All Stories

  1. Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming

    Article • Proceedings of the National Academy of Sciences, September 2018, Proceedings of the National Academy of Sciences

    Gloria Lopez-Castejon

  2. USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation

    Article • EMBO Reports, September 2018, EMBO

    Gloria Lopez-Castejon

  3. The inflammasomes, immune guardians at defence barriers

    Article • Immunology, September 2018, Wiley

    Gloria Lopez-Castejon

  4. Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease

    Article • Journal of Medicinal Chemistry, April 2017, American Chemical Society (ACS)

    Gloria Lopez-Castejon

  5. Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation

    Article • Frontiers in Immunology, January 2017, Frontiers

    Gloria Lopez-Castejon

  6. P2X7 receptor-dependent tuning of gut epithelial responses to infection

    Article • Immunology and Cell Biology, September 2016, Wiley

    Gloria Lopez-Castejon, Dr Jo Pennock

  7. Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?

    Article • Mediators of Inflammation, January 2016, Hindawi Publishing Corporation

    Gloria Lopez-Castejon

  8. Functional Reconstruction of NLRs in HEK293 Cells

    Article • January 2016, Springer Science + Business Media

    Gloria Lopez-Castejon

  9. Method to Measure Ubiquitination of NLRs

    Article • January 2016, Springer Science + Business Media

    Gloria Lopez-Castejon

  10. Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling

    Article • The Journal of Immunology, December 2014, The American Association of Immunologists

    Gloria Lopez-Castejon

  11. Dendritic Cell IL-1α and IL-1β Are Polyubiquitinated and Degraded by the Proteasome

    Article • Journal of Biological Chemistry, November 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Gloria Lopez-Castejon

  12. Zinc depletion regulates the processing and secretion of IL-1β

    Article • Cell Death and Disease, January 2014, Springer Science + Business Media

    Gloria Lopez-Castejon

  13. Acidosis Drives Damage-associated Molecular Pattern (DAMP)-induced Interleukin-1 Secretion via a Caspase-1-independent Pathway

    Article • Journal of Biological Chemistry, September 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Gloria Lopez-Castejon

  14. Response to Boyle et al.

    Article • Immunity, March 2013, Elsevier

    Gloria Lopez-Castejon

  15. Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices

    Article • Glia, February 2013, Wiley

    Gloria Lopez-Castejon

  16. Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

    Article • Journal of Biological Chemistry, December 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Gloria Lopez-Castejon

  17. Cell Volume Regulation Modulates NLRP3 Inflammasome Activation

    Article • Immunity, September 2012, Elsevier

    Gloria Lopez-Castejon

  18. Caspase-1: is IL-1 just the tip of the ICEberg?

    Article • Cell Death and Disease, July 2012, Springer Science + Business Media

    Gloria Lopez-Castejon

  19. Current status of inflammasome blockers as anti-inflammatory drugs

    Article • Expert Opinion on Investigational Drugs, May 2012, Informa Healthcare

    Gloria Lopez-Castejon

  20. Inhibition of Calpain Blocks the Phagosomal Escape of Listeria monocytogenes

    Article • PLoS ONE, April 2012, PLOS

    Gloria Lopez-Castejon

  21. Evolution of inflammasome functions in vertebrates: Inflammasome and caspase-1 trigger fish macrophage cell death but are dispensable for the processing of IL-1β

    Article • Innate Immunity, March 2012, SAGE Publications

    Gloria Lopez-Castejon

  22. NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury

    Article • Frontiers in Immunology, January 2012, Frontiers

    Gloria Lopez-Castejon

  23. Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages

    Article • European Journal of Immunology, December 2011, Wiley

    Gloria Lopez-Castejon

  24. Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness

    Article • Nature Physics, November 2011, Springer Science + Business Media

    Gloria Lopez-Castejon

  25. Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

    Article • Nature Chemical Biology, October 2011, Springer Science + Business Media

    Professor Douglas B Kell, Gloria Lopez-Castejon

  26. Understanding the mechanism of IL-1β secretion

    Article • Cytokine & Growth Factor Reviews, August 2011, Elsevier

    Gloria Lopez-Castejon

  27. Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues

    Article • Journal of Neuroinflammation, January 2011, Springer Science + Business Media

    Gloria Lopez-Castejon

  28. Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules

    Article • Cellular and Molecular Life Sciences, December 2010, Springer Science + Business Media

    Gloria Lopez-Castejon

  29. P2X7 Receptor-Mediated Release of Cathepsins from Macrophages Is a Cytokine-Independent Mechanism Potentially Involved in Joint Diseases

    Article • The Journal of Immunology, July 2010, The American Association of Immunologists

    Gloria Lopez-Castejon

  30. Nanoparticles can cause DNA damage across a cellular barrier

    Article • Nature Physics, November 2009, Springer Science + Business Media

    Gloria Lopez-Castejon

  31. Molecular and functional characterization of gilthead seabream Sparus aurata caspase-1: The first identification of an inflammatory caspase in fish

    Article • Molecular Immunology, January 2008, Elsevier

    Gloria Lopez-Castejon

  32. The type II interleukin-1 receptor (IL-1RII) of the bony fish gilthead seabream Sparus aurata is strongly induced after infection and tightly regulated at transcriptional and post-transcriptional levels

    Article • Molecular Immunology, April 2007, Elsevier

    Gloria Lopez-Castejon

  33. The activation of gilthead seabream professional phagocytes by different PAMPs underlines the behavioural diversity of the main innate immune cells of bony fish

    Article • Molecular Immunology, March 2007, Elsevier

    Gloria Lopez-Castejon

  34. Characterization of ATP-gated P2X7 receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleukin-1β

    Article • Molecular Immunology, February 2007, Elsevier

    Gloria Lopez-Castejon

  35. Turbot TNFα gene: Molecular characterization and biological activity of the recombinant protein

    Article • Molecular Immunology, January 2007, Elsevier

    Gloria Lopez-Castejon

  36. The colony-stimulating factor-1 receptor is a specific marker of macrophages from the bony fish gilthead seabream

    Article • Molecular Immunology, March 2006, Elsevier

    Gloria Lopez-Castejon

  37. Novel Cell Line Selectively Expressing Neuropeptide Y‐Y2Receptors

    Article • Journal of Receptors and Signal Transduction, January 2003, Taylor & Francis

    Gloria Lopez-Castejon