All Stories

  1. PAI-1 and TAFI in advanced carotid plaque

    Article • Journal of Thrombosis and Haemostasis, February 2017, Wiley

    Johanna Deinum

  2. The effect of corn trypsin inhibitor and inhibiting antibodies for FXIa and FXIIa on coagulation of plasma and whole blood: reply

    Article • Journal of Thrombosis and Haemostasis, July 2015, Wiley

    Johanna Deinum

  3. Characterization of thrombin derived from human recombinant prothrombin

    Article • Blood Coagulation & Fibrinolysis, July 2015, Wolters Kluwer Health

    Johanna Deinum

  4. Addition of prothrombin to plasma can result in a paradoxical increase in activated partial thromboplastin time

    Article • Blood Coagulation & Fibrinolysis, December 2014, Wolters Kluwer Health

    Johanna Deinum

  5. The effect of corn trypsin inhibitor and inhibiting antibodies for FXIa and FXIIa on coagulation of plasma and whole blood

    Article • Journal of Thrombosis and Haemostasis, October 2014, Elsevier

    Johanna Deinum

  6. The effect of recombinant and plasma-derived prothrombin on prothrombin time in human plasma

    Article • International Journal of Laboratory Hematology, September 2014, Wiley

    Johanna Deinum

  7. A serendipitously identified novel small molecule procoagulant compound giving rise to a high-throughput screening assay based on human plasma

    Article • Thrombosis Research, August 2013, Elsevier

    Johanna Deinum

  8. Identification of Structural–Kinetic and Structural–Thermodynamic Relationships for Thrombin Inhibitors

    Article • Biochemistry, January 2013, American Chemical Society (ACS)

    Johanna Deinum

  9. produce ecarin in vitro instead of from the venom of the saw-scaled viper

    Article • Journal of Protein Chemistry, April 2012, Springer Science + Business Media

    Johanna Deinum

  10. Platelets Retain High Levels of Active Plasminogen Activator Inhibitor 1

    Article • PLoS ONE, November 2011, PLOS

    Johanna Deinum

  11. Monitoring of Protein Conformational Changes Upon Interaction with Low Molecular Weight Compounds by QCM-D and its Application to Drug Discovery

    Article • Biophysical Journal, February 2011, Elsevier

    Johanna Deinum

  12. Viscoelastic Sensing of Conformational Changes in Plasminogen Induced upon Binding of Low Molecular Weight Compounds

    Article • Analytical Chemistry, October 2010, American Chemical Society (ACS)

    Johanna Deinum

  13. The paradoxical stimulation by a reversible thrombin inhibitor of thrombin generation in plasma measured with thrombinography is caused by α2-macroglobulin-thrombin

    Article • Journal of Thrombosis and Haemostasis, February 2010, Wiley

    Professor Coenraad Hemker, Johanna Deinum

  14. Biochemical and pharmacological effects of the direct thrombin inhibitor AR-H067637

    Article • Thrombosis and Haemostasis, May 2009, Schattauer GmbH

    Johanna Deinum

  15. Synthesis and biological activity of potent, low molecular weight renin inhibitors*

    Article • Journal of Peptide Research, January 2009, Wiley

    Johanna Deinum

  16. A Novel Surface Modification Using Tissue Factor Reconstituted in Phospholipid Vesicles for the Activation of Blood Coagulation

    Article • Journal of Biomaterials Science Polymer Edition, January 2009, Taylor & Francis

    Johanna Deinum

  17. Clavatadine A, A Natural Product with Selective Recognition and Irreversible Inhibition of Factor XIa†

    Article • Journal of Medicinal Chemistry, June 2008, American Chemical Society (ACS)

    Johanna Deinum, Professor Anthony Carroll

  18. Heterogeneous glycosylation patterns of human PAI-1 may reveal its cellular origin

    Article • Thrombosis Research, January 2008, Elsevier

    Johanna Deinum

  19. X-ray crystal structure of endothiapepsin complexed with compound 1

    Article • December 2007, Protein Data Bank, Rutgers University

    Johanna Deinum

  20. Discovery of a Novel Warhead against β-Secretase through Fragment-Based Lead Generation§

    Article • Journal of Medicinal Chemistry, November 2007, American Chemical Society (ACS)

    Johanna Deinum

  21. Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia

    Article • The Journal of Experimental Medicine, July 2007, Rockefeller University Press

