All Stories

  1. Mitochondrial Mechanisms of Metabolic Reprogramming in Proliferating Cells

    Article • Current Medicinal Chemistry, July 2015, Bentham Science Publishers

    Joao Ramalho-Santos

  2. Spermicidal and Microbicidal Compounds: In Search of an Efficient Multipurpose Strategy

    Article • Current Medicinal Chemistry, August 2014, Bentham Science Publishers

    Joao Ramalho-Santos

  3. Low amounts of mitochondrial reactive oxygen species define human sperm quality

    Article • February 2014, Bioscientifica

    Joao Ramalho-Santos

  4. Concentration-dependent Sildenafil citrate (Viagra) effects on ROS production, energy status, and human sperm function

    Article • Systems Biology in Reproductive Medicine, December 2013, Taylor & Francis

    Joao Ramalho-Santos

  5. Inhibition of Mitochondrial Complex III Blocks Neuronal Differentiation and Maintains Embryonic Stem Cell Pluripotency

    Article • PLoS ONE, December 2013, PLOS

    Joao Ramalho-Santos, Sandra I Anjo

  6. Mitochondria and mammalian reproduction

    Article • Molecular and Cellular Endocrinology, October 2013, Elsevier

    Joao Ramalho-Santos

  7. Evaluation of human sperm chromatin status after selection using a modified Diff-Quik stain indicates embryo quality and pregnancy outcomes following in vitro fertilization

    Article • Andrology, September 2013, Wiley

    Joao Ramalho-Santos

  8. The combined human sperm proteome: cellular pathways and implications for basic and clinical science

    Article • Human Reproduction Update, September 2013, Oxford University Press (OUP)

    Joao Ramalho-Santos

  9. p,p'-DDE activates CatSper and compromises human sperm function at environmentally relevant concentrations

    Article • Human Reproduction, September 2013, Oxford University Press (OUP)

    Joao Ramalho-Santos

  10. Dioxin-induced acute cardiac mitochondrial oxidative damage and increased activity of ATP-sensitive potassium channels in Wistar rats

    Article • Environmental Pollution, September 2013, Elsevier

    Joao Ramalho-Santos

  11. Mitochondria functionality and sperm quality

    Article • July 2013, Bioscientifica

    Joao Ramalho-Santos

  12. UVB irradiation as a tool to assess ROS-induced damage in human spermatozoa

    Article • Andrology, July 2013, Wiley

    Joao Ramalho-Santos

  13. Anterior positioning of sex chromosomes on the head of human sperm sorted using visible wavelengths

    Article • Systems Biology in Reproductive Medicine, May 2013, Taylor & Francis

    Joao Ramalho-Santos

  14. In vitro effects of cationic compounds on functional human sperm parameters

    Article • Fertility and Sterility, March 2013, Elsevier

    Joao Ramalho-Santos

  15. Ca2+ Signals Generated by CatSper and Ca2+ Stores Regulate Different Behaviors in Human Sperm

    Article • Journal of Biological Chemistry, January 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Joao Ramalho-Santos

  16. The Male Gamete Is Not a Somatic Cell—the Possible Meaning of Varying Sperm RNA Levels

    Article • Antioxidants & Redox Signaling, January 2013, Mary Ann Liebert Inc

    Joao Ramalho-Santos

  17. Aging and male reproductive function A mitochondrial perspective

    Article • January 2013, Frontiers in Bioscience

    Joao Ramalho-Santos

  18. Human Sperm Tail Proteome Suggests New Endogenous Metabolic Pathways

    Article • Molecular & Cellular Proteomics, November 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Joao Ramalho-Santos

  19. How can ethics relate to science? The case of stem cell research

    Article • European Journal of Human Genetics, November 2012, Springer Science + Business Media

    Joao Ramalho-Santos

  20. From Oocytes and Pluripotent Stem Cells to Fully Differentiated Fates: (Also) a Mitochondrial Odyssey

    Article • September 2012, Springer Science + Business Media

    Joao Ramalho-Santos

  21. Markers of sperm function characterize donors with better fertilization potential, independently of sperm concentration and motility, according to world health organization criteria

    Article • Fertility and Sterility, September 2012, Elsevier

    Joao Ramalho-Santos

  22. Invisible

    Article • Nature, March 2012, Springer Science + Business Media

    Joao Ramalho-Santos

  23. Effects of different storage protocols on cat testis tissue potential for xenografting and recovery of spermatogenesis

