All Stories

  1. Structure of European robin cryptochrome 1 reveals a role in circadian rhythms, not magnetoreception

    Article • iScience, December 2025, Elsevier

    Dr Joseph S Takahashi

  2. Time-Restricted Feeding Extends Healthspan in Female and Lifespan in Male C57BL/6J Mice

    Article • October 2025, Cold Spring Harbor Laboratory Press

    Dr Joseph S Takahashi

  3. Parasite and vector circadian clocks mediate efficient malaria transmission

    Article • Nature Microbiology, March 2025, Springer Science + Business Media

    Dr Joseph S Takahashi

  4. Resetting of the Human Circadian Melatonin Rhythm by Ambient Hypoxia

    Article • Journal of Pineal Research, January 2025, Wiley

    Dr Joseph S Takahashi

  5. The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment

    Article • Proceedings of the National Academy of Sciences, March 2024, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  6. Dietary restriction modulates ultradian rhythms and autocorrelation properties in mice behavior

    Article • Communications Biology, March 2024, Springer Science + Business Media

    Dr Joseph S Takahashi

  7. Mammalian circadian clock proteins form dynamic interacting microbodies distinct from phase separation

    Article • Proceedings of the National Academy of Sciences, December 2023, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  8. Metabolic and chemical architecture of the mammalian circadian clock

    Article • Cell Chemical Biology, September 2023, Elsevier

    Dr Joseph S Takahashi

  9. The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment in the mouse

    Article • June 2023, Cold Spring Harbor Laboratory Press

    Dr Joseph S Takahashi

  10. Coupling-dependent metabolic ultradian rhythms in confluent cells

    Article • Proceedings of the National Academy of Sciences, November 2022, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  11. Extensive Soma-Soma Plate-Like Contact Sites (Ephapses) Connect Suprachiasmatic Nucleus Neurons

    Article • September 2022, Cold Spring Harbor Laboratory Press

    Dr Joseph S Takahashi

  12. A missense mutation in Kcnc3 causes hippocampal learning deficits in mice

    Article • Proceedings of the National Academy of Sciences, July 2022, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi, Dr Vivek Kumar

  13. Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

    Article • Science, June 2022, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  14. Synchronization between peripheral circadian clock and feeding-fasting cycles in microfluidic device sustains oscillatory pattern of transcriptome

    Article • Nature Communications, October 2021, Springer Science + Business Media

    Dr Joseph S Takahashi

  15. The 50th anniversary of the Konopka and Benzer 1971 paper in PNAS: “Clock Mutants of Drosophila melanogaster ”

    Article • Proceedings of the National Academy of Sciences, September 2021, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  16. Importance of circadian timing for aging and longevity

    Article • Nature Communications, May 2021, Springer Science + Business Media

    Dr Joseph S Takahashi

  17. Sleeping Sickness Disrupts the Sleep-Regulating Adenosine System

    Article • Journal of Neuroscience, October 2020, Society for Neuroscience

    Dr Joseph S Takahashi

  18. Dual-Color Single-Cell Imaging of the Suprachiasmatic Nucleus Reveals a Circadian Role in Network Synchrony

    Article • Neuron, October 2020, Elsevier

    Dr Joseph S Takahashi

  19. An essential role for MEF2C in the cortical response to loss of sleep in mice

    Article • eLife, August 2020, eLife

    Dr Joseph S Takahashi

  20. Epigenetic inheritance of circadian period in clonal cells

    Article • eLife, May 2020, eLife

    Dr Joseph S Takahashi

  21. The malaria parasite has an intrinsic clock

    Article • Science, May 2020, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  22. Noise-driven cellular heterogeneity in circadian periodicity

    Article • Proceedings of the National Academy of Sciences, May 2020, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  23. Circadian control of interferon-sensitive gene expression in murine skin

    Article • Proceedings of the National Academy of Sciences, March 2020, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  24. Tissue-specific FAH deficiency alters sleep–wake patterns and results in chronic tyrosinemia in mice

    Article • Proceedings of the National Academy of Sciences, October 2019, Proceedings of the National Academy of Sciences

    Dr Vivek Kumar, Dr Joseph S Takahashi

  25. Neuronal Myocyte-Specific Enhancer Factor 2D (MEF2D) Is Required for Normal Circadian and Sleep Behavior in Mice

    Article • Journal of Neuroscience, August 2019, Society for Neuroscience

    Dr Joseph S Takahashi

  26. A novel mutation inSlc2a4as a mouse model of fatigue

    Article • Genes Brain & Behavior, May 2019, Wiley

    Dr Joseph S Takahashi

  27. Circadian Clock Genes and the Transcriptional Architecture of the Clock Mechanism

    Article • Endocrine Abstracts, November 2018, Bioscientifica

    Dr Joseph S Takahashi

  28. Tissue-specific BMAL1 cistromes reveal that enhancer-enhancer interactions regulate rhythmic transcription

    Article • May 2018, Cold Spring Harbor Laboratory Press

    Dr Joseph S Takahashi

  29. An evolutionary hotspot defines functional differences between CRYPTOCHROMES

    Article • Nature Communications, March 2018, Springer Science + Business Media

    Dr Joseph S Takahashi

  30. Sleeping sickness is a circadian disorder

    Article • Nature Communications, January 2018, Springer Science + Business Media

    Dr Joseph S Takahashi

  31. Circadian rhythms in parasites

    Article • PLoS Pathogens, October 2017, PLOS

    Dr Joseph S Takahashi

  32. Period2 3′-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation

    Article • Proceedings of the National Academy of Sciences, October 2017, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  33. Bmal1 function in skeletal muscle regulates sleep

    Article • eLife, July 2017, eLife

    Dr Joseph S Takahashi

  34. Asleep at the Wheel: Forward Genetic ENU Mutagenesis Screen for Mouse Models of Chronic Fatigue Identifies a Mutation inSlc2a4(GLUT4)

    Article • July 2017, Cold Spring Harbor Laboratory Press

    Dr Joseph S Takahashi

  35. Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System

    Article • Cell Metabolism, July 2017, Elsevier

    Dr Joseph S Takahashi

  36. Trypanosoma brucei metabolism is under circadian control

    Article • Nature Microbiology, March 2017, Springer Science + Business Media

    Dr Joseph S Takahashi

  37. Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1

    Article • Proceedings of the National Academy of Sciences, January 2017, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  38. An actigraphy study investigating sleep in bipolar I patients, unaffected siblings and controls