    Johanna Deinum, MD, PhD Klas Blomgren

  22. Probing the interaction of coagulation factors with phospholipid vesicle surfaces by surface plasma resonance

    Article • Analytical Biochemistry, March 2007, Elsevier

    Johanna Deinum

  23. Biochemical importance of glycosylation of plasminogen activator inhibitor-1

    Article • Thrombosis and Haemostasis, July 2003, Schattauer GmbH

    Johanna Deinum

  24. Hemodynamic improvement and removal of autoantibodies against β1-adrenergic receptor by immunoadsorption therapy in dilated cardiomyopathy

    Article • Journal of Autoimmunity, June 2003, Elsevier

    Johanna Deinum

  25. The interaction between captured human thrombin and antithrombin studied by surface plasmon resonance, and the effect of melagatran

    Article • Spectroscopy An International Journal, January 2002, Hindawi Publishing Corporation

    Johanna Deinum

  26. A Thermodynamic Characterization of the Binding of Thrombin Inhibitors to Human Thrombin, Combining Biosensor Technology, Stopped-Flow Spectrophotometry, and Microcalorimetry

    Article • Analytical Biochemistry, January 2002, Elsevier

    Johanna Deinum

  27. Effect of Different Types of Thrombin Inhibitors on Thrombin/Thrombomodulin Modulated Activation of Protein C In Vitro

    Article • Thrombosis Research, December 2001, Elsevier

    Sven Nylander, Johanna Deinum

  28. Biosensor Analysis of Drug–Target Interactions: Direct and Competitive Binding Assays for Investigation of Interactions between Thrombin and Thrombin Inhibitors

    Article • Analytical Biochemistry, April 2001, Elsevier

    Johanna Deinum

  29. A Regulatory Hydrophobic Area in the Flexible Joint Region of Plasminogen Activator Inhibitor-1, Defined with Fluorescent Activity-neutralizing Ligands. LIGAND-INDUCED SERPIN POLYMERIZATION

    Article • Journal of Biological Chemistry, January 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Johanna Deinum

  30. Biosensor Analysis of Drug–Target Interactions: Direct and Competitive Binding Assays for Investigation of Interactions between Thrombin and Thrombin Inhibitors

    Article • Analytical Biochemistry, February 2000, Elsevier

    Johanna Deinum

  31. Characterization of the interaction of plasminogen activator inhibitor type 1 with vitronectin by surface plasmon resonance

    Article • January 2000, Elsevier

    Johanna Deinum

  32. Protein movement during complex-formation between tissue plasminogen activator and plasminogen activator inhibitor-1

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, April 1999, Elsevier

    Johanna Deinum

  33. HUMAN PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 IN COMPLEX WITH A PENTAPEPTIDE

    Article • March 1999, Protein Data Bank, Rutgers University

    Johanna Deinum

  34. Sideroxylonal C, a New Inhibitor of Human Plasminogen Activator Inhibitor Type-1, from the Flowers of Eucalyptus albens

    Article • Journal of Natural Products, January 1999, American Chemical Society (ACS)

    Johanna Deinum, Professor Anthony Carroll

  35. Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide

    Article • Structure, May 1998, Elsevier

    Johanna Deinum

  36. Identification of the Binding Site for a Low-Molecular-Weight Inhibitor of Plasminogen Activator Inhibitor Type 1 by Site-Directed Mutagenesis

    Article • Biochemistry, February 1998, American Chemical Society (ACS)

    Johanna Deinum

  37. The Mechanism of Binding of Low-Molecular-Weight Active Site Inhibitors to Human α-Thrombin

    Article • Journal of Enzyme Inhibition, January 1998, Taylor & Francis

    Johanna Deinum

  38. Comparison of chromogenic substrates for tissue plasminogen activator and the effects on the stability of plasminogen activator inhibitor type-1

    Article • September 1997, Elsevier

    Johanna Deinum

  39. Epitopes on plasminogen activator inhibitor type-1 important for binding to tissue plasminogen activator

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, August 1997, Elsevier

    Johanna Deinum

  40. Serpin Conformational Change in Ovalbumin. Enhanced Reactive Center Loop Insertion through Hinge Region Mutations†

    Article • Biochemistry, May 1997, American Chemical Society (ACS)

    Johanna Deinum

  41. Detergent tween 80 modifies the specific activity of PAI-1

    Article • May 1997, Elsevier

    Johanna Deinum

  42. Characterisation of the complex of plasminogen activator inhibitor type 1 with tissue-type plasminogen activator by mass spectrometry and size-exclusion chromatography

