All Stories

  1. Structure-activity relationships for a series of (Bis(4-fluorophenyl)methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the dopamine transporter: Bioisosteric replacement of the piperazine improves metabolic stability

    Article • European Journal of Medicinal Chemistry, December 2020, Elsevier

    Dr Gianluigi Tanda

  2. Effects of (R)-Modafinil and Modafinil Analogues on Dopamine Dynamics Assessed by Voltammetry and Microdialysis in the Mouse Nucleus Accumbens Shell

    Article • ACS Chemical Neuroscience, January 2019, American Chemical Society (ACS)

    Dr Gianluigi Tanda

  3. Distinct effects of (R )-modafinil and its (R )- and (S )-fluoro-analogs on mesolimbic extracellular dopamine assessed by voltammetry and microdialysis in rats

    Article • European Journal of Neuroscience, December 2018, Wiley

    Dr Gianluigi Tanda

  4. Pharmacological classification of centrally acting drugs using EEG in freely moving rats: an old tool to identify new atypical dopamine uptake inhibitors

    Article • Neuropharmacology, November 2018, Elsevier

    Dr Gianluigi Tanda

  5. Astrocytic Mechanisms Involving Kynurenic Acid Control Δ9-Tetrahydrocannabinol-Induced Increases in Glutamate Release in Brain Reward-Processing Areas

    Article • Molecular Neurobiology, August 2018, Springer Science + Business Media

    Dr Gianluigi Tanda

  6. Brain activity of anandamide: a rewarding bliss?

    Article • Acta Pharmacologica Sinica, July 2018, Springer Science + Business Media

    Dr Gianluigi Tanda

  7. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats

    Article • Neuropharmacology, March 2018, Elsevier

    Dr Gianluigi Tanda

  8. The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic

    Article • Neuropsychopharmacology, March 2017, Nature

    Dr Gianluigi Tanda

  9. Key role of the dopamine D4receptor in the modulation of corticostriatal glutamatergic neurotransmission

    Article • Science Advances, January 2017, American Association for the Advancement of Science

    Dr Gianluigi Tanda

  10. Oxytocin’s Effects in Cocaine and Other Psychostimulant Addictions

    Article • January 2017, Elsevier

    Dr Gianluigi Tanda

  11. Rapid and sustained antidepressant properties of an NMDA antagonist/monoamine reuptake inhibitor identified via transporter-based virtual screening

    Article • Pharmacology Biochemistry and Behavior, November 2016, Elsevier

    Dr Gianluigi Tanda

  12. The unique psychostimulant profile of (±)-modafinil: investigation of behavioral and neurochemical effects in mice

    Article • European Journal of Neuroscience, September 2016, Wiley

    Dr Gianluigi Tanda, Jonathan L Katz

  13. Lack of Specific Involvement of (+)-Naloxone and (+)-Naltrexone on the Reinforcing and Neurochemical Effects of Cocaine and Opioids

    Article • Neuropsychopharmacology, June 2016, Nature

    Dr Gianluigi Tanda, Jonathan L Katz

  14. Preclinical studies on the reinforcing effects of cannabinoids. A tribute to the scientific research of Dr. Steve Goldberg

    Article • Psychopharmacology, March 2016, Springer Science + Business Media

    Dr Gianluigi Tanda

  15. Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date

    Article • CNS Drugs, February 2016, Springer Science + Business Media

    Dr Gianluigi Tanda

  16. (±)-Modafinil potentiates cocaine self-administration but not the effects on DA levels in rodents

    Article • Drug and Alcohol Dependence, January 2015, Elsevier

    Dr Gianluigi Tanda

  17. Preference for Distinct Functional Conformations of the Dopamine Transporter Alters the Relationship between Subjective Effects of Cocaine and Stimulation of Mesolimbic Dopamine

    Article • Biological Psychiatry, November 2014, Elsevier

    Dr Gianluigi Tanda

  18. A systematic microdialysis study of dopamine transmission in the accumbens shell/core and prefrontal cortex after acute antipsychotics

    Article • Psychopharmacology, October 2014, Springer Science + Business Media

    Dr Gianluigi Tanda

  19. Effect of yohimbine on reinstatement of operant responding in rats is dependent on cue contingency but not food reward history

    Article • Addiction Biology, July 2014, Wiley

    Dr Gianluigi Tanda

  20. Preclinical Efficacy of N-Substituted Benztropine Analogs as Antagonists of Methamphetamine Self-Administration in Rats

    Article • Journal of Pharmacology and Experimental Therapeutics, November 2013, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Gianluigi Tanda