    Article • Journal of Affective Disorders, January 2017, Elsevier

    Dr Joseph S Takahashi

  39. Enriching the Circadian Proteome

    Article • Cell Metabolism, January 2017, Elsevier

    Dr Joseph S Takahashi

  40. Biological Timekeeping: Clocks, Rhythms and Behaviour

    Article • January 2017, Springer Science + Business Media

    Dr Joseph S Takahashi

  41. Transcriptional architecture of the mammalian circadian clock

    Article • Nature Reviews Genetics, December 2016, Springer Science + Business Media

    Dr Joseph S Takahashi

  42. Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

    Article • eLife, November 2016, eLife

    Dr Joseph S Takahashi

  43. Forward-genetics analysis of sleep in randomly mutagenized mice

    Article • Nature, November 2016, Springer Science + Business Media

    Dr Joseph S Takahashi

  44. Circadian Oscillations of NADH Redox State Using a Heterologous Metabolic Sensor in Mammalian Cells

    Article • Journal of Biological Chemistry, November 2016, Elsevier

    Dr Joseph S Takahashi

  45. Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms

    Article • eLife, September 2016, eLife

    Dr Joseph S Takahashi

  46. Identification of mutations through dominant screening for obesity using C57BL/6 substrains

    Article • Scientific Reports, September 2016, Springer Science + Business Media

    Dr Joseph S Takahashi

  47. The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

    Article • Cell Metabolism, April 2016, Elsevier

    Dr Joseph S Takahashi

  48. Molecular Architecture of the Circadian Clock in Mammals

    Article • January 2016, Springer Science + Business Media

    Dr Joseph S Takahashi

  49. Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder

    Article • Proceedings of the National Academy of Sciences, December 2015, Proceedings of the National Academy of Sciences

    Dr. Carrie E Bearden, Dr Joseph S Takahashi

  50. Cycling Transcriptional Networks Optimize Energy Utilization on a Genome Scale

    Article • Cell Reports, December 2015, Elsevier

    Dr Joseph S Takahashi

  51. A tunable artificial circadian clock in clock-defective mice

    Article • Nature Communications, November 2015, Springer Science + Business Media

    Dr Joseph S Takahashi

  52. Molecular components of the circadian clock in mammals

    Article • Diabetes Obesity and Metabolism, September 2015, Wiley

    Dr Joseph S Takahashi

  53. Faculty Opinions recommendation of The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation.

    Article • May 2015, F1000Research

    Dr Joseph S Takahashi

  54. Neuromedin S-Producing Neurons Act as Essential Pacemakers in the Suprachiasmatic Nucleus to Couple Clock Neurons and Dictate Circadian Rhythms

    Article • Neuron, March 2015, Elsevier

    Dr Joseph S Takahashi

  55. Vasoactive Intestinal Polypeptide (VIP)-Expressing Neurons in the Suprachiasmatic Nucleus Provide Sparse GABAergic Outputs to Local Neurons with Circadian Regulation Occurring Distal to the Opening of Postsynaptic GABAAIonotropic Receptors

    Article • Journal of Neuroscience, February 2015, Society for Neuroscience

    Dr Joseph S Takahashi

  56. The Circadian Clock in Skin

    Article • Journal of Biological Rhythms, January 2015, SAGE Publications

    Dr Joseph S Takahashi

  57. In Vivo Single-Cell Detection of Metabolic Oscillations in Stem Cells

    Article • Cell Reports, January 2015, Elsevier

    Dr Vivek Kumar, Dr Joseph S Takahashi

  58. ChIP-seq and RNA-seq Methods to Study Circadian Control of Transcription in Mammals

    Article • January 2015, Elsevier

    Dr Vivek Kumar, Dr Joseph S Takahashi

  59. Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant

    Article • eLife, December 2014, eLife

    Dr Joseph S Takahashi

  60. Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase

    Article • Proceedings of the National Academy of Sciences, December 2014, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  61. Transcriptional program of Kpna2/Importin-α2 regulates cellular differentiation-coupled circadian clock development in mammalian cells

    Article • Proceedings of the National Academy of Sciences, November 2014, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  62. Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex

    Article • eLife, August 2014, eLife

    Dr Joseph S Takahashi

  63. Phosphorylation of LSD1 by PKCα Is Crucial for Circadian Rhythmicity and Phase Resetting

    Article • Molecular Cell, March 2014, Elsevier

    Dr Joseph S Takahashi

  64. Molecular architecture of the mammalian circadian clock

    Article • Trends in Cell Biology, February 2014, Elsevier

    Dr Joseph S Takahashi

  65. Central Circadian Control of Female Reproductive Function

    Article • Frontiers in Endocrinology, January 2014, Frontiers

    Dr Joseph S Takahashi

  66. C57BL/6N Mutation in Cytoplasmic FMRP interacting protein 2 Regulates Cocaine Response

    Article • Science, December 2013, American Association for the Advancement of Science

    Dr Joseph S Takahashi, Dr Vivek Kumar

  67. Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period Length

    Article • Journal of Biological Chemistry, December 2013, Elsevier

    Dr Joseph S Takahashi

  68. T H 17 Cell Differentiation Is Regulated by the Circadian Clock

    Article • Science, November 2013, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  69. Genetic control of the circadian pacemaker

    Article • October 2013, Cambridge University Press

    Dr Joseph S Takahashi

  70. FGF21 regulates metabolism and circadian behavior by acting on the nervous system

    Article • Nature Reports Stem Cells, August 2013, Springer Science + Business Media

    Dr Joseph S Takahashi

  71. Usf1 , a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice

    Article • eLife, April 2013, eLife

    Dr Joseph S Takahashi, Dr Vivek Kumar

  72. Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm

    Article • Cell, February 2013, Elsevier

    Dr Joseph S Takahashi, Dr Vivek Kumar

  73. Molecular Components of the Mammalian Circadian Clock

    Article • January 2013, Springer Science + Business Media

    Dr Joseph S Takahashi

  74. Epidermal stem cells ride the circadian wave

    Article • Genome Biology, January 2013, Springer Science + Business Media

    Dr Joseph S Takahashi, Dr Vivek Kumar

  75. Molecular and Genetic Bases for the Circadian System

    Article • January 2013, Elsevier

    Dr Joseph S Takahashi

  76. Ghrelin-immunopositive hypothalamic neurons tie the circadian clock and visual system to the lateral hypothalamic arousal center

    Article • Molecular Metabolism, December 2012, Elsevier

    Dr Joseph S Takahashi

  77. Small molecule modifiers of circadian clocks

    Article • Cellular and Molecular Life Sciences, November 2012, Springer Science + Business Media

