All Stories
- Impact of Metabolites from Foodborne Pathogens on Cancer
Article
- Mycotoxins in Food: Cancer Risks and Strategies for Control
Article
- Camptothecin and its derivatives: Advancements, mechanisms and clinical potential in cancer therapy
- Aronia melanocarpa L. fruit peels show anti-cancer effects in preclinical models of breast carcinoma: The perspectives in the chemoprevention and therapy modulation
Article
- Natural products‐based antiangiogenic agents: New frontiers in cancer therapy
Article
- Genipin’s potential as an anti-cancer agent: from phytochemical origins to clinical prospects
- Therapeutic potential of ethoxy mansonone G: A comprehensive exploration of its anticancer actions in breast cancer, colorectal cancer, and non‐small cell lung carcinoma
Article
- A Student Doctor's Guide to Tanzania
- GLP-1R Agonists: A New Hope for Obesity, Diabetes, and Cancer
Article
- New insights into the anticancer therapeutic potential of icaritin and its synthetic derivatives
Article
- Ginsenoside Rg5 as an anticancer drug: a comprehensive review on mechanisms, structure–activity relationship, and prospects for clinical advancement
- Unveiling the Protective Role of Melatonin in Osteosarcoma: Current Knowledge and Limitations
- Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling
- B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention
Article
- Sweeteners and the Gut Microbiome: Effects on Gastrointestinal Cancers
- Metabolic heterogeneity in TNBCs: A potential determinant of therapeutic efficacy of 2-deoxyglucose and metformin combinatory therapy
- Resveratrol as sensitizer in colorectal cancer plasticity
- Sweeteners and the Gut Microbiome: Effects on Gastrointestinal Cancers
- Could Metformin and Resveratrol Support Glioblastoma Treatment? A Mechanistic View at the Cellular Level
- The Influence of Gut Microbial Species on Diabetes Mellitus
Article
- Curcumin, calebin A and chemosensitization: How are they linked to colorectal cancer?
- Potential Treatment Options for Neuroblastoma with Polyphenols through Anti-Proliferative and Apoptotic Mechanisms
- Significance of flavonoids targeting PI3K/Akt/HIF-1α signaling pathway in therapy-resistant cancer cells – a potential contribution to the predictive, preventive, and personalized medicine
- Flavonoids’ Dual Benefits in Gastrointestinal Cancer and Diabetes: A Potential Treatment on the Horizon?
- Tirzepatide—Friend or Foe in Diabetic Cancer Patients?
- The Juggernaut of Adaptive Metabolism in Cancers: Implications and Therapeutic Targets
- Immunomodulation by Gut Microbiome on Gastrointestinal Cancers: Focusing on Colorectal Cancer
- COVID-19 Vaccines and Hyperglycemia—Is There a Need for Postvaccination Surveillance?
- Expression of 3-Methylcrotonyl-CoA Carboxylase in Brain Tumors and Capability to Catabolize Leucine by Human Neural Cancer Cells
- Flavonoids Synergistically Enhance the Anti-Glioblastoma Effects of Chemotherapeutic Drugs
- Treating Cancers Using Nature’s Medicine: Significance and Challenges
- Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review
- Caution, “normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021
- Protective Effects of Flavonoids Against Mitochondriopathies and Associated Pathologies: Focus on the Predictive Approach and Personalized Prevention
- Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer
- Targeting phytoprotection in the COVID-19-induced lung damage and associated systemic effects—the evidence-based 3PM proposition to mitigate individual risks
- Micro-RNA: The darkhorse of cancer
- Diabetes and coronavirus (SARS-CoV-2): Molecular mechanism of Metformin intervention and the scientific basis of drug repurposing
- Metabolic Anti-Cancer Effects of Melatonin: Clinically Relevant Prospects
- Flavonoids against the SARS-CoV-2 induced inflammatory storm
- The interplay between the vaginal microbiome and innate immunity in the focus of predictive, preventive, and personalized medical approach to combat HPV-induced cervical cancer
- Flavonoids as an effective sensitizer for anti-cancer therapy: insights into multi-faceted mechanisms and applicability towards individualized patient profiles
- Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook
- Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs
- Therapeutic Potential of Metformin in COVID-19: Reasoning for Its Protective Role
- Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine
- Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
- Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Bacteriophage Treatment: Critical Evaluation of Its Application on World Health Organization Priority Pathogens
Article
- Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma
- Carotenoids in Cancer Metastasis—Status Quo and Outlook
- Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology
- Curcumin’s Beneficial Effects on Neuroblastoma: Mechanisms, Challenges, and Potential Solutions
- The role of plant-derived natural substances as immunomodulatory agents in carcinogenesis
Article
- Implications of flavonoids as potential modulators of cancer neovascularity
- Counteracting Chemoresistance with Metformin in Breast Cancers: Targeting Cancer Stem Cells
- Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back
- Targeting Glucose Metabolism to Overcome Resistance to Anticancer Chemotherapy in Breast Cancer
- Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism
- Cisplatin's dual-effect on the circadian clock triggers proliferation and apoptosis
- Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications
- Calcium Entry through TRPV1: A Potential Target for the Regulation of Proliferation and Apoptosis in Cancerous and Healthy Cells
- Flavonoids in Cancer Metastasis
- Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine
- Chemopreventive and Therapeutic Efficacy of Cinnamomum zeylanicum L. Bark in Experimental Breast Carcinoma: Mechanistic In Vivo and In Vitro Analyses
- Dietary phytochemicals as the potential protectors against carcinogenesis and their role in cancer chemoprevention
- Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer
- Anti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression
- The Plant-Derived Compound Resveratrol in Brain Cancer: A Review
- Phytochemicals and Gastrointestinal Cancer: Cellular Mechanisms and Effects to Change Cancer Progression
- Anticancer Potential of Lichens’ Secondary Metabolites
- Combination Therapy with Vitamin C Could Eradicate Cancer Stem Cells
- Metformin: The Answer to Cancer in a Flower? Current Knowledge and Future Prospects of Metformin as an Anti-Cancer Agent in Breast Cancer
- Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium
- Paclitaxel’s Mechanistic and Clinical Effects on Breast Cancer
- Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy
- Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels
- DNA Methylation Status in Cancer Disease: Modulations by Plant-Derived Natural Compounds and Dietary Interventions
- Health implication of vitamin D on the cardiovascular and the renal system
- Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection
- Why the Gold Standard Approach by Mammography Demands Extension by Multiomics? Application of Liquid Biopsy miRNA Profiles to Breast Cancer Disease Management
- The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression
- Anticancer Activities of Thymus vulgaris L. in Experimental Breast Carcinoma in Vivo and in Vitro
- Controlling metastatic cancer: the role of phytochemicals in cell signaling
- Dietary Phytochemicals Targeting Cancer Stem Cells
- Droplet digital PCR revealed high concordance between primary tumors and lymph node metastases in multiplex screening of KRAS mutations in colorectal cancer
- High Glucose Represses the Anti-Proliferative and Pro-Apoptotic Effect of Metformin in Triple Negative Breast Cancer Cells
- Flavonoids in Cancer and Apoptosis
- Triptolide Decreases Cell Proliferation and Induces Cell Death in Triple Negative MDA-MB-231 Breast Cancer Cells
- Experiencing Tanzania: Reflections of a Medical Service Learning Trip Through the Eyes of Aspiring Physicians
- Plant natural modulators in breast cancer prevention: status quo and future perspectives reinforced by predictive, preventive, and personalized medical approach
- Challenges and perspectives in the treatment of diabetes associated breast cancer
- The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers
- Differential Expression and Pathway Analysis in Drug-Resistant Triple-Negative Breast Cancer Cell Lines Using RNASeq Analysis
- Chemotherapeutic agents for the treatment of metastatic breast cancer: An update
- MicroRNA-15a expression measured in urine samples as a potential biomarker of renal cell carcinoma
- Adipokines in neurovascular diseases
- Melatonin and breast cancer: Evidences from preclinical and human studies
- Open Reading Frame Filtering Methods for Identification of Genic Sequences
- Are plant-based functional foods better choice against cancer than single phytochemicals? A critical review of current breast cancer research
- Therapeutical strategies for anxiety and anxiety-like disorders using plant-derived natural compounds and plant extracts
- Alamandine reverses hyperhomocysteinemia-induced vascular dysfunction via PKA-dependent mechanisms
- Immunomodulatory effects of stem cells: Therapeutic option for neurodegenerative disorders
- Antineoplastic effects of clove buds (Syzygium aromaticumL.) in the model of breast carcinoma
- Targeting Intracellular Calcium Signaling ([Ca2+]i) to Overcome Acquired Multidrug Resistance of Cancer Cells: A Mini-Overview
- Angiomodulators in cancer therapy: New perspectives
- Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)
- Nitric oxide in the pathophysiology of retinopathy: evidences from preclinical and clinical researches
- Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma
- Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect
- Chili pepper as a body weight-loss food
- Creatine and creatine pyruvate reduce hypoxia-induced effects on phrenic nerve activity in the juvenile mouse respiratory system
- TRPV currents and their role in the nociception and neuroplasticity
- The known and missing links between Toxoplasma gondii and schizophrenia
- A few things everybody should know about osteoporosis. Keep you bones healthy and strong!