  21. Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid

    Article • Nature Neuroscience, October 2013, Springer Science + Business Media

    Marco Pistis, Dr Gianluigi Tanda, Sergi Ferre

  22. The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders

    Article • Psychopharmacology, August 2013, Springer Science + Business Media

    Dr Gianluigi Tanda

  23. Cocaine-induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice

    Article • Addiction Biology, August 2013, Wiley

    Dr Gianluigi Tanda, Jonathan L Katz

  24. Stimulants as Specific Inducers of Dopamine-Independent σ Agonist Self-Administration in Rats

    Article • Journal of Pharmacology and Experimental Therapeutics, August 2013, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Gianluigi Tanda

  25. β-Arrestin 2 knockout mice exhibit sensitized dopamine release and increased reward in response to a low dose of alcohol

    Article • Psychopharmacology, June 2013, Springer Science + Business Media

    Dr Gianluigi Tanda

  26. Relations between stimulation of mesolimbic dopamine and place conditioning in rats produced by cocaine or drugs that are tolerant to dopamine transporter conformational change

    Article • Psychopharmacology, April 2013, Springer Science + Business Media

    Dr Gianluigi Tanda

  27. Self-Administration of Cocaine Induces Dopamine-Independent Self-Administration of Sigma Agonists

    Article • Neuropsychopharmacology, November 2012, Springer Science + Business Media

    Dr Gianluigi Tanda, Jonathan L Katz

  28. R-Modafinil (Armodafinil): A Unique Dopamine Uptake Inhibitor and Potential Medication for Psychostimulant Abuse

    Article • Biological Psychiatry, September 2012, Elsevier

    Dr Gianluigi Tanda, Jonathan L Katz

  29. Peroxisome Proliferator-Activated Nuclear Receptors and Drug Addiction

    Article • August 2012, Springer Science + Business Media

    Dr Gianluigi Tanda

  30. Lack of cocaine-like discriminative-stimulus effects of σ-receptor agonists in rats

    Article • Behavioural Pharmacology, September 2011, Wolters Kluwer Health

    Dr Gianluigi Tanda, Jonathan L Katz

  31. Decreases in Cocaine Self-Administration with Dual Inhibition of the Dopamine Transporter and σ Receptors

    Article • Journal of Pharmacology and Experimental Therapeutics, August 2011, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Gianluigi Tanda

  32. A Role for Sigma Receptors in Stimulant Self Administration and Addiction

    Article • Pharmaceuticals, June 2011, MDPI AG

    Dr Gianluigi Tanda

  33. Blockade of Nicotine Reward and Reinstatement by Activation of Alpha-Type Peroxisome Proliferator-Activated Receptors

    Article • Biological Psychiatry, April 2011, Elsevier

    Marco Pistis, Dr Gianluigi Tanda

  34. Sigma Receptor Agonists: Receptor Binding and Effects on Mesolimbic Dopamine Neurotransmission Assessed by Microdialysis

    Article • Biological Psychiatry, February 2011, Elsevier

    Dr Gianluigi Tanda

  35. Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of D2-induced formation of anandamide

    Article • Psychopharmacology, February 2010, Springer Science + Business Media

    Dr Gianluigi Tanda

  36. Reinforcing Effects of σ-Receptor Agonists in Rats Trained to Self-Administer Cocaine

    Article • Journal of Pharmacology and Experimental Therapeutics, November 2009, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Gianluigi Tanda

  37. Combinations of Cocaine with Other Dopamine Uptake Inhibitors: Assessment of Additivity

    Article • Journal of Pharmacology and Experimental Therapeutics, May 2009, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Gianluigi Tanda

  38. Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-  nuclear receptors

    Article • Learning & Memory, April 2009, Cold Spring Harbor Laboratory Press

    Dr Gianluigi Tanda

  39. Discovery of Drugs to Treat Cocaine Dependence: Behavioral and Neurochemical Effects of Atypical Dopamine Transport Inhibitors

    Article • January 2009, Elsevier

    Dr Gianluigi Tanda, Jonathan L Katz

  40. Potential Use of Opioid Antagonists in the Treatment of Marijuana Abuse and Dependence

    Article • January 2009, Springer Science + Business Media

    Dr Gianluigi Tanda

  41. The Endocannabinoid System: A New Molecular Target for the Treatment of Tobacco Addiction

    Article • CNS & Neurological Disorders - Drug Targets, November 2008, Bentham Science Publishers

    Dr Gianluigi Tanda

  42. Inhibition of Anandamide Hydrolysis by Cyclohexyl Carbamic Acid 3′-Carbamoyl-3-yl Ester (URB597) Reverses Abuse-Related Behavioral and Neurochemical Effects of Nicotine in Rats