    Dr Joseph S Takahashi

  78. Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

    Article • Science, August 2012, American Association for the Advancement of Science

    Dr Vivek Kumar, Dr Joseph S Takahashi

  79. Brain-Specific Rescue of Clock Reveals System-Driven Transcriptional Rhythms in Peripheral Tissue

    Article • PLoS Genetics, July 2012, PLOS

    Dr Joseph S Takahashi

  80. Central and Peripheral Circadian Clocks in Mammals

    Article • Annual Review of Neuroscience, July 2012, Annual Reviews

    Dr Joseph S Takahashi

  81. Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex

    Article • Science, July 2012, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  82. Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis

    Article • Proceedings of the National Academy of Sciences, July 2012, Proceedings of the National Academy of Sciences

    Dr Vivek Kumar, Dr Joseph S Takahashi

  83. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

    Article • Nature, March 2012, Springer Science + Business Media

    Dr Joseph S Takahashi

  84. Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening

    Article • Proceedings of the National Academy of Sciences, December 2011, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  85. Generation of N-Ethyl-N-nitrosourea (ENU) Diabetes Models in Mice Demonstrates Genotype-specific Action of Glucokinase Activators

    Article • Journal of Biological Chemistry, November 2011, Elsevier

    Dr Joseph S Takahashi

  86. Second-generation high-throughput forward genetic screen in mice to isolate subtle behavioral mutants

    Article • Proceedings of the National Academy of Sciences, September 2011, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi, Dr Vivek Kumar

  87. Phase-Resetting Sensitivity of the Suprachiasmatic Nucleus and Oscillator Amplitude

    Article • Journal of Biological Rhythms, July 2011, SAGE Publications

    Dr Joseph S Takahashi

  88. Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators

    Article • Trends in Neurosciences, July 2011, Elsevier

    Dr Joseph S Takahashi

  89. Correction: Inducible and Reversible Clock Gene Expression in Brain Using the tTA System for the Study of Circadian Behavior

    Article • PLoS Genetics, June 2011, PLOS

    Dr Joseph S Takahashi

  90. Impaired Limbic Gamma Oscillatory Synchrony during Anxiety-Related Behavior in a Genetic Mouse Model of Bipolar Mania

    Article • Journal of Neuroscience, April 2011, Society for Neuroscience

    Dr Joseph S Takahashi

  91. Redox redux

    Article • Nature, January 2011, Springer Science + Business Media

    Dr Joseph S Takahashi

  92. Genetics of Circadian Rhythms in Mammalian Model Organisms

    Article • January 2011, Elsevier

    Dr Joseph S Takahashi

  93. Circadian Integration of Metabolism and Energetics

    Article • Science, December 2010, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  94. Lithium Ameliorates Nucleus Accumbens Phase-Signaling Dysfunction in a Genetic Mouse Model of Mania

    Article • Journal of Neuroscience, December 2010, Society for Neuroscience

    Dr Joseph S Takahashi

  95. Correction: Emergence of Noise-Induced Oscillations in the Central Circadian Pacemaker

    Article • PLoS Biology, October 2010, PLOS

    Dr Joseph S Takahashi

  96. Divergent and nonuniform gene expression patterns in mouse brain

    Article • Proceedings of the National Academy of Sciences, October 2010, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  97. CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function

    Article • Proceedings of the National Academy of Sciences, October 2010, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  98. Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

    Article • Science, October 2010, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  99. Emergence of Noise-Induced Oscillations in the Central Circadian Pacemaker

    Article • PLoS Biology, October 2010, PLOS

    Dr Joseph S Takahashi

  100. PARP around the Clock

    Article • Cell, September 2010, Elsevier

    Dr Joseph S Takahashi, Dr Vivek Kumar

  101. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

    Article • Nature, June 2010, Springer Science + Business Media

    Dr Joseph S Takahashi

  102. Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway

    Article • Proceedings of the National Academy of Sciences, April 2010, Proceedings of the National Academy of Sciences

    Dr Vivek Kumar, Dr Joseph S Takahashi

  103. Suprachiasmatic Nucleus: Cell Autonomy and Network Properties

    Article • Annual Review of Physiology, March 2010, Annual Reviews

    Dr Joseph S Takahashi

  104. Rhythmic PER Abundance Defines a Critical Nodal Point for Negative Feedback within the Circadian Clock Mechanism

    Article • Molecular Cell, November 2009, Elsevier

    Dr Joseph S Takahashi, Dr Vivek Kumar

  105. CKIε/δ-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock

    Article • Proceedings of the National Academy of Sciences, September 2009, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  106. Identification of genetic loci involved in diabetes using a rat model of depression

    Article • Mammalian Genome, August 2009, Springer Science + Business Media

    Dr Joseph S Takahashi

  107. Circadian Clock Genes Contribute to the Regulation of Hair Follicle Cycling

    Article • PLoS Genetics, July 2009, PLOS

    Dr Joseph S Takahashi, Dr Vivek Kumar

  108. Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD + Biosynthesis

    Article • Science, May 2009, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  109. Searching for Genes Underlying Behavior: Lessons from Circadian Rhythms

    Article • Science, November 2008, American Association for the Advancement of Science

    Dr Vivek Kumar, Dr Joseph S Takahashi

  110. The genetics of mammalian circadian order and disorder: implications for physiology and disease

    Article • Nature Reviews Genetics, October 2008, Springer Science + Business Media

    Dr Joseph S Takahashi

  111. The Meter of Metabolism

    Article • Cell, September 2008, Elsevier

    Dr Joseph S Takahashi

  112. cAMP-Dependent Signaling as a Core Component of the Mammalian Circadian Pacemaker

    Article • Science, May 2008, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  113. Gene Set Enrichment in eQTL Data Identifies Novel Annotations and Pathway Regulators

    Article • PLoS Genetics, May 2008, PLOS

    Dr Joseph S Takahashi

  114. Setting Clock Speed in Mammals: The CK1ɛ tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins

    Article • Neuron, April 2008, Elsevier

    Dr Joseph S Takahashi

  115. Alterations in the Circadian System in Advanced Age

    Article • September 2007, Wiley

    Dr Joseph S Takahashi

  116. Identification of the circadian transcriptome in adult mouse skeletal muscle

    Article • Physiological Genomics, September 2007, American Physiological Society

    Dr Joseph S Takahashi

  117. Interpretation of the mouse electroretinogram

    Article • Documenta Ophthalmologica, July 2007, Springer Science + Business Media

