All Stories

  1. Fukuyama Cross-Coupling Approach to Isoprekinamycin: Discovery of the Highly Active and Bench-Stable Palladium Precatalyst POxAP

    Article • Organic Letters, January 2019, American Chemical Society (ACS)

    Dr Frederic BIHEL

  2. Induction of ATP Release, PPIX Transport, and Cholesterol Uptake by Human Red Blood Cells Using a New Family of TSPO Ligands

    Article • International Journal of Molecular Sciences, October 2018, MDPI AG

    Dr Frederic BIHEL

  3. Aminoguanidine Hydrazone Derivatives as Nonpeptide NPFF1 Receptor Antagonists Reverse Opioid Induced Hyperalgesia

    Article • ACS Chemical Neuroscience, May 2018, American Chemical Society (ACS)

    Dr Frederic BIHEL

  4. Heteroarylguanidines as Allosteric Modulators of ASIC1a and ASIC3 Channels

    Article • ACS Chemical Neuroscience, March 2018, American Chemical Society (ACS)

    Dr Frederic BIHEL

  5. χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds

    Article • ACS Medicinal Chemistry Letters, October 2017, American Chemical Society (ACS)

    Dr Frederic BIHEL

  6. Development of DipeptidichGPR54 Agonists

    Article • ChemMedChem, August 2016, Wiley

    Dr Frederic BIHEL

  7. RF-amide neuropeptides and their receptors in Mammals: Pharmacological properties, drug development and main physiological functions

    Article • Pharmacology & Therapeutics, April 2016, Elsevier

    Dr Frederic BIHEL

  8. Opioid adjuvant strategy: improving opioid effectiveness

    Article • Future Medicinal Chemistry, March 2016, Future Science

    Dr Frederic BIHEL

  9. CMTX Disorder and CamKinase

    Article • Frontiers in Cellular Neuroscience, March 2016, Frontiers

    Dr Frederic BIHEL

  10. Synthesis of 3-amino-3,4-dihydro-1H-quinolin-2-ones through regioselective palladium-catalyzed intramolecular cyclization

    Article • February 2016, Elsevier

    Dr Frederic BIHEL

  11. Erratum to: CMTX1 patients’ cells present genomic instability corrected by CamKII inhibitors

    Article • Orphanet Journal of Rare Diseases, January 2016, Springer Science + Business Media

    Dr Frederic BIHEL

  12. Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103

    Article • Peptides, September 2015, Elsevier

    Dr Frederic BIHEL

  13. Design and validation of a homogeneous time-resolved fluorescence cell-based assay targeting the ligand-gated ion channel 5-HT3A

    Article • Analytical Biochemistry, September 2015, Elsevier

    Dr Frederic BIHEL

  14. The long-lasting love affair between the budding yeastSaccharomyces cerevisiaeand the Epstein-Barr virus

    Article • Biotechnology Journal, August 2015, Wiley

    Dr Frederic BIHEL

  15. Neuropeptide FF receptors as novel targets for limbic seizure attenuation

    Article • Neuropharmacology, August 2015, Elsevier

    Dr Frederic BIHEL

  16. CMTX1 patients’ cells present genomic instability corrected by CamKII inhibitors

    Article • Orphanet Journal of Rare Diseases, May 2015, Springer Science + Business Media

    Dr Frederic BIHEL

  17. ChemInform Abstract: Access to 4-Alkylaminopyridazine Derivatives via Nitrogen-Assisted Regioselective Pd-Catalyzed Reactions.

