All Stories

  1. Ganoderic acid A targets IL-1R1 and disrupts IL-1β binding in human cancer cells
  2. In-silico investigations of novel tacrine derivatives potency against Alzheimer's disease
  3. Inhibition of respiratory syncytial virus by Daclatasvir and its derivatives: synthesis of computational derivatives as a new drug development
  4. Explainable artificial intelligence-assisted virtual screening and bioinformatics approaches for effective bioactivity prediction of phenolic cyclooxygenase-2 (COX-2) inhibitors using PubChem molecular fingerprints
  5. Potential honey bee (Apis mellifera) allergens associated with IgE-mediated allergy- An In-silico study
  6. Fullerene (C60) Supplementation Stimulated Anammox Granules at Low Doses and Inhibition Occurred at High Doses: Phenomenon and Mechanism
  7. Development and optimization of film forming non-pressurized liquid bandage for wound healing by Box-Behnken statistical design
  8. Cheminformatics-based discovery of new organoselenium compounds with potential for the treatment of cutaneous and visceral leishmaniasis
  9. Identification of novel dual acting ligands targeting the adenosine A2A and serotonin 5-HT1A receptors
  10. Relationship between gut microbiota dysbiosis and immune indicator in children with sepsis
  11. Preparation of LSPR enhanced Z-scheme Pd/WO3@SnO2 for photocatalytic decomposition of organic compounds under simulated sunlight
  12. Promising Experimental Anti-SARS-CoV-2 Agent “SLL-0197800”: The Prospective Universal Inhibitory Properties against the Coming Versions of the Coronavirus
  13. Combination of Synonymous and Missense Mutations in JAK3 Gene Contributes to Severe Combined Immunodeficiency in One Child
  14. Metformin as a promising target for DPP4 expression: computational modeling and experimental validation
  15. CTLA-4 and ovarian cancer residual tumors: the dark side of debulking surgery
  16. In-silico screening of Acacia pennata and Bridelia retusa reveals pinocembrin-7-O-β-D-glucopyranoside as a promising β-lactamase inhibitor to combat antibiotic resistance
  17. Potential Effect of Baobab’s Polyphenols as Antihyperlipidemic Agents: In Silico Study
  18. Acute necrotizing encephalopathy in children with COVID-19: a retrospective study of 12 cases
  19. Immune Checkpoint Inhibitors: Recent Clinical Advances and Future Prospects
  20. Molecular interactions, binding stability, and synergistic inhibition on Acetylcholinesterase activity of Safranin O in combination with Quercetin and Gallic acid: In vitro and in silico study
  21. Molecular modeling study of micro and nanocurcumin with in vitro and in vivo antibacterial validation
  22. Interplay between LPL and GPIHBP1 in COVID-19 patients: a possible mechanism for post-recovery cardiomyopathy
  23. Microplastics in canned, salt-dried, and instant sea cucumbers sold for human consumption
  24. Molecular dynamic and bioinformatic studies of metformin-induced ACE2 phosphorylation in the presence of different SARS-CoV-2 S protein mutations
  25. Constituents of Stachys plants as potential dual inhibitors of AChE and NMDAR for the treatment of Alzheimer’s disease: a molecular docking and dynamic simulation study
  26. Syphilis mimetic nanoparticles for cuproptosis-based synergistic cancer therapy via reprogramming copper metabolism
  27. Dual synergistic inhibition of COX and LOX by potential chemicals from Indian daily spices investigated through detailed computational studies
  28. Synthesis, characterization, antimicrobial studies, and molecular docking studies of transition metal complexes formed from a benzothiazole-based azo ligand
  29. Synthesis, characterization, antimicrobial studies, and molecular docking studies of transition metal complexes formed from a benzothiazole-based azo ligand
  30. Exploring particulate methane monooxygenase (pMMO) proteins using experimentation and computational molecular docking
  31. N ‐Aroyl‐ N′ ‐(1‐Naphthyl)‐ N′′ ‐aryl guanidines as a New Entry to Urease Inhibitors: Synthesis, Kinetic Mechanism, Molecular Docking and MD Simulation Studies
  32. Revisiting macrophages in ovarian cancer microenvironment: development, function and interaction
  33. Structure-Based Virtual Screening, Molecular Docking, Molecular Dynamics Simulation of EGFR for the Clinical Treatment of Glioblastoma
