All Stories

  1. Preparation and Optimization of MiR-375 Nano-Vector Using Two Novel Chitosan-Coated Nano-Structured Lipid Carriers as Gene Therapy for Hepatocellular Carcinoma

    Article • Pharmaceutics, April 2024, MDPI AG

    Dr Mahmoud M ElHefnawi, Dr Ming Ming Wen

  2. Progress, pitfalls, and path forward of drug repurposing for COVID-19 treatment

    Article • Therapeutic Advances in Respiratory Disease, January 2022, SAGE Publications

    Dr Mahmoud M ElHefnawi

  3. Derivation of “Egyptian varices prediction (EVP) index”: A novel noninvasive index for diagnosing esophageal varices in HCV Patients

    Article • Journal of Advanced Research, January 2022, Elsevier

    Dr Mahmoud M ElHefnawi

  4. Impact of type 2 diabetes mellitus on the immunoregulatory characteristics of adipose tissue-derived mesenchymal stem cells

    Article • The International Journal of Biochemistry & Cell Biology, November 2021, Elsevier

    Dr Mahmoud M ElHefnawi

  5. In Silico and In Vivo Evaluation of SARS-CoV-2 Predicted Epitopes-Based Candidate Vaccine

    Article • Molecules, October 2021, MDPI AG

    Dr Mahmoud M ElHefnawi

  6. Telaprevir is a potential drug for repurposing against SARS-CoV-2: computational and in vitro studies

    Article • Heliyon, September 2021, Elsevier

    Dr Mahmoud M ElHefnawi

  7. The oral microbiome of treated and untreated chronic HCV infection: A preliminary study

    Article • Oral Diseases, August 2021, Wiley

    Dr Mahmoud M ElHefnawi

  8. Identifying potential novel insights for COVID-19 pathogenesis and therapeutics using an integrated bioinformatics analysis of host transcriptome

    Article • April 2021, Research Square

    Dr Mahmoud M ElHefnawi

  9. Systematic auditing is essential to debiasing machine learning in biology

    Article • Communications Biology, February 2021, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi

  10. Complete genome sequence and bioinformatics analysis of nine Egyptian females with clinical information from different geographic regions in Egypt

    Article • Gene, February 2021, Elsevier

    Dr Mahmoud M ElHefnawi

  11. Clinical Implications of S100A12 and Resolvin D1 Serum Levels, and Related Genes in Children with Familial Mediterranean Fever

    Article • Journal of Child Science, January 2021, Thieme Publishing Group

    Professor Hala T. El-Bassyouni, Dr Mahmoud M ElHefnawi

  12. Machine Learning Prediction Models for Diagnosing Hepatocellular Carcinoma with HCV-related Chronic Liver Disease

    Article • Computer Methods and Programs in Biomedicine, November 2020, Elsevier

    Dr Mahmoud M ElHefnawi

  13. Immunomodulatory and Antioxidative potentials of adipose-derived Mesenchymal stem cells isolated from breast versus abdominal tissue: a comparative study

    Article • Cell Regeneration, October 2020, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi

  14. Systematic auditing is essential to debiasing machine learning in biology

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Dr Mahmoud M ElHefnawi

  15. Expression profiling and analysis of some miRNAs in subcutaneous white adipose tissue during development of obesity

    Article • Genes & Nutrition, May 2020, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi

  16. Custommune: a web tool to design personalized and population-targeted vaccine epitopes

    Article • April 2020, Cold Spring Harbor Laboratory Press

    Dr Mahmoud M ElHefnawi

  17. Complete genome sequence and analysis of nine Egyptian females with clinical information from different geographic regions in Egypt

    Article • March 2020, Cold Spring Harbor Laboratory Press

    Dr Mahmoud M ElHefnawi

  18. Early diagnosis of esophageal varices using Boosted-Naïve Bayes Tree: A multicenter cross-sectional study on chronic hepatitis C patients

    Article • Informatics in Medicine Unlocked, January 2020, Elsevier

    Dr Mahmoud M ElHefnawi

  19. Effect of Tumor Suppressor MiR-34a Loaded on ZSM-5 Nanozeolite in Hepatocellular Carcinoma: In Vitro and In Vivo Approach

