All Stories

  1. A Direct Relationship Between ‘Blood Stasis’ and Fibrinaloid Microclots in Chronic, Inflammatory and Vascular Diseases, and Some Traditional Natural Products Approaches to Treatment

    Article • March 2025, MDPI AG

    Professor Douglas B Kell

  2. A Direct Relationship Between ‘Blood Stasis’ and Fibrinaloid Microclots in Chronic, Inflammatory and Vascular Diseases, and Some Traditional Natural Products Approaches to Treatment

    Article • February 2025, MDPI AG

    Professor Douglas B Kell

  3. The Proteome Content of Blood Clots Observed Under Different Conditions: Successful Role in Predicting Clot Amyloid(ogenicity)

    Article • Molecules, February 2025, MDPI AG

    Professor Douglas B Kell

  4. Treatment of Long COVID With Enoxaparin

    Article • Cardiopulmonary Physical Therapy Journal, January 2025, Wolters Kluwer Health

    Professor Douglas B Kell

  5. The proteome content of blood clots observed under different conditions: successful role in predicting clot amyloid(ogenicity)

    Article • December 2024, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  6. The clots removed from ischaemic stroke patients by mechanical thrombectomy are amyloid in nature

    Article • November 2024, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  7. Proteomic Evidence for Amyloidogenic Cross-Seeding in Fibrinaloid Microclots

    Article • International Journal of Molecular Sciences, October 2024, MDPI AG

    Professor Douglas B Kell

  8. Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook

    Article • Seminars in Thrombosis and Hemostasis, September 2024, Thieme Publishing Group

    Professor Douglas B Kell

  9. The Biology and Biochemistry of Kynurenic Acid, a Potential Nutraceutical with Multiple Biological Effects

    Article • International Journal of Molecular Sciences, August 2024, MDPI AG

    Professor Douglas B Kell

  10. Proteomic evidence for amyloidogenic cross-seeding in fibrinaloid microclots

    Article • July 2024, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  11. Evidence for the Role of the Mitochondrial ABC Transporter MDL1 in the Uptake of Clozapine and Related Molecules into the Yeast Saccharomyces cerevisiae

    Article • Pharmaceuticals, July 2024, MDPI AG

    Professor Douglas B Kell, Chrispian Theron

  12. Flow Clotometry: Measuring Amyloid Microclots in ME/CFS, Long COVID, and Healthy Samples with Imaging Flow Cytometry

    Article • June 2024, Research Square

    Professor Douglas B Kell

  13. Fibrinaloid Microclots and Atrial Fibrillation

    Article • Biomedicines, April 2024, MDPI AG

    Professor Douglas B Kell

  14. Herpesvirus Infection of Endothelial Cells as a Systemic Pathological Axis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

    Article • Viruses, April 2024, MDPI AG

    Professor Douglas B Kell

  15. Automated microscopic measurement of fibrinaloid microclots and their degradation by nattokinase, the main natto protease

    Article • April 2024, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  16. Uncertainties about the roles of anticoagulation and microclots in postacute sequelae of SARS-CoV-2 infection: comment from Kell et al.

    Article • Journal of Thrombosis and Haemostasis, February 2024, Elsevier

    Professor Douglas B Kell

  17. Possible Role of Fibrinaloid Microclots in Postural Orthostatic Tachycardia Syndrome (POTS): Focus on Long COVID

    Article • Journal of Personalized Medicine, January 2024, MDPI AG

    Professor Douglas B Kell

  18. Fibrinaloid Microclots and Atrial Fibrillation

    Article • January 2024, MDPI AG

    Professor Douglas B Kell

  19. Herpesvirus Infection as a Systemic Pathological Axis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

    Article • January 2024, MDPI AG

    Professor Douglas B Kell

  20. A Perspective on How Fibrinaloid Microclots and Platelet Pathology May be Applied in Clinical Investigations

    Article • Seminars in Thrombosis and Hemostasis, September 2023, Thieme Publishing Group

    Professor Douglas B Kell

  21. Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?

    Article • Biochemical Journal, August 2023, Portland Press Ltd.

    Professor Douglas B Kell

  22. Hyperparameter optimisation in differential evolution using Summed Local Difference Strings, a rugged but easily calculated landscape for combinatorial search problems

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  23. Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia

    Article • Bioscience Reports, July 2023, Portland Press Ltd.

    Professor Douglas B Kell

  24. Data sharing: A Long COVID perspective, challenges, and road map for the future

    Article • South African Journal of Science, June 2023, Academy of Science of South Africa

    Professor Douglas B Kell

  25. Increased Levels of Inflammatory and Endothelial Biomarkers in Blood of Long COVID Patients Point to Thrombotic Endothelialitis

    Article • Seminars in Thrombosis and Hemostasis, May 2023, Thieme Publishing Group

    Professor Douglas B Kell

  26. Long COVID: pathophysiological factors and abnormalities of coagulation

    Article • Trends in Endocrinology and Metabolism, April 2023, Elsevier

    Professor Douglas B Kell

  27. Treatment of Long COVID symptoms with triple anticoagulant therapy

    Article • March 2023, Research Square

    Professor Douglas B Kell

  28. Quantitative LC-MS study of compounds found predictive of COVID-19 severity and outcome

    Article • March 2023, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  29. Alzheimer’s Disease: A Systems View Provides a Unifying Explanation of Its Development

    Article • Journal of Alzheimer’s Disease, January 2023, IOS Press

    Professor Douglas B Kell

  30. Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia

    Article • December 2022, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  31. Understanding Functional Redundancy and Promiscuity of Multidrug Transporters in E. coli under Lipophilic Cation Stress

    Article • Membranes, December 2022, MDPI AG

    Professor Douglas B Kell

  32. Increased levels of inflammatory molecules in blood of Long COVID patients point to thrombotic endotheliitis

    Article • October 2022, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  33. Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system

    Article • Cardiovascular Diabetology, September 2022, Springer Science + Business Media

    Professor Douglas B Kell

  34. The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications

    Article • Biochemical Journal, August 2022, Portland Press Ltd.

    Professor Douglas B Kell

  35. Analysis of a Library of Escherichia coli Transporter Knockout Strains to Identify Transport Pathways of Antibiotics

    Article • Antibiotics, August 2022, MDPI AG

    Professor Douglas B Kell

  36. Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC)

    Article • Cardiovascular Diabetology, August 2022, Springer Science + Business Media

    Professor Douglas B Kell

  37. The Occurrence of Hyperactivated Platelets and Fibrinaloid Microclots in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

    Article • Pharmaceuticals, July 2022, MDPI AG

    Professor Douglas B Kell

  38. The occurrence of hyperactivated platelets and fibrinaloid microclots in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

    Article • June 2022, Research Square

    Professor Douglas B Kell

  39. The occurrence of hyperactivated platelets and fibrinaloid microclots in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

    Article • June 2022, Research Square

    Professor Douglas B Kell

  40. Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/ Post-Acute Sequelae of COVID-19 (PASC)

    Article • May 2022, Research Square

    Professor Douglas B Kell

  41. A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications

    Article • Biochemical Journal, February 2022, Portland Press Ltd.

    Professor Douglas B Kell

  42. SpeedyGenesXL: an Automated, High-Throughput Platform for the Preparation of Bespoke Ultralarge Variant Libraries for Directed Evolution

    Article • January 2022, Springer Science + Business Media

    Professor Douglas B Kell

  43. Combined triple treatment of fibrin amyloid microclots and platelet pathology in individuals with Long COVID/ Post-Acute Sequelae of COVID-19 (PASC) can resolve their persistent symptoms

    Article • December 2021, Research Square

    Professor Douglas B Kell

  44. Engineering ergothioneine production in Yarrowia lipolytica

    Article • FEBS Letters, December 2021, Wiley

    Professor Douglas B Kell

  45. MassGenie: A Transformer-Based Deep Learning Method for Identifying Small Molecules from Their Mass Spectra

    Article • Biomolecules, November 2021, MDPI AG

    Professor Douglas B Kell

  46. TEG®, Microclot and Platelet Mapping for Guiding Early Management of Severe COVID-19 Coagulopathy

    Article • Journal of Clinical Medicine, November 2021, MDPI AG

    Professor Douglas B Kell

  47. MassGenie: A Transformer-Based Deep Learning Method for Identifying Small Molecules From Their Mass Spectra

    Article • October 2021, MDPI AG

    Professor Douglas B Kell

  48. Intelligent host engineering for metabolic flux optimisation in biotechnology

    Article • Biochemical Journal, October 2021, Portland Press Ltd.

    Professor Douglas B Kell

  49. Membrane Transporters Involved in the Antimicrobial Activities of Pyrithione in Escherichia coli

    Article • Molecules, September 2021, MDPI AG

    Professor Douglas B Kell

  50. The Transporter-Mediated Cellular Uptake and Efflux of Pharmaceutical Drugs and Biotechnology Products: How and Why Phospholipid Bilayer Transport Is Negligible in Real Biomembranes

    Article • Molecules, September 2021, MDPI AG

    Professor Douglas B Kell

  51. Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin

    Article • Cardiovascular Diabetology, August 2021, Springer Science + Business Media

    Professor Douglas B Kell

  52. SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19

    Article • Bioscience Reports, August 2021, Portland Press Ltd.

    Professor Douglas B Kell

  53. A decision-tree approach to treat platelet hyperactivity and anomalous blood clotting in acute COVID-19 patients

    Article • July 2021, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  54. MassGenie: a transformer-based deep learning method for identifying small molecules from their mass spectra

    Article • June 2021, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  55. Persistent clotting protein pathology in Long COVID/ Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  56. FragNet, a Contrastive Learning-Based Transformer Model for Clustering, Interpreting, Visualizing, and Navigating Chemical Space

    Article • Molecules, April 2021, MDPI AG

    Professor Douglas B Kell

  57. SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: Implications for microclot formation in COVID-19

    Article • March 2021, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  58. A palette of fluorophores that are differentially accumulated by wild-type and mutant strains of Escherichia coli: surrogate ligands for profiling bacterial membrane transporters

    Article • Microbiology, January 2021, Society for General Microbiology

    Professor Douglas B Kell

  59. Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson’s Disease

    Article • Biomolecules, December 2020, MDPI AG

    Professor Douglas B Kell

  60. Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome

    Article • December 2020, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  61. Deep learning and generative methods in cheminformatics and chemical biology: navigating small molecule space intelligently

    Article • Biochemical Journal, December 2020, Portland Press Ltd.

    Professor Douglas B Kell

  62. Structural Similarities between Some Common Fluorophores Used in Biology, Marketed Drugs, Endogenous Metabolites, and Natural Products

    Article • Marine Drugs, November 2020, MDPI AG

    Professor Douglas B Kell

  63. Prevalence of readily detected amyloid blood clots in ‘unclotted’ Type 2 Diabetes Mellitus and COVID-19 plasma: a preliminary report

    Article • Cardiovascular Diabetology, November 2020, Springer Science + Business Media

    Professor Douglas B Kell

  64. Bacteria, Lipopolysaccharides, Amyloid and the Role of Iron Dysregulation in Parkinson’s Disease

    Article • November 2020, MDPI AG

    Professor Douglas B Kell

  65. Erythrocyte, Platelet, Serum Ferritin, and P-Selectin Pathophysiology Implicated in Severe Hypercoagulation and Vascular Complications in COVID-19

    Article • International Journal of Molecular Sciences, November 2020, MDPI AG

    Professor Douglas B Kell

  66. DeepGraphMolGen, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach

    Article • Journal of Cheminformatics, September 2020, Springer Science + Business Media

    Professor Douglas B Kell

  67. A Quantitative Survey of Bacterial Persistence in the Presence of Antibiotics: Towards Antipersister Antimicrobial Discovery

    Article • Antibiotics, August 2020, MDPI AG

    Professor Douglas B Kell

  68. DeepGraphMolGen, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach

    Article • July 2020, Research Square

    Professor Douglas B Kell

  69. Prevalence of amyloid blood clots in COVID-19 plasma

    Article • July 2020, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  70. VAE-Sim: A Novel Molecular Similarity Measure Based on a Variational Autoencoder

    Article • Molecules, July 2020, MDPI AG

    Professor Douglas B Kell

  71. Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes

    Article • International Journal of Molecular Sciences, July 2020, MDPI AG

    Professor Douglas B Kell

  72. COVID-19: The Rollercoaster of Fibrin(ogen), D-dimer, von Willebrand Factor, P-selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes

    Article • July 2020, MDPI AG

    Professor Douglas B Kell

  73. VAE-Sim: a novel molecular similarity measure based on a variational autoencoder

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  74. A palette of fluorophores that are differentially accumulated by wild-type and mutant strains of Escherichia coli: surrogate ligands for bacterial membrane transporters

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  75. DeepGraphMol, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach

    Article • June 2020, Research Square

    Professor Douglas B Kell

  76. An untargeted metabolomics strategy to measure differences in metabolite uptake and excretion by mammalian cell lines

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  77. The Atypical Fibrin Fibre Network in Rheumatoid Arthritis and its Relation to Autoimmunity, Inflammation and Thrombosis

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  78. DeepGraphMol, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  79. Author Correction: Hitchhiking into the cell

    Article • Nature Chemical Biology, April 2020, Springer Science + Business Media

    Professor Douglas B Kell

  80. Hitchhiking into the cell

    Article • Nature Chemical Biology, March 2020, Springer Science + Business Media

    Professor Douglas B Kell

  81. The biology of ergothioneine, an antioxidant nutraceutical

    Article • Nutrition Research Reviews, February 2020, Cambridge University Press

    Professor Douglas B Kell

  82. Why most transporter mutations that cause antibiotic resistance are to efflux pumps rather than to import transporters

    Article • January 2020, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  83. The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data