- Oregano demonstrates distinct tumour-suppressive effects in the breast carcinoma model
- Histone Deacetylase Inhibitor Trichostatin A (TSA) and DNA Methyltransferase Inhibitor 5-aza-2′-deoxycitidine (5-AZA) Enhanced the Cisplatin (CDDP) Induced Cytotoxicity of Neuroblastoma Cells, in Vitro
- Intracellular Calcium in Development and Treatment of Neuroblastoma
- The Role of Intracellular Calcium for the Development and Treatment of Neuroblastoma
- Recent updates on metal compounds in our environment and their implications on human health
- Auranofin, an Anti-Rheumatic Gold Compound, Modulates Apoptosis by Elevating the Intracellular Calcium Concentration ([Ca2+]i) in MCF-7 Breast Cancer Cells
- Effects of Glycinergic Inhibition Failure on Respiratory Rhythm and Pattern Generation
- Cisplatin (CDDP) triggers cell death of MCF-7 cells following disruption of intracellular calcium ([Ca2+]i) homeostasis
- Involvement Of Intracellular Calcium [ca2+]i In The Treatment Of Human Neuroblastoma With Cisplatin (cddp) And Topotecan (topo)
- Lead impairs synaptic transmission by interfering with calcium
- The two opposite facets of arsenic: toxic and anticancer drug
- Breast cancer and possible mechanisms of therapy resistance
- Lead (Pb2+) neurotoxicity: Ion-mimicry with calcium (Ca2+) impairs synaptic transmission. A review with animated illustrations of the pre- and post-synaptic effects of lead
- Editors' page: Introduction
- Disruption of circadian rhythm increases the risk of cancer, metabolic syndrome and cardiovascular disease
- Analgesic ineffectiveness of lacosamide after spinal nerve ligation and its sodium channel activity in injured neurons
- Metals and Disease
- Metal Toxicity at the Synapse: Presynaptic, Postsynaptic, and Long-Term Effects
- Changing Patterns of Fertility and Family Formation in the Islamic World: Dimensions, Causes and Implications
- Additive inhibitory effects of calcitonin and capsaicin on voltage activated calcium channel currents in nociceptive neurones of rat
- Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects
- Metals and Breast Cancer: Risk Factors or Healing Agents?
- Metal toxicity at the synapse: presynaptic, postsynaptic and long-term effects
- Anti-allodynic effect of the flavonoid myricetin in a rat model of neuropathic pain: Involvement of p38 and protein kinase C mediated modulation of Ca2+ channels
- Myricetin reduces voltage activated potassium channel currents in DRG neurons by a p38 dependent mechanism
- Website Resources versus Text Resources: Which do Millenneal Medical Students Utilize Most?
- Sensitization of voltage activated calcium channel currents for capsaicin in nociceptive neurons by tumor-necrosis-factor-α
- Modulation spannungsabhängiger Kalcium- und Kaliumkanäle in sensorischen Neuronen durch Flavonoide: Neue Substanzklasse in der experimentellen Schmerzforschung?
- Anti-cancer drugs interfere with intracellular calcium signaling
- Heat-Induced Action Potential Discharges in Nociceptive Primary Sensory Neurons of Rats
- Co-application of arsenic trioxide (As2O3) and cisplatin (CDDP) on human SY-5Y neuroblastoma cells has differential effects on the intracellular calcium concentration ([Ca2+]i) and cytotoxicity
- Metallic compounds (arsenic trioxide and trimethyltin chloride) interact with calcium homeostasis and trigger cell death in “in vitro” systems
- SnCl2 reduces voltage-activated calcium channel currents of dorsal root ganglion neurons of rats
- Arsenic trioxide in environmentally and clinically relevant concentrations interacts with calcium homeostasis and induces cell type specific cell death in tumor and non-tumor cells
- TNF-α differentially modulates ion channels of nociceptive neurons
- Feedback mechanisms in the regulation of intracellular calcium ([Ca2+]i) in the peripheral nociceptive system: Role of TRPV-1 and pain related receptors
- Modulation of intracellular calcium influences capsaicin-induced currents of TRPV-1and voltage-activated channel currents in nociceptive neurones
- IP3 receptor antagonist, 2-APB, attenuates cisplatin induced Ca2+ -influx in HeLa-S3 cells and prevents activation of calpain and induction of apoptosis
- Medullary pacemaker neurons are essential for both eupnea and gasping in mammals vs. medullary pacemaker neurons are essential for gasping, but not eupnea, in mammals
