All Stories

  1. X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis

    Article • Nature, February 2015, Springer Science + Business Media

    Dr Max J Cryle

  2. Structure of the terminal PCP domain of the non-ribosomal peptide synthetase in teicoplanin biosynthesis

    Article • Proteins Structure Function and Bioinformatics, February 2015, Wiley

    Dr Max J Cryle

  3. Crystal structure of the X-domain from teicoplanin biosynthesis

    Article • February 2015, Protein Data Bank, Rutgers University

    Dr Max J Cryle

  4. Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Dr Max J Cryle

  5. The crystal structure of the versatile cytochrome P450 enzyme CYP109B1 from Bacillus subtilis

    Article • Molecular BioSystems, January 2015, Royal Society of Chemistry

    Dr Stephen G Bell, Dr Max J Cryle

  6. Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products

    Article • Natural Product Reports, January 2015, Royal Society of Chemistry

    Dr Max J Cryle

  7. OxyB from Actinoplanes teichomyceticus

    Article • November 2014, Protein Data Bank, Rutgers University

    Dr Max J Cryle

  8. Cytochrome P450 OxyBteiCatalyzes the First Phenolic Coupling Step in Teicoplanin Biosynthesis

    Article • ChemBioChem, October 2014, Wiley

    Dr Max J Cryle

  9. Die Struktur eines transienten Komplexes einer nicht-ribosomalen Peptidsynthetase mit einer P450-Monooxygenase

    Article • Angewandte Chemie, July 2014, Wiley

    Dr Max J Cryle

  10. The Structure of a Transient Complex of a Nonribosomal Peptide Synthetase and a Cytochrome P450 Monooxygenase

    Article • Angewandte Chemie International Edition, July 2014, Wiley

    Dr Max J Cryle

  11. A Facile Fmoc Solid Phase Synthesis Strategy To Access Epimerization-Prone Biosynthetic Intermediates of Glycopeptide Antibiotics

    Article • Organic Letters, May 2014, American Chemical Society (ACS)

    Dr Max J Cryle

  12. Oxidative transformations of amino acids and peptides catalysed by Cytochromes P450

    Article • November 2013, Royal Society of Chemistry

    Dr Max J Cryle

  13. Cytochrome P450 sky Interacts Directly with the Nonribosomal Peptide Synthetase to Generate Three Amino Acid Precursors in Skyllamycin Biosynthesis

    Article • ACS Chemical Biology, November 2013, American Chemical Society (ACS)

    Dr Max J Cryle

  14. Structure of P450sky (CYP163B3), a cytochrome P450 from skyllamycin biosynthesis (open active site)

    Article • September 2013, Protein Data Bank, Rutgers University

    Dr Max J Cryle

  15. Coulomb explosion imaging of small organic molecules at LCLS

    Article • Journal of Physics Conference Series, November 2012, Institute of Physics Publishing

    Dr Max J Cryle

  16. Enzyme-Substrate Complementarity Governs Access to a Cationic Reaction Manifold in the P450BM3-Catalysed Oxidation of Cyclopropyl Fatty Acids

    Article • Chemistry - A European Journal, October 2012, Wiley

    Dr Max J Cryle

  17. Femtosecond free-electron laser x-ray diffraction data sets for algorithm development

    Article • Optics Express, February 2012, Optical Society of America (OSA)

    Dr Max J Cryle, Filipe RNC Maia

  18. Structural characterization of CYP165D3, a cytochrome P450 involved in phenolic coupling in teicoplanin biosynthesis

    Article • Archives of Biochemistry and Biophysics, March 2011, Elsevier

    Dr Max J Cryle

  19. Carrier protein substrates in cytochrome P450-catalysed oxidation

    Article • Metallomics, January 2011, Royal Society of Chemistry

    Dr Max J Cryle

  20. Structural and Biochemical Characterization of the Cytochrome P450 CypX (CYP134A1) from Bacillus subtilis : A Cyclo- l -leucyl- l -leucyl Dipeptide Oxidase

    Article • Biochemistry, August 2010, American Chemical Society (ACS)

    Dr Stephen G Bell, Dr Max J Cryle

  21. Selectivity in a barren landscape: the P450 BioI –ACP complex

    Article • Biochemical Society Transactions, August 2010, Portland Press Ltd.