    Article • Scientific Reports, November 2019, Springer Science + Business Media

    Professor Douglas B Kell

  84. Structural similarities between some common fluorophores used in biology and marketed drugs, endogenous metabolites, and natural products

    Article • November 2019, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  85. Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli

    Article • BMC Microbiology, August 2019, Springer Science + Business Media

    Professor Douglas B Kell

  86. A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

    Article • Communications Biology, July 2019, Springer Science + Business Media

    Professor Douglas B Kell

  87. GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries

    Article • ACS Synthetic Biology, May 2019, American Chemical Society (ACS)

    Professor Douglas B Kell

  88. Parkinson’s disease: a systemic inflammatory disease accompanied by bacterial inflammagens

    Article • May 2019, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  89. Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli

    Article • April 2019, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  90. Very rapid flow cytometric assessment of antimicrobial susceptibility during the apparent lag phase of microbial (re)growth

    Article • Microbiology, April 2019, Society for General Microbiology

    Professor Douglas B Kell

  91. Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation

    Article • Scientific Reports, February 2019, Springer Science + Business Media

    Professor Douglas B Kell

  92. Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris

    Article • Frontiers in Cellular and Infection Microbiology, February 2019, Frontiers

    Professor Douglas B Kell

  93. Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer’s Type Dementia

    Article • Frontiers in Neuroscience, November 2018, Frontiers

    Professor Douglas B Kell

  94. Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson’s Disease, Alzheimer’s Disease and Type 2 Diabetes Mellitus

    Article • Scientific Reports, November 2018, Springer Science + Business Media

    Professor Douglas B Kell

  95. The Potential of LPS-Binding Protein to Reverse Amyloid Formation in Plasma Fibrin of Individuals With Alzheimer-Type Dementia

    Article • Frontiers in Aging Neuroscience, August 2018, Frontiers

    Professor Douglas B Kell

  96. An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals

    Article • Communications Biology, June 2018, Springer Science + Business Media

    Professor Douglas B Kell

  97. Energetic evolution of cellular Transportomes

    Article • BMC Genomics, May 2018, Springer Science + Business Media

    Professor Douglas B Kell

  98. No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases

    Article • Biological Reviews, March 2018, Wiley

    Professor Douglas B Kell

  99. Belief Book

    Article • March 2018, Center for Open Science

    Professor Douglas B Kell

  100. Control of metabolite efflux in microbial cell factories: current advances and future prospects

    Article • March 2018, Center for Open Science

    Professor Douglas B Kell

  101. Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease

    Article • PLOS One, March 2018, PLOS

    Professor Douglas B Kell

  102. PartsGenie: an integrated tool for optimizing and sharing synthetic biology parts

    Article • Bioinformatics, February 2018, Oxford University Press (OUP)

    Professor Douglas B Kell

  103. Selenzyme: enzyme selection tool for pathway design

    Article • Bioinformatics, February 2018, Oxford University Press (OUP)

    Professor Douglas B Kell

  104. Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker™ stains

    Article • Journal of The Royal Society Interface, February 2018, Royal Society Publishing

    Professor Douglas B Kell

  105. GeneGini: Assessment via the Gini Coefficient of Reference “Housekeeping” Genes and Diverse Human Transporter Expression Profiles

    Article • Cell Systems, February 2018, Elsevier

    Professor Douglas B Kell

  106. Engineering the “Missing Link” in Biosynthetic (−)-Menthol Production: Bacterial Isopulegone Isomerase

    Article • ACS Catalysis, January 2018, American Chemical Society (ACS)

    Professor Douglas B Kell

  107. Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father†

    Article • Frontiers in Medicine, January 2018, Frontiers

    Professor Douglas B Kell

  108. Fast and Flexible Synthesis of Combinatorial Libraries for Directed Evolution

    Article • January 2018, Elsevier

    Professor Douglas B Kell

  109. Ultra-high throughput functional enrichment of large monoamine oxidase (MAO-N) libraries by fluorescence activated cell sorting

    Article • The Analyst, January 2018, Royal Society of Chemistry

    Professor Douglas B Kell

  110. Analysing and Navigating Natural Products Space for Generating Small, Diverse, But Representative Chemical Libraries

    Article • Biotechnology Journal, December 2017, Wiley

    Professor Douglas B Kell

  111. Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains

    Article • Cardiovascular Diabetology, November 2017, Springer Science + Business Media

    Professor Douglas B Kell

  112. Immunological tolerance, pregnancy and pre-eclampsia: the roles of semen microbes and the father

    Article • October 2017, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  113. PartsGenie: an integrated tool for optimising and sharing synthetic biology parts

    Article • September 2017, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  114. Selenzyme: Enzyme selection tool for pathway design

    Article • September 2017, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  115. A Metabolic Reaction Balancing Web Service for Computational Systems Biology

    Article • September 2017, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  116. Lipopolysaccharide-binding protein (LBP) reverses the amyloid state of fibrin seen in plasma of type 2 diabetics with cardiovascular co-morbidities

    Article • Scientific Reports, August 2017, Nature

    Professor Douglas B Kell

  117. Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation

    Article • Scientific Reports, August 2017, Nature

    Professor Douglas B Kell

  118. To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?

    Article • Seminars in Thrombosis and Hemostasis, August 2017, Thieme Publishing Group

    Professor Douglas B Kell

  119. biochem4j: Integrated and extensible biochemical knowledge through graph databases

    Article • PLOS One, July 2017, PLOS

    Professor Douglas B Kell

  120. CodonGenie: optimised ambiguous codon design tools

    Article • PeerJ Computer Science, July 2017, PeerJ

    Professor Douglas B Kell

  121. Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3×Tg Alzheimer mouse model

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, July 2017, Elsevier

    Professor Douglas B Kell

  122. Novel ‘housekeeping’ genes and an unusually heterogeneous distribution of transporter expression profiles in human tissues and cell lines, assessed using the Gini coefficient

    Article • June 2017, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  123. Consensus rank orderings of molecular fingerprints illustrate the most genuine similarities between marketed drugs and small endogenous human metabolites, but highlight exogenous natural products as the most important ‘natural’ drug transporter substrates

    Article • ADMET & DMPK, June 2017, International Association of Physical Chemists (IAPC)

    Professor Douglas B Kell

  124. Both Lipopolysaccharide And Lipoteichoic Acids Potently Induce Anomalous Fibrin Amyloid Formation: Assessment With Novel Amytracker™ Stains

    Article • May 2017, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  125. Lipopolysaccharide-Binding Protein (LBP) Can Reverse The Amyloid State Of Fibrin Seen Or Induced In Parkinson's Disease: Implications For Its Aetiology

    Article • April 2017, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  126. Evolutionary algorithms and synthetic biology for directed evolution: commentary on “on the mapping of genotype to phenotype in evolutionary algorithms” by Peter A. Whigham, Grant Dick, and James Maclaurin

    Article • Genetic Programming and Evolvable Machines, March 2017, Springer Science + Business Media

    Professor Douglas B Kell

  127. Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine

    Article • Frontiers in Pharmacology, March 2017, Frontiers

    Professor Douglas B Kell

  128. Analysis of drug–endogenous human metabolite similarities in terms of their maximum common substructures

    Article • Journal of Cheminformatics, March 2017, Springer Science + Business Media

    Professor Douglas B Kell

  129. Computing exponentially faster: implementing a non-deterministic universal Turing machine using DNA

    Article • Journal of The Royal Society Interface, March 2017, Royal Society Publishing

    Professor Douglas B Kell

  130. Consensus rank orderings of molecular fingerprints illustrate the most genuine similarities between marketed drugs and small endogenous human metabolites, but highlight exogenous natural products as the most important natural drug transporter substrate...

    Article • February 2017, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  131. Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability

    Article • Experimental Biology and Medicine, February 2017, SAGE Publications

    Professor Douglas B Kell

  132. Commentary on “Goodacre R, Timmins ÉM, Rooney PJ, Rowland JJ, Kell DB: Rapid identification of Streptococcus and Enterococcus species using diffuse reflectance-absorbance Fourier transform in...

    Article • FEMS Microbiology Letters, January 2017, Oxford University Press (OUP)

    Professor Douglas B Kell

  133. SYNBIOCHEM Synthetic Biology Research Centre, Manchester – A UK foundry for fine and speciality chemicals production

    Article • Synthetic and Systems Biotechnology, December 2016, Elsevier

    Professor Douglas B Kell

  134. A Dormant Microbial Component in the Development of Preeclampsia

    Article • Frontiers in Medicine, November 2016, Frontiers

    Professor Douglas B Kell

  135. SpeedyGenes: Exploiting an Improved Gene Synthesis Method for the Efficient Production of Synthetic Protein Libraries for Directed Evolution

    Article • September 2016, Springer Science + Business Media

    Professor Douglas B Kell

  136. Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide

    Article • Journal of The Royal Society Interface, September 2016, Royal Society Publishing

    Professor Douglas B Kell

  137. The metabolome 18 years on: a concept comes of age

    Article • Metabolomics, September 2016, Springer Science + Business Media

    Professor Douglas B Kell

  138. MetMaxStruct: A Tversky-Similarity-Based Strategy for Analysing the (Sub)Structural Similarities of Drugs and Endogenous Metabolites

    Article • Frontiers in Pharmacology, August 2016, Frontiers

    Professor Douglas B Kell

  139. A Bacterial Component to Alzheimer’s-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease

    Article • Journal of Alzheimer’s Disease, August 2016, IOS Press

    Professor Douglas B Kell

  140. Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting

    Article • Progress in Biophysics and Molecular Biology, August 2016, Elsevier

    Professor Douglas B Kell

  141. SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals

    Article • Biochemical Society Transactions, June 2016, Portland Press Ltd.

    Professor Douglas B Kell

  142. Recon 2.2: from reconstruction to model of human metabolism

    Article • Metabolomics, June 2016, Springer Science + Business Media

    Professor Douglas B Kell

  143. Microbes and Alzheimer’s Disease

    Article • Journal of Alzheimer’s Disease, April 2016, IOS Press

    Professor George Perry, Professor Douglas B Kell, Dr Christopher Carter, Ruth Itzhaki

  144. Response to ‘The Need for Speed’, by Matsson et al.

    Article • Trends in Pharmacological Sciences, April 2016, Elsevier

    Professor Douglas B Kell

  145. Implications of endogenous roles of transporters for drug discovery: hitchhiking and metabolite-likeness

    Article • Nature Reviews Drug Discovery, February 2016, Nature

    Professor Douglas B Kell

  146. The transporter-mediated cellular uptake of pharmaceutical drugs is based on their metabolite-likeness and not on their bulk biophysical properties: Towards a systems pharmacology

    Article • Perspectives in Science, December 2015, Elsevier

    Professor Douglas B Kell

  147. The apparent permeabilities of Caco-2 cells to marketed drugs: magnitude, and independence from both biophysical properties and endogenite similarities

    Article • PeerJ, November 2015, PeerJ

    Professor Douglas B Kell

  148. Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS)

    Article • Oncotarget, November 2015, Impact Journals, LLC

    Professor Douglas B Kell

  149. Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly

    Article • Trends in Pharmacological Sciences, November 2015, Elsevier

    Professor Douglas B Kell

  150. On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death

    Article • Integrative Biology, September 2015, Oxford University Press (OUP)

    Professor Douglas B Kell

  151. Individuality, phenotypic differentiation, dormancy and ‘persistence’ in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology

    Article • F1000Research, September 2015, Faculty of 1000, Ltd.

    Professor Douglas B Kell

  152. Software review: the KNIME workflow environment and its applications in genetic programming and machine learning

    Article • Genetic Programming and Evolvable Machines, July 2015, Springer Science + Business Media

    Professor Douglas B Kell

  153. Individuality, phenotypic differentiation, dormancy and ‘persistence’ in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology

    Article • F1000Research, July 2015, Faculty of 1000, Ltd.

