysis of renewable aviation fuel from microalgae,Pongamia pinnata, and sugarcane

    Article • Biofuels Bioproducts and Biorefining, April 2013, Wiley

    Lars K Nielsen

  28. Plant genome-scale metabolic reconstruction and modelling

    Article • Current Opinion in Biotechnology, April 2013, Elsevier

    Lars K Nielsen

  29. Physiological and Transcriptional Responses of Saccharomyces cerevisiae tod-Limonene Show Changes to the Cell Wall but Not to the Plasma Membrane

    Article • Applied and Environmental Microbiology, March 2013, ASM Journals

    Lars K Nielsen

  30. Non-Invasive Monitoring of Sucrose Mobilization from Culm Storage Parenchyma by Magnetic Resonance Spectroscopy

    Article • Bioscience Biotechnology and Biochemistry, March 2013, Taylor & Francis

    Lars K Nielsen

  31. Decline in baculovirus-expressed recombinant protein production with increasing cell density is strongly correlated to impairment of virus replication and mRNA expression

    Article • Applied Microbiology and Biotechnology, March 2013, Springer Science + Business Media

    Lars K Nielsen

  32. Saccharopolyspora erythraea’sgenome is organised in high-order transcriptional regions mediated by targeted degradation at the metabolic switch

    Article • BMC Genomics, January 2013, Springer Science + Business Media

    Lars K Nielsen

  33. Engineered Quorum Sensing Using Pheromone-Mediated Cell-to-Cell Communication in Saccharomyces cerevisiae

    Article • ACS Synthetic Biology, January 2013, American Chemical Society (ACS)

    Lars K Nielsen

  34. Dual gene expression cassette vectors with antibiotic selection markers for engineering in Saccharomyces cerevisiae

    Article • Microbial Cell Factories, January 2013, Springer Science + Business Media

    Lars K Nielsen

  35. Re-annotation of the Saccharopolyspora erythraea genome using a systems biology approach

    Article • BMC Genomics, January 2013, Springer Science + Business Media

    Lars K Nielsen

  36. RNAi-mediated abrogation of trehalase expression does not affect trehalase activity in sugarcane

    Article • SpringerPlus, December 2012, Springer Science + Business Media

    Lars K Nielsen

  37. Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption

    Article • Biotechnology and Bioengineering, November 2012, Wiley

    Lars K Nielsen

  38. Molecular Control of Sucrose Utilization in Escherichia coli W, an Efficient Sucrose-Utilizing Strain

    Article • Applied and Environmental Microbiology, November 2012, ASM Journals

    Lars K Nielsen, Suriana Sabri, Professor Claudia Vickers

  39. Engineering and adaptive evolution of Escherichia coli for d-lactate fermentation reveals GatC as a xylose transporter

    Article • Metabolic Engineering, September 2012, Elsevier

    Lars K Nielsen

  40. A transferable sucrose utilization approach for non-sucrose-utilizing Escherichia coli strains

    Article • Biotechnology Advances, September 2012, Elsevier

    Lars K Nielsen

  41. A Multi-Omics Analysis of Recombinant Protein Production in Hek293 Cells

    Article • PLoS ONE, August 2012, PLOS

    Lars K Nielsen

  42. PATHLOGIC-S: A Scalable Boolean Framework for Modelling Cellular Signalling

    Article • PLoS ONE, August 2012, PLOS

    Lars K Nielsen

  43. Suspension culture titration: A simple method for measuring baculovirus titers

    Article • Journal of Virological Methods, August 2012, Elsevier

    Lars K Nielsen

  44. Reconstruction of the Saccharopolyspora erythraea genome-scale model and its use for enhancing erythromycin production

    Article • Antonie van Leeuwenhoek, July 2012, Springer Science + Business Media

    Lars K Nielsen

  45. Bioreactor for Blood Product Production

    Article • Cell Transplantation, June 2012, SAGE Publications

    Lars K Nielsen

  46. Alleviating monoterpene toxicity using a two-phase extractive fermentation for the bioproduction of jet fuel mixtures in Saccharomyces cerevisiae

    Article • Biotechnology and Bioengineering, May 2012, Wiley

    Lars K Nielsen

  47. Transcriptome Sequencing of and Microarray Development for a Helicoverpa zea Cell Line to Investigate In Vitro Insect Cell-Baculovirus Interactions

