All Stories

  1. Genome-wide CRISPR interference screen identifies long non-coding RNA loci required for differentiation and pluripotency

    Article • PLoS ONE, November 2021, PLOS

    Dr Frank John Slack

  2. Cellular microRNA-127-3p suppresses oncogenic herpesvirus-induced transformation and tumorigenesis via down-regulation of SKP2

    Article • Proceedings of the National Academy of Sciences, November 2021, Proceedings of the National Academy of Sciences

    Dr Frank John Slack

  3. Let-7 microRNA as a potential therapeutic target with implications for immunotherapy

    Article • Expert Opinion on Therapeutic Targets, October 2018, Taylor & Francis

    Dr Frank John Slack

  4. acn-1, a C. elegans homologue of ACE, genetically interacts with the let-7 microRNA and other heterochronic genes

    Article • Cell Cycle, September 2017, Taylor & Francis

    Dr Frank John Slack

  5. RACK-1 regulateslet-7microRNA expression and terminal cell differentiation inCaenorhabditis elegans

    Article • Cell Cycle, April 2014, Taylor & Francis

    Dr Frank John Slack

  6. Extensive sequence variation in the 3′ untranslated region of theKRASgene in lung and ovarian cancer cases

    Article • Cell Cycle, February 2014, Taylor & Francis

    Dr Frank John Slack

  7. Autoregulation oflin-4microRNA transcription by RNA activation (RNAa) inC. elegans

    Article • Cell Cycle, January 2014, Taylor & Francis

    Dr Frank John Slack

  8. In this issue ofEpigenetics

    Article • Epigenetics, January 2014, Taylor & Francis

    Dr Frank John Slack

  9. RNA-mediated gene activation

    Article • Epigenetics, November 2013, Taylor & Francis

    Dr Frank John Slack

  10. MicroRNAs and the Genetic Network in Aging

    Article • Journal of Molecular Biology, October 2013, Elsevier

    Dr Frank John Slack

  11. Canonical and Non-Canonical Barriers Facing AntimiR Cancer Therapeutics

    Article • Current Medicinal Chemistry, August 2013, Bentham Science Publishers

    Dr Frank John Slack

  12. Anthranilate Fluorescence Marks a Calcium-Propagated Necrotic Wave That Promotes Organismal Death in C. elegans

    Article • PLoS Biology, July 2013, PLOS

    Alexandre Benedetto, Dr Frank John Slack, Professor Nektarios Tavernarakis

  13. MicroRNAs in the ionizing radiation response and in radiotherapy

    Article • Current Opinion in Genetics & Development, February 2013, Elsevier

    Dr Frank John Slack

  14. MicroRNAs circulate around Alzheimer's disease

    Article • Genome Biology, January 2013, Springer Science + Business Media

    Dr Frank John Slack

  15. Ageing and the small, non-coding RNA world

    Article • Ageing Research Reviews, January 2013, Elsevier

    Dr Frank John Slack

  16. MicroRNAs and the cancer phenotype: profiling, signatures and clinical implications

    Article • Genome Medicine, January 2013, Springer Science + Business Media

    Dr Frank John Slack

  17. The multiple roles of microRNA-155 in oncogenesis

    Article • Journal of Clinical Bioinformatics, January 2013, ClinTransMed, AB

    Dr Frank John Slack

  18. FGF Regulates TGF-β Signaling and Endothelial-to-Mesenchymal Transition via Control of let-7 miRNA Expression

    Article • Cell Reports, December 2012, Elsevier

    Dr Frank John Slack

  19. Novel MicroRNAs Differentially Expressed during Aging in the Mouse Brain

    Article • PLoS ONE, July 2012, PLOS

    Dr Frank John Slack

  20. Biases and Errors on Allele Frequency Estimation and Disease Association Tests of Next‐Generation Sequencing of Pooled Samples

    Article • Genetic Epidemiology, June 2012, Wiley

    Dr Frank John Slack

  21. The Duality of OncomiR Addiction in the Maintenance and Treatment of Cancer

    Article • The Cancer Journal, May 2012, Wolters Kluwer Health

    Dr Frank John Slack

  22. Quantitative analysis of microRNAs in tissue microarrays by in situ hybridization

    Article • BioTechniques, April 2012, Informa UK (Informa Life Sciences)

