All Stories

  1. The False Positive Risk: A Proposal Concerning What to Do About p-Values

    Article • The American Statistician, March 2019, Taylor & Francis

    Professor David Colquhoun

  2. Response to comment by Loiselle & Ramchandra (2015)

    Article • Royal Society Open Science, August 2015, Royal Society Publishing

    Professor David Colquhoun

  3. An investigation of the false discovery rate and the misinterpretation of p-values

    Article • Royal Society Open Science, November 2014, Royal Society Publishing

    Professor David Colquhoun

  4. Alternative Medicine: My Part in its Downfall

    Article • European Review, July 2013, Cambridge University Press

    Professor David Colquhoun

  5. Acupuncture Is Theatrical Placebo

    Article • Anesthesia & Analgesia, June 2013, Wolters Kluwer Health

    Professor David Colquhoun

  6. Krill Oil Claims: Fact or Fiction? An Analysis of the Literature

    Article • Heart Lung and Circulation, January 2013, Elsevier

    Professor David Colquhoun

  7. Allosteric coupling in ligand-gated ion channels

    Article • The Journal of General Physiology, November 2012, Rockefeller University Press

    Professor David Colquhoun

  8. Response to Whitehead

    Article • BMJ, October 2012, BMJ

    Professor David Colquhoun

  9. Scarcely credible treatments do not merit university attention

    Article • BMJ, March 2012, BMJ

    Professor David Colquhoun

  10. In Praise of Randomisation: The Importance of Causality in Medicine and its Subversion by Philosophers of Science

    Article • December 2011, British Academy

    Professor David Colquhoun

  11. Acupuncture for ‘frequent attenders’ with medically unexplained symptoms

    Article • British Journal of General Practice, August 2011, Royal College of General Practitioners

    Professor David Colquhoun

  12. College of Medicine is Prince's Foundation reincarnated

    Article • BMJ, July 2011, BMJ

    Professor David Colquhoun

  13. Wilmshurst in context

    Article • Prometheus, March 2011, Taylor & Francis

    Professor David Colquhoun

  14. The K276E Startle Disease Mutation in the Glycine Receptor: Effects on Channel Gating

    Article • Biophysical Journal, February 2011, Elsevier

    Professor David Colquhoun

  15. Author's reply to the minister

    Article • BMJ, February 2010, BMJ

    Professor David Colquhoun

  16. The Diet Delusion

    Article • BMJ, December 2009, BMJ

    Professor David Colquhoun

  17. Secret remedies: 100 years on

    Article • BMJ, December 2009, BMJ

    Professor David Colquhoun

  18. The highs and lows of policy based evidence

    Article • BMJ, November 2009, BMJ

    Professor David Colquhoun

  19. Agonist and blocking actions of choline and tetramethylammonium on human muscle acetylcholine receptors

    Article • The Journal of Physiology, October 2009, Wiley

    Professor David Colquhoun

  20. Trust me, I'm a scientist

    Article • BMJ, September 2009, BMJ

    Professor David Colquhoun

  21. MHRA label seems to be illegal

    Article • BMJ, June 2009, BMJ

    Professor David Colquhoun

  22. The arrogance of trying to sum up abilities in a number

    Article • Nature, March 2009, Springer Science + Business Media

    Professor David Colquhoun

  23. Channel Blocking Properties Of Tetramethylammonium At The Human Muscle Acetylcholine Receptor

    Article • Biophysical Journal, February 2009, Elsevier

    Professor David Colquhoun

  24. Single Ion Channels

    Article • January 2009, Elsevier

    Professor David Colquhoun

  25. CORRIGENDUM

    Article • The Journal of Physiology, October 2008, Wiley

    Professor David Colquhoun

  26. A very bad report on regulating complementary medicine

    Article • BMJ, August 2008, BMJ

    Professor David Colquhoun

  27. David Colquhoun & Lucia Sivilotti

    Article • Nature, August 2008, Springer Science + Business Media

    Professor David Colquhoun

  28. On the nature of partial agonism in the nicotinic receptor superfamily

    Article • Nature, July 2008, Springer Science + Business Media

    Professor David Colquhoun

  29. Why the Schild method is better than Schild realised

    Article • Trends in Pharmacological Sciences, December 2007, Elsevier

    Professor David Colquhoun

  30. What to do about CAM?

    Article • BMJ, October 2007, BMJ

    Professor David Colquhoun

  31. What have we learned from single ion channels?

    Article • The Journal of Physiology, May 2007, Wiley

    Professor David Colquhoun

  32. Should NICE evaluate complementary and alternative medicines?

    Article • BMJ, March 2007, BMJ

    Professor David Colquhoun

  33. Science degrees without the science

    Article • Nature, March 2007, Springer Science + Business Media

    Professor David Colquhoun

  34. NEUROSCIENCE: Perceptions of a Receptor

    Article • Science, February 2007, American Association for the Advancement of Science

