Contact

All Stories

  1. The synthesis of solid supports carrying base labile linkers to generate 3′-phosphate oligonucleotides

    Article • Bioorganic & Medicinal Chemistry Letters, September 2024, Elsevier

    Ramon Eritja, Prof. Dr. Miguel Ferrero

  2. Synthesis of 2′-O-Methyl/2′-O-MOE-L-Nucleoside Derivatives and Their Applications: Preparation of G-Quadruplexes, Their Characterization, and Stability Studies

    Article • ACS Omega, November 2023, American Chemical Society (ACS)

    Ramon Eritja, Prof. Dr. Miguel Ferrero

  3. Convergent Approaches and Biological Activity of C1 and/or C3 Mono or Diamino Derivatives of 1α,25‐Dihydroxy‐19‐nor‐vitamin D3. Key Enzymatic Desymmetrization of A‐Ring Synthon Precursor

    Article • Advanced Synthesis & Catalysis, January 2023, Wiley

    Prof. Dr. Miguel Ferrero

  4. Sustainable Protocol for the Synthesis of 2′,3′-Dideoxynucleoside and 2′,3′-Didehydro-2′,3′-dideoxynucleoside Derivatives

    Article • Molecules, June 2022, MDPI AG

    Prof. Dr. Miguel Ferrero

  5. Oligonucleotides Containing 1-Aminomethyl or 1-Mercaptomethyl-2-deoxy-d-ribofuranoses: Synthesis, Purification, Characterization, and Conjugation with Fluorophores and Lipids

    Article • Bioconjugate Chemistry, February 2021, American Chemical Society (ACS)

    Ramon Eritja, Prof. Dr. Miguel Ferrero

  6. Strategies for the Synthesis of 19-nor-Vitamin D Analogs

    Article • Pharmaceuticals, July 2020, MDPI AG

    Prof. Dr. Miguel Ferrero

  7. Novel 1′-homo-N-2′-deoxy-α-nucleosides: synthesis, characterization and biological activity

    Article • RSC Advances, January 2020, Royal Society of Chemistry

    Prof. Dr. Miguel Ferrero

  8. Enzymatic Desymmetrization of 19-nor -Vitamin D3 A-Ring Synthon Precursor: Synthesis, Structure Elucidation, and Biological Activity of 1α,25-Dihydroxy-3-epi -19-nor -vitamin D3 and 1β,25-Dihydroxy-19-nor -vitamin D3

    Article • Advanced Synthesis & Catalysis, June 2018, Wiley

    Prof. Dr. Miguel Ferrero

  9. A-Ring-Modified 2-Hydroxyethylidene Previtamin D3 Analogues: Synthesis and Biological Evaluation

    Article • European Journal of Organic Chemistry, January 2017, Wiley

    Prof. Dr. Miguel Ferrero

  10. The impact of an extended nucleobase-2′-deoxyribose linker in the biophysical and biological properties of oligonucleotides

    Article • RSC Advances, January 2017, Royal Society of Chemistry

    Ramon Eritja, Prof. Dr. Miguel Ferrero

  11. Short and Efficient Chemoenzymatic Syntheses of non-Natural (−)-Muscarine and (+)-allo-Muscarine from Cyano-Sugar Precursors Catalyzed by ImmobilizedBurkholderia cepaciaLipase

    Article • Advanced Synthesis & Catalysis, December 2016, Wiley

    Prof. Dr. Miguel Ferrero

  12. Preparation of ORMOSIL nanoparticles conjugated with vitamin D3analogues and their biological evaluation

    Article • RSC Advances, January 2016, Royal Society of Chemistry

    Prof. Dr. Miguel Ferrero

  13. Process Development of Biocatalytic Regioselective 5′-O-Levulinylation of 2′-Deoxynucleosides

    Article • Organic Process Research & Development, June 2015, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  14. Whole-cell biotransformation with recombinant cytochrome P450 for the selective oxidation of Grundmann’s ketone