    Dr Max J Cryle

  22. Röntgenkristallstruktur und Mechanismus der DNA-(6-4)-Photolyase

    Article • Angewandte Chemie, December 2008, Wiley

    Dr Max J Cryle

  23. Crystal Structure and Mechanism of a DNA (6-4) Photolyase

    Article • Angewandte Chemie International Edition, December 2008, Wiley

    Dr Max J Cryle

  24. Crystal Structures of Substrate-Free and Retinoic Acid-Bound Cyanobacterial Cytochrome P450 CYP120A1 † ‡

    Article • Biochemistry, June 2008, American Chemical Society (ACS)

    Dr Max J Cryle

  25. The Role of the Conserved Threonine in P450BM3 Oxygen Activation: Substrate-Determined Hydroxylation Activity of the Thr268Ala Mutant

    Article • ChemBioChem, January 2008, Wiley

    Dr Max J Cryle

  26. Functional expression and characterization of cytochrome P450 52A21 from Candida albicans

    Article • Archives of Biochemistry and Biophysics, August 2007, Elsevier

    Dr Max J Cryle

  27. Carbon-Carbon Bond Cleavage by P450 Systems

    Article • May 2007, Wiley

    Dr Max J Cryle

  28. Facile determination of the absolute stereochemistry of hydroxy fatty acids by GC: application to the analysis of fatty acid oxidation by a P450BM3 mutant

    Article • Tetrahedron Asymmetry, March 2007, Elsevier

    Dr Max J Cryle

  29. The stereochemistry of fatty acid hydroxylation by cytochrome P450BM3

    Article • Tetrahedron Letters, January 2007, Elsevier

    Dr Max J Cryle

  30. Arachidonic acid potentiates exocytosis and allows neuronal SNARE complex to interact with Munc18a

    Article • Journal of Neurochemistry, December 2006, Wiley

    Dr Max J Cryle

  31. Is the Ferric Hydroperoxy Species Responsible for Sulfur Oxidation in Cytochrome P450s?

    Article • Angewandte Chemie, December 2006, Wiley

    Dr Max J Cryle

  32. Is the Ferric Hydroperoxy Species Responsible for Sulfur Oxidation in Cytochrome P450s?

    Article • Angewandte Chemie International Edition, December 2006, Wiley

    Dr Max J Cryle

  33. Are branched chain fatty acids the natural substrates for P450BM3?

    Article • Chemical Communications, January 2006, Royal Society of Chemistry

    Dr Max J Cryle

  34. Cyclopropyl Containing Fatty Acids as Mechanistic Probes for Cytochromes P450

    Article • The Journal of Organic Chemistry, April 2005, American Chemical Society (ACS)

    Dr Max J Cryle

  35. Cyclopropyl Fatty Acids Implicate a Radical but not a Cation as an Intermediate in P450BM3-Catalyzed Hydroxylations.

    Article • ChemInform, July 2004, Wiley

    Dr Max J Cryle

  36. Carbon—Carbon Bond Cleavage by Cytochrome P450BioI (CYP107H1).

    Article • ChemInform, April 2004, Wiley

    Dr Max J Cryle

  37. Reactions Catalyzed by Bacterial Cytochromes P450

    Article • ChemInform, October 2003, Wiley

    Dr Max J Cryle

  38. Products of Cytochrome P450 BioI (CYP107H1)-Catalyzed Oxidation of Fatty Acids

    Article • Organic Letters, September 2003, American Chemical Society (ACS)

    Dr Max J Cryle

  39. Reactions Catalyzed by Bacterial Cytochromes P450

    Article • Australian Journal of Chemistry, January 2003, CSIRO Publishing

    Dr Max J Cryle