  34. Threat of respiratory syncytial virus infection knocking the door: a proposed potential drug candidate through molecular dynamics simulations, a future alternative
  35. Study on Molecular Anti-tumor Mechanism of 2-Thiohydantoin Derivative based on Molecular Docking and Bioinformatic Analyses
  36. GC-MS Based Metabolite Profiling, and Anti-Inflammatory Activity of Aqueous Extract of Myrica esculenta through In Vitro and In Silico Approach
  37. Distinct roles of carbohydrate-binding modules in multidomain β-1,3–1,4-glucanase on polysaccharide degradation
  38. Remodeling articular immune homeostasis with an efferocytosis-informed nanoimitator mitigates rheumatoid arthritis in mice
  39. Multi-target molecular dynamic simulations reveal glutathione-S-transferase as the most favorable drug target of knipholone in Plasmodium falciparum
  40. Novel Investigational Anti-SARS-CoV-2 Agent Ensitrelvir “S-217622”: A Very Promising Potential Universal Broad-Spectrum Antiviral at the Therapeutic Frontline of Coronavirus Species
  41. Above the Invasive and Ornamental Attributes of the Traveler’s Palm: An In Vitro and In Silico Insight into the Anti-Oxidant, Anti-Enzymatic, Cytotoxic and Phytochemical Characterization of Ravenala madagascariensis
  42. Novel slow-binding reversible acetylcholinesterase inhibitors based on uracil moieties for possible treatment of myasthenia gravis and protection from organophosphate poisoning
  43. A bioinformatic analysis of the role of TP53 status on the infiltration of CD8+ T cells into the tumor microenvironment
  44. Evaluation of a series of nucleoside analogs as effective anticoronaviral-2 drugs against the Omicron-B.1.1.529/BA.2 subvariant: A repurposing research study
  45. Trojan Horse Nanocapsule Enabled in Situ Modulation of the Phenotypic Conversion of Th17 Cells to Treg Cells for the Treatment of Multiple Sclerosis in Mice
  46. A Series of Adenosine Analogs as the First Efficacious Anti‐SARS‐CoV‐2 Drugs against the B.1.1.529.4 Lineage: A Preclinical Repurposing Research Study
  47. Antibacterial and antibiofilm activity of mannose-modified chitosan/PMLA nanoparticles against multidrug-resistant Helicobacter pylori
  48. Inhibition of the predicted allosteric site of the SARS-CoV-2 main protease through flavonoids
  49. Novel Copper Oxide Bio-Nanocrystals to Target Outer Membrane Lectin of Vancomycin-Resistant Enterococcus faecium (VREfm): In Silico, Bioavailability, Antimicrobial, and Anticancer Potential
  50. Insight into the Hantaan virus RNA-dependent RNA polymerase inhibition using in-silico approaches
  51. A Comprehensive Study of N-Butyl-1H-Benzimidazole
  52. In-silico studies of glutathione peroxidase4 activators as candidate for multiple sclerosis management
  53. Forodesine and Riboprine Exhibit Strong Anti-SARS-CoV-2 Repurposing Potential: In Silico and In Vitro Studies
  54. GATA3 as an immunomodulator in obesity-related metabolic dysfunction associated with fatty liver disease, insulin resistance, and type 2 diabetes
  55. Hypertension is still a moving target in the context of COVID‐19 and post‐acute COVID‐19 syndrome
  56. Stimulating the Fermentation Process of Industrial Food Waste via Nonionic Surfactant/Graphene Nanosheet Combined Supplementation
  57. Cardiovascular complications in the post-acute COVID-19 syndrome: A novel perspective down the road
  58. Dual Computational and Biological Assessment of Some Promising Nucleoside Analogs against the COVID-19-Omicron Variant
  59. Multifunctional nanoparticles based on marine polysaccharides for apremilast delivery to inflammatory macrophages: Preparation, targeting ability, and uptake mechanism
  60. Identification and Inhibition of the Druggable Allosteric Site of SARS-CoV-2 NSP10/NSP16 Methyltransferase through Computational Approaches
  61. MD Simulation Studies for Selective Phytochemicals as Potential Inhibitors against Major Biological Targets of Diabetic Nephropathy
  62. Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy
  63. In Silico Study and Excito-Repellent Activity of Vitex negundo L. Essential Oil against Anopheles gambiae
  64. Rhamnolipid-Coated Iron Oxide Nanoparticles as a Novel Multitarget Candidate against Major Foodborne E. coli Serotypes and Methicillin-Resistant S. aureus
  65. Epigenetic drug (XL019) JAK2 inhibitor increases mitochondrial function in brown adipocytes by upregulating mitochondrial uncoupling protein 1 (UCP1), screening of epigenetic drug libraries, cell viability, and in-silico studies
