All Stories

  1. Cirrhosis in Hemochromatosis: Independent Risk Factors in 368 HFE p.C282Y Homozygotes

    Article • Annals of Hepatology, August 2018, Index Copernicus

    Professor Nathan Subramaniam

  2. Hemochromatosis: Evaluation of the dietary iron model and regulation of hepcidin

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, August 2018, Elsevier

    Professor Nathan Subramaniam

  3. Phenotypic analysis of hemochromatosis subtypes reveals variations in severity of iron overload and clinical disease

    Article • Blood, May 2018, American Society of Hematology

    Professor Nathan Subramaniam

  4. Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease

    Article • Hepatology Communications, April 2018, Wiley

    Professor Nathan Subramaniam

  5. Evaluation of a bone morphogenetic protein 6 variant as a cause of iron loading

    Article • Human Genomics, April 2018, Springer Science + Business Media

    Professor Nathan Subramaniam

  6. Reversal of end-stage heart failure in juvenile hemochromatosis with iron chelation therapy: a case report

    Article • Journal of Medical Case Reports, January 2018, Springer Science + Business Media

    Professor Nathan Subramaniam

  7. Ferroportin Expression in Adipocytes Does Not Contribute to Iron Homeostasis or Metabolic Responses to a High Calorie Diet

    Article • Cellular and Molecular Gastroenterology and Hepatology, January 2018, Elsevier

    Professor Nathan Subramaniam

  8. Iron Inhibits the Secretion of Apolipoprotein E in Cultured Human Adipocytes

    Article • Cellular and Molecular Gastroenterology and Hepatology, January 2018, Elsevier

    Professor Nathan Subramaniam

  9. The relationship between systemic iron homeostasis and erythropoiesis

    Article • Bioscience Reports, November 2017, Portland Press Ltd.

    Professor Nathan Subramaniam

  10. The liver in regulation of iron homeostasis

    Article • AJP Gastrointestinal and Liver Physiology, September 2017, American Physiological Society

    Professor Nathan Subramaniam

  11. The dynamics of hepcidin-ferroportin internalization and consequences of a novel ferroportin disease mutation

    Article • American Journal of Hematology, July 2017, Wiley

    Professor Nathan Subramaniam

  12. GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes

    Article • Blood Cells Molecules and Diseases, March 2017, Elsevier

    Professor Nathan Subramaniam

  13. Reply:

    Article • Hepatology, February 2017, Wiley

    Professor Nathan Subramaniam

  14. Ironing out Steatohepatitis

    Article • Annals of Hepatology, January 2017, Elsevier

    Professor Nathan Subramaniam

  15. Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice

    Article • World Journal of Gastrointestinal Pathophysiology, January 2017, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Professor Nathan Subramaniam

  16. The functional roles of T-cadherin in mammalian biology

    Article • AIMS Molecular Science, January 2017, American Institute of Mathematical Sciences (AIMS)

    Professor Nathan Subramaniam

  17. Genetic Variants in the BMP6 Pro-Peptide May Not Cause Iron Loading and Should Be Interpreted With Caution

    Article • Gastroenterology, October 2016, Elsevier

    Professor Nathan Subramaniam

  18. Pocket-sized iron regulators: one size fits all?

    Article • Blood, July 2016, American Society of Hematology

    Professor Nathan Subramaniam

  19. Hematopoietic deletion of transferrin receptor 2 in mice leads to a block in erythroid differentiation during iron-deficient anemia

    Article • American Journal of Hematology, June 2016, Wiley

    Professor Nathan Subramaniam

  20. Heterozygous Hfe gene deletion leads to impaired glucose homeostasis, but not liver injury in mice fed a high-calorie diet

    Article • Physiological Reports, June 2016, Wiley

    Professor Nathan Subramaniam

  21. Probiotics modify tight-junction proteins in an animal model of nonalcoholic fatty liver disease

    Article • Therapeutic Advances in Gastroenterology, May 2016, SAGE Publications

    Dr luis vitetta, Professor Nathan Subramaniam

  22. Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, April 2016, Elsevier

    Professor Nathan Subramaniam

  23. Reply

    Article • Hepatology, March 2016, Wiley

    Professor Nathan Subramaniam

  24. Iron and non-alcoholic fatty liver disease

    Article • World Journal of Gastroenterology, January 2016, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Professor Nathan Subramaniam