    Article • ChemInform, April 2015, Wiley

    Dr Frederic BIHEL

  18. Development of a Peptidomimetic Antagonist of Neuropeptide FF Receptors for the Prevention of Opioid-Induced Hyperalgesia

    Article • ACS Chemical Neuroscience, March 2015, American Chemical Society (ACS)

    Dr Frederic BIHEL

  19. Neuropeptide FF and prolactin-releasing peptide decrease cortical excitability through activation of NPFF receptors

    Article • Epilepsia, February 2015, Wiley

    Dr Frederic BIHEL

  20. ChemInform Abstract: t-BuXPhos: A Highly Efficient Ligand for Buchwald-Hartwig Coupling in Water.

    Article • ChemInform, February 2015, Wiley

    Dr Frederic BIHEL

  21. Rapid and scalable synthesis of innovative unnatural α,β or γ-amino acids functionalized with tertiary amines on their side-chains

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Dr Frederic BIHEL

  22. A Yeast/DrosophilaScreen to Identify New Compounds Overcoming Frataxin Deficiency

    Article • Oxidative Medicine and Cellular Longevity, January 2015, Hindawi Publishing Corporation

    Dr Frederic BIHEL

  23. Access to 4-Alkylaminopyridazine Derivatives via Nitrogen-Assisted Regioselective Pd-Catalyzed Reactions

    Article • The Journal of Organic Chemistry, November 2014, American Chemical Society (ACS)

    Dr Frederic BIHEL

  24. Structure–Activity Relationship Study around Guanabenz Identifies Two Derivatives Retaining Antiprion Activity but Having Lost α2-Adrenergic Receptor Agonistic Activity

    Article • ACS Chemical Neuroscience, October 2014, American Chemical Society (ACS)

    Dr Vincent Beringue, Dr Frederic BIHEL

  25. ChemInform Abstract: Buchwald-Hartwig Reactions in Water Using Surfactants.

    Article • ChemInform, October 2014, Wiley

    Dr Frederic BIHEL

  26. ChemInform Abstract: Fully Regiocontrolled Polyarylation of Pyridine.

    Article • ChemInform, July 2014, Wiley

    Professor Yves MELY, Dr Frederic BIHEL

  27. CamKII inhibitors reduce mitotic instability, connexon anomalies and progression of the in vivo behavioral phenotype in transgenic animals expressing a mutated Gjb1 gene

    Article • Frontiers in Neuroscience, June 2014, Frontiers

    Dr Frederic BIHEL

  28. Buchwald–Hartwig reactions in water using surfactants

    Article • Tetrahedron, May 2014, Elsevier

    Dr Frederic BIHEL

  29. ChemInform Abstract: Nucleophilic Substitution of Azide Acting as a Pseudo Leaving Group: One-Step Synthesis of Various Aza Heterocycles.

    Article • ChemInform, March 2014, Wiley

    Dr Frederic BIHEL

  30. Fully Regiocontrolled Polyarylation of Pyridine

    Article • The Journal of Organic Chemistry, February 2014, American Chemical Society (ACS)

    Professor Yves MELY, Dr Frederic BIHEL

  31. t-BuXPhos: a highly efficient ligand for Buchwald–Hartwig coupling in water

    Article • Green Chemistry, January 2014, Royal Society of Chemistry

    Dr Frederic BIHEL

  32. Neuropeptide FF receptors are implicated in epileptic seizures

    Article • Frontiers in Human Neuroscience, January 2014, Frontiers

    Dr Frederic BIHEL

  33. ChemInform Abstract: N-Heteroarylation of Chiral α-Aminoesters by Means of Palladium-Catalyzed Buchwald-Hartwig Reaction.

    Article • ChemInform, December 2013, Wiley

    Dr Frederic BIHEL

  34. Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors

    Article • Neuropharmacology, December 2013, Elsevier

    Dr Frederic BIHEL

  35. Nucleophilic Substitution of Azide Acting as a Pseudo Leaving Group: One-Step Synthesis of Various Aza Heterocycles

    Article • The Journal of Organic Chemistry, November 2013, American Chemical Society (ACS)

    Dr Frederic BIHEL

  36. N -Heteroarylation of Chiral α-Aminoesters by Means of Palladium-Catalyzed Buchwald–Hartwig Reaction

    Article • The Journal of Organic Chemistry, August 2013, American Chemical Society (ACS)

    Dr Frederic BIHEL

  37. The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin induction

    Article • Neuropharmacology, July 2013, Elsevier

    Dr Frederic BIHEL

  38. Synthesis and Antiproliferative Effects of 5,6-Disubstituted Pyridazin-3(2H)-ones Designed as Conformationally Constrained Combretastatin A-4 Analogues

