All Stories

  1. In vivo functional analysis of a class A β-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus

    Article • PLoS ONE, April 2019, PLOS

    Kapil Tahlan

  2. Examination of Mycobacterium avium subspecies paratuberculosis mixed genotype infections in dairy animals using a whole genome sequencing approach

    Article • PeerJ, December 2016, PeerJ

    Kapil Tahlan

  3. δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine synthetase (ACVS): discovery and perspectives

    Article • Journal of Industrial Microbiology & Biotechnology, October 2016, Springer Science + Business Media

    Kapil Tahlan

  4. Genome-Wide Diversity and Phylogeography of Mycobacterium avium subsp. paratuberculosis in Canadian Dairy Cattle

    Article • PLoS ONE, February 2016, PLOS

    Kapil Tahlan, Dr Herman Wildrik Barkema

  5. Proteomics analysis of global regulatory cascades involved in clavulanic acid production and morphological development in Streptomyces clavuligerus

    Article • Journal of Industrial Microbiology & Biotechnology, January 2016, Springer Science + Business Media

    Kapil Tahlan

  6. Genome Sequences of Klebsiella variicola Isolates from Dairy Animals with Bovine Mastitis from Newfoundland, Canada

    Article • Genome Announcements, September 2015, ASM Journals

    Kapil Tahlan

  7. Minimum Information about a Biosynthetic Gene cluster

    Article • Nature Methods, August 2015, Nature

    Dr Jean-Luc Pernodet, Dr Leonilde M Moreira, Kapil Tahlan, Professor Rainer Borriss, Dr Nikos C Kyrpides

  8. Typing of Mycobacterium avium Subspecies paratuberculosis Isolates from Newfoundland Using Fragment Analysis

    Article • PLoS ONE, April 2015, PLOS

    Kapil Tahlan

  9. Regulation of Coronafacoyl Phytotoxin Production by the PAS-LuxR Family Regulator CfaR in the Common Scab Pathogen Streptomyces scabies

    Article • PLoS ONE, March 2015, PLOS

    Kapil Tahlan

  10. Klebsiella Species Associated with Bovine Mastitis in Newfoundland

    Article • PLoS ONE, September 2014, PLOS

    Kapil Tahlan

  11. Origins of the β-lactam rings in natural products

    Article • The Journal of Antibiotics, March 2013, Nature

    Kapil Tahlan

  12. SQ109

    Article • Drugs of the Future, January 2013, Prous Science

    Kapil Tahlan

  13. Carboxyethylarginine Synthase Genes Show Complex Cross-Regulation in Streptomyces clavuligerus

    Article • Applied and Environmental Microbiology, October 2012, ASM Journals

    Kapil Tahlan

  14. A Two-Step Mechanism for the Activation of Actinorhodin Export and Resistance in Streptomyces coelicolor

    Article • mBio, October 2012, ASM Journals

    Kapil Tahlan

  15. 5S Clavam Biosynthesis Is Controlled by an Atypical Two-Component Regulatory System in Streptomyces clavuligerus

    Article • Antimicrobial Agents and Chemotherapy, July 2012, ASM Journals

    Kapil Tahlan

  16. SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

    Article • Antimicrobial Agents and Chemotherapy, January 2012, ASM Journals

    Kapil Tahlan

  17. Bacterial Transmembrane Proteins that Lack N-Terminal Signal Sequences

    Article • PLoS ONE, May 2011, PLOS

    Kapil Tahlan

  18. Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis

    Article • Nature Methods, March 2011, Nature

    Kapil Tahlan

  19. Mechanisms underlying mycobacterial infections

    Article • Drug Discovery Today Disease Mechanisms, March 2010, Elsevier

    Kapil Tahlan

  20. Use of the native flp gene to generate in-frame unmarked mutations in Streptomyces spp.

    Article • Gene, August 2009, Elsevier

    Kapil Tahlan

  21. New cell wall biosynthesis inhibitors under active development for tuberculosis

    Article • Drugs of the Future, January 2009, Prous Science

    Kapil Tahlan

  22. Ligand Recognition by ActR, a TetR-Like Regulator of Actinorhodin Export

    Article • Journal of Molecular Biology, November 2008, Elsevier

    Kapil Tahlan

  23. Biosynthesis and Recycling of Nicotinamide Cofactors in Mycobacterium tuberculosis: AN ESSENTIAL ROLE FOR NAD IN NONREPLICATING BACILLI

    Article • Journal of Biological Chemistry, May 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Kapil Tahlan

  24. Crystal Structures of the Streptomyces coelicolor TetR-Like Protein ActR Alone and in Complex with Actinorhodin or the Actinorhodin Biosynthetic Precursor (S)-DNPA

    Article • Journal of Molecular Biology, March 2008, Elsevier

    Kapil Tahlan

  25. Investigation of Transcription Repression and Small-Molecule Responsiveness by TetR-Like Transcription Factors Using a Heterologous Escherichia coli-Based Assay

    Article • Journal of Bacteriology, July 2007, ASM Journals

    Kapil Tahlan

  26. Initiation of actinorhodin export inStreptomyces coelicolor

    Article • Molecular Microbiology, February 2007, Wiley

    Kapil Tahlan

  27. 5S Clavam Biosynthetic Genes Are Located in Both the Clavam and Paralog Gene Clusters in Streptomyces clavuligerus

    Article • Chemistry & Biology, February 2007, Elsevier

    Kapil Tahlan

  28. Expression of ccaR, Encoding the Positive Activator of Cephamycin C and Clavulanic Acid Production in Streptomyces clavuligerus, Is Dependent on bldG

    Article • Antimicrobial Agents and Chemotherapy, April 2005, ASM Journals

    Kapil Tahlan

  29. Three unlinked gene clusters are involved in clavam metabolite biosynthesis inStreptomyces clavuligerus

    Article • Canadian Journal of Microbiology, October 2004, Canadian Science Publishing

    Kapil Tahlan

  30. The Paralogous Pairs of Genes Involved in Clavulanic Acid and Clavam Metabolite Biosynthesis Are Differently Regulated in Streptomyces clavuligerus

    Article • Journal of Bacteriology, September 2004, ASM Journals

    Kapil Tahlan

  31. Two Sets of Paralogous Genes Encode the Enzymes Involved in the Early Stages of Clavulanic Acid and Clavam Metabolite Biosynthesis in Streptomyces clavuligerus

    Article • Antimicrobial Agents and Chemotherapy, March 2004, ASM Journals

    Kapil Tahlan