  66. Computational studies on potential new anti-Covid-19 agents with a multi-target mode of action
  67. Comprehensive structural and functional characterization of a seed γ-thionin as a potent bioactive molecule against fungal pathogens and insect pests
  68. Berberine chloride (dual topoisomerase I and II inhibitor) modulate mitochondrial uncoupling protein (UCP1) in molecular docking and dynamic with in-vitro cytotoxic and mitochondrial ATP production
  69. Sarcorucinine-D Inhibits Cholinesterases and Calcium Channels: Molecular Dynamics Simulation and In Vitro Mechanistic Investigations
  70. Chalcone Scaffolds Exhibiting Acetylcholinesterase Enzyme Inhibition: Mechanistic and Computational Investigations
  71. Bioinspired nano-painting on orthopedic implants orchestrates periprosthetic anti-infection and osseointegration in a rat model of arthroplasty
  72. In-silico investigation of phenolic compounds from leaves of Phillyrea angustifolia L. as a potential inhibitor against the SARS-CoV-2 main protease (Mpro PDB ID:5R83) using a virtual screening method
  73. Glycyrrhizin (Glycyrrhizic Acid) HMGB1 (high mobility group box 1) inhibitor upregulate mitochondrial function in adipocyte, cell viability and in-silico study
  74. Structure-Based Virtual Screening, Molecular Docking, Molecular Dynamics Simulation and Pharmacokinetic modelling of Cyclooxygenase-2 (COX-2) inhibitor for the clinical treatment of Colorectal Cancer
  75. Anticancer, antioxidant activities and molecular docking study of thiazolidine-4-one and thiadiazol derivatives
  76. The role of GATA3 in the metastasis of triple-negative breast cancer and high-grade serous ovarian cancer
  77. Synthesis, crystal structure, hirshfeld surface analysis, molecular docking and molecular dynamics studies of novel olanzapinium 2,5-dihydroxybenzoate as potential and active antipsychotic compound
  78. Trigonella foenum-graecum Methanolic Extract on Isolated Smooth Muscles and Acetylcholinesterase Enzyme: An In Vitro and Mechanistic In Silico Investigation
  79. Structure-Based Virtual Screening, Molecular Docking, and Molecular Dynamics Simulation of VEGF inhibitors for the clinical treatment of Ovarian Cancer
  80. Computational Investigations for Identification of Bioactive Molecules from Baccaurea ramiflora and Bergenia ciliata as Inhibitors of SARS-CoV-2 Mpro
  81. Inhaled mRNA Nanoformulation with Biogenic Ribosomal Protein Reverses Established Pulmonary Fibrosis in a Bleomycin‐Induced Murine Model
  82. Spectroscopic, Solvation Effects and MD Simulation of an Adamantane-Carbohydrazide Derivative, a Potential Antiviral Agent
  83. Corrigendum: Effects of Zinc Oxide Nanoparticles Synthesized Using Aspergillus niger on Carbapenem-Resistant Klebsiella pneumonia In Vitro and In Vivo
  84. Molecular dynamic study of SARS-CoV-2 with various S protein mutations and their effect on thermodynamic properties
  85. Correction to: Arabidopsis NLP7 improves nitrogen use efficiency and yield in cotton
  86. Arabidopsis NLP7 improves nitrogen use efficiency and yield in cotton
  87. Molecular docking and dynamic simulations of Cefixime, Etoposide and Nebrodenside A against the pathogenic proteins of SARS-CoV-2
  88. Preparation, urease inhibition mechanisms, and anti-Helicobacter pylori activities of hesperetin-7-rhamnoglucoside
  89. Novel Slow-Binding Reversible Acetylcholinesterase Inhibitors Based on Uracil Moieties for Possible Treatment of Myasthenia Gravis and Protection from Organophosphate Poisoning
  90. Computational Study of SARS-CoV-2 RNA Dependent RNA Polymerase Allosteric Site Inhibition
  91. Novel Schiff Bases Ligands and Their Complexes: Thermal Analysis, Antibacterial Activity, and Molecular Docking
  92. In silico identification and study of potential anti-mosquito juvenile hormone binding protein (MJHBP) compounds as candidates for dengue virus - Vector insecticides
  93. In silico studies on phytochemicals to combat the emerging COVID-19 infection
  94. Phenolic profile, antioxidant and enzyme inhibition properties of seed methanolic extract of seven new Sunflower lines: From fields to industrial applications
  95. Repurposing benzimidazole and benzothiazole derivatives as potential inhibitors of SARS-CoV-2: DFT, QSAR, molecular docking, molecular dynamics simulation, and in-silico pharmacokinetic and toxicity studies