    Professor David Colquhoun

  35. Treating Critically Ill Patients With Sugar Pills

    Article • CHEST Journal, February 2007, Elsevier

    Professor David Colquhoun

  36. Playing the numbers game

    Article • Nature, July 2006, Springer Science + Business Media

    Professor David Colquhoun

  37. The quantitative analysis of drug–receptor interactions: a short history

    Article • Trends in Pharmacological Sciences, March 2006, Elsevier

    Professor David Colquhoun

  38. Agonist-activated ion channels

    Article • British Journal of Pharmacology, January 2006, Wiley

    Professor David Colquhoun

  39. From Shut to Open: What Can We Learn from Linear Free Energy Relationships?

    Article • Biophysical Journal, December 2005, Elsevier

    Professor David Colquhoun

  40. Maximum likelihood fitting of single channel NMDA activity with a mechanism composed of independent dimers of subunits

    Article • The Journal of Physiology, November 2005, Wiley

    Professor David Colquhoun

  41. Evidence-based medicine

    Article • The Lancet, September 2005, Elsevier

    Professor David Colquhoun

  42. Commentary

    Article • Evidence-based Cardiovascular Medicine, June 2005, Elsevier

    Professor David Colquhoun

  43. A human congenital myasthenia-causing mutation (ɛL78P) of the muscle nicotinic acetylcholine receptor with unusual single channel properties

    Article • The Journal of Physiology, April 2005, Wiley

    Professor David Colquhoun

  44. Abuse of Prisoners at Abu Ghraib

    Article • Science, March 2005, American Association for the Advancement of Science

    Professor David Colquhoun

  45. How to Impose Microscopic Reversibility in Complex Reaction Mechanisms

    Article • Biophysical Journal, June 2004, Elsevier

    Professor David Colquhoun

  46. Challenging the tyranny of impact factors

    Article • Nature, May 2003, Springer Science + Business Media

    Professor David Colquhoun

  47. The quality of maximum likelihood estimates of ion channel rate constants

    Article • The Journal of Physiology, March 2003, Wiley

    Professor David Colquhoun

  48. The quality of maximum likelihood estimates of ion channel rate constants

    Article • The Journal of Physiology, January 2003, Wiley

    Professor David Colquhoun

  49. Nicotinic Acetylcholine Receptors

    Article • January 2003, Wiley

    Professor David Colquhoun

  50. Acetylcholine Receptor-Nicotinic

    Article • January 2002, Wiley

    Professor David Colquhoun

  51. Single‐channel analysis of an NMDA receptor possessing a mutation in the region of the glutamate binding site

    Article • The Journal of Physiology, September 2000, Wiley

    Professor David Colquhoun

  52. Letters to the editor

    Article • Annals of Allergy Asthma & Immunology, June 2000, Elsevier

    Professor Stephen J Senn, Professor David Colquhoun

  53. Pharmacologic Analysis of Drug–Receptor Interaction (3rd edn)

    Article • Trends in Pharmacological Sciences, December 1998, Elsevier

    Professor David Colquhoun

  54. Binding, gating, affinity and efficacy: The interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

    Article • British Journal of Pharmacology, November 1998, Wiley

    Professor David Colquhoun

  55. Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors

    Article • The Journal of Physiology, July 1998, Wiley

    Professor David Colquhoun

  56. From Muscle Endplate to Brain Synapses: A Short History of Synapses and Agonist-Activated Ion Channels

    Article • Neuron, March 1998, Elsevier

    Professor David Colquhoun

  57. The ion channel properties of a rat recombinant neuronal nicotinic receptor are dependent on the host cell type

    Article • The Journal of Physiology, December 1997, Wiley

    Professor David Colquhoun

  58. Properties of single ion channel currents elicted by a pulse of agonist concentration or voltage

    Article • Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, September 1997, Royal Society Publishing