    Article • Journal of Pharmacology and Experimental Therapeutics, August 2008, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Gianluigi Tanda

  43. Cocaine‐like neurochemical effects of antihistaminic medications

    Article • Journal of Neurochemistry, April 2008, Wiley

    Dr Gianluigi Tanda, Jonathan L Katz

  44. Cocaine-Like Neurochemical Effects of Antihistaminic Medications

    Article • Journal of Neurochemistry, March 2008, Wiley

    Dr Gianluigi Tanda, Jonathan L Katz

  45. Blockade of THC-Seeking Behavior and Relapse in Monkeys by the Cannabinoid CB1-Receptor Antagonist Rimonabant

    Article • Neuropsychopharmacology, February 2008, Springer Science + Business Media

    Dr Gianluigi Tanda

  46. The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition

    Article • Neuropharmacology, January 2008, Elsevier

    Dr Gianluigi Tanda

  47. Brain-Derived Neurotrophic Factor Prevents Human Immunodeficiency Virus Type 1 Protein gp120 Neurotoxicity in the Rat Nigrostriatal System

    Article • Annals of the New York Academy of Sciences, December 2007, Wiley

    Dr Gianluigi Tanda

  48. Modulation of the endocannabinoid system: Therapeutic potential against cocaine dependence

    Article • Pharmacological Research, November 2007, Elsevier

    Dr Gianluigi Tanda

  49. Muscarinic preferential M1 receptor antagonists enhance the discriminative-stimulus effects of cocaine in rats

    Article • Pharmacology Biochemistry and Behavior, October 2007, Elsevier

    Dr Gianluigi Tanda, Jonathan L Katz

  50. Brain-derived neurotrophic factor expression in the substantia nigra does not change after lesions of dopaminergic neurons

    Article • Neurotoxicity Research, June 2007, Springer Science + Business Media

    Dr Gianluigi Tanda

  51. Nicotinic  7 Receptors as a New Target for Treatment of Cannabis Abuse

    Article • Journal of Neuroscience, May 2007, Society for Neuroscience

    Dr Gianluigi Tanda

  52. Nicotinic Facilitation of Δ9-Tetrahydrocannabinol Discrimination Involves Endogenous Anandamide

    Article • Journal of Pharmacology and Experimental Therapeutics, March 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Gianluigi Tanda

  53. Effects of Muscarinic M1 Receptor Blockade on Cocaine-Induced Elevations of Brain Dopamine Levels and Locomotor Behavior in Rats

    Article • Journal of Pharmacology and Experimental Therapeutics, January 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Gianluigi Tanda

  54. The Endogenous Cannabinoid Anandamide Produces δ-9-Tetrahydrocannabinol-Like Discriminative and Neurochemical Effects That Are Enhanced by Inhibition of Fatty Acid Amide Hydrolase but Not by Inhibition of Anandamide Transport

    Article • Journal of Pharmacology and Experimental Therapeutics, January 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Gianluigi Tanda

  55. Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats

    Article • Journal of Neurochemistry, May 2006, Wiley

    Dr Gianluigi Tanda

  56. Metabolic Transformation Plays a Primary Role in the Psychostimulant-Like Discriminative-Stimulus Effects of Selegiline [(R)-(–)-Deprenyl]

    Article • Journal of Pharmacology and Experimental Therapeutics, December 2005, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Gianluigi Tanda

  57. The Endogenous Cannabinoid Anandamide and Its Synthetic Analog R(+)-Methanandamide Are Intravenously Self-Administered by Squirrel Monkeys

    Article • Journal of Neuroscience, June 2005, Society for Neuroscience

    Dr Gianluigi Tanda

  58. Self-administration of cannabinoids by experimental animals and human marijuana smokers

    Article • Pharmacology Biochemistry and Behavior, June 2005, Elsevier

    Dr Gianluigi Tanda

  59. Cannabinoid Agonists but not Inhibitors of Endogenous Cannabinoid Transport or Metabolism Enhance the Reinforcing Efficacy of Heroin in Rats

    Article • Neuropsychopharmacology, May 2005, Springer Science + Business Media

    Dr Gianluigi Tanda

  60. Effects of 4′-Chloro-3α-(diphenylmethoxy)-tropane on Mesostriatal, Mesocortical, and Mesolimbic Dopamine Transmission: Comparison with Effects of Cocaine

    Article • Journal of Pharmacology and Experimental Therapeutics, January 2005, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Gianluigi Tanda

  61. The opioid antagonist naltrexone reduces the reinforcing effects of ? 9 -tetrahydrocannabinol (THC) in squirrel monkeys