    Article • Current Gene Therapy, December 2019, Bentham Science Publishers

    Dr Mahmoud M ElHefnawi

  20. The Promise of miRNA Replacement Therapy for Hepatocellular Carcinoma

    Article • Current Gene Therapy, December 2019, Bentham Science Publishers

    Dr Mahmoud M ElHefnawi

  21. Evaluation of computational techniques for predicting non-synonymous single nucleotide variants pathogenicity

    Article • Genomics, July 2019, Elsevier

    Dr Mahmoud M ElHefnawi

  22. Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

    Article • Nature Communications, June 2019, Springer Science + Business Media

    Dr Olexandr Isayev, Dr Mahmoud M ElHefnawi

  23. Co-regulatory Network of Oncosuppressor miRNAs and Transcription Factors for Pathology of Human Hepatic Cancer Stem Cells (HCSC)

    Article • Scientific Reports, April 2019, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi

  24. A review study: Computational techniques for expecting the impact of non-synonymous single nucleotide variants in human diseases

    Article • Gene, January 2019, Elsevier

    Dr Mahmoud M ElHefnawi

  25. Performance of machine learning approaches on prediction of esophageal varices for Egyptian chronic hepatitis C patients

    Article • Informatics in Medicine Unlocked, January 2019, Elsevier

    Dr Mahmoud M ElHefnawi

  26. MicroRNA-150 down Regulation in Acute Myeloid Leukaemia Patients and Its Prognostic Implication

    Article • Open Access Macedonian Journal of Medical Sciences, November 2018, Macedonian Journal of Medical Science

    Dr Mahmoud M ElHefnawi

  27. Whole genome sequencing and bioinformatics analysis of two Egyptian genomes

    Article • Gene, August 2018, Elsevier

    Dr Mahmoud M ElHefnawi

  28. Altered expression of WFS1 and NOTCH2 genes associated with diabetic nephropathy in T2DM patients

    Article • Diabetes Research and Clinical Practice, June 2018, Elsevier

    Dr Mahmoud M ElHefnawi

  29. Down-regulation of circulating microRNA let-7a in Egyptian smokers

    Article • Journal of Genetic Engineering and Biotechnology, June 2018, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi

  30. Deep feature selection for Identification of Essential Proteins of Learning and Memory in Mouse Model of Down Syndrome

    Article • May 2018, Cold Spring Harbor Laboratory Press

    Dr Mahmoud M ElHefnawi

  31. Comparison of Machine Learning Approaches for Prediction of Advanced Liver Fibrosis in Chronic Hepatitis C Patients

    Article • IEEE/ACM Transactions on Computational Biology and Bioinformatics, May 2018, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Mahmoud M ElHefnawi

  32. Bioinformatics functional analysis of let-7a, miR-34a, and miR-199a/b reveals novel insights into immune system pathways and cancer hallmarks for hepatocellular carcinoma

    Article • Tumor Biology, April 2018, SAGE Publications

    Dr Mahmoud M ElHefnawi

  33. MicroTarget: MicroRNA target gene prediction approach with application to breast cancer

    Article • Journal of Bioinformatics and Computational Biology, August 2017, World Scientific Pub Co Pte Lt

    Dr Mahmoud M ElHefnawi

  34. In silico identification of potential key regulatory factors in smoking-induced lung cancer

    Article • BMC Medical Genomics, June 2017, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi

  35. DETECTING AND ANALYZING COPY NUMBER ALTERNATIONS IN ARRAY-BASED CGH DATA

    Article • Biomedical Engineering Applications Basis and Communications, December 2016, National Taiwan University

    Dr Mahmoud M ElHefnawi

  36. Computational Identification of Tissue-Specific Splicing Regulatory Elements in Human Genes from RNA-Seq Data

    Article • PLoS ONE, November 2016, PLOS

    Dr. Eman Badr, Dr Mahmoud M ElHefnawi

  37. Features selection for building an early diagnosis machine learning model for Parkinson's disease

    Article • September 2016, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Mahmoud M ElHefnawi