  25. Reply

    Article • Hepatology, December 2015, Wiley

    Professor Nathan Subramaniam

  26. The global prevalence of HFE and non-HFE hemochromatosis estimated from analysis of next-generation sequencing data

    Article • Genetics in Medicine, December 2015, Nature

    Professor Nathan Subramaniam

  27. Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2

    Article • AJP Gastrointestinal and Liver Physiology, November 2015, American Physiological Society

    Professor Nathan Subramaniam

  28. Next-generation sequencing: Application of a novel platform to analyze atypical iron disorders

    Article • Journal of Hepatology, November 2015, Elsevier

    Professor Nathan Subramaniam

  29. Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin

    Article • Scientific Reports, September 2015, Nature

    Professor Nathan Subramaniam

  30. Reply

    Article • Hepatology, June 2015, Wiley

    Professor Nathan Subramaniam

  31. Hepcidin: regulation of the master iron regulator

    Article • Bioscience Reports, May 2015, Portland Press Ltd.

    Professor Nathan Subramaniam

  32. Exome sequencing inHFEC282Y homozygous men with extreme phenotypes identifies aGNPATvariant associated with severe iron overload

    Article • Hepatology, March 2015, Wiley

    Professor Nathan Subramaniam

  33. Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox

    Article • Journal of Gastroenterology and Hepatology, February 2015, Wiley

    Professor Nathan Subramaniam

  34. Functional analysis of matriptase-2 mutations and domains: insights into the molecular basis of iron-refractory iron deficiency anemia

    Article • AJP Cell Physiology, January 2015, American Physiological Society

    Professor Nathan Subramaniam

  35. Analysis of IL-22 contribution to hepcidin induction and hypoferremia during the response to LPS in vivo

    Article • International Immunology, January 2015, Oxford University Press (OUP)

    Professor Nathan Subramaniam

  36. A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction

    Article • British Journal of Haematology, November 2014, Wiley

    Professor Nathan Subramaniam

  37. Hepatology Clinical

    Article • Journal of Gastroenterology and Hepatology, October 2014, Wiley

    Professor Nathan Subramaniam

  38. IBD Clinical

    Article • Journal of Gastroenterology and Hepatology, October 2014, Wiley

    Professor Nathan Subramaniam

  39. Luminal Clinical

    Article • Journal of Gastroenterology and Hepatology, October 2014, Wiley

    Professor Nathan Subramaniam

  40. Linking hypoxia and iron homeostasis: a ‘plate’ full of factors

    Article • Gut, April 2014, BMJ

    Professor Nathan Subramaniam

  41. Lack of efficacy of mTOR inhibitors and ACE pathway inhibitors as antifibrotic agents in evolving and established fibrosis in Mdr2 −/− mice

    Article • Liver International, March 2014, Wiley

    Professor Nathan Subramaniam

  42. Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB

    Article • Gut, March 2014, BMJ

    Professor Nathan Subramaniam

  43. Parenteral vs. oral iron: influence on hepcidin signaling pathways through analysis of Hfe/Tfr2-null mice

    Article • AJP Gastrointestinal and Liver Physiology, November 2013, American Physiological Society

    Professor Nathan Subramaniam

  44. Inside Li

    Article • Laboratory Investigation, November 2013, Springer Science + Business Media

    Professor Nathan Subramaniam

  45. Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury

    Article • Laboratory Investigation, October 2013, Springer Science + Business Media

    Professor Nathan Subramaniam

  46. In Situ Proximity Ligation Assays Indicate That Hemochromatosis Proteins Hfe and Transferrin Receptor 2 (Tfr2) Do Not Interact