    Professor David Colquhoun

  59. Worthless ranking

    Article • Nature, March 1997, Springer Science + Business Media

    Professor David Colquhoun

  60. The pharmacological actions of polymethylene bistrimethylammonium salts

    Article • British Journal of Pharmacology, February 1997, Wiley

    Professor David Colquhoun

  61. Joint Distributions of Apparent Open and Shut Times of Single-Ion Channels and Maximum Likelihood Fitting of Mechanisms

    Article • Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, November 1996, Royal Society Publishing

    Professor David Colquhoun

  62. Desensitization of N-methyl-D-aspartate receptors: a problem of interpretation.

    Article • Proceedings of the National Academy of Sciences, October 1995, Proceedings of the National Academy of Sciences

    Professor David Colquhoun

  63. A P2X purinoceptor expressed by a subset of sensory neurons

    Article • Nature, October 1995, Springer Science + Business Media

    Professor David Colquhoun

  64. Acetylcholine receptors: too many channels, too few functions

    Article • Science, September 1995, American Association for the Advancement of Science

    Professor David Colquhoun

  65. Activation of NMDA receptors

    Article • February 1995, Oxford University Press (OUP)

    Professor David Colquhoun

  66. A Q-Matrix Cookbook

    Article • January 1995, Springer Science + Business Media

    Professor David Colquhoun

  67. Fitting and Statistical Analysis of Single-Channel Records

    Article • January 1995, Springer Science + Business Media

    Professor David Colquhoun

  68. The Principles of the Stochastic Interpretation of Ion-Channel Mechanisms

    Article • January 1995, Springer Science + Business Media

    Professor David Colquhoun

  69. Ion channels of excitable cells (Methods in neurosciences Vol. 19)

    Article • Trends in Biochemical Sciences, September 1994, Elsevier

    Professor David Colquhoun

  70. The binding issue

    Article • Nature, December 1993, Springer Science + Business Media

    Professor David Colquhoun

  71. Asymptotic Distributions of Apparent Open Times and Shut Times in a Single Channel Record Allowing for the Omission of Brief Events

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, September 1992, Royal Society Publishing

    Professor David Colquhoun

  72. ATP receptor-mediated synaptic currents in the central nervous system

    Article • Nature, September 1992, Springer Science + Business Media

    Professor David Colquhoun

  73. Unravelling the paradox

    Article • Trends in Pharmacological Sciences, January 1992, Elsevier

    Professor David Colquhoun

  74. Ion channels: this year's Nobel prize in physiology or medicine.

    Article • BMJ, October 1991, BMJ

    Professor David Colquhoun

  75. Conductance and kinetic properties of single nicotinic acetylcholine receptor channels in rat sympathetic neurones.

    Article • The Journal of Physiology, July 1991, Wiley

    Professor David Colquhoun, Professor Alistair Mathie

  76. Trials of homoeopathy

    Article • BMJ, June 1991, BMJ

    Professor David Colquhoun

  77. Activation of ion channels in the frog endplate by several analogues of acetylcholine.

    Article • The Journal of Physiology, February 1991, Wiley

    Professor David Colquhoun

  78. Neher and Sakmann win Nobel Prize for patch-clamp work

    Article • Trends in Pharmacological Sciences, January 1991, Elsevier

    Professor David Colquhoun

  79. The Distributions of the Apparent Open Times and Shut Times in a Single Channel Record when Brief Events Cannot Be Detected

    Article • Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, September 1990, Royal Society Publishing

    Professor David Colquhoun

  80. The actions of suxamethonium (succinyldicholine) as an agonist and channel blocker at the nicotinic receptor of frog muscle.

    Article • The Journal of Physiology, September 1990, Wiley

    Professor David Colquhoun

  81. Re-analysis of clinical trial of homoeopathic treatment in fibrositis

    Article • The Lancet, August 1990, Elsevier

    Professor David Colquhoun

  82. Rectification of currents activated by nicotinic acetylcholine receptors in rat sympathetic ganglion neurones.

    Article • The Journal of Physiology, August 1990, Wiley

    Professor David Colquhoun, Professor Alistair Mathie

  83. Stochastic Properties of Ion Channel Openings and Bursts in a Membrane Patch that Contains Two Channels: Evidence Concerning the Number of Channels Present when a Record Containing Only Single Openings is Observed

    Article • Proceedings of the Royal Society B Biological Sciences, June 1990, Royal Society Publishing