    Professor Douglas B Kell

  154. Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites

    Article • Frontiers in Pharmacology, May 2015, Frontiers

    Professor Douglas B Kell

  155. The dormant blood microbiome in chronic, inflammatory diseases

    Article • FEMS Microbiology Reviews, May 2015, Oxford University Press (OUP)

    Professor Douglas B Kell

  156. Membrane transporter engineering in industrial biotechnology and whole cell biocatalysis

    Article • Trends in Biotechnology, April 2015, Elsevier

    Professor Douglas B Kell

  157. The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)

    Article • Integrative Biology, January 2015, Oxford University Press (OUP)

    Professor Douglas B Kell

  158. Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently

    Article • Chemical Society Reviews, January 2015, Royal Society of Chemistry

    Professor Douglas B Kell

  159. What would be the observable consequences if phospholipid bilayer diffusion of drugs into cells is negligible?

    Article • Trends in Pharmacological Sciences, January 2015, Elsevier

    Professor Douglas B Kell

  160. Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics

    Article • Cardiovascular Diabetology, January 2015, Springer Science + Business Media

    Professor Douglas B Kell

  161. The virtue of innovation: innovation through the lenses of biological evolution

    Article • Journal of The Royal Society Interface, December 2014, Royal Society Publishing

    Professor Douglas B Kell

  162. Alignment by numbers: sequence assembly using compressed numerical representations

    Article • November 2014, Cold Spring Harbor Laboratory Press

    Professor Douglas B Kell

  163. Corrigendum to “Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery” [Drug Discov. Today 19 (2014), 171–182

    Article • Drug Discovery Today, November 2014, Elsevier

    Professor Douglas B Kell

  164. How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion

    Article • Frontiers in Pharmacology, October 2014, Frontiers

    Professor Douglas B Kell

  165. Eryptosis as a marker of Parkinson's disease

    Article • Aging, October 2014, Impact Journals, LLC

    Professor Douglas B Kell

  166. Erratum to: A ‘rule of 0.5’ for the metabolite-likeness of approved pharmaceutical drugs

    Article • Metabolomics, October 2014, Springer Science + Business Media

    Professor Douglas B Kell

  167. A ‘rule of 0.5’ for the metabolite-likeness of approved pharmaceutical drugs

    Article • Metabolomics, September 2014, Springer Science + Business Media

    Professor Douglas B Kell

  168. Evidence That Multiple Defects in Lipid Regulation Occur before Hyperglycemia during the Prodrome of Type-2 Diabetes

    Article • PLOS One, September 2014, PLOS

    Professor Douglas B Kell

  169. SpeedyGenes: an improved gene synthesis method for the efficient production of error-corrected, synthetic protein libraries for directed evolution

    Article • Protein Engineering Design and Selection, August 2014, Oxford University Press (OUP)

    Professor Douglas B Kell

  170. Molecular phenotyping of a UK population: defining the human serum metabolome

    Article • Metabolomics, July 2014, Springer Science + Business Media

    Professor Douglas B Kell

  171. Event-based text mining for biology and functional genomics

    Article • Briefings in Functional Genomics, June 2014, Oxford University Press (OUP)

    Professor Douglas B Kell

  172. GeneGenie: optimized oligomer design for directed evolution

    Article • Nucleic Acids Research, April 2014, Oxford University Press (OUP)

    Professor Douglas B Kell

  173. Controlled vocabularies and semantics in systems biology

    Article • Molecular Systems Biology, April 2014, EMBO

    Professor Douglas B Kell, Jun.-Prof. Dr. Andreas Dräger

  174. Resuscitation of “Uncultured” Microorganisms

    Article • April 2014, ASM Journals

    Professor Douglas B Kell

  175. Mental health: Drug search on risky path

    Article • Nature, April 2014, Springer Science + Business Media

    Professor Douglas B Kell

  176. Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery

    Article • Drug Discovery Today, February 2014, Elsevier

    Professor Douglas B Kell

  177. Profound Morphological Changes in the Erythrocytes and Fibrin Networks of Patients with Hemochromatosis or with Hyperferritinemia, and Their Normalization by Iron Chelators and Other Agents

    Article • PLOS One, January 2014, PLOS

    Professor Douglas B Kell

  178. Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases

    Article • Integrative Biology, January 2014, Oxford University Press (OUP)

    Professor Douglas B Kell

  179. Yeast cells with impaired drug resistance accumulate glycerol and glucose

    Article • Molecular BioSystems, January 2014, Royal Society of Chemistry

    Professor Douglas B Kell

  180. Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

    Article • Metallomics, January 2014, Oxford University Press (OUP)

    Professor Douglas B Kell

  181. An analysis of a ‘community-driven’ reconstruction of the human metabolic network

    Article • Metabolomics, July 2013, Springer Science + Business Media

    Professor Douglas B Kell

  182. A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes

    Article • FEBS Letters, July 2013, Wiley

    Professor Douglas B Kell

  183. A method for integrating and ranking the evidence for biochemical pathways by mining reactions from text

    Article • Bioinformatics, June 2013, Oxford University Press (OUP)

    Professor Douglas B Kell

  184. Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it

    Article • FEBS Journal, April 2013, Wiley

    Professor Douglas B Kell

  185. A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy

    Article • Toxicology Mechanisms and Methods, April 2013, Taylor & Francis

    Professor Douglas B Kell

  186. Genetics and iron in the systems biology of Parkinson’s disease and some related disorders

    Article • Neurochemistry International, April 2013, Elsevier

    Professor Douglas B Kell

  187. A community-driven global reconstruction of human metabolism

    Article • Nature Biotechnology, March 2013, Nature

    Professor Douglas B Kell

  188. The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so

    Article • Drug Discovery Today, March 2013, Elsevier

    Professor Douglas B Kell

  189. Kinetic Parameter Information Resource, KiPar

    Article • January 2013, Springer Science + Business Media

    Professor Douglas B Kell

  190. High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease

    Article • Frontiers in Aging Neuroscience, January 2013, Frontiers

    Professor Douglas B Kell

  191. Path2Models: large-scale generation of computational models from biochemical pathway maps

    Article • BMC Systems Biology, January 2013, Springer Science + Business Media

    Professor Douglas B Kell, Professor Julio Saez-Rodriguez, Jun.-Prof. Dr. Andreas Dräger

  192. Exploiting Genomic Knowledge in Optimising Molecular Breeding Programmes: Algorithms from Evolutionary Computing

    Article • PLOS One, November 2012, PLOS

    Professor Douglas B Kell

  193. Reviews turn facts into understanding

    Article • Nature, October 2012, Springer Science + Business Media

    Professor Douglas B Kell

  194. Extracting semantically enriched events from biomedical literature

    Article • BMC Bioinformatics, May 2012, Springer Science + Business Media

    Professor Douglas B Kell

  195. Large-scale sequestration of atmospheric carbon via plant roots in natural and agricultural ecosystems: why and how

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, April 2012, Royal Society Publishing

    Professor Douglas B Kell

  196. A systematic survey of the response of a model NF-

    Article • Journal of Theoretical Biology, March 2012, Elsevier

    Professor Douglas B Kell

  197. Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals importance of recycling in maintaining cell viability

    Article • Environmental Microbiology, February 2012, Wiley

    Professor Douglas B Kell

  198. Scientific discovery as a combinatorial optimisation problem: How best to navigate the landscape of possible experiments?

    Article • BioEssays, January 2012, Wiley

    Professor Douglas B Kell

  199. Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment

    Article • Molecular BioSystems, January 2012, Royal Society of Chemistry

    Professor Douglas B Kell

  200. The genetic control of growth rate: a systems biology study in yeast

    Article • BMC Systems Biology, January 2012, Springer Science + Business Media

    Professor Douglas B Kell

  201. Improving metabolic flux predictions using absolute gene expression data

    Article • BMC Systems Biology, January 2012, Springer Science + Business Media

    Professor Douglas B Kell

  202. Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

    Article • Bioinformatics, December 2011, Oxford University Press (OUP)

    Professor Douglas B Kell

  203. Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

    Article • Nature Chemical Biology, October 2011, Springer Science + Business Media

    Professor Douglas B Kell, Gloria Lopez-Castejon

  204. Absolute Quantification of the Glycolytic Pathway in Yeast:: DEPLOYMENT OF A COMPLETE QconCAT APPROACH

    Article • Molecular & Cellular Proteomics, September 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Douglas B Kell

  205. Concussion's impact

    Article • The New Scientist, September 2011, Elsevier

    Professor Douglas B Kell

  206. The metabolome of human placental tissue: investigation of first trimester tissue and changes related to preeclampsia in late pregnancy

    Article • Metabolomics, August 2011, Springer Science + Business Media

    Professor Douglas B Kell, Alexander Heazell

  207. Breeding crop plants with deep roots: their role in sustainable carbon, nutrient and water sequestration

    Article • Annals of Botany, August 2011, Oxford University Press (OUP)

    Professor Douglas B Kell

  208. Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only

    Article • Drug Discovery Today, August 2011, Elsevier

    Professor Douglas B Kell

  209. Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

    Article • Nature Protocols, June 2011, Springer Science + Business Media

    Professor Douglas B Kell

  210. Metabolic Profiling Uncovers a Phenotypic Signature of Small for Gestational Age in Early Pregnancy

    Article • Journal of Proteome Research, June 2011, American Chemical Society (ACS)

    Professor Douglas B Kell

  211. Defrosting the Digital Library

    Article • April 2011, Taylor & Francis

    Professor Douglas B Kell

  212. Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

    Article • Bioinformatics, February 2011, Oxford University Press (OUP)

    Professor Douglas B Kell

  213. Interactions among oscillatory pathways in NF-kappa B signaling

    Article • BMC Systems Biology, February 2011, Springer Science + Business Media

    Professor Douglas B Kell

  214. Predicting the points of interaction of small molecules in the NF-κB pathway

    Article • BMC Systems Biology, January 2011, Springer Science + Business Media

    Professor Douglas B Kell

  215. Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast

    Article • BMC Biology, January 2011, Springer Science + Business Media

    Professor Douglas B Kell

  216. Metabolites do social networking

    Article • Nature Chemical Biology, December 2010, Springer Science + Business Media

    Professor Douglas B Kell

  217. Systematic integration of experimental data and models in systems biology

    Article • BMC Bioinformatics, November 2010, Springer Science + Business Media

    Professor Douglas B Kell

  218. Mining metabolites: extracting the yeast metabolome from the literature

    Article • Metabolomics, October 2010, Springer Science + Business Media

    Professor Douglas B Kell

  219. Changes in the Metabolic Footprint of Placental Explant-Conditioned Medium Cultured in Different Oxygen Tensions from Placentas of Small for Gestational Age and Normal Pregnancies

    Article • Placenta, October 2010, Elsevier

    Professor Douglas B Kell, Alexander Heazell

  220. Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers

    Article • Hypertension, September 2010, Wolters Kluwer Health

    Professor Douglas B Kell

  221. Utopia documents: linking scholarly literature with research data

    Article • Bioinformatics, September 2010, Oxford University Press (OUP)

    Professor Douglas B Kell

  222. Convergent evolution to an aptamer observed in small populations on DNA microarrays

    Article • Physical Biology, September 2010, Institute of Physics Publishing

    Professor Douglas B Kell

  223. Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

    Article • Archives of Toxicology, August 2010, Springer Science + Business Media

    Professor Douglas B Kell

  224. Enzyme kinetics informatics: from instrument to browser

    Article • FEBS Journal, August 2010, Wiley

    Professor Douglas B Kell

  225. Predictive models for population performance on real biological fitness landscapes

    Article • Bioinformatics, July 2010, Oxford University Press (OUP)

    Professor Douglas B Kell

  226. Event extraction for systems biology by text mining the literature

    Article • Trends in Biotechnology, July 2010, Elsevier

    Professor Douglas B Kell

  227. Arcadia: a visualization tool for metabolic pathways

    Article • Bioinformatics, May 2010, Oxford University Press (OUP)

    Professor Douglas B Kell

  228. Further developments towards a genome-scale metabolic model of yeast

    Article • BMC Systems Biology, January 2010, Springer Science + Business Media

    Professor Douglas B Kell

  229. Calling International Rescue: knowledge lost in literature and data landslide!

    Article • Biochemical Journal, December 2009, Portland Press Ltd.

    Professor Douglas B Kell

  230. Real-time vapour sensing using an OFET-based electronic nose and genetic programming

    Article • Sensors and Actuators B Chemical, December 2009, Elsevier

    Professor Douglas B Kell

  231. Changes in the Metabolic Footprint of Placental Explant-Conditioned Culture Medium Identifies Metabolic Disturbances Related to Hypoxia and Pre-Eclampsia

    Article • Placenta, November 2009, Elsevier

    Professor Douglas B Kell, Alexander Heazell

  232. Erratum: The Systems Biology Graphical Notation

    Article • Nature Biotechnology, September 2009, Nature

    Professor Douglas B Kell

  233. Development and Performance of a Gas Chromatography−Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum

    Article • Analytical Chemistry, August 2009, American Chemical Society (ACS)

    Professor Douglas B Kell

  234. Journal club

    Article • Nature, August 2009, Springer Science + Business Media

    Professor Douglas B Kell

  235. The Systems Biology Graphical Notation

    Article • Nature Biotechnology, August 2009, Springer Science + Business Media

    Professor Douglas B Kell, Steven Watterson

  236. Analysis of a complete DNA-protein affinity landscape

    Article • Journal of The Royal Society Interface, July 2009, Royal Society Publishing

    Professor Douglas B Kell

  237. Aptamer evolution for array-based diagnostics

    Article • Analytical Biochemistry, July 2009, Elsevier

    Professor Douglas B Kell

  238. Serum Metabolite Biomarkers In Alzheimer's Disease

    Article • Alzheimer s & Dementia, July 2009, Elsevier

    Professor Douglas B Kell

  239. Visualising biological data: a semantic approach to tool and database integration

    Article • BMC Bioinformatics, June 2009, Springer Science + Business Media

    Professor Douglas B Kell

  240. Pulsatile Stimulation Determines Timing and Specificity of NF- B-Dependent Transcription

    Article • Science, April 2009, American Association for the Advancement of Science

    Professor Douglas B Kell

  241. Low cost, portable, fast multiparameter data acquisition system for organic transistor odour sensors

    Article • Sensors and Actuators B Chemical, April 2009, Elsevier

    Professor Douglas B Kell

  242. Systems approach

    Article • Nature, April 2009, Springer Science + Business Media

    Professor Douglas B Kell

  243. Dormant microbes: time to revive some old ideas

    Article • Nature, April 2009, Springer Science + Business Media

    Professor Douglas B Kell

  244. KiPar, a tool for systematic information retrieval regarding parameters for kinetic modelling of yeast metabolic pathways

    Article • Bioinformatics, March 2009, Oxford University Press (OUP)

    Professor Douglas B Kell

  245. In silico modelling of directed evolution: Implications for experimental design and stepwise evolution

    Article • Journal of Theoretical Biology, March 2009, Elsevier

    Professor Douglas B Kell

  246. Scientific Abstracts

    Article • Reproductive Sciences, March 2009, SAGE Publications

    Professor Douglas B Kell

  247. Development of a Robust and Repeatable UPLC−MS Method for the Long-Term Metabolomic Study of Human Serum

    Article • Analytical Chemistry, February 2009, American Chemical Society (ACS)

    Professor Douglas B Kell

  248. Anaesthetic function

    Article • The New Scientist, February 2009, Elsevier

    Professor Douglas B Kell

  249. Implications of the Dominant Role of Transporters in Drug Uptake by Cells (Supplementary Material)

    Article • Current Topics in Medicinal Chemistry, February 2009, Bentham Science Publishers

