All Stories

  1. Identifying, studying and making good use of macromolecular crystals

    Article • Acta Crystallographica Section F Structural Biology Communications, July 2014, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  2. Statistical Analysis of Crystallization Database Links Protein Physico-Chemical Features with Crystallization Mechanisms

    Article • PLoS ONE, July 2014, PLOS

    Joseph R Luft, Dr Edward H Snell

  3. Crystallization screening: the influence of history on current practice

    Article • Acta Crystallographica Section F Structural Biology Communications, June 2014, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  4. Comparing Chemistry to Outcome: The Development of a Chemical Distance Metric, Coupled with Clustering and Hierarchal Visualization Applied to Macromolecular Crystallography

    Article • PLoS ONE, June 2014, PLOS

    Joseph R Luft, Dr Edward H Snell

  5. A new view on crystal harvesting

    Article • Journal of Applied Crystallography, May 2014, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  6. The Structure of Yeast Glutaminyl-tRNA Synthetase and Modeling of Its Interaction with tRNA

    Article • Journal of Molecular Biology, July 2013, Elsevier

    Joseph R Luft, Dr Edward H Snell

  7. Purification and SAXS Analysis of the Integrin Linked Kinase, PINCH, Parvin (IPP) Heterotrimeric Complex

    Article • PLoS ONE, January 2013, PLOS

    Joseph R Luft, Dr Edward H Snell

  8. On the need for an international effort to capture, share and use crystallization screening data

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, February 2012, International Union of Crystallography

    Dr Thomas S Peat, Joseph R Luft, Dr Edward H Snell

  9. 13th International Conference on the Crystallization of Biological Macromolecules (ICCBM13) Proceedings Overview

    Article • Crystal Growth & Design, December 2011, American Chemical Society (ACS)

    Joseph R Luft

  10. Small angle X‐ray scattering as a complementary tool for high‐throughput structural studies

    Article • Biopolymers, April 2011, Wiley

    Joseph R Luft, Dr Edward H Snell

  11. Lessons from high-throughput protein crystallization screening: 10 years of practical experience

    Article • Expert Opinion on Drug Discovery, March 2011, Informa Healthcare

    Joseph R Luft, Dr Edward H Snell

  12. What’s in a Drop? Correlating Observations and Outcomes to Guide Macromolecular Crystallization Experiments

    Article • Crystal Growth & Design, January 2011, American Chemical Society (ACS)

    Joseph R Luft, Dr Edward H Snell

  13. Crystal cookery – using high-throughput technologies and the grocery store as a teaching tool

    Article • Journal of Applied Crystallography, August 2010, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  14. The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase

    Article • Journal of Molecular Biology, March 2010, Elsevier

    Joseph R Luft

  15. Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica

    Article • Molecular and Biochemical Parasitology, February 2010, Elsevier

    Joseph R Luft

  16. Determination and application of empirically derived detergent phase boundaries to effectively crystallize membrane proteins

    Article • Protein Science, August 2009, Wiley

    Joseph R Luft

  17. Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data

    Article • Nature Biotechnology, December 2008, Springer Science + Business Media

    Joseph R Luft

  18. The application and use of chemical space mapping to interpret crystallization screening results

    Article • Acta Crystallographica Section D Biological Crystallography, November 2008, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  19. Establishing a training set through the visual analysis of crystallization trials. Part I: ∼150 000 images

    Article • Acta Crystallographica Section D Biological Crystallography, October 2008, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  20. Establishing a training set through the visual analysis of crystallization trials. Part II: crystal examples

    Article • Acta Crystallographica Section D Biological Crystallography, October 2008, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  21. AutoSherlock: a program for effective crystallization data analysis

    Article • Journal of Applied Crystallography, October 2008, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  22. Structures of Substrate- and Inhibitor-Bound Adenosine Deaminase from a Human Malaria Parasite Show a Dramatic Conformational Change and Shed Light on Drug Selectivity

    Article • Journal of Molecular Biology, September 2008, Elsevier

    Joseph R Luft

  23. Structure of aTrypanosoma bruceiα/β-hydrolase fold protein with unknown function

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, May 2008, International Union of Crystallography

    Joseph R Luft

  24. Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

    Article • Molecular Microbiology, February 2008, Wiley

    Joseph R Luft

  25. Structural Genomics of Pathogenic Protozoa: an Overview

    Article • January 2008, Springer Science + Business Media

    Joseph R Luft

  26. The structure ofPlasmodium vivaxphosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, February 2007, International Union of Crystallography

    Joseph R Luft

  27. Using Fragment Cocktail Crystallography To Assist Inhibitor Design of Trypanosoma brucei Nucleoside 2-Deoxyribosyltransferase

    Article • Journal of Medicinal Chemistry, September 2006, American Chemical Society (ACS)

    Joseph R Luft

  28. Structure of ribose 5-phosphate isomerase fromPlasmodium falciparum

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, April 2006, International Union of Crystallography

    Joseph R Luft

  29. Structure of Lmaj006129AAA, a hypothetical protein fromLeishmania major

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, February 2006, International Union of Crystallography

    Joseph R Luft

  30. Structure of the conserved hypothetical protein MAL13P1.257 fromPlasmodium falciparum

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, February 2006, International Union of Crystallography

    Joseph R Luft

  31. Crystal structure of glyceraldehyde‐3‐phosphate dehydrogenase from Plasmodium falciparum at 2.25 Å resolution reveals intriguing extra electron density in the active site

    Article • Proteins Structure Function and Bioinformatics, December 2005, Wiley

    Joseph R Luft

  32. Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily

    Article • Protein Science, November 2005, Wiley

    Joseph R Luft

  33. Structures ofPlasmodium falciparumpurine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine

    Article • Acta Crystallographica Section D Biological Crystallography, August 2005, International Union of Crystallography

