All Stories

  1. A SAXS-based approach to rationally evaluate radical scavengers – toward eliminating radiation damage in solution and crystallographic studies

    Article • Journal of Synchrotron Radiation, August 2021, International Union of Crystallography

    Dr Edward H Snell

  2. SAXS studies of X-ray induced disulfide bond damage: Engineering high-resolution insight from a low-resolution technique

    Article • PLoS ONE, November 2020, PLOS

    Dr Edward H Snell

  3. Crystal structure of Latency Associated Peptide unbound to TGF-beta1

    Article • March 2020, Protein Data Bank, Rutgers University

    Dr Edward H Snell

  4. Structural insights into conformational switching in latency-associated peptide between transforming growth factor β-1 bound and unbound states

    Article • IUCrJ, February 2020, International Union of Crystallography

    Dr Edward H Snell

  5. High-Throughput PIXE as an Essential Quantitative Assay for Accurate Metalloprotein Structural Analysis: Development and Application

    Article • Journal of the American Chemical Society, December 2019, American Chemical Society (ACS)

    Dr Edward H Snell

  6. Structural knowledge or X-ray damage? A case study on xylose isomerase illustrating both

    Article • Journal of Synchrotron Radiation, June 2019, International Union of Crystallography

    Dr Edward H Snell

  7. Using low X-ray doses to understand therapeutically relevant structural changes

    Article • Journal of Synchrotron Radiation, June 2019, International Union of Crystallography

    Dr Edward H Snell

  8. Protein and RNA dynamical fingerprinting

    Article • Nature Communications, March 2019, Springer Science + Business Media

    Dr Edward H Snell

  9. Classification of crystallization outcomes using deep convolutional neural networks

    Article • PLoS ONE, June 2018, PLOS

    Dr Edward H Snell

  10. Moving in the Right Direction: Protein Vibrations Steering Function

    Article • Biophysical Journal, December 2017, Elsevier

    Dr Edward H Snell

  11. Double-flow focused liquid injector for efficient serial femtosecond crystallography

    Article • Scientific Reports, March 2017, Springer Science + Business Media

    Dr Edward H Snell

  12. Moving in the Right Direction: Protein Vibrations Steering Function

    Article • Biophysical Journal, March 2017, Elsevier

    Dr Edward H Snell

  13. Touchscreen interfaces make complex tasks simple.

    Article • Journal of Applied Crystallography, November 2016, International Union of Crystallography

    Dr Edward H Snell

  14. Predicting crystallization from bioinformatic properties

    Article • Archives of Biochemistry and Biophysics, July 2016, Elsevier

    Dr Edward H Snell

  15. The detection and subsequent volume optimization of biological nanocrystals

    Article • Structural Dynamics, May 2015, American Institute of Physics

    Dr Edward H Snell

  16. The Structure of the PanD/PanZ Protein Complex Reveals Negative Feedback Regulation of Pantothenate Biosynthesis by Coenzyme A

    Article • Chemistry & Biology, April 2015, Elsevier

    Dr Edward H Snell

  17. Wild type T4 lysozyme structure

    Article • February 2015, Protein Data Bank, Rutgers University

    Dr Edward H Snell

  18. How to confirm your SAXS data quality

    Article • Acta Crystallographica Section D Biological Crystallography, January 2015, International Union of Crystallography

    Dr Edward H Snell

  19. A hybrid NMR/SAXS-based approach for discriminating oligomeric protein interfaces using Rosetta

    Article • Proteins Structure Function and Bioinformatics, December 2014, Wiley

    Dr Edward H Snell

  20. Identifying, studying and making good use of macromolecular crystals

    Article • Acta Crystallographica Section F Structural Biology Communications, July 2014, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  21. Statistical Analysis of Crystallization Database Links Protein Physico-Chemical Features with Crystallization Mechanisms