    Professor Douglas B Kell

  250. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

    Article • BMC Medical Genomics, January 2009, Springer Science + Business Media

    Professor Douglas B Kell

  251. Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics

    Article • The Analyst, January 2009, Royal Society of Chemistry

    Professor Douglas B Kell

  252. Optimal construction of a fast and accurate polarisable water potential based on multipole moments trained by machine learning

    Article • Physical Chemistry Chemical Physics, January 2009, Royal Society of Chemistry

    Professor Douglas B Kell, Professor Paul Popelier

  253. Analysis of aptamer sequence activity relationships

    Article • Integrative Biology, January 2009, Oxford University Press (OUP)

    Professor Douglas B Kell

  254. ‘Metabolite-likeness’ as a criterion in the design and selection of pharmaceutical drug libraries

    Article • Drug Discovery Today, January 2009, Elsevier

    Professor Douglas B Kell

  255. Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae

    Article • BMC Systems Biology, January 2009, Springer Science + Business Media

    Professor Douglas B Kell

  256. Information management for high content live cell imaging

    Article • BMC Bioinformatics, January 2009, Springer Science + Business Media

    Professor Douglas B Kell

  257. Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

    Article • Nucleic Acids Research, November 2008, Oxford University Press (OUP)

    Professor Douglas B Kell

  258. Progress being made on standards for use in data sharing

    Article • Nature, November 2008, Springer Science + Business Media

    Professor Douglas B Kell

  259. Sensitivity analysis and robust experimental design of a signal transduction pathway system

    Article • International Journal of Chemical Kinetics, November 2008, Wiley

    Professor Douglas B Kell

  260. Defrosting the Digital Library: Bibliographic Tools for the Next Generation Web

    Article • PLoS Computational Biology, October 2008, PLOS

    Professor Douglas B Kell

  261. A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology

    Article • Nature Biotechnology, October 2008, Springer Science + Business Media

    Professor Douglas B Kell

  262. Performing statistical analyses on quantitative data in Taverna workflows: An example using R and maxdBrowse to identify differentially-expressed genes from microarray data

    Article • BMC Bioinformatics, August 2008, Springer Science + Business Media

    Professor Douglas B Kell

  263. Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system

    Article • Journal of Chromatography B, August 2008, Elsevier

    Professor Douglas B Kell

  264. Analysis of the Metabolic Footprint and Tissue Metabolome of Placental Villous Explants Cultured at Different Oxygen Tensions Reveals Novel Redox Biomarkers

    Article • Placenta, August 2008, Elsevier

    Professor Douglas B Kell, Alexander Heazell

  265. Detection and Identification of Novel Metabolomic Biomarkers in Preeclampsia

    Article • Reproductive Sciences, July 2008, SAGE Publications

    Professor Douglas B Kell

  266. The markup is the model: Reasoning about systems biology models in the Semantic Web era

    Article • Journal of Theoretical Biology, June 2008, Elsevier

    Professor Douglas B Kell

  267. Facilitating the development of controlled vocabularies for metabolomics technologies with text mining

    Article • BMC Bioinformatics, April 2008, Springer Science + Business Media

    Professor Douglas B Kell

  268. Bayesian inference of the sites of perturbations in metabolic pathways via Markov chain Monte Carlo

    Article • Bioinformatics, March 2008, Oxford University Press (OUP)

    Professor Douglas B Kell

  269. Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

    Article • Nature Reviews Drug Discovery, March 2008, Springer Science + Business Media

    Professor Douglas B Kell

  270. Comparative evaluation of software for deconvolution of metabolomics data based on GC-TOF-MS

    Article • TrAC Trends in Analytical Chemistry, March 2008, Elsevier

    Professor Douglas B Kell

  271. A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols

    Article • International Journal of Epidemiology, February 2008, Oxford University Press (OUP)

    Professor Douglas B Kell

  272. Information-theoretic sensitivity analysis: a general method for credit assignment in complex networks

    Article • Journal of The Royal Society Interface, February 2008, Royal Society Publishing

    Professor Douglas B Kell

  273. Proximate parameter tuning for biochemical networks with uncertain kinetic parameters

    Article • Molecular BioSystems, January 2008, Royal Society of Chemistry

    Professor Douglas B Kell

  274. The landscape adaptive particle swarm optimizer

    Article • Applied Soft Computing, January 2008, Elsevier

    Professor Douglas B Kell

  275. Rapid prediction of optimum population size in genetic programming using a novel genotype -

    Article • January 2008, ACM (Association for Computing Machinery)

    Professor Douglas B Kell

  276. Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures

    Article • Nature Genetics, December 2007, Springer Science + Business Media

    Professor Douglas B Kell

  277. Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, Stereum hirsutum with its competitors Coprinus micaceus and Coprinus disseminatus

    Article • Metabolomics, December 2007, Springer Science + Business Media

    Professor Douglas B Kell

  278. Automated manipulation of systems biology models using libSBML within Taverna workflows

    Article • Bioinformatics, December 2007, Oxford University Press (OUP)

    Professor Douglas B Kell

  279. Something from nothing − bridging the gap between constraint-based and kinetic modelling

    Article • FEBS Journal, October 2007, Wiley

    Professor Douglas B Kell

  280. Transcriptional and metabolic response of Saccharomyces cerevisiae to a nutritional perturbation when under stress

    Article • Journal of Biotechnology, September 2007, Elsevier

    Professor Douglas B Kell

  281. Proposed minimum reporting standards for data analysis in metabolomics

    Article • Metabolomics, August 2007, Springer Science + Business Media

    Professor Douglas B Kell

  282. Metabolic footprinting as a tool for discriminating between brewing yeasts

    Article • Yeast, August 2007, Wiley

    Professor Douglas B Kell

  283. Metabolomic biomarkers: search, discovery and validation

    Article • Expert Review of Molecular Diagnostics, July 2007, Taylor & Francis

    Professor Douglas B Kell

  284. Improving Data Fitting of a Signal Transduction Model by Global Sensitivity Analysis

    Article • July 2007, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Douglas B Kell

  285. Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate

    Article • Metabolomics, June 2007, Springer Science + Business Media

    Professor Douglas B Kell

  286. Towards a mathematical model of the cAMP pathway in S. cerevisiae

    Article • BMC Systems Biology, May 2007, Springer Science + Business Media

    Professor Douglas B Kell

  287. Multiobjective Optimization in Bioinformatics and Computational Biology

    Article • IEEE/ACM Transactions on Computational Biology and Bioinformatics, April 2007, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Douglas B Kell

  288. The methodologies of systems biology

    Article • January 2007, Elsevier

    Professor Douglas B Kell

  289. The virtual human: Towards a global systems biology of multiscale, distributed biochemical network models

    Article • IUBMB Life, January 2007, Wiley

    Professor Douglas B Kell

  290. Peptide detectability following ESI mass spectrometry

    Article • January 2007, ACM (Association for Computing Machinery)

    Professor Douglas B Kell, Prof Claire E Eyers

  291. Growth control of the eukaryote cell: a systems biology study in yeast

    Article • Journal of Biology, January 2007, Springer Science + Business Media

    Professor Douglas B Kell

  292. Automated tracking of gene expression in individual cells and cell compartments

    Article • Journal of The Royal Society Interface, December 2006, Royal Society Publishing

    Professor Douglas B Kell

  293. Closed-Loop, Multiobjective Optimization of Two-Dimensional Gas Chromatography/Mass Spectrometry for Serum Metabolomics

    Article • Analytical Chemistry, December 2006, American Chemical Society (ACS)

    Professor Douglas B Kell

  294. Systems biology, metabolic modelling and metabolomics in drug discovery and development

    Article • Drug Discovery Today, December 2006, Elsevier

    Professor Douglas B Kell

  295. Text mining and its potential applications in systems biology

    Article • Trends in Biotechnology, December 2006, Elsevier

    Professor Douglas B Kell

  296. Statistical strategies for avoiding false discoveries in metabolomics and related experiments

    Article • Metabolomics, November 2006, Springer Science + Business Media

    Professor Douglas B Kell

  297. Metabolomics: The new science of metabolic integration

    Article • Journal of Molecular and Cellular Cardiology, June 2006, Elsevier

    Professor Douglas B Kell

  298. Automatic tracking of biological cells and compartments using particle filters and active contours

    Article • Chemometrics and Intelligent Laboratory Systems, May 2006, Elsevier

    Professor Douglas B Kell

  299. The Role of Modeling in Systems Biology

    Article • March 2006, The MIT Press

    Professor Douglas B Kell

  300. Metabolomics, modelling and machine learning in systems biology - towards an understanding of the languages of cells. Delivered on 3 July 2005 at the 30th FEBS Congress and 9th IUBMB conference in Budapest

    Article • FEBS Journal, March 2006, Wiley

    Professor Douglas B Kell

  301. Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles

    Article • Brain, February 2006, Oxford University Press (OUP)

    Professor Douglas B Kell

  302. Insights into the behaviour of systems biology models from dynamic sensitivity and identifiability analysis: a case study of an NF-κB signalling pathway

    Article • Molecular BioSystems, January 2006, Royal Society of Chemistry

    Professor Douglas B Kell

  303. Muralytic activity of Micrococcus luteus Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation

    Article • Molecular Microbiology, January 2006, Wiley

    Professor Douglas B Kell

  304. Article • BMC Bioinformatics, January 2006, Springer Science + Business Media

    Professor Douglas B Kell

  305. Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops

    Article • Proceedings of the National Academy of Sciences, September 2005, Proceedings of the National Academy of Sciences

    Professor Douglas B Kell

  306. Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning

    Article • Metabolomics, July 2005, Springer Science + Business Media

    Professor Douglas B Kell

  307. A laser desorption ionisation mass spectrometry approach for high throughput metabolomics

    Article • Metabolomics, July 2005, Springer Science + Business Media

    Professor Douglas B Kell

  308. Metabolic footprinting and systems biology: the medium is the message

    Article • Nature Reviews Microbiology, June 2005, Springer Science + Business Media

    Professor Douglas B Kell

  309. A general model of error-prone PCR

    Article • Journal of Theoretical Biology, June 2005, Elsevier

    Professor Douglas B Kell

  310. Metabolomics, machine learning and modelling: towards an understanding of the language of cells

    Article • Biochemical Society Transactions, June 2005, Portland Press Ltd.

    Professor Douglas B Kell

  311. Computational cluster validation in post-genomic data analysis

    Article • Bioinformatics, May 2005, Oxford University Press (OUP)

    Professor Douglas B Kell

  312. A metabolome pipeline: from concept to data to knowledge

    Article • Metabolomics, March 2005, Springer Science + Business Media

    Professor Douglas B Kell

  313. Closed-Loop, Multiobjective Optimization of Analytical Instrumentation:  Gas Chromatography/Time-of-Flight Mass Spectrometry of the Metabolomes of Human Serum and of Yeast Fermentations

    Article • Analytical Chemistry, January 2005, American Chemical Society (ACS)

    Professor Douglas B Kell

  314. Article • BMC Bioinformatics, January 2005, Springer Science + Business Media

    Professor Douglas B Kell

  315. Synergistic control of oscillations in the NF-B signalling pathway

    Article • Systems Biology, January 2005, the Institution of Engineering and Technology (the IET)

    Professor Douglas B Kell

  316. Vacuum packing: a model system for laboratory-scale silage fermentations

    Article • Journal of Applied Microbiology, January 2005, Wiley

    Professor Douglas B Kell

  317. A proposed framework for the description of plant metabolomics experiments and their results

    Article • Nature Biotechnology, December 2004, Springer Science + Business Media

    Professor Douglas B Kell

  318. Differentiation of Micromonospora Isolates from a Coastal Sediment in Wales on the Basis of Fourier Transform Infrared Spectroscopy, 16S rRNA Sequence Analysis, and the Amplified Fragment Length Polymorphism Technique

    Article • Applied and Environmental Microbiology, November 2004, ASM Journals

    Professor Douglas B Kell

  319. Oscillations in NF- B Signaling Control the Dynamics of Gene Expression

    Article • Science, October 2004, American Association for the Advancement of Science

    Professor Douglas B Kell

  320. Discrimination of Modes of Action of Antifungal Substances by Use of Metabolic Footprinting

    Article • Applied and Environmental Microbiology, October 2004, ASM Journals

    Professor Douglas B Kell

  321. OBSERVED DYNAMICS OF LARGE SCALE PARALLEL EVOLUTIONARY ALGORITHMS WITH IMPLICATIONS FOR PROTEIN ENGINEERING

    Article • August 2004, World Scientific Pub Co Pte Lt

    Professor Douglas B Kell

  322. Selective Detection of Proteins in Mixtures Using Electrospray Ionization Mass Spectrometry:  Influence of Instrumental Settings and Implications for Proteomics

    Article • Analytical Chemistry, July 2004, American Chemical Society (ACS)

    Professor Douglas B Kell

  323. Estimation of Microbial Viability Using Flow Cytometry

    Article • Current Protocols in Cytometry, July 2004, Wiley

    Professor Douglas B Kell

  324. Metabolomics and systems biology: making sense of the soup

    Article • Current Opinion in Microbiology, June 2004, Elsevier

    Professor Douglas B Kell

  325. Sensitivity analysis of parameters controlling oscillatory signalling in the NF-κB pathway: the roles of IKK and IκBα

    Article • Systems Biology, June 2004, the Institution of Engineering and Technology (the IET)