- Arsenic trioxide (As2O3) induced calcium signals and cytotoxicity in two human cell lines: SY-5Y neuroblastoma and 293 embryonic kidney (HEK)
- Cisplatin modulates voltage gated channel currents of dorsal root ganglion neurons of rats
- New pharmaceutic interventions in the therapy of chronic pain
- Anti-cancer drugs elevate intracellular calcium by different mechanisms
- Various „drugs“ influence the respiratory rhythm
- Occurrence, use and potential toxic effects of metals and metal compounds
- Toxic effects of metals: modulation of intracellular calcium homeostasis
- Modulation of intracellular calcium homeostasis by trimethyltin chloride in human tumour cells: Neuroblastoma SY5Y and cervix adenocarcinoma HeLa S3
- Capsaicin differentially modulates voltage-activated calcium channel currents in dorsal root ganglion neurones of rats
- Elevated Ca2+i transients induced by trimethyltin chloride in HeLa cells: types and levels of response
- Modulation of voltage-gated channel currents by harmaline and harmane
- Actions of metals on membrane channels, calcium homeostasis and synaptic plasticity
- A combined blockade of glycine and calcium-dependent potassium channels abolishes the respiratory rhythm
- The Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on membrane currents and intrasynaptosomal calcium
- The respiratory rhythm in mutant oscillator mice
- Reorganisation of respiratory network activity after loss of glycinergic inhibition
- Inactivation and tachyphylaxis of heat‐evoked inward currents in nociceptive primary sensory neurones of rats
- Respiratory Rhythm Generation: Plasticity of a Neuronal Network
- 1-Methyl-4-Phenyl-l,2,3,6-Tetrahydropyridine and 1-Methyl-4-Phenylpyridinium Ions have Opposite Effects on Membrane Currents of Cultured Dorsal Root Ganglia Neurons
- Interference of Lead with the Calcium Release Activated Calcium Flux of Osteoblast-Like Cells
- Effects of (±)-kavain on voltage-activated inward currents of dorsal root ganglion cells from neonatal rats
- Effects of Lead, Mercury, and Methyl Mercury on Gap Junctions and [Ca2+]i in Bone Cells
- A Calcium Release Activated Calcium Influx in Primary Cultures of Rat Osteoblast-like Cells
- Lead interferes with calcium entry through membrane pores
- Histaminergic System in Co-cultures of Hippocampus and Posterior Hypothalamus: A Morphological and Electrophysiological Study in the Rat
- Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons
- Voltage-activated calcium channel currents of rat dorsal root ganglion cells are reduced by trimethyl lead
- Neurotoxikologie in vitro mit Hilfe der Elektrophysiologie
- Methyl mercury reduces voltage-activated currents of rat dorsal root ganglion neurons
- Calcium channels as target sites of heavy metals
- Aluminum Impairs Hippocampal Long-Term Potentiation in Rats in Vitro and in Vivo
- Pb2+ reduces voltage- andN-methyl-d-aspartate (NMDA)-activated calcium channel currents
- Mercury (Hg2+) and zinc (Zn2+): Two divalent cations with different actions on voltage-activated calcium channel currents
- Combined actions of Pb2+, Zn2+, and Al3+ on voltage-activated calcium channel currents
- Actions of aluminum on voltage-activated calcium channel currents
- Aluminium reduces glutamate-activated currents of rat hippocampal neurones
- Mammalian voltage-activated calcium channel currents are blocked by Pb2+, Zn2+, and Al3+
- Mercury (Hg2+) decreases voltage-gated calcium channel currents in rat DRG and Aplysia neurons
- Voltage gated calcium channel currents of rat dorsal root ganglion (DRG) cells are blocked by Al3+
- Extracellular pH modulates aluminium-blockade of mammalian voltage-activated calcium channel currents
- Pb2+ modulates the NMDA-receptor-channel complex
- Lead Blocks LTP by an Action Not at NMDA Receptors
- Zinc (Zn2+) blocks voltage gated calcium channels in cultured rat dorsal root ganglion cells
- Pb2+ blocks calcium currents of cultured dorsal root ganglion cells
- Properties of tuberomammillary histamine neurones and their response to galanin
- Lead and zinc block a voltage-activated calcium channel of Aplysia neurons
- Zn2+ blocks the voltage activated calcium current of Aplysia neurons
- Lead inhibits the voltage-activated calcium current of aplysia neurons
- EFFECTS OF EXOGENOUS LIPID APPLICATION ON EXCITABILITY OF APLYSIA NEURONS
- Effects of Exogenous Ganglioside and Cholesterol Application on Excitability ofAplysiaNeurons