    Professor David Colquhoun

  84. Validity of the operational model

    Article • Trends in Pharmacological Sciences, January 1989, Elsevier

    Professor David Colquhoun

  85. Ion channels (vol. 1)

    Article • Trends in Pharmacological Sciences, October 1988, Elsevier

    Professor David Colquhoun

  86. On the Kinetics of Large-Conductance Glutamate-Receptor Ion Channels in Rat Cerebellar Granule Neurons

    Article • Proceedings of the Royal Society B Biological Sciences, May 1988, Royal Society Publishing

    Professor David Colquhoun

  87. Single channel analysis costs time

    Article • Trends in Pharmacological Sciences, May 1988, Elsevier

    Professor David Colquhoun

  88. Activation of ion channels in the frog end-plate by high concentrations of acetylcholine.

    Article • The Journal of Physiology, January 1988, Wiley

    Professor David Colquhoun

  89. Nicotinic acetylcholine receptors of nerve and muscle: Functional aspects

    Article • Trends in Pharmacological Sciences, December 1987, Elsevier

    Professor David Colquhoun, Professor Alistair Mathie

  90. Single-Channel and Whole-Cell Currents Evoked by Acetylcholine in Dissociated Sympathetic Neurons of the Rat

    Article • Proceedings of the Royal Society B Biological Sciences, November 1987, Royal Society Publishing

    Professor David Colquhoun, Professor Alistair Mathie

  91. Ogden et al. reply

    Article • Trends in Pharmacological Sciences, September 1987, Elsevier

    Professor David Colquhoun

  92. A new type of ion-channel block

    Article • Nature, September 1987, Springer Science + Business Media

    Professor David Colquhoun

  93. Regulation of the acetylcholine receptor

    Article • Trends in Pharmacological Sciences, August 1987, Elsevier

    Professor David Colquhoun

  94. A Note on Correlations in Single Ion Channel Records

    Article • Proceedings of the Royal Society B Biological Sciences, February 1987, Royal Society Publishing

    Professor David Colquhoun

  95. Molecular pharmacology: Structure and function of acetyl-choline-receptor ion channels

    Article • Nature, May 1986, Springer Science + Business Media

    Professor David Colquhoun

  96. Practical statistics for experimental biologists

    Article • Trends in Pharmacological Sciences, January 1986, Elsevier

    Professor David Colquhoun

  97. Caution: agonists are complex

    Article • Trends in Pharmacological Sciences, January 1986, Elsevier

    Professor David Colquhoun

  98. Mechanism of action of the nicotinic acetylcholine receptor, Advanced Research Workshop, Island of Santorini, Greece. May 19–23, 1986

    Article • Trends in Pharmacological Sciences, January 1986, Elsevier

    Professor David Colquhoun

  99. On the Principles of Postsynaptic Action of Neuromuscular Blocking Agents

    Article • January 1986, Springer Science + Business Media

    Professor David Colquhoun

  100. States of the Nicotinic Acetylcholine Receptor: Enumeration, Characteristics and Structure

    Article • January 1986, Springer Science + Business Media

    Professor David Colquhoun

  101. Ion Channel Block by Acetylcholine, Carbachol and Suberyldicholine at the Frog Neuromuscular Junction

    Article • Proceedings of the Royal Society B Biological Sciences, September 1985, Royal Society Publishing

    Professor David Colquhoun

  102. Imprecision in presentation of binding studies

    Article • Trends in Pharmacological Sciences, January 1985, Elsevier

    Professor David Colquhoun

  103. Conductances of single ion channels opened by nicotinic agonists are indistinguishable

    Article • Nature, May 1984, Springer Science + Business Media

    Professor David Colquhoun

  104. Kinetics of acetylcholine activated ion channels in chick ciliary ganglion neurones grown in tissue culture

    Article • Pflügers Archiv - European Journal of Physiology, January 1984, Springer Science + Business Media

    Professor David Colquhoun

  105. The efficacy of agonists at the frog neuromuscular junction studied with single channel recording

    Article • Pflügers Archiv - European Journal of Physiology, November 1983, Springer Science + Business Media

    Professor David Colquhoun

  106. Introduction to Membrane Noise Louis J. DeFelice

    Article • The Quarterly Review of Biology, June 1983, University of Chicago Press