    Dr Frank John Slack

  23. MiR-33 connects cholesterol to the cell cycle

    Article • Cell Cycle, March 2012, Taylor & Francis

    Dr Frank John Slack

  24. A 'pivotal' new rule for microRNA-mRNA interactions

    Article • Nature Structural & Molecular Biology, March 2012, Springer Science + Business Media

    Dr Frank John Slack

  25. KRAS alleles: The LCS6 3′UTR variant and KRAS coding sequence mutations in the NCI-60 panel

    Article • Cell Cycle, January 2012, Taylor & Francis

    Dr Frank John Slack

  26. Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis

    Article • Pulmonary Medicine, January 2012, Hindawi Publishing Corporation

    Dr Frank John Slack

  27. Arresting the Culprit: Targeted Antagomir Delivery to Sequester Oncogenic miR-221 in HCC

    Article • Molecular Therapy — Nucleic Acids, January 2012, Elsevier

    Dr Frank John Slack, Andrea Kasinski

  28. MicroRNAs in Mutagenesis, Genomic Instability, and DNA Repair

    Article • Seminars in Oncology, December 2011, Elsevier

    Dr Frank John Slack

  29. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy

    Article • Nature Reviews Drug Discovery, November 2011, Springer Science + Business Media

    Dr Frank John Slack, Andrea Kasinski

  30. Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells

    Article • Cancer Biology & Therapy, November 2011, Taylor & Francis

    Dr Frank John Slack

  31. MicroRNA Predictors of Longevity in Caenorhabditis elegans

    Article • PLoS Genetics, September 2011, PLOS

    Dr Frank John Slack

  32. Prevention of K-Ras- and Pten-mediated intravaginal tumors by treatment with camptothecin-loaded PLGA nanoparticles

    Article • Drug Delivery and Translational Research, September 2011, Springer Science + Business Media

    Dr Frank John Slack

  33. Association between KRAS rs61764370 and triple-negative breast cancer—a false positive? – Authors' reply

    Article • The Lancet Oncology, August 2011, Elsevier

    Dr Frank John Slack

  34. The POU transcription factor UNC‐86 controls the timing and ventral guidance of Caenorhabditis elegans axon growth

    Article • Developmental Dynamics, June 2011, Wiley

    Dr Frank John Slack

  35. Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

    Article • Molecular Therapy, June 2011, Elsevier

    Dr Frank John Slack

  36. MicroRNA signatures differentiate melanoma subtypes

    Article • Cell Cycle, June 2011, Taylor & Francis

    Dr Frank John Slack

  37. MicroRNA therapeutics in preclinical cancer models

    Article • The Lancet Oncology, April 2011, Elsevier

    Dr Frank John Slack, Andrea Kasinski

  38. A 3′-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis

    Article • The Lancet Oncology, April 2011, Elsevier

    Dr Frank John Slack

  39. Analysis of microRNA Expression and Function

    Article • January 2011, Elsevier

    Dr Frank John Slack

  40. kin-19/casein kinase Iαhas dual functions in regulating asymmetric division and terminal differentiation inC. elegansepidermal stem cells