    Article • Anti-Cancer Agents in Medicinal Chemistry, July 2013, Bentham Science Publishers

    Dr Frederic BIHEL

  39. ChemInform Abstract: Palladium-Catalyzed Synthesis of Substituted Pyrido[2,3-d]pyridazines at Positions 5 and 8.

    Article • ChemInform, January 2013, Wiley

    Dr Frederic BIHEL

  40. Trisubstitution of pyridine through sequential and regioselective palladium cross-coupling reactions affording analogs of known GPR54 antagonists

    Article • RSC Advances, January 2013, Royal Society of Chemistry

    Dr Frederic BIHEL

  41. Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors

    Article • Bioorganic & Medicinal Chemistry Letters, December 2012, Elsevier

    Dr Frederic BIHEL

  42. Palladium-Catalyzed Synthesis of Substituted Pyrido[2,3-d]pyridazines at Positions 5 and 8

    Article • Synthesis, August 2012, Thieme Publishing Group

    Dr Frederic BIHEL

  43. 1-Phenyl-3H-2,3-benzodiazepin-4(5H)-one

    Article • Acta Crystallographica Section E Structure Reports Online, July 2012, International Union of Crystallography

    Dr Frederic BIHEL

  44. ChemInform Abstract: Direct Guanidinylation of Aryl and Heteroaryl Halides via Copper-Catalyzed Cross-Coupling Reaction.

    Article • ChemInform, April 2012, Wiley

    Dr Frederic BIHEL

  45. Direct Guanidinylation of Aryl and Heteroaryl Halides via Copper-Catalyzed Cross-Coupling Reaction

    Article • The Journal of Organic Chemistry, January 2012, American Chemical Society (ACS)

    Dr Frederic BIHEL

  46. Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments

    Article • British Journal of Pharmacology, December 2011, Wiley

    Dr Frederic BIHEL

  47. New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam

    Article • Bioorganic & Medicinal Chemistry Letters, November 2011, Elsevier

    Dr Frederic BIHEL

  48. ChemInform Abstract: New 3′-Azido-3′-deoxythymidin-5′-yl O-(ω-Hydroxyalkyl) Carbonate Prodrugs: Synthesis and Anti-HIV Evaluation.

    Article • ChemInform, May 2010, Wiley

    Dr Frederic BIHEL

  49. ChemInform Abstract: Design of Potential New HIV Protease Inhibitors: Enantioconvergent Synthesis of New Pyrrolidin-3-ol, and Pyrrolidin-3-one Peptide Conjugates.

    Article • ChemInform, May 2010, Wiley

    Dr Frederic BIHEL

  50. Pharmacological characterization of the mouse NPFF2 receptor

    Article • Peptides, February 2010, Elsevier

    Dr Frederic BIHEL

  51. ChemInform Abstract: Synthesis and Reactivity of 2,3-Dihydro-1H-2,3-benzodiazepine-1,4(5H)-dione.

    Article • ChemInform, May 2008, Wiley

    Dr Frederic BIHEL

  52. ChemInform Abstract: 6-endo-Dig Cyclization of Heteroarylesters to Alkynes Promoted by Lewis Acid Catalyst in the Presence of Broensted Acid.

    Article • ChemInform, April 2008, Wiley

    Dr Frederic BIHEL

  53. 6-endo-dig Cyclization of heteroarylesters to alkynes promoted by Lewis acid catalyst in the presence of Brønsted acid

    Article • Tetrahedron Letters, January 2008, Elsevier

    Dr Frederic BIHEL

  54. Synthesis and Reactivity of 2,3-Dihydro-1H-2,3-benzodiazepine-1,4(5H)-dione

    Article • Synthesis, December 2007, Thieme Publishing Group

    Dr Frederic BIHEL

  55. Microwave-Assisted Cyclic Amidine Synthesis Using TiCl4.

    Article • ChemInform, December 2006, Wiley

    Dr Frederic BIHEL

  56. Microwave-assisted cyclic amidine synthesis using TiCl4

    Article • Organic & Biomolecular Chemistry, January 2006, Royal Society of Chemistry