    Article • Theriogenology, January 2012, Elsevier

    Joao Ramalho-Santos

  24. Exogenous glucose improves long-standing human sperm motility, viability, and mitochondrial function

    Article • Fertility and Sterility, October 2011, Elsevier

    Joao Ramalho-Santos

  25. A sperm's tail: the importance of getting it right

    Article • Human Reproduction, June 2011, Oxford University Press (OUP)

    Joao Ramalho-Santos

  26. Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts

    Article • PLoS ONE, June 2011, PLOS

    Joao Ramalho-Santos, Gerald Schatten

  27. Variants

    Article • Nature, June 2011, Springer Science + Business Media

    Joao Ramalho-Santos

  28. In Vitro Surfactant Structure-Toxicity Relationships: Implications for Surfactant Use in Sexually Transmitted Infection Prophylaxis and Contraception

    Article • PLoS ONE, May 2011, PLOS

    Joao Ramalho-Santos

  29. Human procreation in unchartered territory: new twists in ethical discussions

    Article • Human Reproduction, April 2011, Oxford University Press (OUP)

    Joao Ramalho-Santos

  30. Metabolic Remodeling During H9c2 Myoblast Differentiation: Relevance for In Vitro Toxicity Studies

    Article • Cardiovascular Toxicology, March 2011, Springer Science + Business Media

    Joao Ramalho-Santos

  31. Not All Sperm Are Equal: Functional Mitochondria Characterize a Subpopulation of Human Sperm with Better Fertilization Potential

    Article • PLoS ONE, March 2011, PLOS

    Joao Ramalho-Santos

  32. Level of Glycolyzable Substrates in Stallion Semen: Effect of Ejaculation Frequency on Sperm Survival after Cool Storage during the Nonbreeding Season

    Article • Journal of Equine Veterinary Science, March 2011, Elsevier

    Joao Ramalho-Santos

  33. Mitochondrial dysfunction in reproductive and developmental toxicity

    Article • January 2011, Elsevier

    Joao Ramalho-Santos

  34. Xenografting as a Tool to Preserve Endangered Species: Outcomes and Challenges in Model Systems

    Article • Veterinary Medicine International, January 2011, Hindawi Publishing Corporation

    Joao Ramalho-Santos

  35. Differential effects of p,p′-DDE on testis and liver mitochondria:Implications for reproductive toxicology

    Article • Reproductive Toxicology, January 2011, Elsevier

    Joao Ramalho-Santos

  36. Seasonal functional relevance of sperm characteristics in equine spermatozoa

    Article • Theriogenology, April 2010, Elsevier

    Joao Ramalho-Santos

  37. Proton leak modulation in testicular mitochondria affects reactive oxygen species production and lipid peroxidation

    Article • Cell Biochemistry and Function, March 2010, Wiley

    Joao Ramalho-Santos

  38. Assessment of mitochondrial potential: implications for the correct monitoring of human sperm function

    Article • International Journal of Andrology, January 2010, Wiley

    Joao Ramalho-Santos

  39. Aging, Mitochondria and Male Reproductive Function

    Article • Current Aging Science, December 2009, Bentham Science Publishers

    Joao Ramalho-Santos

  40. Spermicides, Microbicides and Antiviral Agents: Recent Advances in the Development of Novel Multi-Functional Compounds

    Article • Mini-Reviews in Medicinal Chemistry, November 2009, Bentham Science Publishers

    Joao Ramalho-Santos

  41. Enhancement of human embryonic stem cell pluripotency through inhibition of the mitochondrial respiratory chain

    Article • Stem Cell Research, September 2009, Elsevier

    Joao Ramalho-Santos

  42. Chd1 regulates open chromatin and pluripotency of embryonic stem cells

    Article • Nature, July 2009, Springer Science + Business Media

    Joao Ramalho-Santos

  43. Seminal traits, suitability for semen preservation and fertility in the native Portuguese horse breeds Puro Sangue Lusitano and Sorraia: Implications for stallion classification and assisted reproduction

    Article • Animal Reproduction Science, July 2009, Elsevier

    Joao Ramalho-Santos

  44. Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells

    Article • Human Reproduction Update, May 2009, Oxford University Press (OUP)