    Article • PLoS ONE, October 2013, PLOS

    Professor Nathan Subramaniam

  47. IBD Clinical

    Article • Journal of Gastroenterology and Hepatology, September 2013, Wiley

    Professor Nathan Subramaniam

  48. Luminal Clinical

    Article • Journal of Gastroenterology and Hepatology, September 2013, Wiley

    Professor Nathan Subramaniam

  49. Author Index

    Article • Journal of Gastroenterology and Hepatology, September 2013, Wiley

    Professor Nathan Subramaniam

  50. Basic Science Luminal

    Article • Journal of Gastroenterology and Hepatology, September 2013, Wiley

    Professor Nathan Subramaniam

  51. Motility/Neurogastroenterology

    Article • Journal of Gastroenterology and Hepatology, September 2013, Wiley

    Professor Nathan Subramaniam

  52. Transthyretin-thyroid hormone internalization by trophoblasts

    Article • Placenta, August 2013, Elsevier

    Professor Nathan Subramaniam

  53. Iron storage disease in Asia-Pacific populations: The importance of non-HFEmutations

    Article • Journal of Gastroenterology and Hepatology, June 2013, Wiley

    Professor Nathan Subramaniam

  54. A Corn Oil-Based Diet Protects Against Combined Ethanol and Iron-Induced Liver Injury in a Mouse Model of Hemochromatosis

    Article • Alcoholism Clinical and Experimental Research, June 2013, Wiley

    Professor Nathan Subramaniam

  55. Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitment

    Article • Cell Cycle, March 2013, Taylor & Francis

    Professor Nathan Subramaniam

  56. Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis

    Article • World Journal of Gastroenterology, January 2013, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Professor Nathan Subramaniam

  57. Hepatic Iron Deposition Does Not Predict Extrahepatic Iron Loading in Mouse Models of Hereditary Hemochromatosis

    Article • American Journal Of Pathology, October 2012, Elsevier

    Professor Nathan Subramaniam

  58. Iron Predicts Tolerance in Liver Transplantation

    Article • Gastroenterology, September 2012, Elsevier

    Professor Nathan Subramaniam

  59. A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity

    Article • Gut, July 2012, BMJ

    Professor Nathan Subramaniam

  60. Non-HFE Hemochromatosis

    Article • November 2011, Springer Science + Business Media

    Professor Nathan Subramaniam

  61. The Control of Iron Homeostasis: microRNAS Join the Party

    Article • Gastroenterology, October 2011, Elsevier

    Professor Nathan Subramaniam

  62. Altered lipid metabolism in Hfe-knockout mice promotes severe NAFLD and early fibrosis

    Article • AJP Gastrointestinal and Liver Physiology, August 2011, American Physiological Society

    Professor Nathan Subramaniam

  63. G80S-linked ferroportin disease: Classical ferroportin disease in an Asian family and reclassification of the mutant as iron transport defective

    Article • Journal of Hepatology, March 2011, Elsevier

    Professor Nathan Subramaniam

  64. Iron loading and oxidative stress in the Atm-/- mouse liver

    Article • AJP Gastrointestinal and Liver Physiology, February 2011, American Physiological Society