    Dr Frederic BIHEL

  57. New 2-Bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and Biological Properties.

    Article • ChemInform, May 2005, Wiley

    Dr Frederic BIHEL

  58. The initial substrate-binding site of γ-secretase is located on presenilin near the active site

    Article • Proceedings of the National Academy of Sciences, February 2005, Proceedings of the National Academy of Sciences

    Dr Frederic BIHEL

  59. Substituted thiazolamide coupled to a redox delivery system: a new γ-secretase inhibitor with enhanced pharmacokinetic profile

    Article • Organic & Biomolecular Chemistry, January 2005, Royal Society of Chemistry

    Dr Frederic BIHEL

  60. New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties

    Article • Bioorganic & Medicinal Chemistry Letters, January 2005, Elsevier

    Dr Frederic BIHEL

  61. N-Acyl Substituted 7-Amino-4-chloroisocoumarin: A Peptide Degradation Model via an Imide Mechanism.

    Article • ChemInform, August 2004, Wiley

    Dr Frederic BIHEL

  62. Discovery of a Subnanomolar Helicald-Tridecapeptide Inhibitor of γ-Secretase

    Article • Journal of Medicinal Chemistry, July 2004, American Chemical Society (ACS)

    Dr Frederic BIHEL

  63. P4-347 Discovery of a subnanomolar inhibitor of γ-secretase

    Article • Neurobiology of Aging, July 2004, Elsevier

    Dr Frederic BIHEL

  64. N-Acyl substituted 7-amino-4-chloroisocoumarin: A peptide degradation model via an imide mechanism

    Article • Bioorganic & Medicinal Chemistry Letters, April 2004, Elsevier

    Dr Frederic BIHEL

  65. Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new β-amyloid peptide production inhibitors and their activities on various classes of protease

    Article • Bioorganic & Medicinal Chemistry, July 2003, Elsevier

    Dr Frederic BIHEL

  66. Reactivity studies of 3-alkoxy-7-amino-4-chloroisocoumarins (β-amyloid peptide inhibitors)versus different classes of amines

    Article • Organic & Biomolecular Chemistry, January 2003, Royal Society of Chemistry

    Dr Frederic BIHEL

  67. Novel synthesis of 3,4-dihydro-5-bromo[1,4]oxazin-2-one derivatives, new protease inhibitor scaffold

    Article • Organic & Biomolecular Chemistry, January 2003, Royal Society of Chemistry

    Dr Frederic BIHEL

  68. New β-strand macrocyclic peptidomimetic analogues containing α-(O-, S- or NH-)aryl substituted glycine residues: synthesis, chemical and enzymatic properties

    Article • Organic & Biomolecular Chemistry, January 2003, Royal Society of Chemistry

    Dr Frederic BIHEL

  69. Synthesis and Antiviral Activity of New Anti-HIV Amprenavir Bioisosteres

    Article • Journal of Medicinal Chemistry, July 2002, American Chemical Society (ACS)

    Dr Frederic BIHEL

  70. New Non-Peptidic Inhibitors of γ-Secretase Abolish Aβ Production Without Modifying Notch Cleavage

    Article • January 2002, Springer Science + Business Media

    Dr Frederic BIHEL

  71. Article • Nature, April 2001, Nature

    Dr Frederic BIHEL

  72. New 3‘-Azido-3‘-deoxythymidin-5‘-yl O -( ω -Hydroxyalkyl) Carbonate Prodrugs:  Synthesis and Anti-HIV Evaluation

    Article • Journal of Medicinal Chemistry, March 2001, American Chemical Society (ACS)

    Dr Frederic BIHEL

  73. Design of potential new HIV protease inhibitors: enantioconvergent synthesis of new pyrrolidin-3-ol, and pyrrolidin-3-one peptide conjugates

    Article • Journal of the Chemical Society Perkin Transactions 1, January 2001, Royal Society of Chemistry

    Dr Frederic BIHEL