  38. In Silico Design and Experimental Validation of siRNAs Targeting Conserved Regions of Multiple Hepatitis C Virus Genotypes

    Article • PLoS ONE, July 2016, PLOS

    Dr Mahmoud M ElHefnawi

  39. Modified gold nanoparticles for intracellular delivery of anti-liver cancer siRNA

    Article • International Journal of Pharmaceutics, May 2016, Elsevier

    Dr Mahmoud M ElHefnawi

  40. Accurate Prediction of Advanced Liver Fibrosis Using the Decision Tree Learning Algorithm in Chronic Hepatitis C Egyptian Patients

    Article • Gastroenterology Research and Practice, January 2016, Hindawi Publishing Corporation

    Dr Mahmoud M ElHefnawi

  41. DeNovo: virus-host sequence-based protein–protein interaction prediction

    Article • Bioinformatics, December 2015, Oxford University Press (OUP)

    Dr Mahmoud M ElHefnawi

  42. Comparing PCA to information gain as a feature selection method for Influenza-A classification

    Article • November 2015, Institute of Electrical & Electronics Engineers (IEEE)

    Ahmed Moustafa, Dr Mahmoud M ElHefnawi

  43. New Benzimidazoles and Their Antitumor Effects with Aurora A Kinase and KSP Inhibitory Activities

    Article • Archiv der Pharmazie, April 2015, Wiley

    Dr Mahmoud M ElHefnawi

  44. Correction: MysiRNA-Designer: A Workflow for Efficient siRNA Design

    Article • PLoS ONE, March 2015, PLOS

    Dr Mahmoud M ElHefnawi

  45. Hsa-miR-195 targets PCMT1 in hepatocellular carcinoma that increases tumor life span

    Article • Tumor Biology, August 2014, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi

  46. Genetic variability of the core protein in hepatitis C virus genotype 4 in Saudi Arabian patients and its implication on pegylated interferon and ribavirin therapy

    Article • Journal of Translational Medicine, April 2014, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi

  47. Human microRNAs targeting hepatitis C virus

    Article • February 2014, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Mahmoud M ElHefnawi

  48. Accurate classification and hemagglutinin amino acid signatures for influenza A virus host-origin association and subtyping

    Article • Virology, January 2014, Elsevier

    Dr Fayroz Farouk Sherif, Dr Mahmoud M ElHefnawi

  49. Ensemble-based classification approach for micro-RNA mining applied on diverse metagenomic sequences

    Article • BMC Research Notes, January 2014, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi, Amin Shoukry

  50. An Integrative Meta-analysis of MicroRNAs in Hepatocellular Carcinoma

    Article • Genomics Proteomics & Bioinformatics, December 2013, Oxford University Press (OUP)

    Dr Mahmoud M ElHefnawi

  51. Hepatitis C virus genotype 1: How genetic variability of the core protein affects the response to pegylated‐interferon and ribavirin therapy

    Article • Journal of Medical Virology, October 2013, Wiley

    Dr Mahmoud M ElHefnawi

  52. 283 PREDICTION OF miRNA TARGET GENES INVOLVED IN LIVER CANCER PATHWAYS AND ITS VALIDATION

    Article • Journal of Hepatology, April 2013, Elsevier

    Dr Mahmoud M ElHefnawi

  53. Synthesis, pharmacological activity evaluation and molecular modeling of new polynuclear heterocyclic compounds containing benzimidazole derivatives

    Article • Archives of Pharmacal Research, December 2012, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi, Professor Mohamed Abdel-Rehim

  54. Multiple virtual screening approaches for finding new Hepatitis c virus RNA-dependent RNA polymerase inhibitors: Structure-based screens and molecular dynamics for the pursue of new poly pharmacological inhibitors

    Article • BMC Bioinformatics, December 2012, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi

  55. Rational Drug Design for Identifying Novel Multi-target Inhibitors for Hepatocellular Carcinoma

    Article • Anti-Cancer Agents in Medicinal Chemistry, October 2012, Bentham Science Publishers