    Joao Ramalho-Santos

  45. Manifesto

    Article • Nature, April 2009, Springer Science + Business Media

    Joao Ramalho-Santos

  46. Mitochondrial bioenergetics of testicular cells from the domestic cat (Felis catus)—A model for endangered species

    Article • Reproductive Toxicology, April 2009, Elsevier

    Joao Ramalho-Santos

  47. Testicular mitochondrial alterations in untreated streptozotocin-induced diabetic rats

    Article • Mitochondrion, February 2009, Elsevier

    Joao Ramalho-Santos

  48. Parabens in male infertility—Is there a mitochondrial connection?

    Article • Reproductive Toxicology, January 2009, Elsevier

    Joao Ramalho-Santos

  49. Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak

    Article • FEBS Letters, November 2008, Wiley

    Joao Ramalho-Santos

  50. Adição de piruvato de sódio e trolox ao diluidor utilizado para congelação de sêmen de garanhões férteis e subférteis

    Article • Ciência Rural, November 2008, FapUNIFESP (SciELO)

    Joao Ramalho-Santos

  51. Dual use of Diff-Quik-like stains for the simultaneous evaluation of human sperm morphology and chromatin status

    Article • Human Reproduction, October 2008, Oxford University Press (OUP)

    Joao Ramalho-Santos

  52. Application of fluorescence microscopy in the routine analysis of equine spermatozoa

    Article • Animal Reproduction Science, September 2008, Elsevier

    Joao Ramalho-Santos

  53. Surfactants as Microbicides and Contraceptive Agents: A Systematic In Vitro Study

    Article • PLoS ONE, August 2008, PLOS

    Joao Ramalho-Santos

  54. The quantification of lipid and protein oxidation in stallion spermatozoa and seminal plasma: Seasonal distinctions and correlations with DNA strand breaks, classical seminal parameters and stallion fertility

    Article • Animal Reproduction Science, June 2008, Elsevier

    Joao Ramalho-Santos

  55. Freeze-dried primate sperm retains early reproductive potential after intracytoplasmic sperm injection

    Article • Fertility and Sterility, March 2008, Elsevier

    Joao Ramalho-Santos

  56. Diabetes and the Impairment of Reproductive Function: Possible Role of Mitochondria and Reactive Oxygen Species

    Article • Current Diabetes Reviews, February 2008, Bentham Science Publishers

    Joao Ramalho-Santos

  57. The expression of polymerase gamma and mitochondrial transcription factor A and the regulation of mitochondrial DNA content in mature human sperm

    Article • Human Reproduction, March 2007, Oxford University Press (OUP)

    Joao Ramalho-Santos

  58. Characterization of human sperm populations using conventional parameters, surface ubiquitination, and apoptotic markers

    Article • Fertility and Sterility, March 2007, Elsevier

    Joao Ramalho-Santos

  59. Flow cytometry evaluation of lead and cadmium effects on mouse spermatogenesis

    Article • Reproductive Toxicology, October 2006, Elsevier

    Joao Ramalho-Santos, Dr João Loureiro

  60. Histopathological Effects of Hexavalent Chronium in Mouse Kidney

    Article • Bulletin of Environmental Contamination and Toxicology, June 2006, Springer Science + Business Media

    Joao Ramalho-Santos

  61. Comparison between different markers for sperm quality in the cat: Diff-Quik as a simple optical technique to assess changes in the DNA of feline epididymal sperm

    Article • Theriogenology, April 2006, Elsevier

    Joao Ramalho-Santos

  62. LOCALIZATION OF SNARES, NSF AND CAVEOLIN 1 IN HUMAN SPERMATOZOA: RELATIONSHIP WITH SEMINAL PARAMETERS

    Article • Archives of Andrology, January 2006, Taylor & Francis

    Joao Ramalho-Santos

  63. The Expression of Mitochondrial DNA Transcription Factors during Early CardiomyocyteIn VitroDifferentiation from Human Embryonic Stem Cells

    Article • Cloning and Stem Cells, September 2005, Mary Ann Liebert Inc

    Joao Ramalho-Santos, Gerald Schatten

  64. SNARE proteins and caveolin-1 in stallion spermatozoa: possible implications for fertility

    Article • Theriogenology, July 2005, Elsevier

    Joao Ramalho-Santos

  65. Simultaneous analysis of cytoskeletal patterns and chromosome positioning in human fertilization failures

    Article • Fertility and Sterility, December 2004, Elsevier

    Joao Ramalho-Santos

  66. PRESENCE OF N-ETHYL MALEIMIDE SENSITIVE FACTOR (NSF) ON THE ACROSOME OF MAMMALIAN SPERM

    Article • Archives of Andrology, January 2004, Taylor & Francis

    Joao Ramalho-Santos

  67. LIS1 association with dynactin is required for nuclear motility and genomic union in the fertilized mammalian oocyte

    Article • Cell Motility and the Cytoskeleton, October 2003, Wiley

    Joao Ramalho-Santos, Gerald Schatten

  68. Control of Membrane Fusion During Spermiogenesis and the Acrosome Reaction

    Article • Biology of Reproduction, October 2002, Society for the Study of Reproduction