    Professor Douglas B Kell

  326. Metabolomics by numbers: acquiring and understanding global metabolite data

    Article • Trends in Biotechnology, May 2004, Elsevier

    Professor Douglas B Kell

  327. Metabolomics by numbers: acquiring and understanding global metabolite data

    Article • Trends in Biotechnology, May 2004, Elsevier

    Professor Douglas B Kell

  328. Single-nucleotide polymorphism detection using nanomolar nucleotides and single-molecule fluorescence

    Article • Analytical Biochemistry, April 2004, Elsevier

    Professor Douglas B Kell

  329. High-Throughput Metabolic Fingerprinting of Legume Silage Fermentations via Fourier Transform Infrared Spectroscopy and Chemometrics

    Article • Applied and Environmental Microbiology, March 2004, ASM Journals

    Professor Douglas B Kell

  330. Functional genomic hypothesis generation and experimentation by a robot scientist

    Article • January 2004, Nature

    Professor Douglas B Kell

  331. Fast automatic registration of images using the phase of a complex wavelet transform: application to proteome gels

    Article • The Analyst, January 2004, Royal Society of Chemistry

    Professor Douglas B Kell

  332. Comparative Genomic Assessment of Novel Broad-Spectrum Targets for Antibacterial Drugs

    Article • Comparative and Functional Genomics, January 2004, Hindawi Publishing Corporation

    Professor Douglas B Kell

  333. Explanatory Optimization of Protein Mass Spectrometry via Genetic Search

    Article • Analytical Chemistry, December 2003, American Chemical Society (ACS)

    Professor Douglas B Kell

  334. High-throughput classification of yeast mutants for functional genomics using metabolic footprinting

    Article • Nature Biotechnology, May 2003, Springer Science + Business Media

    Professor Douglas B Kell

  335. A systematic approach to modeling, capturing, and disseminating proteomics experimental data

    Article • Nature Biotechnology, March 2003, Springer Science + Business Media

    Professor Douglas B Kell

  336. Evolutionary Computation for the Interpretation of Metabolomic Data

    Article • January 2003, Springer Science + Business Media

    Professor Douglas B Kell

  337. Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era

    Article • BioEssays, January 2003, Wiley

    Professor Douglas B Kell

  338. Adoption of the transiently non-culturable state — a bacterial survival strategy?

    Article • January 2003, Elsevier

    Professor Douglas B Kell

  339. Functional Genomics via Metabolic Footprinting: Monitoring Metabolite Secretion byEscherichia coliTryptophan Metabolism Mutants Using FT–IR and Direct Injection Electrospray Mass Spectrometry

    Article • Comparative and Functional Genomics, January 2003, Hindawi Publishing Corporation

    Professor Douglas B Kell

  340. Primary and secondary metabolism, and post-translational protein modifications, as portrayed by proteomic analysis of Streptomyces coelicolor

    Article • Molecular Microbiology, November 2002, Wiley

    Professor Douglas B Kell

  341. Genotype–phenotype mapping: genes as computer programs

    Article • Trends in Genetics, November 2002, Elsevier

    Professor Douglas B Kell

  342. A family of autocrine growth factors in Mycobacterium tuberculosis

    Article • Molecular Microbiology, October 2002, Wiley

    Professor Douglas B Kell

  343. The rpf gene of Micrococcus luteus encodes an essential secreted growth factor

    Article • Molecular Microbiology, October 2002, Wiley

    Professor Douglas B Kell

  344. Metabolic profiling using direct infusion electrospray ionisation mass spectrometry for the characterisation of olive oils

    Article • The Analyst, September 2002, Royal Society of Chemistry

    Professor Douglas B Kell

  345. Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis

    Article • FEBS Journal, August 2002, Wiley

    Professor Douglas B Kell

  346. Monitoring of complex industrial bioprocesses for metabolite concentrations using modern spectroscopies and machine learning: Application to gibberellic acid production

    Article • Biotechnology and Bioengineering, June 2002, Wiley

    Professor Douglas B Kell

  347. Rapid and Quantitative Detection of the Microbial Spoilage of Meat by Fourier Transform Infrared Spectroscopy and Machine Learning

    Article • Applied and Environmental Microbiology, June 2002, ASM Journals

    Professor Douglas B Kell

  348. Monitoring of complex industrial bioprocesses for metabolite concentrations using modern spectroscopies and machine learning: Application to gibberellic acid production

    Article • Biotechnology and Bioengineering, April 2002, Wiley

    Professor Douglas B Kell

  349. The Cytochrome P450 Complement (CYPome) of Streptomyces coelicolor A3(2)

    Article • Journal of Biological Chemistry, April 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Douglas B Kell

  350. Flow-injection electrospray ionization mass spectrometry of crude cell extracts for high-throughput bacterial identification

    Article • Journal of the American Society for Mass Spectrometry, February 2002, American Chemical Society (ACS)

    Professor Douglas B Kell

  351. Differentiation of Phytophthora infestans Sporangia from Other Airborne Biological Particles by Flow Cytometry

    Article • Applied and Environmental Microbiology, January 2002, ASM Journals

    Professor Douglas B Kell

  352. Comprehensive Natural Products Chemistry, Volume 4: Amino Acids, Peptides, Porphyrins and Alkaloids

    Article • Phytochemistry, January 2002, Elsevier

    Professor Douglas B Kell

  353. Sample preparation in matrix-assisted laser desorption/ionization mass spectrometry of whole bacterial cells and the detection of high mass (>20?kDa) proteins

    Article • Rapid Communications in Mass Spectrometry, January 2002, Wiley

    Professor Douglas B Kell

  354. Article • Molecular Biology Reports, January 2002, Springer Science + Business Media

    Professor Douglas B Kell

  355. Article • Molecular Biology Reports, January 2002, Springer Science + Business Media

    Professor Douglas B Kell

  356. Histometrics: Improvement of the dynamic range of fluorescently stained proteins resolved in electrophoretic gels using hyperspectral imaging

    Article • PROTEOMICS, November 2001, Wiley

    Professor Douglas B Kell

  357. Histometrics: Improvement of the dynamic range of fluorescently stained proteins resolved in electrophoretic gels using hyperspectral imaging

    Article • PROTEOMICS, November 2001, Wiley

    Professor Douglas B Kell

  358. Discrimination of Aerobic Endospore-forming Bacteria via Electrospray-Ionization Mass Spectrometry of Whole Cell Suspensions

    Article • Analytical Chemistry, September 2001, American Chemical Society (ACS)

    Professor Douglas B Kell

  359. Genomic Computing. Explanatory Analysis of Plant Expression Profiling Data Using Machine Learning

    Article • PLANT PHYSIOLOGY, July 2001, American Society of Plant Biologists (ASPB)

    Professor Douglas B Kell

  360. Chemometric criteria for the characterisation of Italian Protected Denomination of Origin (DOP) olive oils from their metabolic profiles

    Article • European Journal of Lipid Science and Technology, March 2001, Wiley

    Professor Douglas B Kell

  361. Chemometric criteria for the characterisation of Italian Protected Denomination of Origin (DOP) olive oils from their metabolic profiles

    Article • European Journal of Lipid Science and Technology, March 2001, Wiley

    Professor Douglas B Kell

  362. MEG (Model Extender for Gepasi): a program for the modelling of complex, heterogeneous, cellular systems

    Article • Bioinformatics, March 2001, Oxford University Press (OUP)

    Professor Douglas B Kell

  363. Macromolecular interactions: tracing the roots

    Article • Trends in Biochemical Sciences, February 2001, Elsevier

    Professor Douglas B Kell

  364. Article • Nature Biotechnology, January 2001, Nature

    Professor Douglas B Kell

  365. Culturability of Mycobacterium tuberculosis cells isolated from murine macrophages: a bacterial growth factor promotes recovery

    Article • FEMS Immunology & Medical Microbiology, December 2000, Oxford University Press (OUP)

    Professor Douglas B Kell

  366. Culturability of Mycobacterium tuberculosis cells isolated from murine macrophages: a bacterial growth factor promotes recovery

    Article • FEMS Immunology & Medical Microbiology, December 2000, Wiley

    Professor Douglas B Kell

  367. On-Line, Real-Time Measurements of Cellular Biomass using Dielectric Spectroscopy

    Article • Biotechnology and Genetic Engineering Reviews, August 2000, Taylor & Francis

    Professor Douglas B Kell

  368. Bacterial dormancy and culturability: the role of autocrine growth factors Commentary

    Article • Current Opinion in Microbiology, June 2000, Elsevier

    Professor Douglas B Kell

  369. Screen idols: faster, smaller, cheaper and smarter

    Article • Trends in Biotechnology, May 2000, Elsevier

    Professor Douglas B Kell

  370. Efficient Improvement of Silage Additives by Using Genetic Algorithms

    Article • Applied and Environmental Microbiology, April 2000, ASM Journals

    Professor Douglas B Kell

  371. On the optimization of classes for the assignment of unidentified reading frames in functional genomics programmes: the need for machine learning

    Article • Trends in Biotechnology, March 2000, Elsevier

    Professor Douglas B Kell

  372. Non-linear dielectric spectroscopy: antifouling and stabilisation of electrodes by a polymer coating

    Article • Bioelectrochemistry, February 2000, Elsevier

    Professor Douglas B Kell

  373. Correction of the influence of baseline artefacts and electrode polarisation on dielectric spectra

    Article • Bioelectrochemistry, February 2000, Elsevier

    Professor Douglas B Kell

  374. Snapshots of Systems

    Article • January 2000, Springer Science + Business Media

    Professor Douglas B Kell

  375. The use of nonlinear dielectric spectroscopy to monitor the bioelectromagnetic effects of a weak pulsed magnetic field in real time

    Article • Bioelectromagnetics, January 2000, Wiley

    Professor Douglas B Kell

  376. The use of nonlinear dielectric spectroscopy to monitor the bioelectromagnetic effects of a weak pulsed magnetic field in real time

    Article • Bioelectromagnetics, January 2000, Wiley

    Professor Douglas B Kell

  377. Dormancy in Non-Sporulating Bacteria: Its Significance for Environmental Monitoring

    Article • January 2000, Springer Science + Business Media

    Professor Douglas B Kell

  378. A Portable Flow Cytometer for the Detection and Identification of Microorganisms

    Article • January 2000, Springer Science + Business Media

    Professor Douglas B Kell

  379. Intelligent Systems for the Characterization of Microorganisms from Hyperspectral Data

    Article • January 2000, Springer Science + Business Media

    Professor Douglas B Kell

  380. Detection of the Dipicolinic Acid Biomarker in Bacillus Spores Using Curie-Point Pyrolysis Mass Spectrometry and Fourier Transform Infrared Spectroscopy

    Article • Analytical Chemistry, January 2000, American Chemical Society (ACS)

    Professor Douglas B Kell

  381. Intelligent systems for the characterization and quantification of microbial systems from advanced analytical techniques

    Article • December 1999, SPIE

    Professor Douglas B Kell

  382. Noninvasive, On-Line Monitoring of the Biotransformation by Yeast of Glucose to Ethanol Using Dispersive Raman Spectroscopy and Chemometrics

    Article • Applied Spectroscopy, November 1999, SAGE Publications

    Professor Douglas B Kell

  383. Use of 13 C nuclear magnetic resonance distortionless enhancement by polarization transfer pulse sequence and multivariate analysis to discriminate olive oil cultivars

    Article • Oil & Soap, October 1999, Wiley

    Professor Douglas B Kell

  384. Rapid analysis of the expression of heterologous proteins in Escherichia coli using pyrolysis mass spectrometry and Fourier transform infrared spectroscopy with chemometrics: application to α2-interferon production

    Article • Journal of Biotechnology, July 1999, Elsevier

    Professor Douglas B Kell

  385. Characterisation of intact microorganisms using electrospray ionisation mass spectrometry

    Article • FEMS Microbiology Letters, July 1999, Oxford University Press (OUP)

    Professor Douglas B Kell

  386. Characterisation of intact microorganisms using electrospray ionisation mass spectrometry

    Article • FEMS Microbiology Letters, July 1999, Oxford University Press (OUP)

    Professor Douglas B Kell

  387. Stimulation of the multiplication of Micrococcus luteus by an autocrine growth factor

    Article • Archives of Microbiology, June 1999, Springer Science + Business Media

    Professor Douglas B Kell

  388. Genetic programming as an analytical tool for non-linear dielectric spectroscopy

    Article • Bioelectrochemistry and Bioenergetics, May 1999, Elsevier

    Professor Douglas B Kell

  389. Screensavers: trends in high-throughput analysis

    Article • Trends in Biotechnology, March 1999, Elsevier

    Professor Douglas B Kell

  390. Revolutionary ideas come round again

    Article • Nature, February 1999, Springer Science + Business Media

    Professor Douglas B Kell

  391. Variable selection and multivariate methods for the identification of microorganisms by flow cytometry

    Article • Cytometry Part A, February 1999, Wiley

    Professor Douglas B Kell

  392. A weak pulsed magnetic field affects adenine nucleotide oscillations, and related parameters in aggregating Dictyostelium discoideum amoebae

    Article • Bioelectrochemistry and Bioenergetics, February 1999, Elsevier

    Professor Douglas B Kell

  393. Estimation of Microbial Viability Using Flow Cytometry

    Article • Current Protocols in Cytometry, January 1999, Wiley

    Professor Douglas B Kell

  394. From code to mode for orphan genes

    Article • Trends in Biotechnology, December 1998, Elsevier

    Professor Douglas B Kell

  395. Non-linear optimization of biochemical pathways: applications to metabolic engineering and parameter estimation

    Article • Bioinformatics, November 1998, Oxford University Press (OUP)

    Professor Douglas B Kell

  396. Variable Selection in Discriminant Partial Least-Squares Analysis

    Article • Analytical Chemistry, October 1998, American Chemical Society (ACS)