    Article • Psychopharmacology, April 2004, Springer Science + Business Media

    Dr Gianluigi Tanda

  62. Histamine H3 Receptor Antagonists Potentiate Methamphetamine Self-Administration and Methamphetamine-Induced Accumbal Dopamine Release

    Article • Neuropsychopharmacology, January 2004, Springer Science + Business Media

    Dr Gianluigi Tanda

  63. Cannabinoids: reward, dependence, and underlying neurochemical mechanisms?a review of recent preclinical data

    Article • Psychopharmacology, September 2003, Springer Science + Business Media

    Dr Gianluigi Tanda

  64. Self-administration of ?9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys

    Article • Psychopharmacology, September 2003, Springer Science + Business Media

    Dr Gianluigi Tanda

  65. Differential Effects of Caffeine on Dopamine and Acetylcholine Transmission in Brain Areas of Drug-naive and Caffeine-pretreated Rats

    Article • Neuropsychopharmacology, August 2002, Springer Science + Business Media

    Dr Gianluigi Tanda

  66. Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys

    Article • Nature Neuroscience, November 2000, Springer Science + Business Media

    Dr Gianluigi Tanda

  67. Alteration of the Behavioral Effects of Nicotine by Chronic Caffeine Exposure

    Article • Pharmacology Biochemistry and Behavior, May 2000, Elsevier

    Dr Gianluigi Tanda

  68. Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: implications for the psychobiology of depression

    Article • Biological Psychiatry, December 1999, Elsevier

    Dr Gianluigi Tanda

  69. Reduced dopamine in peripheral blood lymphocytes in Parkinsonʼs disease

    Article • Neuroreport, September 1999, Wolters Kluwer Health

    Dr Gianluigi Tanda

  70. Dependence of mesolimbic dopamine transmission on Δ9-tetrahydrocannabinol

    Article • European Journal of Pharmacology, July 1999, Elsevier

    Dr Gianluigi Tanda

  71. Drug Addiction as a Disorder of Associative Learning: Role of Nucleus Accumbens Shell/Extended Amygdala Dopamine

    Article • Annals of the New York Academy of Sciences, June 1999, Wiley

    Dr Gianluigi Tanda, PhD Cristina Cadoni

  72. A dopamine‐μ1 opioid link in the rat ventral tegmentum shared by palatable food (Fonzies) and non‐psychostimulant drugs of abuse

    Article • European Journal of Neuroscience, March 1998, Wiley

    Dr Gianluigi Tanda

  73. Blunting of reactivity of dopamine transmission to palatable food: a biochemical marker of anhedonia in the CMS model?

    Article • Psychopharmacology, December 1997, Springer Science + Business Media

    Dr Gianluigi Tanda

  74. Contribution of Blockade of the Noradrenaline Carrier to the Increase of Extracellular Dopamine in the Rat Prefrontal Cortex by Amphetamine and Cocaine

    Article • European Journal of Neuroscience, October 1997, Wiley

    Dr Gianluigi Tanda

  75. Cannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common µ1 Opioid Receptor Mechanism

    Article • Science, June 1997, American Association for the Advancement of Science

    Dr Gianluigi Tanda

  76. Homologies and Differences in the Action of Drugs of Abuse and a Conventional Reinforcer (Food) on Dopamine Transmission: An Interpretative Framework of the Mechanism of Drug Dependence

    Article • January 1997, Elsevier

    Dr Gianluigi Tanda

  77. Estimation of in-vivo neurotransmitter release by brain microdialysis

    Article • Behavioural Pharmacology, November 1996, Wolters Kluwer Health

    Dr Gianluigi Tanda

  78. Erratum: Non-psychostimulant drugs of abuse and anxiogenic drugs activate with differential selectivity dopamine transmission in the nucleus accumbens and in the medial prefrontal cortex of the rat

    Article • Psychopharmacology, October 1996, Springer Science + Business Media

    Dr Gianluigi Tanda

  79. Non-psychostimulant drugs of abuse and anxiogenic drugs activate with differential selectivity dopamine transmission in the nucleus accumbens and in the medial prefrontal cortex of the rat

    Article • Psychopharmacology, October 1996, Springer Science + Business Media

    Dr Gianluigi Tanda

  80. Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs

    Article • Nature, July 1996, Springer Science + Business Media

    Dr Gianluigi Tanda

  81. Chronic desipramine and fluoxetine differentially affect extracellular dopamine in the rat prefrontal cortex

    Article • Psychopharmacology, June 1996, Springer Science + Business Media

    Dr Gianluigi Tanda

  82. Non-psychostimulant drugs of abuse and anxiogenic drugs activate with differential selectivity dopamine transmission in the nucleus accumbens and in the medial prefrontal cortex of the rat