    Dr Mahmoud M ElHefnawi

  56. Structure-based predictive model for some benzimidazole inhibitors of hepatitis C virus NS5B polymerase

    Article • Medicinal Chemistry Research, August 2012, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi

  57. Accurate Prediction of Response to Interferon-based Therapy in Egyptian Patients with Chronic Hepatitis C Using Machine-learning Approaches

    Article • August 2012, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Mahmoud M ElHefnawi

  58. MysiRNA: Improving siRNA efficacy prediction using a machine-learning model combining multi-tools and whole stacking energy (ΔG)

    Article • Journal of Biomedical Informatics, June 2012, Elsevier

    Dr Mahmoud M ElHefnawi

  59. INFLUENZA A SUBTYPING AND HOST ORIGIN CLASSIFICATION USING PROFILE HIDDEN MARKOV MODELS

    Article • Journal of Mechanics in Medicine and Biology, April 2012, World Scientific Pub Co Pte Lt

    Dr Mahmoud M ElHefnawi

  60. Recurrent Neural Networks and Soft Computing

    Article • March 2012, IntechOpen

    Dr Mahmoud M ElHefnawi

  61. In-silico Approaches for RNAi Post-Transcriptional Gene Regulation: Optimizing siRNA Design and Selection

    Article • November 2011, IntechOpen

    Dr Mahmoud M ElHefnawi

  62. MysiRNA-Designer: A Workflow for Efficient siRNA Design

    Article • PLoS ONE, October 2011, PLOS

    Dr Mahmoud M ElHefnawi

  63. The design of optimal therapeutic small interfering RNA molecules targeting diverse strains of influenza A virus

    Article • Bioinformatics, October 2011, Oxford University Press (OUP)

    Dr Mahmoud M ElHefnawi

  64. Generation, characterization, and docking studies of DNA‐hydrolyzing recombinant Fab antibodies

    Article • Journal of Molecular Recognition, August 2011, Wiley

    Dr Mahmoud M ElHefnawi

  65. ChemInform Abstract: Part 1. Synthesis, Cancer Chemopreventive Activity and Molecular Docking Study of Novel Quinoxaline Derivatives.

    Article • ChemInform, May 2011, Wiley

    Dr Mahmoud M ElHefnawi

  66. Genomic signatures and associative classification of the Hemagglutinin protein for Human versus Avian versus Swine influenza A viruses

    Article • April 2011, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Mahmoud M ElHefnawi

  67. Classification of human vs. non-human, and subtyping of human influenza viral strains using Profile Hidden Markov Models

    Article • February 2011, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Mahmoud M ElHefnawi

  68. Identification of novel conserved functional motifs across most Influenza A viral strains

    Article • Virology Journal, January 2011, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi

  69. Part I: Synthesis, cancer chemopreventive activity and molecular docking study of novel quinoxaline derivatives

    Article • European Journal of Medicinal Chemistry, January 2011, Elsevier

    Dr Mahmoud M ElHefnawi

  70. Prediction of prognostic biomarkers for Interferon-based therapy to Hepatitis C Virus patients: a metaanalysis of the NS5A protein in subtypes 1a, 1b, and 3a

    Article • Virology Journal, June 2010, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi

  71. An Integrated Methodology for Mining Promiscuous Proteins: A Case Study of an Integrative Bioinformatics Approach for Hepatitis C Virus Non-structural 5a Protein

    Article • January 2010, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi

  72. Natural Genetic Engineering of Hepatitis C Virus NS5A for Immune System Counterattack

    Article • Annals of the New York Academy of Sciences, October 2009, Wiley

    Dr Mahmoud M ElHefnawi

  73. Correlating novel variable and conserved motifs in the Hemagglutinin protein with significant biological functions

    Article • Virology Journal, August 2008, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi

  74. Phylogenetic analysis and comparison between cow and buffalo (including Egyptian buffaloes) mitochondrial displacement-loop regions

    Article • DNA Sequence, January 2008, Taylor & Francis

    Dr Mahmoud M ElHefnawi

  75. Article • Virology Journal, January 2007, Springer Science + Business Media

    Dr Mahmoud M ElHefnawi