    Professor Douglas B Kell

  397. Systematic functional analysis of the yeast genome

    Article • Trends in Biotechnology, September 1998, Elsevier

    Professor Douglas B Kell

  398. The influence of electrode polarisation on dielectric spectra, with special reference to capacitive biomass measurements:

    Article • Bioelectrochemistry and Bioenergetics, August 1998, Elsevier

    Professor Douglas B Kell

  399. The influence of electrode polarisation on dielectric spectra, with special reference to capacitive biomass measurements

    Article • Bioelectrochemistry and Bioenergetics, August 1998, Elsevier

    Professor Douglas B Kell

  400. A bacterial cytokine

    Article • Proceedings of the National Academy of Sciences, July 1998, Proceedings of the National Academy of Sciences

    Professor Douglas B Kell

  401. Quantification of microbial productivity via multi-angle light scattering and supervised learning

    Article • Biotechnology and Bioengineering, July 1998, Wiley

    Professor Douglas B Kell

  402. Variable selection in wavelet regression models

    Article • Analytica Chimica Acta, July 1998, Elsevier

    Professor Douglas B Kell

  403. The effect of heteroscedastic noise on the chemometric modelling of frequency domain data

    Article • Chemometrics and Intelligent Laboratory Systems, May 1998, Elsevier

    Professor Douglas B Kell

  404. Rapid analysis of microbial systems using vibrational spectroscopy and supervised learning methods: application to the discrimination between methicillin-resistant and methicillin-susceptible Staphy

    Article • April 1998, SPIE

    Professor Douglas B Kell

  405. Dielectric estimation of microbial biomass using the Aber Instruments Biomass Monitor

    Article • Trends in Biotechnology, April 1998, Elsevier

    Professor Douglas B Kell

  406. The deconvolution of pyrolysis mass spectra using genetic programming: application to the identification of some Eubacterium species

    Article • FEMS Microbiology Letters, March 1998, Oxford University Press (OUP)

    Professor Douglas B Kell

  407. The deconvolution of pyrolysis mass spectra using genetic programming: application to the identification of some Eubacterium species

    Article • FEMS Microbiology Letters, March 1998, Oxford University Press (OUP)

    Professor Douglas B Kell

  408. A DRASTIC (Diffuse Reflectance Absorbance Spectroscopy Taking in Chemometrics) approach for the rapid analysis of microbial fermentation products: Quantification of aristeromycin and neplanocin A in Streptomyces citricolor broths

    Article • January 1998, Elsevier

    Professor Douglas B Kell

  409. DRASTIC(Diffuse Reflectance Absorbance Spectroscopy Taking In Chemometrics). A novel, rapid, hyperspectral, FT-IR-based approach to screening for biocatalytic activity and metabolite overproduction

    Article • January 1998, Elsevier

    Professor Douglas B Kell

  410. Discrimination between methicillin-resistant and methicillin- susceptible Staphylococcus aureus using pyrolysis mass spectrometry and artificial neural networks

    Article • Journal of Antimicrobial Chemotherapy, January 1998, Oxford University Press (OUP)

    Professor Douglas B Kell

  411. Article • Antonie van Leeuwenhoek, January 1998, Springer Science + Business Media

    Professor Douglas B Kell

  412. Rheological phenomena occurring during the shearing flow of mayonnaise

    Article • Journal of Rheology, January 1998, Society of Rheology

    Professor Douglas B Kell

  413. Article • Antonie van Leeuwenhoek, January 1998, Springer Science + Business Media

    Professor Douglas B Kell

  414. Genetic Programming:  A Novel Method for the Quantitative Analysis of Pyrolysis Mass Spectral Data

    Article • Analytical Chemistry, November 1997, American Chemical Society (ACS)

    Professor Douglas B Kell

  415. Article • Nature, September 1997, Nature

    Professor Douglas B Kell

  416. Target practice — novel approaches to antimicrobial chemotherapy

    Article • Trends in Biotechnology, September 1997, Elsevier

    Professor Douglas B Kell

  417. Standardized basis sets for high-level-correlated relativistic calculations of atomic and molecular electric properties in the spin-averaged Douglas-Kroll approximation

    Article • Theoretical Chemistry Accounts, August 1997, Springer Science + Business Media

    Professor Douglas B Kell

  418. Fluorescent brighteners: Novel stains for the flow cytometric analysis of microorganisms

    Article • Cytometry Part A, August 1997, Wiley

    Professor Douglas B Kell

  419. Enantioselectivity of sulcatone reduction by some anaerobic bacteria

    Article • Enzyme and Microbial Technology, August 1997, Elsevier

    Professor Douglas B Kell

  420. Diffuse reflectance absorbance spectroscopy taking in chemometrics (DRASTIC). A hyperspectral FT-IR-based approach to rapid screening for metabolite overproduction

    Article • Analytica Chimica Acta, August 1997, Elsevier

    Professor Douglas B Kell

  421. Discrimination of the variety and region of origin of extra virgin olive oils using 13C NMR and multivariate calibration with variable reduction

    Article • Analytica Chimica Acta, August 1997, Elsevier

    Professor Douglas B Kell

  422. On mass spectrometer instrument standardization and interlaboratory calibration transfer using neural networks

    Article • Analytica Chimica Acta, August 1997, Elsevier

    Professor Douglas B Kell

  423. Genetic algorithms as a method for variable selection in multiple linear regression and partial least squares regression, with applications to pyrolysis mass spectrometry

    Article • Analytica Chimica Acta, August 1997, Elsevier

    Professor Douglas B Kell

  424. Classification of pyrolysis mass spectra by fuzzy multivariate rule induction-comparison with regression, K-nearest neighbour, neural and decision-tree methods

    Article • Analytica Chimica Acta, August 1997, Elsevier

    Professor Douglas B Kell

  425. An introduction to wavelet transforms for chemometricians: A time-frequency approach

    Article • Chemometrics and Intelligent Laboratory Systems, June 1997, Elsevier

    Professor Douglas B Kell

  426. Quantitative analysis of the adulteration of orange juice with sucrose using pyrolysis mass spectrometry and chemometrics

    Article • Journal of Analytical and Applied Pyrolysis, May 1997, Elsevier

    Professor Douglas B Kell

  427. Determination of the geographical origin of Italian extra virgin olive oil using pyrolysis mass spectrometry and artificial neural networks

    Article • Journal of Analytical and Applied Pyrolysis, May 1997, Elsevier

    Professor Douglas B Kell

  428. If you've got it, flaunt it — rapid screening for microbial biocatalysts

    Article • Trends in Biotechnology, April 1997, Elsevier

    Professor Douglas B Kell

  429. Improving the interpretation of multivariate and rule induction models by using a peak parameter representation

    Article • Chemometrics and Intelligent Laboratory Systems, April 1997, Elsevier

    Professor Douglas B Kell

  430. Wavelet Denoising of Infrared Spectra

    Article • The Analyst, January 1997, Royal Society of Chemistry

    Professor Douglas B Kell

  431. Making cells work — metabolic engineering for everyone

    Article • Trends in Biotechnology, January 1997, Elsevier

    Professor Douglas B Kell

  432. An instrument for the acquisition and analysis of the nonlinear dielectric spectra of biological samples

    Article • Transactions of the Institute of Measurement and Control, January 1997, SAGE Publications

    Professor Douglas B Kell

  433. What Biotechnologists Knew All Along...?

    Article • Journal of Theoretical Biology, October 1996, Elsevier

    Professor Douglas B Kell

  434. Going places: forced and natural molecular evolution

    Article • Trends in Biotechnology, September 1996, Elsevier

    Professor Douglas B Kell

  435. Plant seed classification using pyrolysis mass spectrometry with unsupervised learning: The application of auto-associative and Kohonen artificial neural networks

    Article • Chemometrics and Intelligent Laboratory Systems, August 1996, Elsevier

    Professor Douglas B Kell

  436. Quantitative Analysis of Multivariate Data Using Artificial Neural Networks: A Tutorial Review and Applications to the Deconvolution of Pyrolysis Mass Spectra

    Article • Zentralblatt für Bakteriologie, August 1996, Elsevier

    Professor Douglas B Kell

  437. Rapid and non-invasive quantification of metabolic substrates in biological cell suspensions using non-linear dielectric spectroscopy with multivariate calibration and artificial neural networks. Principles and applications

    Article • Bioelectrochemistry and Bioenergetics, August 1996, Elsevier

    Professor Douglas B Kell

  438. Rapid identification of Streptococcus and Enterococcus species using diffuse reflectance-absorbance Fourier transform infrared spectroscopy and artificial neural networks

    Article • FEMS Microbiology Letters, July 1996, Oxford University Press (OUP)

    Professor Douglas B Kell

  439. Rapid identification of Streptococcus and Enterococcus species using diffuse reflectance-absorbance Fourier transform infrared spectroscopy and artificial neural networks

    Article • FEMS Microbiology Letters, July 1996, Oxford University Press (OUP)

    Professor Douglas B Kell

  440. Do bacteria need to communicate with each other for growth?

    Article • Trends in Microbiology, June 1996, Elsevier

    Professor Douglas B Kell

  441. Membrane tension

    Article • Trends in Cell Biology, May 1996, Elsevier

    Professor Douglas B Kell

  442. Why and when channelling can decrease pool size at constant net flux in a simple dynamic channel

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, March 1996, Elsevier

    Professor Douglas B Kell

  443. Deconvolution of the dielectric spectra of microbial cell suspensions using multivariate calibration and artificial neural networks

    Article • Bioelectrochemistry and Bioenergetics, March 1996, Elsevier

    Professor Douglas B Kell

  444. Pyrolysis mass spectrometry and its applications in biotechnology

    Article • Current Opinion in Biotechnology, February 1996, Elsevier

    Professor Douglas B Kell

  445. Correction of Mass Spectral Drift Using Artificial Neural Networks

    Article • Analytical Chemistry, January 1996, American Chemical Society (ACS)

    Professor Douglas B Kell

  446. On the analysis of the inverse problem of metabolic pathways using artificial neural networks

    Article • Biosystems, January 1996, Elsevier

    Professor Douglas B Kell

  447. Rapid authentication of animal cell lines using pyrolysis mass spectrometry and auto-associative artificial neural networks

    Article • Cytotechnology, January 1996, Springer Science + Business Media

    Professor Douglas B Kell

  448. Oscillatory, stochastic and chaotic growth rate fluctuations in permittistatically controlled yeast cultures

    Article • Biosystems, January 1996, Elsevier

    Professor Douglas B Kell

  449. GMP — good modelling practice: an essential component of good manufacturing practice

    Article • Trends in Biotechnology, November 1995, Elsevier

    Professor Douglas B Kell

  450. Preparation for university

    Article • Nature, October 1995, Springer Science + Business Media

    Professor Douglas B Kell

  451. Rapid and quantitative analysis of metabolites in fermentor broths using pyrolysis mass spectrometry with supervised learning: application to the screening of Penicillium chrysogenum fermentations for the overproduction of penicillins

    Article • Analytica Chimica Acta, September 1995, Elsevier

    Professor Douglas B Kell

  452. Biochemical changes accompanying the long-term starvation of Micrococcus luteus cells in spent growth medium

    Article • Archives of Microbiology, May 1995, Springer Science + Business Media

    Professor Douglas B Kell

  453. Pheromones, social behaviour and the functions of secondary metabolism in bacteria

    Article • Trends in Ecology & Evolution, March 1995, Elsevier

    Professor Douglas B Kell

  454. The low-frequency dielectric properties of biological cells

    Article • January 1995, Springer Science + Business Media

    Professor Douglas B Kell

  455. Secretion of an antibacterial factor during resuscitation of dormant cells inMicrococcus luteus cultures held in an extended stationary phase

    Article • Antonie van Leeuwenhoek, January 1995, Springer Science + Business Media

    Professor Douglas B Kell

  456. Use of dielectric permittivity for the control of the biomass level during biotransformations of toxic substrates in continuous culture

    Article • Biotechnology Progress, January 1995, Wiley

    Professor Douglas B Kell

  457. Metabolic Channeling in Organized Enzyme Systems: Experiments and Models

    Article • January 1995, Elsevier

    Professor Douglas B Kell

  458. On harmonic generation in nonlinear biological systems

    Article • Biosensors and Bioelectronics, January 1995, Elsevier

    Professor Douglas B Kell

  459. Solvent Selection for Whole Cell Biotransformations in Organic Media

    Article • Critical Reviews in Biotechnology, January 1995, Taylor & Francis

    Professor Douglas B Kell

  460. Rapid screening for metabolite overproduction in fermentor broths, using pyrolysis mass spectrometry with multivariate calibration and artificial neural networks

    Article • Biotechnology and Bioengineering, November 1994, Wiley

    Professor Douglas B Kell

  461. The dogs that did not bark

    Article • Trends in Biotechnology, November 1994, Elsevier

    Professor Douglas B Kell

  462. Rapid and quantitative analysis of recombinant protein expression using pyrolysis mass spectrometry and artificial neural networks: application to mammalian cytochrome b5 in Escherichia coli

    Article • Journal of Biotechnology, May 1994, Elsevier

    Professor Douglas B Kell

  463. The rainbow and the worm: the physics of organisms

    Article • Trends in Biochemical Sciences, April 1994, Elsevier

    Professor Douglas B Kell

  464. Rapid and Quantitative Analysis of the Pyrolysis Mass Spectra of Complex Binary and Tertiary Mixtures Using Multivariate Calibration and Artificial Neural Networks

    Article • Analytical Chemistry, April 1994, American Chemical Society (ACS)

    Professor Douglas B Kell

  465. Rapid identification using pyrolysis mass spectrometry and artificial neural networks ofPropionibacterium acnesisolated from dogs