    Article • Bioorganic & Medicinal Chemistry, October 2014, Elsevier

    Prof. Dr. Miguel Ferrero

  15. Biocatalysis: green processes for the preparation of protected nucleosides

    Article • January 2014, Institute of Organic Chemistry & Biochemistry

    Prof. Dr. Miguel Ferrero

  16. Synthesis of vitamin D3 analogues with A-ring modifications to directly measure vitamin D levels in biological samples

    Article • Bioorganic & Medicinal Chemistry, December 2013, Elsevier

    Prof. Dr. Miguel Ferrero

  17. Biocatalytic Methodologies for Selective Modified Nucleosides

    Article • February 2013, Wiley

    Prof. Dr. Miguel Ferrero

  18. Synthesis, evaluation of anti-HIV-1 and anti-HCV activity of novel 2′,3′-dideoxy-2′,2′-difluoro-4′-azanucleosides

    Article • Bioorganic & Medicinal Chemistry, December 2012, Elsevier

    Prof. Dr. Miguel Ferrero

  19. CAL-B-Catalyzed Acylation of Nucleosides and Role of the Sugar Conformation: An Improved Understanding of the Enzyme-Substrate Recognition

    Article • European Journal of Organic Chemistry, August 2012, Wiley

    Prof. Dr. Miguel Ferrero

  20. Design and Divergent Synthesis of Aza Nucleosides from a Chiral Imino Sugar

    Article • The Journal of Organic Chemistry, May 2012, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  21. An expedient biocatalytic procedure for abasic site precursors useful in oligonucleotide synthesis

    Article • Organic & Biomolecular Chemistry, January 2011, Royal Society of Chemistry

    Prof. Dr. Miguel Ferrero

  22. Chemoenzymatic Syntheses and Anti-HIV-1 Activity of Glucose−Nucleoside Conjugates as Prodrugs

    Article • Bioconjugate Chemistry, December 2010, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  23. Enzymatic Parallel Kinetic Resolution of Mixtures ofd/l2′-Deoxy and Ribonucleosides: An Approach for the Isolation of β-l-Nucleosides†

    Article • The Journal of Organic Chemistry, October 2010, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  24. Synthesis of81Br-Labeled Polybrominated Diphenyl Ethers and Their Characterization Using GC(EI)MS and GC(ICP)MS

    Article • Analytical Chemistry, April 2010, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  25. Chemoenzymatic Synthesis of 3′-O-Acetal-Protected 2′-Deoxynucleosides as Building Blocks for Nucleic Acid Chemistry

    Article • European Journal of Organic Chemistry, March 2010, Wiley

    Prof. Dr. Miguel Ferrero

  26. Synthesis, Conformational Analysis, and Biological Evaluation of 19-nor-Vitamin D3Analogues with A-Ring Modifications

    Article • Journal of Medicinal Chemistry, October 2009, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  27. Improved Synthesis and Isolation of 2′-O-Methyladenosine: Effective and Scalable Enzymatic Separation of 2′/3′-O-Methyladenosine Regioisomers

    Article • European Journal of Organic Chemistry, July 2009, Wiley

    Prof. Dr. Miguel Ferrero

  28. Synthesis and anti-HIV activity of conformationally restricted bicyclic hexahydroisobenzofuran nucleoside analogs

    Article • Organic & Biomolecular Chemistry, January 2009, Royal Society of Chemistry

    Prof. Dr. Miguel Ferrero

  29. Synthesis and biological activity of previtamin D3 analogues with A-ring modifications

    Article • Bioorganic & Medicinal Chemistry, December 2008, Elsevier

    Prof. Dr. Miguel Ferrero

  30. Preparation of Nucleoside-Carbohydrate Phosphodiester Prodrug Analogues by Chemoenzymatic Procedure

    Article • Nucleic Acids Symposium Series, September 2008, Oxford University Press (OUP)

    Prof. Dr. Miguel Ferrero

  31. Novel and Efficient Chemoenzymatic Synthesis ofD-Glucose 6-Phosphate and Molecular Modeling Studies on the Selective Biocatalysis