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, June 1996, Elsevier

    Johanna Deinum

  43. Characterisation of novel indenoindoles. Part II. Redox-recycling with ascorbate

    Article • Biochemical Pharmacology, May 1996, Elsevier

    Johanna Deinum

  44. Design and synthesis of thrombin inhibitors

    Article • International Journal of Peptide Research and Therapeutics, January 1995, Springer Science + Business Media

    Johanna Deinum

  45. Inhibitors of thrombin containing arginine ketone derivatives

    Article • January 1995, Springer Science + Business Media

    Johanna Deinum

  46. Thrombin Inhibitors as Antithrombotic Agents: The Importance of Rapid Inhibition

    Article • Journal of Enzyme Inhibition, January 1995, Taylor & Francis

    Johanna Deinum

  47. Plasminogen activator inhibitor type-1 interacts exclusively with the proteinase domain of tissue plasminogen activator

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, December 1994, Elsevier

    Johanna Deinum

  48. Separation of Active and Inactive Forms of Recombinant Human Plasminogen Activator Inhibitor Type 1 (PAI-1) Expressed in Chinese Hamster Ovary Cells: Comparison with Native Human PAI-1

    Article • Protein Expression and Purification, August 1994, Elsevier

    Johanna Deinum

  49. An EPR Study of the Alkylhydrazyl Radicals Formed at Room Temperature in the Photochemical Reaction of 2,2'-Azobis(2,4-dimethylvaleronitrile) or 2,2'-Azobis(propane-2-carboxamidine) Dihydrochloride in the Presence of Sensitizers.

    Article • Acta Chemica Scandinavica, January 1994, Danish Chemical Society

    Dr Anna Napoli, Johanna Deinum

  50. An antibody ragment against PAI-1 inhibits PAI-1 activity and stimulates fibrinolysis in vitro and in vivo

    Article • Fibrinolysis and Proteolysis, January 1994, Elsevier

    Johanna Deinum

  51. The interaction of PAI-1 with immobilised vitronectin and the effect of tPA and the protease domain of tpa

    Article • Fibrinolysis and Proteolysis, January 1994, Elsevier

    Johanna Deinum

  52. PAI-1 Binds exclusively to the protease domain of tPA

    Article • Fibrinolysis and Proteolysis, January 1994, Elsevier

    Johanna Deinum

  53. The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent

    Article • Biochemical Pharmacology, August 1991, Elsevier

    Johanna Deinum

  54. Stereochemistry of colchicinoids. Enantiomeric stability and binding to tubulin of desacetamidocolchicine and desacetamidoisocolchicine

    Article • Bioorganic Chemistry, March 1991, Elsevier

    Johanna Deinum

  55. Conformation of thiocolchicine and two B-ring-modified analogs bound to tubulin studied with optical spectroscopy

    Article • Biochemistry, February 1991, American Chemical Society (ACS)

    Johanna Deinum

  56. Small, potent and stable inhibitors of renin

    Article • January 1991, Springer Science + Business Media

    Johanna Deinum

  57. Cis-trans isomerization of an angiotensin I-converting enzyme inhibitor. An enzyme kinetic and nuclear magnetic resonance study

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, October 1990, Elsevier

    Johanna Deinum

  58. Conformational differences between latent and active plasminogen activator inhibitor, PAI-1: A spectroscopic study

    Article • Thrombosis Research, September 1990, Elsevier

    Johanna Deinum

  59. Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases

    Article • Journal of General Virology, September 1990, Society for General Microbiology

    Johanna Deinum

  60. Effects of proteolysis of the extending parts of the high-molecular-weight microtubule-associated proteins on interactions between microtubules

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, July 1988, Elsevier

    Johanna Deinum

  61. Effect of estramustine phosphate on the assembly of trypsin-treated microtubules and microtubules reconstituted from purified tubulin with either tau, MAP2, or the tubulin-binding fragment of MAP2

    Article • Archives of Biochemistry and Biophysics, August 1987, Elsevier

    Johanna Deinum

  62. Flow orientation of brain microtubules studies by linear dichroism

    Article • European Biophysics Journal, December 1986, Springer Science + Business Media