    Article • Cell Cycle, December 2010, Taylor & Francis

    Dr Frank John Slack

  41. MicroRNAs Both Promote and Antagonize Longevity in C. elegans

    Article • Current Biology, December 2010, Elsevier

    Dr Frank John Slack

  42. Micrornas in Development and Cancer

    Article • October 2010

    Dr Frank John Slack

  43. Single Nucleotide Polymorphisms in MicroRNAs and MicroRNA Binding Sites with Roles in Cancer

    Article • October 2010, World Scientific Pub Co Pte Lt

    Dr Frank John Slack

  44. OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma

    Article • Nature, August 2010, Springer Science + Business Media

    Dr Frank John Slack

  45. A Developmental Timing Switch Promotes Axon Outgrowth Independent of Known Guidance Receptors

    Article • PLoS Genetics, August 2010, PLOS

    Dr Frank John Slack

  46. The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition

    Article • Developmental Biology, August 2010, Elsevier

    Dr Frank John Slack

  47. MicroRNAs and Cancer: A meeting summary of the eponymous Keystone Conference

    Article • Epigenetics, February 2010, Taylor & Francis

    Dr Frank John Slack

  48. Big roles for small RNAs

    Article • Nature, February 2010, Springer Science + Business Media

    Dr Frank John Slack

  49. Developmental biomarkers of aging in Caenorhabditis elegans

    Article • Developmental Dynamics, January 2010, Wiley

    Dr Frank John Slack

  50. Robust and specific inhibition of microRNAs in Caenorhabditis elegans

    Article • Journal of Biology, January 2010, Springer Science + Business Media

    Dr Frank John Slack

  51. C. elegans sym-1is a downstream target of the Hunchback-like-1 developmental timing transcription factor

    Article • Cell Cycle, December 2009, Taylor & Francis

    Dr Frank John Slack

  52. Ribosomal protein RPS-14 modulates let-7 microRNA function in Caenorhabditis elegans

    Article • Developmental Biology, October 2009, Elsevier

    Dr Frank John Slack

  53. Transcription of the C. elegans let-7 microRNA is temporally regulated by one of its targets, hbl-1

    Article • Developmental Biology, October 2009, Elsevier

    Dr Frank John Slack

  54. RNAi and microRNA-oriented therapy in cancer: rationales, promises and challenges

    Article • Current Oncology, July 2009, MultiMed Inc.

    Dr Frank John Slack

  55. An interview with Dr. Frank Slack on his highly cited paper published inCell Cycle

    Article • Cell Cycle, June 2009, Taylor & Francis

    Dr Frank John Slack

  56. Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegansdevelopment

    Article • Genome Biology, May 2009, Springer Science + Business Media

    Dr Frank John Slack

  57. The microRNAs of Caenorhabditis elegans

    Article • April 2009, Taylor & Francis

    Dr Frank John Slack

  58. An elegant miRror: microRNAs in stem cells, developmental timing and cancer

    Article • Chromosoma, April 2009, Springer Science + Business Media

    Dr Frank John Slack

  59. Inhibiting microRNA function in vivo

    Article • Nature Chemical Biology, January 2009, Springer Science + Business Media

    Dr Frank John Slack

  60. Transcriptional control of microRNA expression inC. elegans: Promoting better understanding

    Article • RNA Biology, January 2009, Taylor & Francis

    Dr Frank John Slack

  61. MicroRNA in Cancer Prognosis

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, December 2008, New England Journal of Medicine (NEJM/MMS)

    Dr Frank John Slack

  62. The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure

    Article • Cell Cycle, December 2008, Taylor & Francis

    Dr Frank John Slack

  63. Epstein-Barr virus-mediated dysregulation of human microRNA expression

    Article • Cell Cycle, November 2008, Taylor & Francis

    Dr Frank John Slack

  64. A truth serum for cancer — microRNAs have major potential as cancer biomarkers

    Article • BDJ, October 2008, Springer Science + Business Media

    Dr Frank John Slack

  65. The let-7 family of microRNAs

    Article • Trends in Cell Biology, October 2008, Elsevier

    Dr Frank John Slack

  66. The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation

    Article • Cell Cycle, October 2008, Taylor & Francis

    Dr Frank John Slack

  67. let-7 microRNAs in development, stem cells and cancer

    Article • Trends in Molecular Medicine, September 2008, Elsevier

    Dr Frank John Slack

  68. MicroRNAs and cancer: An overview

    Article • Cell Cycle, August 2008, Taylor & Francis

    Dr Frank John Slack

  69. miRNA modulation of the cellular stress response

    Article • Future Oncology, April 2008, Future Medicine

    Dr Frank John Slack

  70. Thelet-7microRNA reduces tumor growth in mouse models of lung cancer

    Article • Cell Cycle, March 2008, Taylor & Francis

    Dr Frank John Slack

  71. Small non-coding RNAs in animal development

    Article • Nature Reviews Molecular Cell Biology, March 2008, Springer Science + Business Media

    Dr Frank John Slack

  72. The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans

    Article • Developmental Biology, March 2008, Elsevier

    Dr Frank John Slack

  73. microRNAs: small molecules with big roles –C. elegans to human cancer

    Article • Biology of the Cell, February 2008, Wiley

    Dr Frank John Slack

  74. Transcriptional (dys)regulation and aging in Caenorhabditis elegans

    Article • Genome Biology, January 2008, Springer Science + Business Media

    Dr Frank John Slack

  75. And Now Introducing Mammalian Mirtrons

    Article • Developmental Cell, November 2007, Elsevier

    Dr Frank John Slack

  76. The Caenorhabditis elegans pumilio homolog, puf-9, is required for the 3′UTR-mediated repression of the let-7 microRNA target gene, hbl-1

