All Stories

  1. Citrullination of histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myeloma

    Article • Leukemia, July 2016, Nature

    Dr Daniel A Tennant

  2. HG-100THE ROLE OF HYPOXIA ON LIPID DROPLET PRODUCTION IN GLIOBLASTOMA

    Article • Neuro-Oncology, June 2016, Oxford University Press (OUP)

    Dr Daniel A Tennant

  3. Mitochondrial metabolic remodeling in response to genetic and environmental perturbations

    Article • WIREs Systems Biology and Medicine, May 2016, Wiley

    Dr Daniel A Tennant

  4. Probing Cancer Cell Metabolism Using NMR Spectroscopy

    Article • January 2016, Springer Science + Business Media

    Dr Daniel A Tennant

  5. A New Method for Module Identification with Application to Cancer Disease Module Discovery

    Article • IEEE Transactions on Evolutionary Computation, January 2016, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Daniel A Tennant, Dr Qiang Huang

  6. Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

    Article • Nature Communications, November 2015, Nature

    Dr Daniel A Tennant

  7. GENO-34UNBIASED BIOINFORMATIC CLUSTERING ANALYSIS REVEALS HIGH RISK PATIENT POPULATION OF GRADE 2 GLIOMAS

    Article • Neuro-Oncology, November 2015, Oxford University Press (OUP)

    Dr Daniel A Tennant

  8. PO27IDH1 MUTATIONS COMPROMISE THE ADAPTIVE RESPONSE TO HYPOXIA

    Article • Neuro-Oncology, November 2015, Oxford University Press (OUP)

    Dr Daniel A Tennant

  9. Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma

    Article • Blood Cancer Journal, October 2015, Nature

    Dr Daniel A Tennant

  10. A roadmap for interpreting 13C metabolite labeling patterns from cells

    Article • Current Opinion in Biotechnology, August 2015, Elsevier

    Dr Emmanuelle J Meuillet, Dr Daniel A Tennant, Prof. Markus Ralser

  11. Metabolic plasticity in CLL: adaptation to the hypoxic niche

    Article • Leukemia, July 2015, Nature

    Dr Daniel A Tennant

  12. Metabolomic Analysis of Perfusate During Hypothermic Machine Perfusion of Human Cadaveric Kidneys

    Article • Transplantation, April 2015, Wolters Kluwer Health

    Dr Daniel A Tennant

  13. Metabolomic Perfusate Analysis during Kidney Machine Perfusion: The Pig Provides an Appropriate Model for Human Studies

    Article • PLoS ONE, December 2014, PLOS

    Dr Daniel A Tennant

  14. Hypoxia inducible factors in liver disease and hepatocellular carcinoma: Current understanding and future directions

    Article • Journal of Hepatology, December 2014, Elsevier

    Dr Daniel A Tennant

  15. The role of HIFs in ischemia-reperfusion injury

    Article • Hypoxia, July 2014, Dove Medical Press

    Dr Daniel A Tennant

  16. P191 HEPATITIS B AND C VIRUS PROMOTE CROSSTALK BETWEEN HYPOXIA AND GLUCOCORTICOID SIGNALLING PATHWAYS TO RE-PROGRAMME HEPATOCYTE METABOLISM AND TO EVADE HOST INTERFERONS

    Article • Journal of Hepatology, April 2014, Elsevier

    Dr Daniel A Tennant

  17. DiME: A Scalable Disease Module Identification Algorithm with Application to Glioma Progression

    Article • PLoS ONE, February 2014, PLOS

    Dr Daniel A Tennant

  18. A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

    Article • Cell Reports, May 2013, Elsevier

    Dr Patrick J Pollard, Dr Daniel A Tennant

  19. Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells

    Article • Cell Metabolism, December 2012, Elsevier

    Dr Daniel A Tennant

  20. Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway

    Article • Cell Metabolism, March 2012, Elsevier

    Dr Mogens Johannsen, Dr Patrick J Pollard, Dr Daniel A Tennant

  21. From Transcriptional Profiling to Tumor Biology in Pheochromocytoma and Paraganglioma

    Article • Endocrine Pathology, February 2012, Springer Science + Business Media

    Dr Daniel A Tennant

  22. Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival

    Article • PLoS ONE, September 2011, PLOS

    Dr Daniel A Tennant

  23. PK-M2 Makes Cells Sweeter on HIF1

    Article • Cell, May 2011, Elsevier

    Dr Daniel A Tennant

  24. HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression

    Article • Journal of Molecular Medicine, April 2010, Springer Science + Business Media

    Dr Daniel A Tennant

  25. Targeting metabolic transformation for cancer therapy

    Article • Nature Reviews Drug Discovery, March 2010, Nature

    Dr Daniel A Tennant

  26. IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip

    Article • Cancer Cell, January 2010, Elsevier

    Dr Daniel A Tennant

  27. Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death

    Article • Oncogene, August 2009, Nature

    Dr Daniel A Tennant

  28. Metabolic transformation in cancer

    Article • Carcinogenesis, March 2009, Oxford University Press (OUP)

    Dr Daniel A Tennant

  29. Cell-Permeating α-Ketoglutarate Derivatives Alleviate Pseudohypoxia in Succinate Dehydrogenase-Deficient Cells

    Article • Molecular and Cellular Biology, February 2007, ASM Journals

    Dr Daniel A Tennant