    Dr Joseph S Takahashi

  118. Circadian Mutant Overtime Reveals F-box Protein FBXL3 Regulation of Cryptochrome and Period Gene Expression

    Article • Cell, June 2007, Elsevier

    Dr Joseph S Takahashi, Dr Vivek Kumar

  119. Intercellular Coupling Confers Robustness against Mutations in the SCN Circadian Clock Network

    Article • Cell, May 2007, Elsevier

    Dr Joseph S Takahashi

  120. Genomewide Association Analysis in Diverse Inbred Mice: Power and Population Structure

    Article • Genetics, May 2007, Oxford University Press (OUP)

    Dr Joseph S Takahashi

  121. Mania-like behavior induced by disruption of CLOCK

    Article • Proceedings of the National Academy of Sciences, April 2007, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  122. Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation

    Article • Proceedings of the National Academy of Sciences, February 2007, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  123. Inducible and Reversible Clock Gene Expression in Brain Using the tTA System for the Study of Circadian Behavior

    Article • PLoS Genetics, February 2007, PLOS

    Dr Joseph S Takahashi

  124. System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock

    Article • PLoS Biology, January 2007, PLOS

    Dr Joseph S Takahashi

  125. A Circadian Sleep Disorder Reveals a Complex Clock

    Article • Cell, January 2007, Elsevier

    Dr Joseph S Takahashi

  126. Generation, identification and functional characterization of thenob4mutation ofGrm6in the mouse

    Article • Visual Neuroscience, January 2007, Maximum Academic Press

    Dr Joseph S Takahashi

  127. Genetics and Neurobiology of Circadian Clocks in Mammals

    Article • Cold Spring Harbor Symposia on Quantitative Biology, January 2007, Cold Spring Harbor Laboratory Press

    Dr Joseph S Takahashi

  128. The Mammalian Circadian System: from Genes to Behavior

    Article • January 2007, Springer Science + Business Media

    Dr Joseph S Takahashi

  129. Genetic analysis of the stress-responsive adrenocortical axis

    Article • Physiological Genomics, December 2006, American Physiological Society

    Dr Joseph S Takahashi

  130. Dissecting the Functions of the Mammalian Clock Protein BMAL1 by Tissue-Specific Rescue in Mice

    Article • Science, November 2006, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  131. Vasopressin Regulation of the Proestrous Luteinizing Hormone Surge in Wild-Type and Clock Mutant Mice1

    Article • Biology of Reproduction, November 2006, Oxford University Press (OUP)

    Dr Joseph S Takahashi

  132. Molecular components of the mammalian circadian clock

    Article • Human Molecular Genetics, October 2006, Oxford University Press (OUP)

    Dr Joseph S Takahashi

  133. Erratum: BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output

    Article • Nature Neuroscience, September 2006, Springer Science + Business Media

    Dr Joseph S Takahashi

  134. BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output

    Article • Nature Neuroscience, July 2006, Springer Science + Business Media

    Dr Joseph S Takahashi

  135. Xenobiotic metabolism in the fourth dimension: PARtners in time

    Article • Cell Metabolism, July 2006, Elsevier

    Dr Joseph S Takahashi

  136. The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase–response curve amplitude

    Article • Proceedings of the National Academy of Sciences, June 2006, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  137. Test- and behavior-specific genetic factors affect WKY hypoactivity in tests of emotionality

    Article • Behavioural Brain Research, May 2006, Elsevier

    Dr Joseph S Takahashi

  138. Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice

    Article • Trends in Neurosciences, April 2006, Elsevier

    Dr Joseph S Takahashi

  139. Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse

    Article • Genome Research, February 2006, Cold Spring Harbor Laboratory Press

    Dr Joseph S Takahashi

  140. Generation, characterization, and molecular cloning of theNoerg-1mutation of rhodopsin in the mouse

    Article • Visual Neuroscience, September 2005, Maximum Academic Press

    Dr Joseph S Takahashi

  141. Loss of Circadian Photoentrainment and Abnormal Retinal Electrophysiology inMath5Mutant Mice

    Article • Investigative Ophthalmology & Visual Science, July 2005, Association for Research in Vision and Ophthalmology (ARVO)

    Dr Joseph S Takahashi

  142. Regulation of dopaminergic transmission and cocaine reward by the Clock gene

    Article • Proceedings of the National Academy of Sciences, June 2005, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  143. Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

    Article • Science, May 2005, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  144. Circadian Clock Genes as Modulators of Sensitivity to Genotoxic Stress

    Article • Cell Cycle, May 2005, Taylor & Francis

    Dr Joseph S Takahashi

  145. Lineage is an Epigenetic Modifier of QTL Influencing Behavioral Coping with Stress

    Article • Behavior Genetics, March 2005, Springer Science + Business Media

    Dr Joseph S Takahashi

  146. A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo

    Article • Proceedings of the National Academy of Sciences, February 2005, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  147. Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex

    Article • Proceedings of the National Academy of Sciences, February 2005, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  148. Quantitative Trait Loci Associated with Elevated Thyroid-Stimulating Hormone in the Wistar-Kyoto Rat

    Article • Endocrinology, February 2005, Endocrine Society

    Dr Joseph S Takahashi

  149. Circadian Rhythm Generation and Entrainment in Astrocytes

    Article • Journal of Neuroscience, January 2005, Society for Neuroscience

    Dr Joseph S Takahashi

  150. Forward Genetic Screens to Identify Circadian Rhythm Mutants in Mice

    Article • January 2005, Elsevier

    Dr Joseph S Takahashi

  151. Methods to Record Circadian Rhythm Wheel Running Activity in Mice

    Article • January 2005, Elsevier

    Dr Joseph S Takahashi

  152. Real-Time Luminescence Reporting of Circadian Gene Expression in Mammals

    Article • January 2005, Elsevier

    Dr Joseph S Takahashi

  153. Mouse Chimeras and Their Application to Circadian Biology

    Article • January 2005, Elsevier

    Dr Joseph S Takahashi

  154. Inducible and Reversible Clock Gene Expression in Brain Using the tTA System for the Study of Circadian Behavior

    Article • PLoS Genetics, January 2005, PLOS

    Dr Joseph S Takahashi

  155. Bioluminescence Imaging of Individual Fibroblasts Reveals Persistent, Independently Phased Circadian Rhythms of Clock Gene Expression