    Article • European Journal of Organic Chemistry, June 2007, Wiley

    Dr Ivan Lavandera, Prof. Dr. Miguel Ferrero

  32. Synthesis and biological evaluation of new 6-s-cis locked 1,2,25-trihydroxyprevitamin D3 analogues

    Article • Bioorganic & Medicinal Chemistry, June 2007, Elsevier

    Prof. Dr. Miguel Ferrero

  33. Enzymatic resolution of hindered cyanohydrins, key precursors of muscarinic receptor antagonists

    Article • Tetrahedron Asymmetry, May 2007, Elsevier

    Prof. Dr. Miguel Ferrero

  34. New Concept for the Separation of an Anomeric Mixture of α/β-d-Nucleosides through Regioselective Enzymatic Acylation or Hydrolysis Processes

    Article • The Journal of Organic Chemistry, December 2006, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  35. Novel A-ring homodimeric C-3-carbamate analogues of 1α,25-dihydroxyvitamin D3: Synthesis and preliminary biological evaluation

    Article • Bioorganic & Medicinal Chemistry, November 2006, Elsevier

    Prof. Dr. Miguel Ferrero

  36. Novel and Efficient Syntheses of (−)-Methyl 4-epi-Shikimate and 4,5-Epoxy-Quinic and -Shikimic Acid Derivatives as Key Precursors to Prepare New Analogues

    Article • The Journal of Organic Chemistry, July 2006, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  37. Influence of intramolecular hydrogen bonds in the enzyme-catalyzed regioselective acylation of quinic and shikimic acid derivatives

    Article • Tetrahedron, June 2006, Elsevier

    Prof. Dr. Miguel Ferrero

  38. Novel Chemoenzymatic Protocol for the Synthesis of 3‘-O-Dimethoxytrityl-2‘-deoxynucleoside Derivatives as Building Blocks for Oligonucleotide Synthesis

    Article • Organic Process Research & Development, May 2006, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  39. Remote Interactions Explain the Unusual Regioselectivity of Lipase from Pseudomonas cepacia toward the Secondary Hydroxyl of 2′-Deoxynucleosides

    Article • ChemBioChem, February 2006, Wiley

    Dr Ivan Lavandera, Prof. Dr. Miguel Ferrero

  40. Versatile synthesis and biological evaluation of 1,3-diamino-substituted 1α,25-dihydroxyvitamin D3 analogues

    Article • Bioorganic & Medicinal Chemistry, February 2006, Elsevier

    Prof. Dr. Miguel Ferrero

  41. Novel and efficient regioselective enzymatic approach to 3′-, 5′- and 3′,5′-di-O-crotonyl 2′-deoxynucleoside derivatives

    Article • Tetrahedron Letters, August 2005, Elsevier

    Dr Ivan Lavandera, Prof. Dr. Miguel Ferrero

  42. An Inverse Substrate Orientation for the Regioselective Acylation of 3′,5′-Diaminonucleosides Catalyzed by Candida antarctica lipase B?

    Article • ChemBioChem, June 2005, Wiley

    Dr Ivan Lavandera, Prof. Dr. Miguel Ferrero

  43. Chemoenzymatic Syntheses of Homo‐ and Heterodimers of AZT and d4T, and Evaluation of Their Anti‐HIV Activity

    Article • Nucleosides Nucleotides & Nucleic Acids, December 2004, Taylor & Francis

    Prof. Dr. Miguel Ferrero

  44. Chemoenzymatic synthesis and biological evaluation of C-3 carbamate analogues of 1α,25-dihydroxyvitamin D3

    Article • Bioorganic & Medicinal Chemistry, October 2004, Elsevier

    Prof. Dr. Miguel Ferrero

  45. Regioselective Enzymatic Acylation of β-l-2‘-Deoxynucleosides:  Application in Resolution of β-d/l-2‘-Deoxynucleosides