    Article • Developmental Biology, May 2007, Elsevier

    Dr Frank John Slack

  77. The evolution of animal microRNA function

    Article • Current Opinion in Genetics & Development, April 2007, Elsevier

    Dr Frank John Slack

  78. microRNA-Mediated Silencing Inside P Bodies

    Article • RNA Biology, July 2006, Taylor & Francis

    Dr Frank John Slack

  79. microRNA Control of Lifespan and Metabolism

    Article • Cell Cycle, April 2006, Taylor & Francis

    Dr Frank John Slack

  80. Micromanagement: A Role for MicroRNAs in mRNA Stability

    Article • ACS Chemical Biology, April 2006, American Chemical Society (ACS)

    Dr Frank John Slack

  81. Oncomirs — microRNAs with a role in cancer

    Article • Nature Reviews Drug Discovery, April 2006, Springer Science + Business Media

    Dr Frank John Slack

  82. MicroRNAs as a potential magic bullet in cancer

    Article • Future Oncology, February 2006, Future Medicine

    Dr Frank John Slack

  83. Reciprocal expression of lin‐41 and the microRNAs let‐7 and mir‐125 during mouse embryogenesis

    Article • Developmental Dynamics, October 2005, Wiley

    Dr Frank John Slack

  84. RAS Is Regulated by the let-7 MicroRNA Family

    Article • Cell, March 2005, Elsevier

    Dr Frank John Slack

  85. The Temporal Patterning MicroRNA let-7 Regulates Several Transcription Factors at the Larval to Adult Transition in C. elegans

    Article • Developmental Cell, March 2005, Elsevier

    Dr Frank John Slack

  86. Developmental Timing in C. elegans Is Regulated by kin-20 and tim-1, Homologs of Core Circadian Clock Genes

    Article • Developmental Cell, February 2005, Elsevier

    Dr Frank John Slack

  87. The age of high-throughput microRNA profiling

    Article • Nature Chemical Biology, November 2004, Springer Science + Business Media

    Dr Frank John Slack

  88. The Silent Revolution

    Article • Nature Cell Biology, April 2004, Springer Science + Business Media

    Dr Frank John Slack

  89. The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter

    Article • Developmental Biology, July 2003, Elsevier

    Dr Frank John Slack

  90. The C. elegans hunchback Homolog, hbl-1, Controls Temporal Patterning and Is a Probable MicroRNA Target

    Article • Developmental Cell, May 2003, Elsevier

    Dr Frank John Slack

  91. siRNA

    Article • Chemistry & Biology, October 2002, Elsevier

    Dr Frank John Slack

  92. Control of developmental timing by small temporal RNAs: a paradigm for RNA‐mediated regulation of gene expression

    Article • BioEssays, January 2002, Wiley

    Dr Frank John Slack

  93. The lin-41 RBCC Gene Acts in the C. elegans Heterochronic Pathway between the let-7 Regulatory RNA and the LIN-29 Transcription Factor

    Article • Molecular Cell, April 2000, Elsevier

    Dr Frank John Slack

  94. Expression and Function of Members of a Divergent Nuclear Receptor Family in Caenorhabditis elegans

    Article • Developmental Biology, November 1999, Elsevier

    Dr Frank John Slack

  95. Heterochronic Genes in Development and Evolution

    Article • Biological Bulletin, December 1998, JSTOR

    Dr Frank John Slack

  96. A novel repeat domain that is often associated with RING finger and B-box motifs

    Article • Trends in Biochemical Sciences, December 1998, Elsevier

    Dr Frank John Slack

  97. TEMPORAL PATTERN FORMATION BY HETEROCHRONIC GENES

    Article • Annual Review of Genetics, December 1997, Annual Reviews

    Dr Frank John Slack

  98. A gene required for nutritional repression of the Bacillus subtilis dipeptide permease operon

    Article • Molecular Microbiology, February 1995, Wiley

    Dr Frank John Slack