    Professor David Colquhoun

  107. Medical pharmacology, principles and concepts

    Article • Trends in Pharmacological Sciences, January 1983, Elsevier

    Professor David Colquhoun

  108. Fitting and Statistical Analysis of Single-Channel Records

    Article • January 1983, Springer Science + Business Media

    Professor David Colquhoun

  109. Bursts of Openings in Transmitter-Activated Ion Channels

    Article • January 1983, Springer Science + Business Media

    Professor David Colquhoun

  110. The Principles of the Stochastic Interpretation of Ion-Channel Mechanisms

    Article • January 1983, Springer Science + Business Media

    Professor David Colquhoun

  111. On the Stochastic Properties of Bursts of Single Ion Channel Openings and of Clusters of Bursts

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, December 1982, Royal Society Publishing

    Professor David Colquhoun

  112. Introductory statistics

    Article • Trends in Pharmacological Sciences, January 1982, Elsevier

    Professor David Colquhoun

  113. THE EFFECT OF TUBOCURARINE COMPETITION ON THE KINETICS OF AGONIST ACTION ON THE NICOTINIC RECEPTOR

    Article • British Journal of Pharmacology, January 1982, Wiley

    Professor David Colquhoun

  114. THE ACTION OF GANGLIONIC BLOCKING DRUGS ON THE SYNAPTIC RESPONSES OF RAT SUBMANDIBULAR GANGLION CELLS

    Article • British Journal of Pharmacology, January 1982, Wiley

    Professor David Colquhoun

  115. Inward current channels activated by intracellular Ca in cultured cardiac cells

    Article • Nature, December 1981, Springer Science + Business Media

    Professor David Colquhoun

  116. Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels

    Article • Nature, December 1981, Springer Science + Business Media

    Professor David Colquhoun

  117. On the Stochastic Properties of Single Ion Channels

    Article • Proceedings of the Royal Society B Biological Sciences, March 1981, Royal Society Publishing

    Professor David Colquhoun

  118. Block of acetylcholine-activated ion channels by an uncharged local anaesthetic

    Article • Nature, February 1981, Springer Science + Business Media

    Professor David Colquhoun

  119. How fast do drugs work?

    Article • Trends in Pharmacological Sciences, January 1981, Elsevier

    Professor David Colquhoun

  120. Cooperative Equilibrium in Physical Biochemistry

    Article • Biometrics, September 1979, JSTOR

    Professor David Colquhoun

  121. The actions of tubocurarine at the frog neuromuscular junction.

    Article • The Journal of Physiology, August 1979, Wiley

    Professor David Colquhoun

  122. The Link between Drug Binding and Response: Theories and Observations

    Article • January 1979, Springer Science + Business Media

    Professor David Colquhoun

  123. Relaxation and Fluctuations of Membrane Currents that Flow through Drug-Operated Channels

    Article • Proceedings of the Royal Society B Biological Sciences, November 1977, Royal Society Publishing

    Professor David Colquhoun

  124. An analysis of the action of a false transmitter at the neuromuscular junction.

    Article • The Journal of Physiology, April 1977, Wiley

    Professor David Colquhoun

  125. Mechanisms of Drug Action at the Voluntary Muscle Endplate

    Article • Annual Review of Pharmacology, April 1975, Annual Reviews

    Professor David Colquhoun

  126. The binding of tetrodotoxin and α-bungarotoxin to normal and denervated mammalian muscle

    Article • The Journal of Physiology, July 1974, Wiley

    Professor David Colquhoun

  127. Lectures on Biostatistics.

    Article • Journal of the American Statistical Association, September 1972, JSTOR

    Professor David Colquhoun

  128. The interaction at equilibrium between tetrodotoxin and mammalian non-myelinated nerve fibres

    Article • The Journal of Physiology, March 1972, Wiley

    Professor David Colquhoun

  129. Rapid histamine assays: a method and some theoretical considerations

    Article • British Journal of Pharmacology, January 1970, Wiley

    Professor David Colquhoun

  130. A Comparison of Estimators for a Two-Parameter Hyperbola

    Article • Journal of the Royal Statistical Society Series C (Applied Statistics), January 1969, JSTOR

    Professor David Colquhoun

  131. Adsorption and diffusion of gamma-globulin during passive sensitization of chopped guinea-pig lung.

    Article • The Journal of Physiology, December 1965, Wiley

    Professor David Colquhoun

  132. BALANCED INCOMPLETE BLOCK DESIGNS IN BIOLOGICAL ASSAY ILLUSTRATED BY THE ASSAY OF GASTRIN USING A YOUDEN SQUARE

    Article • British Journal of Pharmacology and Chemotherapy, August 1963, Wiley

    Professor David Colquhoun