    Article • Current Biology, December 2004, Elsevier

    Dr Joseph S Takahashi

  156. Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function

    Article • Molecular Brain Research, December 2004, Elsevier

    Dr Joseph S Takahashi

  157. Results from screening over 9000 mutation-bearing mice for defects in the electroretinogram and appearance of the fundus

    Article • Vision Research, December 2004, Elsevier

    Dr Joseph S Takahashi

  158. The orphan receptor Rev-erbα gene is a target of the circadian clock pacemaker

    Article • Journal of Molecular Endocrinology, December 2004, Bioscientifica

    Dr Joseph S Takahashi

  159. Finding New Clock Components: Past and Future

    Article • Journal of Biological Rhythms, October 2004, SAGE Publications

    Dr Joseph S Takahashi

  160. MAMMALIAN CIRCADIAN BIOLOGY: Elucidating Genome-Wide Levels of Temporal Organization

    Article • Annual Review of Genomics and Human Genetics, September 2004, Annual Reviews

    Dr Joseph S Takahashi

  161. Implementing Large-Scale ENU Mutagenesis Screens in North America

    Article • Genetica, September 2004, Springer Science + Business Media

    Dr Joseph S Takahashi

  162. Circadian Clock Mutation Disrupts Estrous Cyclicity and Maintenance of Pregnancy

    Article • Current Biology, August 2004, Elsevier

    Dr Joseph S Takahashi

  163. Sex- and lineage-specific inheritance of depression-like behavior in the rat

    Article • Mammalian Genome, August 2004, Springer Science + Business Media

    Dr Joseph S Takahashi

  164. Maternal behavior modulates x-linked inheritance of behavioral coping in the defensive burying test

    Article • Biological Psychiatry, June 2004, Elsevier

    Dr Joseph S Takahashi

  165. Maternal behavior modulates x-linked inheritance of behavioral coping in the defensive burying test

    Article • Biological Psychiatry, June 2004, Elsevier

    Dr Joseph S Takahashi

  166. A genome end-game: understanding gene function in the nervous system

    Article • Nature Neuroscience, May 2004, Springer Science + Business Media

    Dr Joseph S Takahashi

  167. Biography of Joseph S. Takahashi

    Article • Proceedings of the National Academy of Sciences, April 2004, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  168. Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice

    Article • Neurobiology of Aging, April 2004, Elsevier

    Dr Joseph S Takahashi

  169. PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

    Article • Proceedings of the National Academy of Sciences, February 2004, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  170. The gene for soluble N -ethylmaleimide sensitive factor attachment protein α is mutated in hydrocephaly with hop gait ( hyh ) mice

    Article • Proceedings of the National Academy of Sciences, January 2004, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  171. X-linked and lineage-dependent inheritance of coping responses to stress

    Article • Mammalian Genome, November 2003, Springer Science + Business Media

    Dr Joseph S Takahashi

  172. Circadian Transcriptional Output in the SCN and Liver of the Mouse

    Article • October 2003, Wiley

    Dr Joseph S Takahashi

  173. Aging Alters Circadian and Light-Induced Expression of Clock Genes in Golden Hamsters

    Article • Journal of Biological Rhythms, April 2003, SAGE Publications

    Dr Joseph S Takahashi

  174. Depressive-like behavior and stress reactivity are independent traits in a Wistar Kyoto × Fisher 344 cross

    Article • Molecular Psychiatry, April 2003, Springer Science + Business Media

    Dr Joseph S Takahashi

  175. Molecular genetics of circadian clocks in mammals

    Article • March 2003, Elsevier

    Dr Joseph S Takahashi

  176. Chemically Induced Mutations in the Mouse that Affect the Fundus and Electroretinogram

    Article • January 2003, Springer Science + Business Media

    Dr Joseph S Takahashi

  177. Article • Genome Biology, January 2003, Springer Science + Business Media

    Dr Joseph S Takahashi

  178. Measurement of hypocretin/orexin content in the mouse brain using an enzyme immunoassay: the effect of circadian time, age and genetic background

    Article • Peptides, December 2002, Elsevier

    Dr Joseph S Takahashi

  179. The cancer connection

    Article • Nature, November 2002, Springer Science + Business Media

    Dr Joseph S Takahashi

  180. Future of genetics of mood disorders research

    Article • Biological Psychiatry, September 2002, Elsevier

    Dr Joseph S Takahashi

  181. Joseph S. Takahashi, Fred W. Turek and Robert Y.Moore (eds): Circadian Clocks (Handbook of Behavioral Neurobiology, Vol 12)

    Article • Genes Brain & Behavior, July 2002, Wiley

    Dr Joseph S Takahashi

  182. Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

    Article • Cell, May 2002, Elsevier

    Dr Joseph S Takahashi

  183. Photic and circadian expression of luciferase in mPeriod1 - luc transgenic mice in vivo

    Article • Proceedings of the National Academy of Sciences, December 2001, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  184. Functional Identification of Neural Genes

    Article • September 2001, Taylor & Francis

    Dr Joseph S Takahashi

  185. Familial Advanced Sleep Phase Syndrome

    Article • Archives of Neurology, July 2001, American Medical Association (AMA)

    Dr Joseph S Takahashi

  186. Genome-Wide Epistatic Interaction Analysis Reveals Complex Genetic Determinants of Circadian Behavior in Mice

    Article • Genome Research, June 2001, Cold Spring Harbor Laboratory Press

    Dr Joseph S Takahashi

  187. Effect of circadian phase on context and cued fear conditioning in C57BL/6J mice

    Article • Animal Learning & Behavior, May 2001, Springer Science + Business Media

    Dr Joseph S Takahashi

  188. Chimera Analysis of the Clock Mutation in Mice Shows that Complex Cellular Integration Determines Circadian Behavior

    Article • Cell, April 2001, Elsevier

    Dr Joseph S Takahashi

  189. STOPPINGTIME: The Genetics of Fly and Mouse Circadian Clocks

    Article • Annual Review of Neuroscience, March 2001, Annual Reviews

    Dr Joseph S Takahashi

  190. Functional Annotation of Mouse Genome Sequences

    Article • Science, February 2001, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  191. Handbook of Behavioral Neurobiology

    Article • January 2001

    Dr Joseph S Takahashi

  192. Introduction to Circadian Rhythms

    Article • January 2001, Springer Science + Business Media

    Dr Joseph S Takahashi

  193. Genetics of the Mammalian Circadian System: Photic Entrainment, Circadian Pacemaker Mechanisms, and Posttranslational Regulation