    Professor Nathan Subramaniam

  65. Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2

    Article • Blood, January 2011, American Society of Hematology

    Professor Nathan Subramaniam

  66. Syntaxin 5 Is Required for Copper Homeostasis in Drosophila and Mammals

    Article • PLoS ONE, December 2010, PLOS

    Professor Nathan Subramaniam, Philip Batterham

  67. Transferrin Receptor 1: A Ferritin Receptor as Well?

    Article • Gastroenterology, September 2010, Elsevier

    Professor Nathan Subramaniam

  68. Increased Iron Stores Correlate with Worse Disease Outcomes in a Mouse Model of Schistosomiasis Infection

    Article • PLoS ONE, March 2010, PLOS

    Professor Nathan Subramaniam

  69. Centrobin regulates the assembly of functional mitotic spindles

    Article • Oncogene, March 2010, Nature

    Professor Nathan Subramaniam

  70. Identification of Ferritin Receptors: Their Role in Iron Homeostasis, Hepatic Injury, and Inflammation

    Article • Gastroenterology, November 2009, Elsevier

    Professor Nathan Subramaniam

  71. Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype

    Article • AJP Cell Physiology, October 2009, American Physiological Society

    Professor Nathan Subramaniam

  72. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload

    Article • Hepatology, October 2009, Wiley

    Dr David M Frazer, Professor Nathan Subramaniam

  73. Hepcidin Regulation by HFE and TFR2: Is It Enough to Give a Hepatocyte a Complex?

    Article • Gastroenterology, September 2009, Elsevier

    Professor Nathan Subramaniam

  74. Co-factors in liver disease: The role of HFE-related hereditary hemochromatosis and iron

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, July 2009, Elsevier

    Professor Nathan Subramaniam

  75. Carrier-Mediated Thyroid Hormone Transport into Placenta by Placental Transthyretin

    Article • The Journal of Clinical Endocrinology & Metabolism, July 2009, Endocrine Society

    Professor Nathan Subramaniam

  76. Regulation of Iron Homeostasis: Is It All in the HBD?

    Article • Gastroenterology, April 2009, Elsevier

    Professor Nathan Subramaniam

  77. Juvenile iron overload—Advances, but no answers

    Article • The Journal of Pediatrics, October 2008, Elsevier

    Professor Nathan Subramaniam

  78. Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis

    Article • Hepatology, September 2008, Wiley

    Professor Nathan Subramaniam

  79. Lymphotoxin-β receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury

    Article • Hepatology, August 2008, Wiley

    Professor Nathan Subramaniam

  80. Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression

    Article • Journal of Molecular Medicine, June 2008, Springer Science + Business Media

    Professor Nathan Subramaniam

  81. How much iron is too much?

    Article • Expert Review of Gastroenterology & Hepatology, June 2008, Taylor & Francis

    Dr David M Frazer, Professor Nathan Subramaniam

  82. Defective trafficking and localization of mutated transferrin receptor 2: implications for type 3 hereditary hemochromatosis

    Article • AJP Cell Physiology, December 2007, American Physiological Society

    Professor Nathan Subramaniam

  83. A novel mutation in ferroportin implicated in iron overload

    Article • Journal of Hepatology, May 2007, Elsevier

    Professor Nathan Subramaniam

  84. [119] TARGETED DISRUPTION OF THE HEPATIC TRANSFERRIN RECEPTOR 2 GENE IN MICE LEADS TO IRON OVERLOAD

    Article • Journal of Hepatology, April 2007, Elsevier

    Professor Nathan Subramaniam

  85. Targeted Disruption of the Hepatic Transferrin Receptor 2 Gene in Mice Leads to Iron Overload

    Article • Gastroenterology, January 2007, Elsevier

    Professor Nathan Subramaniam

  86. The Clinical Relevance of Compound Heterozygosity for the C282Y and H63D Substitutions in Hemochromatosis

    Article • Clinical Gastroenterology and Hepatology, November 2006, Elsevier

    Professor Nathan Subramaniam

  87. Clinical expression of C282Y homozygous HFE haemochromatosis at 14 years of age

    Article • Annals of Clinical Biochemistry International Journal of Laboratory Medicine, May 2006, SAGE Publications

    Professor Nathan Subramaniam

  88. Screening for Hemochromatosis in Asymptomatic Subjects With or Without a Family History

    Article • Archives of Internal Medicine, February 2006, American Medical Association (AMA)

    Professor Nathan Subramaniam

  89. Purification and partial characterisation of recombinant human hepcidin

    Article • Biochimie, January 2006, Elsevier

    Professor Nathan Subramaniam

  90. Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes

    Article • Journal of Hepatology, October 2005, Elsevier

    Professor Nathan Subramaniam

  91. Ferroportin disease due to the A77D mutation in Australia

    Article • Gut, July 2005, BMJ

    Professor Nathan Subramaniam

  92. First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin

    Article • Gut, July 2005, BMJ

    Professor Nathan Subramaniam

  93. Identification of ferroportin disease in the Indian subcontinent

    Article • Gut, April 2005, BMJ

    Professor Nathan Subramaniam

  94. Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus

    Article • Journal of Cell Science, February 2005, The Company of Biologists

    Professor Nathan Subramaniam

  95. HFE gene and hemochromatosis

    Article • Journal of Gastroenterology and Hepatology, June 2004, Wiley

    Professor Nathan Subramaniam

  96. Autosomal dominant iron overload due to a novel mutation of ferroportin1 associated with parenchymal iron loading and cirrhosis