    Article • PLoS ONE, May 2012, PLOS

    Lars K Nielsen, Dr Quan Hoang Nguyen

  48. Metabolite profiling of CHO cells with different growth characteristics

    Article • Biotechnology and Bioengineering, March 2012, Wiley

    Lars K Nielsen

  49. Improving the robustness of a low-cost insect cell medium for baculovirus biopesticides production, via hydrolysate streamlining using a tube bioreactor-based statistical optimization routine

    Article • Biotechnology Progress, March 2012, Wiley

    Lars K Nielsen

  50. Sucrose Mobilisation in Sugarcane Stalk Induced by Heterotrophic Axillary Bud Growth

    Article • Tropical Plant Biology, March 2012, Springer Science + Business Media

    Lars K Nielsen

  51. Development of quenching and washing protocols for quantitative intracellular metabolite analysis of uninfected and baculovirus-infected insect cells

    Article • Methods, March 2012, Elsevier

    Lars K Nielsen

  52. Enhanced polyhydroxybutyrate production in transgenic sugarcane

    Article • Plant Biotechnology Journal, February 2012, Wiley

    Lars K Nielsen, Dr Richard Bruce McQualter

  53. Mammalian cells as biopharmaceutical production hosts in the age of omics

    Article • Biotechnology Journal, December 2011, Wiley

    Lars K Nielsen

  54. Deletion of cscR in Escherichia coli W improves growth and poly-3-hydroxybutyrate (PHB) production from sucrose in fed batch culture

    Article • Journal of Biotechnology, December 2011, Elsevier

    Lars K Nielsen, Suriana Sabri

  55. Manufactured RBC — Rivers of blood, or an oasis in the desert?

    Article • Biotechnology Advances, November 2011, Elsevier

    Lars K Nielsen

  56. Ultra-High-Yield Manufacture of Red Blood Cells from Hematopoietic Stem Cells

    Article • Tissue Engineering Part C Methods, November 2011, Mary Ann Liebert Inc

    Lars K Nielsen

  57. Metabolic Pathway Engineering for Hyaluronic Ac id Production

    Article • October 2011, Taylor & Francis

    Lars K Nielsen

  58. HR Index-A Simple Method for the Prediction of Oxygen Uptake

    Article • Medicine & Science in Sports & Exercise, October 2011, Wolters Kluwer Health

    Lars K Nielsen

  59. Deep sequencing-based transcriptome analysis of Plutella xylostella larvae parasitized by Diadegma semiclausum

    Article • BMC Genomics, September 2011, Springer Science + Business Media

    Lars K Nielsen

  60. Quantification of l-alanyl-l-glutamine in mammalian cell culture broth: Evaluation of different detectors

    Article • Analytical Biochemistry, September 2011, Elsevier

    Lars K Nielsen

  61. Synthesis of Short-Chain-Length/Medium-Chain Length Polyhydroxyalkanoate (PHA) Copolymers in Peroxisomes of Transgenic Sugarcane Plants

    Article • Tropical Plant Biology, August 2011, Springer Science + Business Media

    Lars K Nielsen

  62. In vitro production of Helicoverpa baculovirus biopesticides—Automated selection of insect cell clones for manufacturing and systems biology studies

    Article • Journal of Virological Methods, August 2011, Elsevier

    Lars K Nielsen, Dr Quan Hoang Nguyen

  63. Metabolomic Analysis of CHO Cultures with Different Growth Characteristics – Development of a Metabolite Extraction Protocol for Suspension Adapted Mammalian Cells

    Article • July 2011, Springer Science + Business Media

    Lars K Nielsen

  64. Large Scale Ex Vivo Manufacture of Blood Cells

    Article • July 2011, Springer Science + Business Media

    Lars K Nielsen

  65. From retrofitting to green field

    Article • Nature Chemical Biology, June 2011, Springer Science + Business Media

    Lars K Nielsen

  66. Metabolic and practical considerations on microbial electrosynthesis

    Article • Current Opinion in Biotechnology, June 2011, Elsevier

    Lars K Nielsen

  67. Kinetic characterization of the group II helicoverpa armigera nucleopolyhedrovirus propagated in suspension cell cultures: Implications for development of a biopesticides production process