  96. What are the challenges faced by COVID-19 vaccines?
  97. Effects of Zinc Oxide Nanoparticles Synthesized Using Aspergillus niger on Carbapenem-Resistant Klebsiella pneumonia In Vitro and In Vivo
  98. Long-Term Impact of Transhumance Pastoralism and Associated Disturbances in High-Altitude Forests of Indian Western Himalaya
  99. Species Distribution Pattern and Their Contribution in Plant Community Assembly in Response to Ecological Gradients of the Ecotonal Zone in the Himalayan Region
  100. Botrytis cinerea alcohol dehydrogenase mediates fungal development, environmental adaptation and pathogenicity
  101. Design of lipid-based nanocarrier for drug delivery has a double therapy for six common pathogens eradication
  102. Ebselen suitably interacts with the potential SARS-CoV-2 targets: an in-silico approach
  103. In the face of the future, what do we learn from COVID-19?
  104. Plant Resources Utilization among Different Ethnic Groups of Ladakh in Trans-Himalayan Region
  105. GATA3 as a regulator for naughty cancer-associated fibroblasts in the microenvironment of high-grade serous ovarian cancer
  106. Species-specific and altitude-related variations in stomatal features ofBerberis lyciumRoyle and B. parkeriana C.K. Schneid
  107. Co-delivery of hesperidin and clarithromycin in a nanostructured lipid carrier for the eradication of Helicobacter pylori in vitro
  108. Future Directions of Fibrosis in Medicine
  109. Are the new SARS-CoV-2 variants resistant against the vaccine?
  110. Caffeic acid derivatives (CAFDs) as inhibitors of SARS-CoV-2: CAFDs-based functional foods as a potential alternative approach to combat COVID-19
  111. Progress in research on the S protein as the target of COVID-19 vaccines
  112. Neuropilin-1 may be responsible for retinal findings in patients with COVID-19
  113. Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensis Leaf: In Vivo and in Silico Studies
  114. Reply to “Comment on ‘In Situ Mannosylated Nanotrinity-Mediated Macrophage Remodeling Combats Candida Albicans Infection’”
  115. Transplacental transmission of SARS-CoV-2 infection via NRP1
  116. Ovarian cancer immunotherapy of NF-κB may have a dark side
  117. Emerging mutations in envelope protein of SARS-CoV-2 and their effect on thermodynamic properties
  118. SnapShot: TP53 status and macrophages infiltration in TCGA-analyzed tumors
  119. Metformin and COVID‐19: A novel deal of an old drug
  120. GATA3 and stemness of high-grade serous ovarian carcinoma: novel hope for the deadliest type of ovarian cancer
  121. In situ tuning proangiogenic factor-mediated immunotolerance synergizes the tumoricidal immunity via a hypoxia-triggerable liposomal bio-nanoreactor
  122. Formononetin: Novel Deal for Androgenetic Alopecia
  123. Alkaline hydrogen peroxide pretreatment of bamboo culm for improved enzymatic release of reducing sugars using recombinant cellulases
  124. Molecular cloning, expression, purification, and functional characterization of SP‐22 gene from Bombyx mori
  125. Metformin: Ongoing Journey with Superdrug Revolution
  126. Rifabutin induced multinucleated hepatocytes in rats: an overview with future prospects
  127. Comparison of structures among Saccharomyces cerevisiae Grxs proteins
  128. Key Factors for Successful Protein Purification and Crystallization
  129. Structure analysis of yeast glutaredoxin Grx6 protein produced in Escherichia coli
  130. Structural and Biochemical Insights into the Multiple Functions of Yeast Grx3
  131. Identification of new pathogenicity related to the gene encoding hypothetical protein in the gray mold fungus (Botrytis cinerea)
  132. Effect of Coriolus versicolor glucan on the stimulation of cytokine production in sarcoma-180-bearing mice
  133. Number of Cysteine Interactions with the Activity in GRX Family
  134. Important Factors Influencing Protein Crystallization
  135. Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe–2S] cluster