    Article • Journal of Hepatology, April 2004, Elsevier

    Professor Nathan Subramaniam

  97. Inactivation of the murineTransferrin Receptor 2 gene using the Cre recombinase:LoxP system

    Article • genesis, January 2004, Wiley

    Professor Nathan Subramaniam

  98. A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient

    Article • Gut, August 2003, BMJ

    Professor Nathan Subramaniam

  99. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis

    Article • The Lancet, February 2003, Elsevier

    Dr David M Frazer, Professor Nathan Subramaniam

  100. Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis

    Article • Blood, June 2002, American Society of Hematology

    Professor Nathan Subramaniam

  101. Frequency of the S65C mutation of HFE and iron overload in 309 subjects heterozygous for C282Y

    Article • Journal of Hepatology, April 2002, Elsevier

    Professor Nathan Subramaniam

  102. Molecular and Cellular Characterization of Transferrin Receptor 2

    Article • Cell Biochemistry and Biophysics, January 2002, Springer Science + Business Media

    Professor Nathan Subramaniam

  103. Role of p97 and Syntaxin 5 in the Assembly of Transitional Endoplasmic Reticulum

    Article • Molecular Biology of the Cell, August 2000, American Society for Cell Biology (ASCB)

    Professor Nathan Subramaniam

  104. Haemochromatosis in the new millenium

    Article • Journal of Hepatology, January 2000, Elsevier

    Professor Nathan Subramaniam

  105. cDNA Characterization and Chromosomal Mapping of Human Golgi SNARE GS27 and GS28 to Chromosome 17

    Article • Genomics, April 1999, Elsevier

    Professor Nathan Subramaniam

  106. A 29-Kilodalton Golgi SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Vti1-rp2) Implicated in Protein Trafficking in the Secretory Pathway

    Article • Journal of Biological Chemistry, August 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Nathan Subramaniam

  107. The Mammalian Protein (rbet1) Homologous to Yeast Bet1p Is Primarily Associated with the Pre-Golgi Intermediate Compartment and Is Involved in Vesicular Transport from the Endoplasmic Reticulum to the Golgi Apparatus

    Article • Journal of Cell Biology, December 1997, Rockefeller University Press

    Professor Nathan Subramaniam

  108. Article • Nature, October 1997, Nature

    Professor Nathan Subramaniam

  109. N-Ethylmaleimide-sensitive Factor (NSF) and  -Soluble NSF Attachment Proteins (SNAP) Mediate Dissociation of GS28-Syntaxin 5 Golgi SNAP Receptors (SNARE) Complex

    Article • Journal of Biological Chemistry, October 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Nathan Subramaniam

  110. GS15, a 15-Kilodalton Golgi SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (SNARE) Homologous to rbet1

    Article • Journal of Biological Chemistry, August 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Nathan Subramaniam

  111. GS28, a 28-Kilodalton Golgi SNARE That Participates in ER-Golgi Transport

    Article • Science, May 1996, American Association for the Advancement of Science

    Professor Nathan Subramaniam

  112. cDNA Cloning and Characterization of Rat Salivary Glycoproteins. Novel Members of the Proline-Rich-Protein Multigene Families

    Article • European Journal of Biochemistry, March 1995, Wiley

    Professor Nathan Subramaniam

  113. cDNA Cloning and Characterization of Rat Salivary Glycoproteins. Novel Members of the Proline-Rich-Protein Multigene Families

    Article • European Journal of Biochemistry, March 1995, Wiley

    Professor Nathan Subramaniam

  114. cDNA Cloning and Characterization of Rat Salivary Glycoproteins. Novel Members of the Proline-Rich-Protein Multigene Families

    Article • European Journal of Biochemistry, March 1995, Wiley

    Professor Nathan Subramaniam