    Article • PLoS ONE, July 2014, PLOS

    Joseph R Luft, Dr Edward H Snell

  22. Crystallization screening: the influence of history on current practice

    Article • Acta Crystallographica Section F Structural Biology Communications, June 2014, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  23. Comparing Chemistry to Outcome: The Development of a Chemical Distance Metric, Coupled with Clustering and Hierarchal Visualization Applied to Macromolecular Crystallography

    Article • PLoS ONE, June 2014, PLOS

    Joseph R Luft, Dr Edward H Snell

  24. A new view on crystal harvesting

    Article • Journal of Applied Crystallography, May 2014, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  25. Neutron structure of the cyclic glucose-bound xylose isomerase E186Q mutant

    Article • Acta Crystallographica Section D Biological Crystallography, January 2014, International Union of Crystallography

    Dr Edward H Snell

  26. Optical measurements of long-range protein vibrations

    Article • Nature Communications, January 2014, Nature

    Dr Edward H Snell

  27. Insights into the mechanism of X-ray-induced disulfide-bond cleavage in lysozyme crystals based on EPR, optical absorption and X-ray diffraction studies

    Article • Acta Crystallographica Section D Biological Crystallography, November 2013, International Union of Crystallography

    Dr Edward H Snell

  28. Faculty of 1000 evaluation for Accurate assessment of mass, models and resolution by small-angle scattering.

    Article • August 2013, Faculty of 1000, Ltd.

    Dr Edward H Snell

  29. The Structure of Yeast Glutaminyl-tRNA Synthetase and Modeling of Its Interaction with tRNA

    Article • Journal of Molecular Biology, July 2013, Elsevier

    Joseph R Luft, Dr Edward H Snell

  30. Purification and SAXS Analysis of the Integrin Linked Kinase, PINCH, Parvin (IPP) Heterotrimeric Complex

    Article • PLoS ONE, January 2013, PLOS

    Joseph R Luft, Dr Edward H Snell

  31. Faculty of 1000 evaluation for Breaking the radiation damage limit with cryo-SAXS.

    Article • January 2013, Faculty of 1000, Ltd.

    Dr Edward H Snell

  32. Orientation sensitive Terahertz resonances observed in protein crystals

    Article • September 2012, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Edward H Snell

  33. On the need for an international effort to capture, share and use crystallization screening data

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, February 2012, International Union of Crystallography

    Dr Thomas S Peat, Joseph R Luft, Dr Edward H Snell

  34. Structural conservation of an ancient tRNA sensor in eukaryotic glutaminyl-tRNA synthetase

    Article • Nucleic Acids Research, December 2011, Oxford University Press (OUP)

    Dr Edward H Snell

  35. Macromolecular crystallization and crystal perfection, by Naomi E. Chayen, John R. Helliwell, and Edward H. Snell

    Article • Crystallography Reviews, July 2011, Taylor & Francis

    Dr Edward H Snell

  36. Small angle X‐ray scattering as a complementary tool for high‐throughput structural studies

    Article • Biopolymers, April 2011, Wiley

    Joseph R Luft, Dr Edward H Snell

  37. Lessons from high-throughput protein crystallization screening: 10 years of practical experience

    Article • Expert Opinion on Drug Discovery, March 2011, Informa Healthcare

    Joseph R Luft, Dr Edward H Snell

  38. What’s in a Drop? Correlating Observations and Outcomes to Guide Macromolecular Crystallization Experiments

    Article • Crystal Growth & Design, January 2011, American Chemical Society (ACS)

    Joseph R Luft, Dr Edward H Snell

  39. Crystal cookery – using high-throughput technologies and the grocery store as a teaching tool

    Article • Journal of Applied Crystallography, August 2010, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  40. A book about Macromolecular Crystallization and Crystal Perfection

    Article • March 2010, Oxford University Press (OUP)

    Professor John Richard Helliwell, Professor Naomi Esther Chayen, Dr Edward H Snell

  41. Crystallization theory

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  42. Optimization

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  43. Experimental aspects

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  44. Introduction

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  45. Screening

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  46. Unusual diffraction geometries

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  47. Alternative approaches

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  48. Membrane proteins

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  49. The X‐ray laser and the single molecule — no crystal needed?