    Article • Organic Letters, October 2004, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  46. Regioselective enzymatic syntheses of C-3 and C-5 carbonate A-ring stereoisomeric precursors of vitamin D

    Article • Tetrahedron Asymmetry, September 2004, Elsevier

    Prof. Dr. Miguel Ferrero

  47. First Regioselective Enzymatic Alkoxycarbonylation of Primary Amines. Synthesis of Novel 5‘- and 3‘-Carbamates of Pyrimidine 3‘,5‘-Diaminonucleoside Derivatives Including BVDU Analogues

    Article • The Journal of Organic Chemistry, March 2004, American Chemical Society (ACS)

    Dr Ivan Lavandera, Prof. Dr. Miguel Ferrero

  48. A mild, efficient and regioselective enzymatic procedure for 5′-O-benzoylation of 2′-deoxynucleosides

    Article • Tetrahedron Letters, February 2004, Elsevier

    Prof. Dr. Miguel Ferrero

  49. Novel enzymatic synthesis of levulinyl protected nucleosides useful for solution phase synthesis of oligonucleotides

    Article • Tetrahedron Asymmetry, November 2003, Elsevier

    Prof. Dr. Miguel Ferrero

  50. Synthesis, Protonation Behavior, Conformational Analysis, and Regioselective Enzymatic Acylation of the Novel Diamino Analogue of (E)-5-(2-Bromovinyl)-2′-deoxyuridine (BVDU)

    Article • Nucleosides Nucleotides & Nucleic Acids, October 2003, Taylor & Francis

    Dr Ivan Lavandera, Prof. Dr. Miguel Ferrero

  51. Synthesis and Antiviral Activity Assay of Novel (E)-3′,5′-Diamino-5-(2-bromovinyl)-2′,3′,5′-trideoxyuridine

    Article • Nucleosides Nucleotides & Nucleic Acids, October 2003, Taylor & Francis

    Dr Ivan Lavandera, Prof. Dr. Miguel Ferrero

  52. Direct Regioselective Enzymatic Acylation of Nucleosides: Building-Blocks for the Solution Phase Synthesis of Oligonucleotides

    Article • Nucleosides Nucleotides & Nucleic Acids, October 2003, Taylor & Francis

    Prof. Dr. Miguel Ferrero

  53. Novel and efficient syntheses of 3′,5′-diamino derivatives of 2′,3′,5′-trideoxycytidine and 2′,3′,5′-trideoxyadenosine. Protonation behavior of 3′,5′-diaminonucleosides

    Article • Tetrahedron, July 2003, Elsevier

    Dr Ivan Lavandera, Prof. Dr. Miguel Ferrero

  54. Novel Enzymatic Synthesis of 4-O-Cinnamoyl Quinic and Shikimic Acid Derivatives

    Article • The Journal of Organic Chemistry, July 2003, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  55. Efficient Synthesis of Novel 1α-Amino and 3β-Amino Analogues of 1α,25-Dihydroxyvitamin D3

    Article • The Journal of Organic Chemistry, February 2003, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  56. Clean-chemistry synthesis of biodegradable tertiary α-substituted carboxylic acids from the corresponding esters through enzymatic processes

    Article • Journal of Molecular Catalysis B Enzymatic, December 2002, Elsevier

    Prof. Dr. Miguel Ferrero

  57. Regioselective Enzymatic Acylation of Methyl Shikimate. Influence of Acyl Chain Length and Solvent Polarity on Enzyme Specificity

    Article • The Journal of Organic Chemistry, July 2002, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  58. Building Blocks for the Solution Phase Synthesis of Oligonucleotides:  Regioselective Hydrolysis of 3‘,5‘-Di-O-levulinylnucleosides Using an Enzymatic Approach

    Article • The Journal of Organic Chemistry, June 2002, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  59. DIFFICULTIES IN THE DEPROTECTION OF 1,2-KETALS IN NUCLEOSIDES CONTAINING ALKYLIDENCARBAZOYL GROUPS