    Article • Annual Review of Genetics, December 2000, Annual Reviews

    Dr Joseph S Takahashi

  194. Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals

    Article • Cell, December 2000, Elsevier

    Dr Joseph S Takahashi

  195. The Mouse Clock Locus: Sequence and Comparative Analysis of 204 Kb from Mouse Chromosome 5

    Article • Genome Research, December 2000, Cold Spring Harbor Laboratory Press

    Dr Joseph S Takahashi

  196. Locomotor response to an open field during C57BL/6J active and inactive phases

    Article • Physiology & Behavior, May 2000, Elsevier

    Dr Joseph S Takahashi

  197. Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau

    Article • Science, April 2000, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  198. Molecular Genetics of Circadian Rhythms in Mammals

    Article • Annual Review of Neuroscience, March 2000, Annual Reviews

    Dr Joseph S Takahashi

  199. Nonphotic phase-shifting in Clock mutant mice

    Article • Brain Research, March 2000, Elsevier

    Dr Joseph S Takahashi

  200. The Xenopus Clock gene is constitutively expressed in retinal photoreceptors

    Article • Molecular Brain Research, February 2000, Elsevier

    Dr Joseph S Takahashi

  201. Differential regulation of mammalian Period genes and circadian rhythmicity by cryptochromes 1 and 2

    Article • Proceedings of the National Academy of Sciences, October 1999, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  202. Narcolepsy Genes Wake Up the Sleep Field

    Article • Science, September 1999, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  203. Genetic Influences on Circadian Rhythms in Mammals

    Article • July 1999, Taylor & Francis

    Dr Joseph S Takahashi

  204. Targeted Deletion of the Vgf Gene Indicates that the Encoded Secretory Peptide Precursor Plays a Novel Role in the Regulation of Energy Balance

    Article • Neuron, July 1999, Elsevier

    Dr Joseph S Takahashi

  205. Molecular Cloning and Characterization of the HumanCLOCKGene: Expression in the Suprachiasmatic Nuclei

    Article • Genomics, April 1999, Elsevier

    Dr Joseph S Takahashi

  206. Chapter 2.1.7 Genetic dissection of mouse behavior using induced mutagenesis

    Article • January 1999, Elsevier

    Dr Joseph S Takahashi

  207. Effects of aging on lens transmittance and retinal input to the suprachiasmatic nucleus in golden hamsters

    Article • Neuroscience Letters, December 1998, Elsevier

    Dr Joseph S Takahashi

  208. Clock controls circadian period in isolated suprachiasmatic nucleus neurons

    Article • Nature Neuroscience, December 1998, Springer Science + Business Media

    Dr Joseph S Takahashi

  209. Day/Night Differences in the Stimulation of Adenylate Cyclase Activity by Calcium/Calmodulin in Chick Pineal Cell Cultures: Evidence for Circadian Regulation of Cyclic AMP

    Article • Journal of Biological Rhythms, December 1998, SAGE Publications

    Dr Joseph S Takahashi

  210. Role of Mouse Cryptochrome Blue-Light Photoreceptor in Circadian Photoresponses

    Article • Science, November 1998, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  211. Strategies for Dissecting the Molecular Mechanisms of Mammalian Circadian Rhythmicity

    Article • November 1998, Taylor & Francis

    Dr Joseph S Takahashi

  212. Strategies for Dissecting the Molecular Mechanisms of Mammalian Circadian Rhythmicity

    Article • November 1998, Taylor & Francis

    Dr Joseph S Takahashi

  213. Mammalian Circadian Autoregulatory Loop

    Article • Neuron, November 1998, Elsevier

    Dr Joseph S Takahashi

  214. Light-dependent Activation of Rod Transducin by Pineal Opsin

    Article • Journal of Biological Chemistry, October 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Robert F Margolskee, Dr Joseph S Takahashi

  215. Circadian rhythms: molecular basis of the clock

    Article • Current Opinion in Genetics & Development, October 1998, Elsevier

    Dr Joseph S Takahashi

  216. Circadian Behavior and Plasticity of Light-Induced c-fos Expression in SCN of tau Mutant Hamsters

    Article • Journal of Biological Rhythms, August 1998, SAGE Publications

    Dr Joseph S Takahashi

  217. Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim

    Article • Science, June 1998, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  218. Role of the CLOCK Protein in the Mammalian Circadian Mechanism

    Article • Science, June 1998, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  219. Mutant Mice and Neuroscience: Recommendations Concerning Genetic Background

    Article • Neuron, October 1997, Elsevier

    Dr Joseph S Takahashi

  220. Lability of Circadian Pacemaker Amplitude in Chick Pineal Cells: A Temperature-Dependent Process

    Article • Journal of Biological Rhythms, August 1997, SAGE Publications

    Dr Joseph S Takahashi

  221. Bristol-Myers squibb unrestricted biomedical research grants programme

    Article • Trends in Pharmacological Sciences, July 1997, Elsevier

    Dr Joseph S Takahashi

  222. Visual sensitivities of nur77 (NGFI-B) and zif268 (NGFI-A) induction in the suprachiasmatic nucleus are dissociated from c-fos induction and behavioral phase-shifting responses

    Article • Molecular Brain Research, June 1997, Elsevier

    Dr Joseph S Takahashi

  223. Positional Cloning of the Mouse Circadian Gene

    Article • Cell, May 1997, Elsevier

    Dr Joseph S Takahashi

  224. Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue

    Article • Cell, May 1997, Elsevier

    Dr Joseph S Takahashi

  225. Regulation of the vgf gene in the golden hamster suprachiasmatic nucleus by light and by the circadian clock

    Article • The Journal of Comparative Neurology, February 1997, Wiley

    Dr Joseph S Takahashi

  226. Regulation of thevgf gene in the golden hamster suprachiasmatic nucleus by light and by the circadian clock

    Article • The Journal of Comparative Neurology, February 1997, Wiley

    Dr Joseph S Takahashi

  227. Molecular cloning of chick pineal tryptophan hydroxylase and circadian oscillation of its mRNA levels

    Article • Molecular Brain Research, November 1996, Elsevier

    Dr Joseph S Takahashi

  228. Critical period for cycloheximide blockade of light-induced phase advances of the circadian locomotor activity rhythm in golden hamsters

    Article • Brain Research, November 1996, Elsevier

    Dr Joseph S Takahashi

  229. Quantitative Two-Dimensional Gel Electrophoretic Analysis of Clock-Controlled Proteins in Cultured Chick Pineal Cells: Circadian Regulation of Tryptophan Hydroxylase