    Joseph R Luft

  34. Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase

    Article • Acta Crystallographica Section D Biological Crystallography, August 2003, International Union of Crystallography

    Joseph R Luft

  35. A deliberate approach to screening for initial crystallization conditions of biological macromolecules

    Article • Journal of Structural Biology, April 2003, Elsevier

    Joseph R Luft

  36. Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9—C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase

    Article • Acta Crystallographica Section D Biological Crystallography, March 2003, International Union of Crystallography

    Joseph R Luft

  37. Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9—C10 reversed-bridge antifolates in complex with NADP+andPneumocystis cariniidihydrofolate reductase

    Article • Acta Crystallographica Section D Biological Crystallography, August 2002, International Union of Crystallography

    Joseph R Luft

  38. Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis ofPneumocystis cariniidihydrofolate reductase ternary complex with PT653 and NADPH

    Article • Acta Crystallographica Section D Biological Crystallography, May 2002, International Union of Crystallography

    Joseph R Luft

  39. Macromolecular crystallization in a high throughput laboratory—the search phase

    Article • Journal of Crystal Growth, November 2001, Elsevier

    Joseph R Luft

  40. Macromolecular crystallization in a high throughput setting

    Article • August 2001, American Institute of Aeronautics and Astronautics (AIAA)

    Joseph R Luft

  41. Structure of rat transthyretin (rTTR) complex with thyroxine at 2.5 Å resolution: first non-biased insight into thyroxine binding reveals different hormone orientation in two binding sites

    Article • Acta Crystallographica Section D Biological Crystallography, July 2001, International Union of Crystallography

    Joseph R Luft

  42. Structure of the insecticidal bacterial δ-endotoxin Cry3Bb1 ofBacillus thuringiensis

    Article • Acta Crystallographica Section D Biological Crystallography, July 2001, International Union of Crystallography

    Joseph R Luft

  43. Structural Studies on Bioactive Compounds. 30. Crystal Structure and Molecular Modeling Studies on the Pneumocystis carinii Dihydrofolate Reductase Cofactor Complex with TAB, a Highly Selective Antifolate,,

    Article • Biochemistry, March 2000, American Chemical Society (ACS)

    Joseph R Luft

  44. A method to produce microseed stock for use in the crystallization of biological macromolecules

    Article • Acta Crystallographica Section D Biological Crystallography, May 1999, International Union of Crystallography

    Joseph R Luft

  45. Ligand-Induced Conformational Changes in the Crystal Structures ofPneumocystis cariniiDihydrofolate Reductase Complexes with Folate and NADP+ ,

    Article • Biochemistry, March 1999, American Chemical Society (ACS)

    Joseph R Luft

  46. Microbatch macromolecular crystallization on a thermal gradient

    Article • Journal of Crystal Growth, January 1999, Elsevier

    Joseph R Luft

  47. Microbatch macromolecular crystallization in micropipettes

    Article • Journal of Crystal Growth, January 1999, Elsevier

    Joseph R Luft

  48. COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE

    Article • January 1998, Protein Data Bank, Rutgers University

    Joseph R Luft

  49. COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE

    Article • January 1998, Protein Data Bank, Rutgers University

    Joseph R Luft

  50. COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE

    Article • January 1998, Protein Data Bank, Rutgers University

    Joseph R Luft

  51. Comparison of Two Independent Crystal Structures of Human Dihydrofolate Reductase Ternary Complexes Reduced with Nicotinamide Adenine Dinucleotide Phosphate and the Very Tight-Binding Inhibitor PT523,

    Article • Biochemistry, November 1997, American Chemical Society (ACS)

    Joseph R Luft

  52. [7] Kinetic aspects of macromolecular crystallization

    Article • January 1997, Elsevier

    Joseph R Luft

  53. Conformational analysis of flavonoids: crystal and molecular structures of morin hydrate and myricetin (1:2) triphenylphosphine oxide complex

    Article • Journal of Molecular Structure, January 1994, Elsevier

    Joseph R Luft

  54. Purification and crystallization of insecticidal δ‐endotoxin CryIIIB2 from Bacillus thuringiensis

    Article • Proteins Structure Function and Bioinformatics, October 1992, Wiley

    Joseph R Luft

  55. Experiences with HANGMAN: a macromolecular hanging drop vapor diffusion technique

    Article • Journal of Crystal Growth, August 1992, Elsevier

    Joseph R Luft

  56. ChemInform Abstract: Conformational Analysis of Flavonoids: Crystal and Molecular Structure of 3′,5′‐Dibromo‐3‐methyl‐6,4′‐dihydroxyflavone (1:2) Triphenylphosphine Oxide Complex

    Article • ChemInform, January 1992, Wiley

    Joseph R Luft

  57. Flavonoid conformational analysis: comparison of the molecular structures of (Z)-4,4',6-triacetoxyaurone and (Z)-3',5'-dibromo-2',4,4',6-tetrahydroxyaurone monohydrate by crystallographic and molecular orbital methods

    Article • Journal of Molecular Structure THEOCHEM, December 1991, Elsevier

    Joseph R Luft

  58. Conformational analysis of flavonoids: Crystal and molecular structure of 3?,5?-dibromo-3-methyl-6,4?-dihydroxyflavone (1:2) triphenylphosphine oxide complex

    Article • Structural Chemistry, October 1991, Springer Science + Business Media

    Joseph R Luft

  59. Protein crystal growth in the presence of poly(vinylidene difluoride) membrane

    Article • Journal of Applied Crystallography, August 1991, International Union of Crystallography

    Joseph R Luft