    Article • Nucleosides Nucleotides & Nucleic Acids, April 2002, Taylor & Francis

    Prof. Dr. Miguel Ferrero

  60. Novel chiral precursors of 6-s-cis locked 1α,25-dihydroxyvitamin D3 analogues through selective enzymatic acylation

    Article • Tetrahedron Asymmetry, April 2002, Elsevier

    Prof. Dr. Miguel Ferrero

  61. Synthesis of Monoacyl A-Ring Precursors of 1α,25-Dihydroxyvitamin D3 through Selective Enzymatic Hydrolysis

    Article • The Journal of Organic Chemistry, January 2002, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  62. First Regioselective Enzymatic Acylation of Amino Groups Applied to Pyrimidine 3‘,5‘-Diaminonucleoside Derivatives. Improved Synthesis of Pyrimidine 3‘,5‘-Diamino-2‘,3‘,5‘-trideoxynucleosides

    Article • The Journal of Organic Chemistry, June 2001, American Chemical Society (ACS)

    Dr Ivan Lavandera, Prof. Dr. Miguel Ferrero

  63. CAL-B-Catalyzed Alkoxycarbonylation of A-Ring Stereoisomeric Synthons of 1α,25-Dihydroxyvitamin D3and 1α,25-Dihydroxy-19-nor-previtamin D3:  A Comparative Study. First Regioselective Chemoenzymatic Synthesis of 19-nor-A-Ring Carbonates

    Article • The Journal of Organic Chemistry, June 2001, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  64. SYNTHESIS OF NEW HOMO AND HETERODINUCLEOSIDES CONTAINING THE 2′,3′-DIDEOXYNUCLEOSIDES AZT AND D4T

    Article • Nucleosides Nucleotides & Nucleic Acids, March 2001, Taylor & Francis

    Prof. Dr. Miguel Ferrero

  65. SYNTHESIS OF IMIDAZOYLTHIOCARBONYL INTERMEDIATES FOR THE RADICAL DEOXYGENATION OF HINDERED SECONDARY ALCOHOLS

    Article • Synthetic Communications, January 2001, Taylor & Francis

    Prof. Dr. Miguel Ferrero

  66. Biocatalytic Selective Modifications of Conventional Nucleosides, Carbocyclic Nucleosides, andC-Nucleosides

    Article • Chemical Reviews, December 2000, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  67. Efficient synthesis of (−)-methyl 3-epi-shikimate and methyl 3-epi-quinate by one-pot selective protection of trans-1,2-diols

    Article • Tetrahedron Letters, November 2000, Elsevier

    Prof. Dr. Miguel Ferrero

  68. 6-s-cisLocked Analogues of the Steroid Hormone 1α,25-Dihydroxyvitamin D3. Synthesis of Novel A-Ring Stereoisomeric 1,25-Dihydroxy-3-epi-19-nor-previtamin D3Derivatives

    Article • The Journal of Organic Chemistry, September 2000, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  69. Chemoenzymatic Transformationsin Nucleoside Chemistry

    Article • Monatshefte für Chemie - Chemical Monthly, June 2000, Springer Science + Business Media

    Prof. Dr. Miguel Ferrero

  70. Biocatalytic Synthesis of Steroids

    Article • January 2000, Taylor & Francis

    Prof. Dr. Miguel Ferrero

  71. Chemoenzymatic Transformations in Nucleoside Chemistry

    Article • January 2000, Springer Science + Business Media

    Prof. Dr. Miguel Ferrero

  72. Synthesis of two 6-s-cis locked stereoisomeric analogues of the steroid hormone 1α,25-dihydroxyvitamin D3: 1α,25-dihydroxy-19-nor-previtamin D3 and 1β,25-dihydroxy-19-nor-previtamin D3

    Article • Tetrahedron Letters, January 2000, Elsevier

    Prof. Dr. Miguel Ferrero

  73. Enzymatic Regioselective Transformations in Natural Products

    Article • January 2000, Springer Science + Business Media

    Prof. Dr. Miguel Ferrero

  74. 1α,25-Dihydroxyvitamin D3 A-Ring Precursors:  Studies on Regioselective Enzymatic Alkoxycarbonylation Reactions of Their Stereoisomers. Chemoenzymatic Synthesis of A-Ring Synthon Carbamate Derivatives, Including Carbazates and Polyamino Carb...