    Article • Journal of Applied Bacteriology, February 1994, Wiley

    Professor Douglas B Kell

  466. Estimation of dormant Micrococcus luteus cells by penicillin lysis and by resuscitation in cell-free spent culture medium at high dilution

    Article • FEMS Microbiology Letters, January 1994, Oxford University Press (OUP)

    Professor Douglas B Kell

  467. Dielectric properties of human blood and erythrocytes at radio frequencies (0.2?10 MHz); dependence on cell volume fraction and medium composition

    Article • European Biophysics Journal, January 1994, Springer Science + Business Media

    Professor Douglas B Kell

  468. Quantitative analysis of the pyrolysis—mass spectra of complex mixtures using artificial neural networks: Application to amino acids in glycogen

    Article • Journal of Analytical and Applied Pyrolysis, August 1993, Elsevier

    Professor Douglas B Kell

  469. Rapid and quantitative analysis and bioprocesses using pyrolysis mass spectrometry and neural networks: application to indole production

    Article • Analytica Chimica Acta, July 1993, Elsevier

    Professor Douglas B Kell

  470. Introduction to the dielectric estimation of cellular biomass in real time, with special emphasis on measurements at high volume fractions

    Article • Analytica Chimica Acta, July 1993, Elsevier

    Professor Douglas B Kell

  471. On the role of enzyme kinetic parameters in determining the effectiveness with which channelling can decrease the size of a metabolite pool

    Article • Acta Biotheoretica, June 1993, Springer Science + Business Media

    Professor Douglas B Kell

  472. Dormancy in non-sporulating bacteria

    Article • FEMS Microbiology Letters, April 1993, Oxford University Press (OUP)

    Professor Douglas B Kell

  473. Dormancy in non-sporulating bacteria

    Article • FEMS Microbiology Letters, April 1993, Oxford University Press (OUP)

    Professor Douglas B Kell

  474. The use of 5-cyano-2,3-ditolyl tetrazolium chloride and flow cytometry for the visualisation of respiratory activity in individual cells of Micrococcus luteus

    Article • Journal of Microbiological Methods, March 1993, Elsevier

    Professor Douglas B Kell

  475. Control Analysis of Metabolic Channeling

    Article • January 1993, Springer Science + Business Media

    Professor Douglas B Kell

  476. On the Determination of the Size of Microbial Cells Using Flow Cytometry

    Article • January 1993, Springer Science + Business Media

    Professor Douglas B Kell

  477. Flow Cytometric Analysis, Using Rhodamine 123, of Micrococcus luteus at Low Growth Rate in Chemostat Culture

    Article • January 1993, Springer Science + Business Media

    Professor Douglas B Kell

  478. When Going Backwards Means Progress: On the Solution of Biochemical Inverse Problems Using Artificial Neural Networks

    Article • January 1993, Springer Science + Business Media

    Professor Douglas B Kell

  479. Rapid assessment of the adulteration of virgin olive oils by other seed oils using pyrolysis mass spectrometry and artificial neural networks

    Article • Journal of the Science of Food and Agriculture, January 1993, Wiley

    Professor Douglas B Kell

  480. On the dielectric method of monitoring cellular viability

    Article • Pure and Applied Chemistry, January 1993, De Gruyter

    Professor Douglas B Kell

  481. Non-linear dielectric properties of Rhodobacter capsulatus

    Article • Bioelectrochemistry and Bioenergetics, December 1992, Elsevier

    Professor Douglas B Kell

  482. Neural networks and olive oil

    Article • Nature, October 1992, Springer Science + Business Media

    Professor Douglas B Kell

  483. On fitting dielectric spectra using artificial neural networks

    Article • Bioelectrochemistry and Bioenergetics, October 1992, Elsevier

    Professor Douglas B Kell

  484. On fitting dielectric spectra using artificial neural networks

    Article • Journal of Electroanalytical Chemistry, October 1992, Elsevier

    Professor Douglas B Kell

  485. On the dielectric properties of cell suspensions at high volume fractions

    Article • Bioelectrochemistry and Bioenergetics, August 1992, Elsevier

    Professor Douglas B Kell

  486. On the dielectric properties of cell suspensions at high volume fractions

    Article • Journal of Electroanalytical Chemistry, August 1992, Elsevier

    Professor Douglas B Kell

  487. New materials and technology for cell immobilization

    Article • Current Biology, May 1992, Elsevier

    Professor Douglas B Kell

  488. Rapid assessment of bacterial viability and vitality by rhodamine 123 and flow cytometry

    Article • Journal of Applied Bacteriology, May 1992, Wiley

    Professor Douglas B Kell

  489. Scanning tunnelling microscopy in biology

    Article • Bioelectrochemistry and Bioenergetics, April 1992, Elsevier

    Professor Douglas B Kell

  490. New materials and technology for cell immobilization

    Article • Current Opinion in Biotechnology, April 1992, Elsevier

    Professor Douglas B Kell

  491. Scanning tunnelling microscopy in biology

    Article • Journal of Electroanalytical Chemistry, April 1992, Elsevier

    Professor Douglas B Kell

  492. Channelling can decrease pool size

    Article • FEBS Journal, February 1992, Wiley

    Professor Douglas B Kell

  493. Rapid Determination, Using Dielectric Spectroscopy, of the Toxicity of Organic Solvents to Intact Cells

    Article • January 1992, Elsevier

    Professor Douglas B Kell

  494. Quantifying heterogeneity: flow cytometry of bacterial cultures

    Article • January 1992, Springer Science + Business Media

    Professor Douglas B Kell

  495. Physiological studies on the solid-state quinoa tempe fermentation, using on-line measurements of fungal biomass production

    Article • Journal of the Science of Food and Agriculture, January 1992, Wiley

    Professor Douglas B Kell

  496. On the relationship between the nonlinear dielectric properties and respiratory activity of the obligately aerobic bacterium Micrococcus luteus

    Article • Bioelectrochemistry and Bioenergetics, December 1991, Elsevier

    Professor Douglas B Kell

  497. On the relationship between the nonlinear dielectric properties and respiratory activity of the obligately aerobic bacterium Micrococcus luteus

    Article • Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, December 1991, Elsevier

    Professor Douglas B Kell

  498. Confirmation by using mutant strains that the membrane-bound H + -ATPase is the major source of non-linear dielectricity in Saccharomyces cerevisiae

    Article • FEMS Microbiology Letters, November 1991, Oxford University Press (OUP)

    Professor Douglas B Kell

  499. Confirmation by using mutant strains that the membrane-bound H+-ATPase is the major source of non-linear dielectricity in Saccharomyces cerevisiae

    Article • FEMS Microbiology Letters, November 1991, Oxford University Press (OUP)

    Professor Douglas B Kell

  500. The dielectric permittivity at radio frequencies and the bruggeman probe: novel techniques for the on-line determination of biomass concentrations in plant cell cultures

    Article • Journal of Biotechnology, October 1991, Elsevier

    Professor Douglas B Kell

  501. On the physiological significance of metabolite channelling: If, how, and where, but not why

    Article • Journal of Theoretical Biology, September 1991, Elsevier

    Professor Douglas B Kell

  502. Quantitative approaches to the analysis of the control and regulation of microbial metabolism

    Article • Antonie van Leeuwenhoek, September 1991, Springer Science + Business Media

    Professor Douglas B Kell

  503. New materials and technology for cell immobilization

    Article • Current Opinion in Biotechnology, June 1991, Elsevier

    Professor Douglas B Kell

  504. Dual-frequency excitation: A novel method for probing the nonlinear dielectric properties of biological systems, and its application to suspensions of S. cerevisiae

    Article • Bioelectrochemistry and Bioenergetics, June 1991, Elsevier

    Professor Douglas B Kell

  505. Dual-frequency excitation: a novel method for probing the nonlinear dielectric properties of biological systems, and its application to suspensions of S. cerevisiae

    Article • Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, June 1991, Elsevier

    Professor Douglas B Kell

  506. To what extent is the magnitude of the Cole-Cole α of the β-dielectric dispersion of cell suspensions explicable in terms of the cell size distribution?

    Article • Bioelectrochemistry and Bioenergetics, April 1991, Elsevier

    Professor Douglas B Kell

  507. To what extent is the magnitude of the Cole—Cole α of the β-dielectric dispersion of cell suspensions explicable in terms of the cell size distribution?

    Article • Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, April 1991, Elsevier

    Professor Douglas B Kell

  508. Lacuna seeker

    Article • Nature, March 1991, Springer Science + Business Media

    Professor Douglas B Kell

  509. Real-time monitoring of the accretion of Rhizopus oligosporus biomass during the solid-substrate tempe fermentation

    Article • World Journal of Microbiology and Biotechnology, March 1991, Springer Science + Business Media

    Professor Douglas B Kell

  510. Stimulation by potassium ions of the growth of Rhizopus oligosporus during liquid-and solid-substrate fermentations

    Article • World Journal of Microbiology and Biotechnology, March 1991, Springer Science + Business Media

    Professor Douglas B Kell

  511. Non-Faradaic electrochemical sensors: principles and practice

    Article • Analytical Proceedings, January 1991, Royal Society of Chemistry

    Professor Douglas B Kell

  512. Solutions, but no answers

    Article • Trends in Biochemical Sciences, January 1991, Elsevier

    Professor Douglas B Kell

  513. Quantifying heterogeneity: flow cytometry of bacterial cultures

    Article • Antonie van Leeuwenhoek, January 1991, Springer Science + Business Media

    Professor Douglas B Kell

  514. On the nonlinear dielectric properties of biological systems

    Article • Bioelectrochemistry and Bioenergetics, October 1990, Elsevier

    Professor Douglas B Kell

  515. On the nonlinear dielectric properties of biological systems

    Article • Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, October 1990, Elsevier

    Professor Douglas B Kell

  516. Dielectric spectroscopy as a tool for the measurement of the formation of biofilms and of their removal by electrolytic cleaning pulses and biocides

    Article • Biofouling, September 1990, Taylor & Francis

    Professor Douglas B Kell

  517. Real-time monitoring of cellular biomass: Methods and applications

    Article • TrAC Trends in Analytical Chemistry, June 1990, Elsevier

    Professor Douglas B Kell

  518. Evidence from its temperature dependence that the ?-dielectric dispersion of cell suspensions is not due solely to the charging of a static membrane capacitance

    Article • European Biophysics Journal, June 1990, Springer Science + Business Media

    Professor Douglas B Kell

  519. Hydrodynamic deposition: A novel method of cell immobilization

    Article • Enzyme and Microbial Technology, June 1990, Elsevier

    Professor Douglas B Kell

  520. Substitution and spreadsheet methods for analysing dielectric spectra of biological systems

    Article • European Biophysics Journal, June 1990, Springer Science + Business Media

    Professor Douglas B Kell

  521. The Dielectric Properties of Cells and Tissues: What can They Tell Us about the Mechanisms of Field/Cell Interactions?

    Article • January 1990, Springer Science + Business Media

    Professor Douglas B Kell

  522. The control and measurement of ‘CO2’ during fermentations

    Article • Journal of Microbiological Methods, November 1989, Elsevier

    Professor Douglas B Kell

  523. The inhibition by CO2of the growth and metabolism of micro-organisms

    Article • Journal of Applied Bacteriology, August 1989, Wiley

    Professor Douglas B Kell

  524. Electromicrobial transformations using the pyruvate synthase system of Clostridium sporogenes

    Article • Bioelectrochemistry and Bioenergetics, June 1989, Elsevier

    Professor Douglas B Kell

  525. Electromicrobial transformations using the pyruvate synthase system of Clostridium sporogenes

    Article • Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, June 1989, Elsevier

    Professor Douglas B Kell

  526. Immobilisation ofCandida cylindracea lipase on a new range of ceramic supports

    Article • Biotechnology Techniques, May 1989, Springer Science + Business Media

    Professor Douglas B Kell

  527. Window boxes?

    Article • Nature, April 1989, Springer Science + Business Media

    Professor Douglas B Kell

  528. Biosensors.

    Article • Bioelectrochemistry and Bioenergetics, February 1989, Elsevier

    Professor Douglas B Kell

  529. Dielectric Spectroscopy: a Rapid Method for the Determination of Solvent Biocompatibility During Biotransformations

    Article • Biocatalysis, January 1989, Taylor & Francis

    Professor Douglas B Kell

  530. Electrosynthesis and electroanalysis using Clostridium sporogenes

    Article • Bioelectrochemistry and Bioenergetics, December 1988, Elsevier

    Professor Douglas B Kell

  531. On the audio- and radio-frequency dielectric behaviour of anchorage-independent, mouse L929-derived LS fibroblasts

    Article • Bioelectrochemistry and Bioenergetics, December 1988, Elsevier

    Professor Douglas B Kell

  532. Electrosynthesis and electroanalysis using Clostridium sporogenes

    Article • Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, December 1988, Elsevier

    Professor Douglas B Kell

  533. On the audio- and radio-frequency dielectric behaviour of anchorage-independent, mouse L929-derived LS fibroblasts

    Article • Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, December 1988, Elsevier

    Professor Douglas B Kell

  534. Thermodynamics and control of biological free-energy transduction

    Article • Trends in Biochemical Sciences, October 1988, Elsevier

    Professor Douglas B Kell

  535. Mechanisms for the interaction between nonstationary electric fields and biological systems II. Nonlinear dielectric theory and free-energy transduction

    Article • Ferroelectrics, October 1988, Taylor & Francis

    Professor Douglas B Kell

  536. Mechanisms for the interaction between nonstationary electric fields and biological systems I. Linear dielectric theory and its limitations