    Article • Biotechnology Progress, April 2011, Wiley

    Lars K Nielsen

  68. Short-term exposure of umbilical cord blood CD34+ cells to granulocyte–macrophage colony-stimulating factor early in culture improves ex vivo expansion of neutrophils

    Article • Cytotherapy, March 2011, Elsevier

    Lars K Nielsen

  69. Engineering a mammalian super producer

    Article • Journal of Chemical Technology & Biotechnology, February 2011, Wiley

    Lars K Nielsen

  70. Altered Fatty Acid Metabolism in Long Duration Road Transport: An NMR-based Metabonomics Study in Sheep

    Article • Journal of Proteome Research, January 2011, American Chemical Society (ACS)

    Lars K Nielsen

  71. The genome sequence of E. coli W (ATCC 9637): comparative genome analysis and an improved genome-scale reconstruction of E. coli

    Article • BMC Genomics, January 2011, Springer Science + Business Media

    Lars K Nielsen, Professor Sang Yup Lee

  72. AlgaGEM – a genome-scale metabolic reconstruction of algae based on the Chlamydomonas reinhardtii genome

    Article • BMC Genomics, January 2011, Springer Science + Business Media

    Lars K Nielsen

  73. C4GEM, a Genome-Scale Metabolic Model to Study C4 Plant Metabolism

    Article • PLANT PHYSIOLOGY, October 2010, American Society of Plant Biologists (ASPB)

    Lars K Nielsen

  74. The ascorbic acid paradox

    Article • Biochemical and Biophysical Research Communications, October 2010, Elsevier

    Lars K Nielsen

  75. Towards quantitative metabolomics of mammalian cells: Development of a metabolite extraction protocol

    Article • Analytical Biochemistry, September 2010, Elsevier

    Lars K Nielsen

  76. Development of sucrose-utilizing Escherichia coli K-12 strain by cloning β-fructofuranosidases and its application for l-threonine production

    Article • Applied Microbiology and Biotechnology, August 2010, Springer Science + Business Media

    Lars K Nielsen, Professor Sang Yup Lee

  77. Membrane Bioreactors Enhance Microenvironmental Conditioning and Tissue Development

    Article • Tissue Engineering Part C Methods, June 2010, Mary Ann Liebert Inc

    Lars K Nielsen

  78. Baculovirus Kinetics, Insect Cell Culture

    Article • April 2010, Wiley

    Lars K Nielsen

  79. Metabolic flux analysis in mammalian cell culture

    Article • Metabolic Engineering, March 2010, Elsevier

    Lars K Nielsen

  80. Production of bacteriocins byStreptococcus bovisstrains from Australian ruminants

    Article • Journal of Applied Microbiology, February 2010, Wiley

    Lars K Nielsen

  81. Tissue transplantation by stealth—Coherent alginate microcapsules for immunoisolation

    Article • Biochemical Engineering Journal, February 2010, Elsevier

    Lars K Nielsen

  82. Understanding plasmid effect on hyaluronic acid molecular weight produced by Streptococcus equi subsp. zooepidemicus

    Article • Metabolic Engineering, January 2010, Elsevier

    Lars K Nielsen

  83. AraGEM, a Genome-Scale Reconstruction of the Primary Metabolic Network in Arabidopsis

    Article • PLANT PHYSIOLOGY, December 2009, American Society of Plant Biologists (ASPB)

    Lars K Nielsen

  84. Properties of a unique mutant of Helicoverpa armigera single-nucleocapsid nucleopolyhedrovirus that exhibits a partial Many Polyhedra and Few Polyhedra phenotype upon extended serial passaging in suspension cell cultures

    Article • In Vitro Cellular & Developmental Biology - Animal, January 2005, Springer Science + Business Media

    Lars K Nielsen

  85. PROPERTIES OF A UNIQUE MUTANT OF HELICOVERPA ARMIGERA SINGLE-NUCLEOCAPSID NUCLEOPOLYHEDROVIRUS THAT EXHIBITS A PARTIAL MANY POLYHEDRA AND FEW POLYHEDRA PHENOTYPE ON EXTENDED SERIAL PASSAGING IN SUSPENSION CELL CULTURES

    Article • In Vitro Cellular & Developmental Biology - Animal, January 2005, Springer Science + Business Media

    Lars K Nielsen