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  50. Other macromolecular crystal diffraction disorders

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  51. Practical methods of crystallization

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  52. Protein powders — making the most of tiny crystallites in bulk

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  53. Degradation and improvement of crystal perfection

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  54. Overall summary and future thoughts

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  55. Macromolecular crystals and twinning

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  56. Making the most of difficult crystals — beamline and detector optimization

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  57. Strategies to apply when high‐quality crystals cannot be obtained

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  58. Analysis of the molecular short‐range order

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  59. Analysis of long‐range order

    Article • March 2010, Oxford University Press (OUP)

    Dr Edward H Snell

  60. Sliding Clamp–DNA Interactions Are Required for Viability and Contribute to DNA Polymerase Management in Escherichia coli

    Article • Journal of Molecular Biology, March 2009, Elsevier

    Dr Edward H Snell

  61. The application and use of chemical space mapping to interpret crystallization screening results

    Article • Acta Crystallographica Section D Biological Crystallography, November 2008, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  62. Establishing a training set through the visual analysis of crystallization trials. Part I: ∼150 000 images

    Article • Acta Crystallographica Section D Biological Crystallography, October 2008, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  63. Establishing a training set through the visual analysis of crystallization trials. Part II: crystal examples

    Article • Acta Crystallographica Section D Biological Crystallography, October 2008, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  64. AutoSherlock: a program for effective crystallization data analysis

    Article • Journal of Applied Crystallography, October 2008, International Union of Crystallography

    Joseph R Luft, Dr Edward H Snell

  65. Glycerol concentrations required for the successful vitrification of cocktail conditions in a high-throughput crystallization screen

    Article • Acta Crystallographica Section D Biological Crystallography, February 2008, International Union of Crystallography

    Dr Edward H Snell

  66. Structure of the Full-length Human RPA14/32 Complex Gives Insights into the Mechanism of DNA Binding and Complex Formation

    Article • Journal of Molecular Biology, December 2007, Elsevier

    Dr Edward H Snell

  67. Changes to crystals ofEscherichia coliβ-galactosidase during room-temperature/low-temperature cycling and their relation to cryo-annealing

    Article • Acta Crystallographica Section D Biological Crystallography, October 2007, International Union of Crystallography

    Dr Edward H Snell

  68. Efficient optimization of crystallization conditions by manipulation of drop volume ratio and temperature

    Article • Protein Science, February 2007, Wiley

    Dr Edward H Snell

  69. Non-invasive measurement of X-ray beam heating on a surrogate crystal sample

    Article • Journal of Synchrotron Radiation, December 2006, International Union of Crystallography

    Dr Edward H Snell

  70. Optimizing crystal volume for neutron diffraction: D-xylose isomerase

    Article • European Biophysics Journal, May 2006, Springer Science + Business Media

    Dr Edward H Snell

  71. A quasi-Laue neutron crystallographic study of d-xylose isomerase

    Article • European Biophysics Journal, May 2006, Springer Science + Business Media

    Dr Edward H Snell

  72. Extracting trends from two decades of microgravity macromolecular crystallization history

    Article • Acta Crystallographica Section D Biological Crystallography, May 2005, International Union of Crystallography

    Dr Edward H Snell

  73. The why, how, when, and what happened of crystallization in space

    Article • Reports on Progress in Physics, March 2005, Institute of Physics Publishing

    Professor John Richard Helliwell, Dr Edward H Snell

  74. Finding a cold needle in a warm haystack: infrared imaging applied to locating cryocooled crystals in loops

    Article • Journal of Applied Crystallography, January 2005, International Union of Crystallography

    Dr Edward H Snell

  75. First results of digital topography applied to macromolecular crystals

    Article • Journal of Applied Crystallography, May 2004, International Union of Crystallography