    Article • Ferroelectrics, October 1988, Taylor & Francis

    Professor Douglas B Kell

  537. The dynamics of electrostatic interactions between membrane proteins

    Article • Journal of Electrostatics, September 1988, Elsevier

    Professor Douglas B Kell

  538. Growth energetics ofClostridium sporogenesNCIB 8053: modulation by CO2

    Article • Journal of Applied Bacteriology, August 1988, Wiley

    Professor Douglas B Kell

  539. Energetics of Microbial Growth Edwin H. Battley

    Article • The Quarterly Review of Biology, December 1987, University of Chicago Press

    Professor Douglas B Kell

  540. Effects ofpCO2on the growth and metabolism ofClostridium sporogenesNCIB 8053 in defined media

    Article • Journal of Applied Bacteriology, August 1987, Wiley

    Professor Douglas B Kell

  541. The passive electrical properties of biological systems: their significance in physiology, biophysics and biotechnology

    Article • Physics in Medicine and Biology, August 1987, Institute of Physics Publishing

    Professor Douglas B Kell

  542. Matrix method for determining steps most rate-limiting to metabolic fluxes in biotechnological processes

    Article • Biotechnology and Bioengineering, July 1987, Wiley

    Professor Douglas B Kell

  543. Dielectric permittivity of microbial suspensions at radio frequencies: a novel method for the real-time estimation of microbial biomass

    Article • Enzyme and Microbial Technology, March 1987, Elsevier

    Professor Douglas B Kell

  544. The growth and nutrition ofClostridium sporogenesNCIB 8053 in defined media

    Article • Journal of Applied Bacteriology, January 1987, Wiley

    Professor Douglas B Kell

  545. The physiology ofClostridium sporogenesNCIB 8053 growing in defined media

    Article • Journal of Applied Bacteriology, January 1987, Wiley

    Professor Douglas B Kell

  546. Solvent production byClostridium pasteurianum in media of high sugar content

    Article • Biotechnology Letters, December 1986, Springer Science + Business Media

    Professor Douglas B Kell

  547. Metabolic control theory: its role in microbiology and biotechnology

    Article • FEMS Microbiology Letters, October 1986, Oxford University Press (OUP)

    Professor Douglas B Kell

  548. Metabolic control theory: its role in microbiology and biotechnology

    Article • FEMS Microbiology Letters, October 1986, Oxford University Press (OUP)

    Professor Douglas B Kell

  549. Proline reduction by Clostridium sporogenes is coupled to vectorial proton ejection

    Article • FEMS Microbiology Letters, September 1986, Oxford University Press (OUP)

    Professor Douglas B Kell

  550. Proline reduction by Clostridium sporogenes is coupled to vectorial proton ejection

    Article • FEMS Microbiology Letters, September 1986, Oxford University Press (OUP)

    Professor Douglas B Kell

  551. Dielectric spectroscopy of energy coupling membranes: Chloroplast thylakoids

    Article • Bioelectrochemistry and Bioenergetics, August 1986, Elsevier

    Professor Douglas B Kell

  552. Towards a rational approach to the optimization of flux in microbial biotransformations

    Article • Trends in Biotechnology, June 1986, Elsevier

    Professor Douglas B Kell

  553. Dielectric spectroscopy of protein translational diffusion in prokaryotic membranes and membrane vesicles

    Article • Bioelectrochemistry and Bioenergetics, April 1986, Elsevier

    Professor Douglas B Kell

  554. [40] Localized protonic coupling: Overview and critical evaluation of techniques

    Article • January 1986, Elsevier

    Professor Douglas B Kell

  555. Organization and Control of Energy Metabolism in Anaerobic Microorganisms

    Article • January 1986, Springer Science + Business Media

    Professor Douglas B Kell

  556. A Nomograph for Calculating the Optimal Frequency for Dielectrophoresis and the Characteristic Frequency of the β-Dispersion of Cell Membrane Vesicles

    Article • Journal of Bioelectricity, January 1986, Taylor & Francis

    Professor Douglas B Kell

  557. Conductimetric assessment of the biomass content in suspensions of immobilised (gel-entrapped) microorganisms

    Article • Applied Microbiology and Biotechnology, January 1986, Springer Science + Business Media

    Professor Douglas B Kell

  558. On the dielectrically observable consequences of the diffusional motions of lipids and proteins in membranes

    Article • European Biophysics Journal, October 1985, Springer Science + Business Media

    Professor Douglas B Kell

  559. On the dielectrically observable consequences of the diffusional motions of lipids and proteins in membranes

    Article • European Biophysics Journal, September 1985, Springer Science + Business Media

    Professor Douglas B Kell

  560. Tinopal AN as a selective agent for the differentiation of phytopathogenic and saprophyticPseudomonasspecies

    Article • Journal of Applied Bacteriology, March 1985, Wiley

    Professor Douglas B Kell

  561. Catalytic Facilitation and Membrane Bioenergetics

    Article • January 1985, Elsevier

    Professor Douglas B Kell

  562. Dielectric Spectroscopy and Membrane Organisation

    Article • Journal of Bioelectricity, January 1985, Taylor & Francis

    Professor Douglas B Kell

  563. The estimation of microbial biomass

    Article • Biosensors, January 1985, Elsevier

    Professor Douglas B Kell

  564. A minimal hypothesis for membrane-linked free-energy transduction

    Article • Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, December 1984, Elsevier

    Professor Douglas B Kell

  565. Constraints on the lateral diffusion of membrane proteins in prokaryotes

    Article • Trends in Biochemical Sciences, September 1984, Elsevier

    Professor Douglas B Kell

  566. On the effects of thiocyanate and venturicidin on respiration-driven proton translocation in Paracoccus denitrificans

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 1984, Elsevier

    Professor Douglas B Kell

  567. Diffusion of protein complexes in prokaryotic membranes: fast, free, random or directed?

    Article • Trends in Biochemical Sciences, March 1984, Elsevier

    Professor Douglas B Kell

  568. Mosaic protonic coupling hypothesis for free energy transduction

    Article • FEBS Letters, January 1984, Wiley

    Professor Douglas B Kell

  569. Is the Transmembrane Electrochemical Potential a Competent Intermediate in Membrane Associated ATP Synthesis?

    Article • January 1984, Springer Science + Business Media

    Professor Douglas B Kell

  570. Dielectric properties of bacterial chromatophores

    Article • Bioelectrochemistry and Bioenergetics, December 1983, Elsevier

    Professor Douglas B Kell

  571. The radio-frequency dielectric properties of yeast cells measured with a rapid, automated, frequency-domain dielectric spectrometer

    Article • Bioelectrochemistry and Bioenergetics, October 1983, Elsevier

    Professor Douglas B Kell

  572. Coupling factor B and the bovine mitochondrial H+-ATP synthase

    Article • Trends in Biochemical Sciences, May 1983, Elsevier

    Professor Douglas B Kell

  573. On the functional unit of energy coupling in photophosphorylation by bacterial chromatophores

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, May 1983, Elsevier

    Professor Douglas B Kell

  574. Non-linear systems: Coherent excitation in biology

    Article • Nature, February 1983, Nature

    Professor Douglas B Kell

  575. Coherent Properties of the Membranous Systems of Electron Transport Phosphorylation

    Article • January 1983, Springer Science + Business Media

    Professor Douglas B Kell

  576. Dielectric properties of bacterial chromatophores

    Article • Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, January 1983, Elsevier

    Professor Douglas B Kell

  577. The radio-frequency dielectric properties of yeast cells measured with a rapid, automated, frequency-domain dielectric spectrometer

    Article • Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, January 1983, Elsevier

    Professor Douglas B Kell

  578. Enzymes as energy ‘funnels’?

    Article • Trends in Biochemical Sciences, October 1982, Elsevier

    Professor Douglas B Kell

  579. Localized energy coupling during photophosphorylation by chromatophores ofRhodopseudomonas capsulata N22

    Article • Bioscience Reports, October 1982, Portland Press Ltd.

    Professor Douglas B Kell

  580. On the Mode of Action of the Bacteriocin Butyricin 7423. Effects on Membrane Potential and Potassium-Ion Accumulation in Clostridium pasteurianum

    Article • FEBS Journal, September 1982, Wiley

    Professor Douglas B Kell

  581. A novel inhibitor of NADH dehydrogenase in Paracoccus denitrificans

    Article • FEBS Letters, April 1982, Wiley

    Professor Douglas B Kell

  582. Butyricin 7423 and the membrane H+-ATPase of Clostridium pasteurianum

    Article • Archives of Microbiology, February 1982, Springer Science + Business Media

    Professor Douglas B Kell

  583. General discussion

    Article • Faraday Discussions of the Chemical Society, January 1982, Royal Society of Chemistry

    Professor Douglas B Kell

  584. Proton-coupled energy transduction by biological membranes. Principles, pathways and praxis

    Article • Faraday Discussions of the Chemical Society, January 1982, Royal Society of Chemistry

    Professor Douglas B Kell

  585. A rose by any other name

    Article • Trends in Biochemical Sciences, January 1982, Elsevier

    Professor Douglas B Kell

  586. Bacteria that are resistant to uncouplers—what can they tell us?

    Article • Trends in Biochemical Sciences, January 1982, Elsevier

    Professor Douglas B Kell

  587. Quantitative Problems in Biochemistry (Sixth Edition)

    Article • FEBS Letters, December 1981, Wiley

    Professor Douglas B Kell

  588. A benzoxazole inhibitor of NADH dehydrogenase in Paracoccus denitrificans

    Article • FEMS Microbiology Letters, July 1981, Oxford University Press (OUP)

    Professor Douglas B Kell

  589. A benzoxazole inhibitor of NADH dehydrogenase in Paracoccus denitrificans

    Article • FEMS Microbiology Letters, June 1981, Oxford University Press (OUP)

    Professor Douglas B Kell

  590. Polarographic investigation of some cytokinins

    Article • Journal of Electroanalytical Chemistry (1959), May 1981, Elsevier

    Professor Douglas B Kell

  591. On proton-coupled information transfer along the surface of biological membranes and the mode of action of certain colicins

    Article • FEMS Microbiology Letters, May 1981, Oxford University Press (OUP)

    Professor Douglas B Kell

  592. Polarographic investigation of some cytokinins

    Article • Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, May 1981, Elsevier

    Professor Douglas B Kell

  593. On proton-coupled information transfer along the surface of biological membranes and the mode of action of certain colicins

    Article • FEMS Microbiology Letters, May 1981, Oxford University Press (OUP)

    Professor Douglas B Kell

  594. On the permeability to weak acids and bases of the cytoplasmic membrane of Clostridiumpasteurianum

    Article • Biochemical and Biophysical Research Communications, March 1981, Elsevier

    Professor Douglas B Kell

  595. The Electron Transport System and Hydrogenase of Paracoccus denitrificans

    Article • January 1981, Elsevier

    Professor edith sim, Professor Douglas B Kell

  596. Medical and biological applications of electrochemical devices

    Article • Talanta, December 1980, Elsevier

    Professor Douglas B Kell

  597. Edited by G. Milazzo J. Wiley; Brisbane, Chichester, New York, Toronto

    Article • FEBS Letters, November 1980, Wiley

    Professor Douglas B Kell

  598. Edited by P. L. Dutton, J. S. Leigh and A. Scarpa Academic Press; London, New York

    Article • FEBS Letters, November 1980, Wiley

    Professor Douglas B Kell

  599. Formulation and some biological uses of a buffer mixture whose buffering capacity is relatively independent of pH in the range pH 4–9

    Article • Journal of Biochemical and Biophysical Methods, September 1980, Elsevier

    Professor Douglas B Kell

  600. An adenine nucleotide translocase in the procaryote Methanobacterium thermoautotrophicum

    Article • Biochemical and Biophysical Research Communications, August 1980, Elsevier

    Professor Douglas B Kell

  601. Oxidation-reduction properties of coenzyme M (2-mercaptoethane sulphonate) at the mercury electrode

    Article • FEBS Letters, December 1979, Wiley

    Professor Douglas B Kell

  602. Physical Aspects of Protein Interactions

    Article • FEBS Letters, November 1979, Wiley

    Professor Douglas B Kell

  603. Physiochemical Aspects of Protein Denaturation

    Article • FEBS Letters, September 1979, Wiley

    Professor Douglas B Kell

  604. Biochemical Thermodynamics

    Article • FEBS Letters, September 1979, Wiley

    Professor Douglas B Kell

  605. On the functional proton current pathway of electron transport phosphorylation

    Article • Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, July 1979, Elsevier

    Professor Douglas B Kell

  606. Measurement by a flow dialysis technique of the steady-state proton-motive force in chromatophores from Rhodospirillum rubrum. Comparison with phosphorylation potential

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, April 1978, Elsevier

    Professor Douglas B Kell

  607. Resolution of Paracoccus denitrificans membrane vesicles of differing configuration using affinity chromatography

    Article • FEMS Microbiology Letters, March 1978, Oxford University Press (OUP)

    Professor Douglas B Kell

  608. Continuous monitoring of the electrical potential across energy-transducing membranes using ion-selective electrodes Application to submitochondrial particles and chromatophores

    Article • FEBS Letters, February 1978, Wiley

    Professor Douglas B Kell

  609. BCG inhibition of murine leudemia: local suppression and systemic tumor immunity require different doses

    Article • Science, January 1976, American Association for the Advancement of Science

    Professor Douglas B Kell

  610. Douglas Kell Comments on ‘Methodology’ During the Workshop

    Article • Springer Science + Business Media

    Professor Douglas B Kell

  611. Taverna/myGrid: Aligning a Workflow System with the Life Sciences Community

    Article • Springer Science + Business Media

    Professor Douglas B Kell

  612. Molecular Structure Elucidation Using Ant Colony Optimization: A Preliminary Study

    Article • Springer Science + Business Media

    Professor Douglas B Kell

  613. Nonlinear Dielectric Spectroscopy of Biological Systems: Principles ans Applications

    Article • Springer Science + Business Media

    Professor Douglas B Kell