    Joao Ramalho-Santos

  69. VAMP/synaptobrevin as an acrosomal marker for human sperm

    Article • Fertility and Sterility, January 2002, Elsevier

    Joao Ramalho-Santos, Gerald Schatten

  70. Acrosome components after intracytoplasmic sperm injection: the decondensation frontier

    Article • Fertility and Sterility, July 2001, Elsevier

    Joao Ramalho-Santos, Gerald Schatten

  71. Membrane Trafficking Machinery Components Associated with the Mammalian Acrosome during Spermiogenesis

    Article • Experimental Cell Research, July 2001, Elsevier

    Joao Ramalho-Santos, Edward K. L. Chan

  72. Targeting and fusion proteins during mammalian spermiogenesis

    Article • Biological Research, January 2001, SciELO Comision Nacional de Investigacion Cientifica Y Tecnologica (CONICYT)

    Joao Ramalho-Santos

  73. ICSI choreography: fate of sperm structures after monospermic rhesus ICSI and first cell cycle implications

    Article • Human Reproduction, December 2000, Oxford University Press (OUP)

    Joao Ramalho-Santos

  74. SNAREs in Mammalian Sperm: Possible Implications for Fertilization

    Article • Developmental Biology, July 2000, Elsevier

    Joao Ramalho-Santos, Gerald Schatten

  75. The Golgi Apparatus Segregates from the Lysosomal/Acrosomal Vesicle during Rhesus Spermiogenesis: Structural Alterations

    Article • Developmental Biology, March 2000, Elsevier

    Joao Ramalho-Santos, Gerald Schatten, Edward K. L. Chan

  76. Optimization Strategies for Production of Mammalian Embryos by Nuclear Transfer

    Article • Cloning, September 1999, Mary Ann Liebert Inc

    Joao Ramalho-Santos

  77. Role of a transbilayer pH gradient in the membrane fusion activity of the influenza virus hemagglutinin: Use of the R18 assay to monitor membrane merging

    Article • Biological Procedures Online, March 1999, Springer Science + Business Media

    Joao Ramalho-Santos

  78. Interactions of Influenza Virus with Cultured Cells:  Detailed Kinetic Modeling of Binding and Endocytosis

    Article • Biochemistry, December 1998, American Chemical Society (ACS)

    Joao Ramalho-Santos

  79. The influenza virus hemagglutinin: a model protein in the study of membrane fusion

    Article • Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, June 1998, Elsevier

    Joao Ramalho-Santos

  80. Fusion activity of the influenza virus hemagglutinin does not require a transbilayer pH gradient

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, December 1997, Elsevier

    Joao Ramalho-Santos

  81. Evidence That Synaptobrevin Is Involved in Fusion between Synaptic Vesicles and Synaptic Plasma Membrane Vesicles

    Article • Biochemical and Biophysical Research Communications, July 1997, Elsevier

    Joao Ramalho-Santos

  82. Mass action model of virus fusion

    Article • January 1995, Springer Science + Business Media

    Joao Ramalho-Santos

  83. Entry of Enveloped Viruses Into Host Cells: Fusion Activity of the Influenza Virus Hemagglutinin

    Article • January 1995, Springer Science + Business Media

    Joao Ramalho-Santos

  84. Parameters affecting fusion between liposomes and synaptosomes. Role of proteins, lipid peroxidation, pH and temperature

    Article • The Journal of Membrane Biology, November 1994, Springer Science + Business Media

    Joao Ramalho-Santos

  85. Role of hydrophobic interactions in the fusion activity of influenza and sendai viruses towards model membranes

    Article • Bioscience Reports, February 1994, Portland Press Ltd.

    Joao Ramalho-Santos

  86. A common mechanism for influenza virus fusion activity and inactivation

    Article • Biochemistry, March 1993, American Chemical Society (ACS)

    Joao Ramalho-Santos

  87. Interaction of clathrin with large unilamellar phospholipid vesicles at neutral pH. Lipid dependence and protein penetration

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, April 1992, Elsevier

    Joao Ramalho-Santos

  88. Kinetic modeling of Sendai virus fusion with PC‐12 cells

    Article • European Journal of Biochemistry, April 1992, Wiley

    Joao Ramalho-Santos

  89. The Analysis of Mitochondria and Mitochondrial DNA in Human Embryonic Stem Cells

    Article • Springer Science + Business Media

    Joao Ramalho-Santos, Gerald Schatten