    Dr Alexei S Soares, Dr Edward H Snell

  76. Imaging modulated reflections from a semi-crystalline state of profilin:actin crystals

    Article • Journal of Applied Crystallography, March 2004, International Union of Crystallography

    Dr Edward H Snell

  77. Macromolecular Crystal Quality

    Article • January 2003, Elsevier

    Dr Edward H Snell

  78. The development and application of a method to quantify the quality of cryoprotectant solutions using standard area-detector X-ray images

    Article • Journal of Applied Crystallography, September 2002, International Union of Crystallography

    Dr Edward H Snell

  79. Investigating the Effect of Impurities on Macromolecule Crystal Growth in Microgravity

    Article • Crystal Growth & Design, March 2001, American Chemical Society (ACS)

    Dr Edward H Snell

  80. Microgravity and Macromolecular Crystallography

    Article • Crystal Growth & Design, January 2001, American Chemical Society (ACS)

    Dr Edward H Snell

  81. BEAM-ish: a graphical user interface for the physical characterization of macromolecular crystals

    Article • Journal of Applied Crystallography, August 2000, International Union of Crystallography

    Dr Edward H Snell

  82. Cryo-trapping the six-coordinate, distorted-octahedral active site of manganese superoxide dismutase 1 1Edited by R. Huber

    Article • Journal of Molecular Biology, March 2000, Elsevier

    Dr Edward H Snell

  83. The Effect of Temperature and Solution pH on the Nucleation of Tetragonal Lysozyme Crystals

    Article • Biophysical Journal, September 1999, Elsevier

    Dr Edward H Snell

  84. Crystallization of chicken egg white lysozyme from assorted sulfate salts

    Article • Journal of Crystal Growth, January 1999, Elsevier

    Dr Edward H Snell

  85. Protein crystal movements and fluid flows during microgravity growth

    Article • Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, April 1998, Royal Society Publishing

    Dr Edward H Snell

  86. Crystallization of chicken egg-white lysozyme from ammonium sulfate

    Article • Acta Crystallographica Section D Biological Crystallography, November 1997, International Union of Crystallography

    Dr Edward H Snell

  87. Partial Improvement of Crystal Quality for Microgravity-Grown Apocrustacyanin C1

    Article • Acta Crystallographica Section D Biological Crystallography, May 1997, International Union of Crystallography

    Professor John Richard Helliwell, Dr Edward H Snell

  88. CCD video observation of microgravity crystallization: apocrustacyanin C1

    Article • Journal of Crystal Growth, January 1997, Elsevier

    Dr Edward H Snell

  89. Trends and Challenges in Experimental Macromolecular Crystallography

    Article • Quarterly Reviews of Biophysics, August 1996, Cambridge University Press

    Dr Edward H Snell

  90. Lysozyme Crystal Growth Kinetics Monitored Using a Mach–Zehnder Interferometer

    Article • Acta Crystallographica Section D Biological Crystallography, May 1996, International Union of Crystallography

    Dr Edward H Snell

  91. Microgravity crystal growth improved long range crystal order

    Article • Acta Crystallographica Section D Biological Crystallography, November 1995, International Union of Crystallography

    Professor John Richard Helliwell, Dr Edward H Snell

  92. Time-resolved biological and perturbation chemical crystallography: Laue and monochromatic developments

    Article • September 1995, SPIE

    Professor John Richard Helliwell, Dr Edward H Snell

  93. Image-Plate Synchrotron Laue Data Collection and Subsequent Structural Analysis of a Small Test Crystal of a Nickel-Containing Aluminophosphate

    Article • Journal of Synchrotron Radiation, January 1995, International Union of Crystallography

    Dr Edward H Snell

  94. An investigation of the perfection of lysozyme protein crystals grown in microgravity and on earth

    Article • Springer Science + Business Media

    Dr Edward H Snell