    Johanna Deinum

  63. Estramustine Phosphate Inhibits Microtubule Assembly by Binding to the Microtubule-Associated Proteins

    Article • Annals of the New York Academy of Sciences, June 1986, Wiley

    Johanna Deinum

  64. The effect of gossypol on fast axonal transport and microtubule assembly

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, April 1986, Elsevier

    Johanna Deinum

  65. Binding to tubulin of an allocolchicine spin probe: interaction with the essential SH groups and other active sites

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, March 1986, Elsevier

    Johanna Deinum

  66. Changes in the hydrodynamic properties of microtubules induced by taxol

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, February 1986, Elsevier

    Johanna Deinum

  67. Diethylstilbestrol induces metaphase arrest and inhibits microtubule assembly

    Article • Mutation Research Letters, August 1985, Elsevier

    Johanna Deinum

  68. The binding of Ruthenium red to tubulin

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, February 1985, Elsevier

    Johanna Deinum

  69. Interaction of estramustine phosphate with microtubule-associated proteins

    Article • FEBS Letters, January 1985, Wiley

    Johanna Deinum

  70. Molecular weight dependency of heparin inhibition of microtubule assembly in vitro

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, November 1984, Elsevier

    Johanna Deinum

  71. The effect of S-100a and S-100b proteins and Zn2+ on the assembly of brain microtubule proteins in vitro

    Article • FEBS Letters, November 1983, Wiley

    Johanna Deinum

  72. Tubulin

    Article • January 1983, Springer Science + Business Media

    Johanna Deinum

  73. Effect of cibacron blue on tubulin assembly in the absence and presence of microtubule-associated proteins

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, November 1982, Elsevier

    Johanna Deinum

  74. Effect of S-100 proteins and calmodulin on Ca2+ -induced disassembly of brain microtubule proteins in vitro

    Article • FEBS Letters, October 1982, Wiley

    Johanna Deinum

  75. ChemInform Abstract: SYNTHESIS AND BINDING TO TUBULIN OF AN ALLOCOLCHICINE SPIN PROBE

    Article • Chemischer Informationsdienst, April 1982, Wiley

    Johanna Deinum

  76. Iron, an Essential Component of 4-Hydroxyphenylpyruvate Dioxygenase from Pseudomonas sp. Strain P.J. 874

    Article • January 1982, Elsevier

    Johanna Deinum

  77. Spatial separation of the two essential thiol groups and the binding site of the exchangeable GTP in brain tubulin

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure, November 1981, Elsevier

    Johanna Deinum

  78. The effect of ruthenium red on the assembly and disassembly of microtubules and on rapid axonal transport

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, July 1981, Elsevier

    Johanna Deinum

  79. Synthesis and Binding to Tubulin of an Allocolchicine Spin Probe.

    Article • Acta Chemica Scandinavica, January 1981, Danish Chemical Society

    Johanna Deinum

  80. Metal analysis by energy dispersive X-ray fluorescence of bovine brain tubulin and microtubule-associated proteins prepared by phosphocellulose chromatography

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure, June 1980, Elsevier

    Johanna Deinum

  81. The reaction of mercaptans with tyrosinases and hemocyanins

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure, August 1978, Elsevier

    Johanna Deinum

  82. The effect of pH on the oxygen intermediate and the dioxygen reducing site in blue oxidases

    Article • Biochimica et Biophysica Acta (BBA) - Enzymology, June 1978, Elsevier

    Johanna Deinum

  83. A mass spectrometric investigation of the reaction between 18 O2 and reduced tree laccase A differentiation between the two water molecules formed

    Article • FEBS Letters, May 1978, Wiley

    Johanna Deinum

  84. Type 2 copper(II) as a component of the dioxygen reducing site in laccase: Evidence from EPR experiments with17O

    Article • FEBS Letters, February 1977, Wiley

    Johanna Deinum

  85. An EPR study of Neurospora tyrosinase

    Article • FEBS Letters, October 1976, Wiley

    Johanna Deinum

  86. A 17O-effect on the EPR spectrum of the intermediate in the dioxygen-laccase reaction

    Article • Biochemical and Biophysical Research Communications, June 1976, Elsevier

    Johanna Deinum

  87. A paramagnetic intermediate in the reduction of oxygen by reduced laccase

    Article • FEBS Letters, January 1976, Wiley

    Johanna Deinum

  88. 17O hyperfine interaction in the EPR spectrum of fungal laccase A

    Article • FEBS Letters, October 1975, Wiley

    Johanna Deinum

  89. Sulfhydryl groups, disulfide bridges and the state of copper in three blue oxidases

    Article • FEBS Letters, March 1975, Wiley

    Johanna Deinum

  90. The stoichiometry of the three different types of copper in ascorbate oxidase from green zucchini squash

    Article • FEBS Letters, June 1974, Wiley

    Johanna Deinum

  91. The stoichiometry of the paramagnetic copper and the oxidation-reduction potentials of type I copper in human ceruloplasmin

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure, June 1973, Elsevier

    Johanna Deinum