    Article • Journal of Biological Rhythms, September 1996, SAGE Publications

    Dr Joseph S Takahashi

  230. Ion channels get the message

    Article • Nature, July 1996, Springer Science + Business Media

    Dr Joseph S Takahashi

  231. Regulation of Tryptophan Hydroxylase by Cyclic AMP, Calcium, Norepinephrine, and Light in Cultured Chick Pineal Cells

    Article • Journal of Neurochemistry, July 1996, Wiley

    Dr Joseph S Takahashi

  232. Light, immediate-early genes, and circadian rhythms

    Article • Behavior Genetics, May 1996, Springer Science + Business Media

    Dr Joseph S Takahashi

  233. Calcium modulates circadian variation in cAMP-stimulated melatonin in chick pineal cells

    Article • Brain Research, April 1996, Elsevier

    Dr Joseph S Takahashi

  234. Effects of aging on light-induced phase-shifting of circadian behavioral rhythms, Fos expression and creb phosphorylation in the hamster suprachiasmatic nucleus

    Article • Neuroscience, February 1996, Elsevier

    Dr Joseph S Takahashi

  235. Chapter 1 The biological clock: it's all in the genes

    Article • January 1996, Elsevier

    Dr Joseph S Takahashi

  236. Chapter 10 Light entrainment and activation of signal transduction pathways in the SCN

    Article • January 1996, Elsevier

    Dr Joseph S Takahashi

  237. Temperature compensation and temperature entrainment of the chick pineal cell circadian clock

    Article • Journal of Neuroscience, August 1995, Society for Neuroscience

    Dr Joseph S Takahashi

  238. The Circadian Clock: From Molecules to Behaviour

    Article • Annals of Medicine, August 1995, Taylor & Francis

    Dr Joseph S Takahashi

  239. Pharmacological and Genetic Approaches for the Study of Circadian Rhythms in Mammals

    Article • Frontiers in Neuroendocrinology, July 1995, Elsevier

    Dr Joseph S Takahashi

  240. Pineal opsin: a nonvisual opsin expressed in chick pineal

    Article • Science, March 1995, American Association for the Advancement of Science

    Dr Robert F Margolskee, Dr Joseph S Takahashi

  241. Genetic analysis of the circadian system of mammals: properties and prospects

    Article • Seminars in Neuroscience, February 1995, Elsevier

    Dr Joseph S Takahashi

  242. The Circadian Clock: From Molecules to Behaviour

    Article • Annals of Medicine, January 1995, Taylor & Francis

    Dr Joseph S Takahashi

  243. Molecular Neurobiology and Genetics of Circadian Rhythms in Mammals

    Article • Annual Review of Neuroscience, January 1995, Annual Reviews

    Dr Joseph S Takahashi

  244. Neuropeptide Y stimulates luteinizing hormone-releasing hormone release from superfused hypothalamic GT1-7 cells

    Article • Endocrinology, October 1994, Endocrine Society

    Dr Joseph S Takahashi

  245. Characterization of the Chicken Rhodopsin Promoter: Identification of Retina-Specific and glass-like Protein Binding Domains

    Article • Molecular and Cellular Neuroscience, August 1994, Elsevier

    Dr Joseph S Takahashi

  246. Forward and Reverse Genetic Approaches to Behavior in the Mouse

    Article • Science, June 1994, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  247. Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior

    Article • Science, April 1994, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  248. RNA synthesis inhibitors increase melatonin production in Y79 human retinoblastoma cells

    Article • Molecular Brain Research, April 1994, Elsevier

    Dr Joseph S Takahashi

  249. Circadian Rhythms: ICER is nicer at night (sir!)

    Article • Current Biology, February 1994, Elsevier

    Dr Joseph S Takahashi

  250. Fos protein expression in the circadian clock is not associated with phase shifts induced by a nonphotic stimulus, triazolam

    Article • Neuroscience Letters, December 1993, Elsevier

    Dr Joseph S Takahashi

  251. Circadian clocks à la CREM

    Article • Nature, September 1993, Springer Science + Business Media

    Dr Joseph S Takahashi

  252. A cholinergic antagonist, mecamylamine, blocks light-induced Fos immunoreactivity in specific regions of the hamster suprachiasmatic nucleus

    Article • Brain Research, June 1993, Elsevier

    Dr Joseph S Takahashi

  253. Regulation of CREB Phosphorylation in the Suprachiasmatic Nucleus by Light and a Circadian Clock

    Article • Science, April 1993, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  254. Circadian regulation of lodopsin gene expression in embryonic photoreceptors in retinal cell culture

    Article • Neuron, April 1993, Elsevier

    Dr Joseph S Takahashi

  255. Circadian-clock regulation of gene expression

    Article • Current Opinion in Genetics & Development, January 1993, Elsevier

    Dr Joseph S Takahashi

  256. Biological Rhythms: From Gene Expression to Behavior**This paper is dedicated to Dr Aaron B. Lerner for his seminal work on melatonin.

    Article • January 1993, Elsevier

    Dr Joseph S Takahashi

  257. Molecular Approaches to Understanding Circadian Oscillations

    Article • Annual Review of Physiology, January 1993, Annual Reviews

    Dr Joseph S Takahashi

  258. Circadian Clock Genes Are Ticking

    Article • Science, October 1992, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  259. Regulation of jun -B Messenger RNA and AP-1 Activity by Light and a Circadian Clock

    Article • Science, March 1992, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  260. Circadian rhythms: from gene expression to behaviour

    Article • Current Biology, January 1992, Elsevier

    Dr Joseph S Takahashi

  261. Light Regulates c-fos Gene Expression in the Hamster SCN: Implications for Circadian and Seasonal Control of Reproduction

    Article • January 1992, Springer Science + Business Media

    Dr Joseph S Takahashi

  262. Circadian rhythms: From gene expression to behavior

    Article • Current Opinion in Neurobiology, December 1991, Elsevier

    Dr Joseph S Takahashi

  263. Comparison of visual sensitivity for suppression of pineal melatonin and circadian phase-shifting in the golden hamster