    Article • Psychopharmacology, June 1996, Springer Science + Business Media

    Dr Gianluigi Tanda

  83. THE MATURATION OF A CROSS-SPECIES MODEL OF SENSORIMOTOR GATING DEFICITS IN SCHIZOPHRENIA

    Article • Behavioural Pharmacology, May 1996, Wolters Kluwer Health

    Dr Gianluigi Tanda

  84. A COMPARISON OF BEHAVIOURAL EFFECTS OF RO 19???8022 AND NITRAZEPAM IN MICE

    Article • Behavioural Pharmacology, May 1996, Wolters Kluwer Health

    Dr Gianluigi Tanda

  85. Ethanol as a neurochemical surrogate of conventional reinforcers: The dopamine-opioid link

    Article • Alcohol, January 1996, Elsevier

    Dr Gianluigi Tanda

  86. Mianserin markedly and selectively increases extracellular dopamine in the prefrontal cortex as compared to the nucleus accumbens of the rat

    Article • Psychopharmacology, January 1996, Springer Science + Business Media

    Dr Gianluigi Tanda

  87. Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens.

    Article • Proceedings of the National Academy of Sciences, December 1995, Proceedings of the National Academy of Sciences

    Dr Gianluigi Tanda

  88. Increase of extracellular dopamine in the medial prefrontal cortex during spontaneous and naloxone-precipitated opiate abstinence

    Article • Psychopharmacology, November 1995, Springer Science + Business Media

    Dr Gianluigi Tanda

  89. Local 5HT3 receptors mediate fluoxetine but not desipramine-induced increase of extracellular dopamine in the prefrontal cortex

    Article • Psychopharmacology, May 1995, Springer Science + Business Media

    Dr Gianluigi Tanda

  90. Effect of repeated administration of antidepressant drugs on dopamine transmission in the rat prefrontal cortex

    Article • Behavioural Pharmacology, May 1995, Wolters Kluwer Health

    Dr Gianluigi Tanda

  91. Intravenous administration of psychostimulants preferentially increases dopamine release in the shell of the rat nucleus accumbens

    Article • Behavioural Pharmacology, May 1995, Wolters Kluwer Health

    Dr Gianluigi Tanda

  92. Increase of extracellular dopamine in the prefrontal cortex: a trait of drugs with antidepressant potential?

    Article • Psychopharmacology, June 1994, Springer Science + Business Media

    Dr Gianluigi Tanda

  93. On the preferential release of dopamine in the nucleus accumbens by amphetamine: further evidence obtained by vertically implanted concentric dialysis probes

    Article • Psychopharmacology, September 1993, Springer Science + Business Media

    Dr Gianluigi Tanda

  94. ON THE PREFERENTIAL EFFECT OF AMPHETAMINE IN THE MESOLIMBIC SYSTEM

    Article • Behavioural Pharmacology, August 1993, Wolters Kluwer Health

    Dr Gianluigi Tanda

  95. Stimulation of dopamine transmission in the dorsal caudate nucleus by pargyline as demonstrated by dopamine and acetylcholine microdialysis and Fos immunohistochemistry

    Article • Neuroscience, July 1993, Elsevier

    Dr Gianluigi Tanda

  96. Extracellular Striatal Concentrations of Endogenous 3,4‐Dihydroxyphenylalanine in the Absence of a Decarboxylase Inhibitor: A Dynamic Index of Dopamine Synthesis In Vivo

    Article • Journal of Neurochemistry, December 1992, Wiley

    Dr Gianluigi Tanda

  97. Combined Microdialysis and Fos Immunohistochemistry for the Estimation of Dopamine Neurotransmission in the Rat Caudate-Putamen

    Article • Journal of Neurochemistry, September 1992, Wiley

    Dr Gianluigi Tanda

  98. Blockade of the Noradrenaline Carrier Increases Extracellular Dopamine Concentrations in the Prefrontal Cortex: Evidence that Dopamine Is Taken up In Vivo by Noradrenergic Terminals

    Article • Journal of Neurochemistry, September 1990, Wiley

    Dr Gianluigi Tanda

  99. Calcium-Dependent, Tetrodotoxin-Sensitive Stimulation of Cortical Serotonin Release After a Tryptophan Load

    Article • Journal of Neurochemistry, September 1989, Wiley

    Dr Gianluigi Tanda, PhD Cristina Cadoni

  100. Effect of temperature and ionic environment on the specific binding of 3H(—)sulpiride to membranes from different rat brain regions

    Article • Neurochemistry International, January 1985, Elsevier

    Dr Gianluigi Tanda