    Article • The Journal of Organic Chemistry, September 1999, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  75. Synthesis of novel carbazoyl linked pyrimidine-pyrimidine and pyrimidine-purine dinucleotide analogues

    Article • Tetrahedron Letters, February 1999, Elsevier

    Prof. Dr. Miguel Ferrero

  76. Chemoenzymatic Synthesis of Novel 3‘- and 5‘-Carbazoyl Nucleoside Derivatives. Regioselective Preparation of 3‘- and 5‘-Alkylidencarbazoyl Nucleosides

    Article • The Journal of Organic Chemistry, November 1998, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  77. New and efficient enantiospecific synthesis of (−)-Methyl 5-epi-shikimate and methyl 5-epi-quinate from (−)-quinic acid

    Article • Tetrahedron Letters, July 1997, Elsevier

    Prof. Dr. Miguel Ferrero

  78. Selective Alkoxycarbonylation of A-Ring Precursors of Vitamin D Using Enzymes in Organic Solvents. Chemoenzymatic Synthesis of 1α,25-Dihydroxyvitamin D3C-5 A-Ring Carbamate Derivatives1

    Article • The Journal of Organic Chemistry, June 1997, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  79. Synthesis of pentasubstituted pyridines. Cycloadditions of N -vinylic heterocumulenes with 1-( N , N -diethylamine)prop-1-yne

    Article • Tetrahedron, March 1997, Elsevier

    Prof. Dr. Miguel Ferrero

  80. Synthesis of Pentasubstituted Pyridines. IV—Structural Characterization of the Addition Products of 1-(N,N-Diethylamine)prop-1-yne toN-Vinylcarbodiimides and -ketenimines

    Article • Magnetic Resonance in Chemistry, May 1996, Wiley

    Prof. Dr. Miguel Ferrero

  81. Selective Acylation of A-Ring Precursors of Vitamin D Using Enzymes in Organic Solvents

    Article • The Journal of Organic Chemistry, September 1995, American Chemical Society (ACS)

    Prof. Dr. Miguel Ferrero

  82. Synthesis of pentasubstituted pyridines. II—NMR study of the addition products of 1-(N,N-diethylamine)prop-1-yne to methyl 2-isothiocyanato-3-phenylpropenoate

    Article • Magnetic Resonance in Chemistry, November 1994, Wiley

    Prof. Dr. Miguel Ferrero

  83. A new domino synthesis of polyfunctionalized pentasubstituted pyridines

    Article • Journal of the Chemical Society Chemical Communications, January 1994, Royal Society of Chemistry

    Prof. Dr. Miguel Ferrero

  84. Reactivity and selectivity of N-vinylic λ5-phosphazenes towards electrophiles. Synthesis of 2-aza-1,3-dienes

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1990, Royal Society of Chemistry

    Prof. Dr. Miguel Ferrero

  85. A simple and efficient “one-pot” synthesis of 2-aza-1,3-butadienes from N-vinylic λ5phosphazenes

    Article • Tetrahedron Letters, January 1990, Elsevier

    Prof. Dr. Miguel Ferrero

  86. Reaction of α-metallated N-acyl-λ5-phosphazenes with aryl cyanides

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1989, Royal Society of Chemistry

    Prof. Dr. Miguel Ferrero

  87. An efficient and mild conditions synthesis of 2-aza-1,3-dienes fromphospha-λ5-azenes.

    Article • Tetrahedron Letters, January 1988, Elsevier

    Prof. Dr. Miguel Ferrero

  88. Enzymatic Selectivity in Synthetic Methods

    Article • Wiley

    Prof. Dr. Miguel Ferrero