    Article • Brain Research, July 1991, Elsevier

    Dr Joseph S Takahashi

  264. Sensitivity and integration in a visual pathway for circadian entrainment in the hamster (Mesocricetus auratus).

    Article • The Journal of Physiology, July 1991, Wiley

    Dr Joseph S Takahashi

  265. N-acetyltransferase and protein synthesis modulate melatonin production by Y79 human retinoblastoma cells

    Article • Brain Research, February 1991, Elsevier

    Dr Joseph S Takahashi

  266. Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus

    Article • Neuron, August 1990, Elsevier

    Dr Joseph S Takahashi

  267. Photic threshold for stimulation of testicular growth and pituitary FSH release in male Djungarian hamsters

    Article • Brain Research, April 1990, Elsevier

    Dr Joseph S Takahashi

  268. Vasoactive Intestinal Polypeptide and α2-Adrenoceptor Agonists Regulate Adenosine 3′,5′-Monophosphate Accumulation and Melatonin Release in Chick Pineal Cell Cultures*

    Article • Endocrinology, November 1989, Endocrine Society

    Dr Joseph S Takahashi

  269. Twenty-four hour oscillation of cAMP in chick pineal cells: Role of cAMP in the acute and circadian regulation of melatonin production

    Article • Neuron, November 1989, Elsevier

    Dr Joseph S Takahashi

  270. Phase shifting the circadian clock with cycloheximide: response of hamster with an intact or a split rhythm of locomotor activity

    Article • Brain Research, September 1989, Elsevier

    Dr Joseph S Takahashi

  271. Characteristics and Autoradiographic Localization of 2-[125I]Iodomelatonin Binding Sites in Djungarian Hamster Brain*

    Article • Endocrinology, August 1989, Endocrine Society

    Dr Joseph S Takahashi

  272. Cyclic AMP‐Dependent Melatonin Production in Y79 Human Retinoblastoma Cells

    Article • Journal of Neurochemistry, July 1989, Wiley

    Dr Joseph S Takahashi

  273. The Avian Pineal, a Vertebrate Model System of the Circadian Oscillator: Cellular Regulation of Circadian Rhythms by Light, Second Messengers, and Macromolecular Synthesis

    Article • January 1989, Elsevier

    Dr Joseph S Takahashi

  274. Immunocytochemical localization of serotonergic fibers innervating the ocular circadian system of Aplysia

    Article • Neuroscience, January 1989, Elsevier

    Dr Joseph S Takahashi

  275. A Pertussis Toxin-Sensitive G-Protein Mediates the α2-Adrenergic Receptor Inhibition of Melatonin Release in Photoreceptive Chick Pineal Cell Cultures*

    Article • Endocrinology, July 1988, Endocrine Society

    Dr Joseph S Takahashi

  276. 2-[125I]Iodomelatonin Binding Sites in Hamster Brain Membranes: Pharmacological Characteristics and Regional Distribution*

    Article • Endocrinology, May 1988, Endocrine Society

    Dr Joseph S Takahashi

  277. Circadian clock in cell culture: II. In vitro photic entrainment of melatonin oscillation from dissociated chick pineal cells

    Article • Journal of Neuroscience, January 1988, Society for Neuroscience

    Dr Joseph S Takahashi

  278. Alpha-2 adrenergic regulation of melatonin release in chick pineal cell cultures

    Article • Journal of Neuroscience, November 1987, Society for Neuroscience

    Dr Joseph S Takahashi

  279. Use of 2-[125I]iodomelatonin to characterize melatonin binding sites in chicken retina.

    Article • Proceedings of the National Academy of Sciences, June 1987, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  280. Anisomycin, an inhibitor of protein synthesis, perturbs the phase of a mammalian circadian pacemaker

    Article • Brain Research, March 1987, Elsevier

    Dr Joseph S Takahashi

  281. A cholinergic antagonist, mecamylamine, blocks the phase-shifting effects of light on the circadian rhythm of locomotor activity in the golden hamster

    Article • Brain Research, February 1987, Elsevier

    Dr Joseph S Takahashi, David Earnest

  282. Why the neuroendocrine system is important in aging processes

    Article • Experimental Gerontology, January 1987, Elsevier

    Dr Joseph S Takahashi

  283. Characterization of 2-[125I]iodomelatonin binding sites in hamster brain

    Article • European Journal of Pharmacology, December 1986, Elsevier

    Dr Joseph S Takahashi

  284. Dynamics of noradrenergic circadian input to the chicken pineal gland

    Article • Brain Research, October 1986, Elsevier

    Dr Joseph S Takahashi

  285. Light-dependent regulation of dopamine receptors in mammalian retina

    Article • Brain Research, June 1985, Elsevier

    Dr Joseph S Takahashi

  286. Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythms

    Article • Nature, March 1984, Springer Science + Business Media

    Dr Joseph S Takahashi

  287. Circadian Rhythmicity

    Article • January 1984, Springer Science + Business Media

    Dr Joseph S Takahashi

  288. Multiple redundant circadian oscillators within the isolated avian pineal gland

    Article • Journal of Comparative Physiology A, January 1984, Springer Science + Business Media

    Dr Joseph S Takahashi

  289. Light-induced decrease of serotonin N-acetyltransferase activity and melatonin in the chicken pineal gland and retina

    Article • Brain Research, May 1983, Elsevier

    Dr Joseph S Takahashi

  290. Adenylate Cyclase Activation Shifts the Phase of a Circadian Pacemaker

    Article • Science, April 1983, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  291. Regulation of Circadian Rhythmicity

    Article • Science, September 1982, American Association for the Advancement of Science

    Dr Joseph S Takahashi

  292. Role of the suprachiasmatic nuclei in the circadian system of the house sparrow, Passer domesticus

    Article • Journal of Neuroscience, June 1982, Society for Neuroscience

    Dr Joseph S Takahashi

  293. Entrainment of the circadian system of the house sparrow: A population of oscillators in pinealectomized birds

    Article • Journal of Comparative Physiology A, January 1982, Springer Science + Business Media

    Dr Joseph S Takahashi

  294. Circadian Rhythms of the Isolated Chicken Pineal in Vitro

    Article • January 1982, Springer Science + Business Media

    Dr Joseph S Takahashi

  295. Neural Mechanisms in Avian Circadian Systems: Hypothalamic Pacemaking Systems

    Article • January 1982, Springer Science + Business Media

    Dr Joseph S Takahashi

  296. Circadian rhythms of melatonin release from individual superfused chicken pineal glands in vitro.

    Article • Proceedings of the National Academy of Sciences, April 1980, Proceedings of the National Academy of Sciences

    Dr Joseph S Takahashi

  297. The Physiology of Circadian Pacemakers

    Article • Annual Review of Physiology, March 1978, Annual Reviews

    Dr Joseph S Takahashi

  298. Implementing large-scale ENU mutagenesis screens in North America

    Article • Springer Science + Business Media

    Dr Joseph S Takahashi