All Stories

  1. Neutron scattering from myelin revisited: bilayer asymmetry and water-exchange kinetics

    Article • Acta Crystallographica Section D Biological Crystallography, November 2014, International Union of Crystallography

    Professor D.A. Kirschner

  2. Myelin Organization in the Nodal, Paranodal, and Juxtaparanodal Regions Revealed by Scanning X-Ray Microdiffraction

    Article • PLoS ONE, July 2014, PLOS

    Professor D.A. Kirschner

  3. A Bacteriophage Capsid Protein Provides a General Amyloid Interaction Motif (GAIM) That Binds and Remodels Misfolded Protein Assemblies

    Article • Journal of Molecular Biology, June 2014, Elsevier

    Dr Rajaraman Krishnan, Professor D.A. Kirschner

  4. 22 NPT002: a novel approach for targeting β-amyloid and tau aggregates in Alzheimer's disease

    Article • Neurobiology of Aging, May 2012, Elsevier

    Professor D.A. Kirschner

  5. Myelin structure is unaltered in chemotherapy-induced peripheral neuropathy

    Article • NeuroToxicology, January 2012, Elsevier

    Professor D.A. Kirschner

  6. P4‐412: NPT001: A candidate therapeutic for clearance of beta‐amyloid and tau aggregates in Alzheimer's disease

    Article • Alzheimer s & Dementia, July 2011, Wiley

    Dr Rajaraman Krishnan, Professor D.A. Kirschner

  7. P2‐456: NPT001: A candidate therapeutic for clearance of β‐amyloid and tau aggregates in Alzheimer's disease

    Article • Alzheimer s & Dementia, July 2011, Wiley

    Dr Rajaraman Krishnan, Professor D.A. Kirschner

  8. P0 (Protein Zero) Mutation S34C Underlies Instability of Internodal Myelin in S63C Mice

    Article • Journal of Biological Chemistry, October 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor D.A. Kirschner

  9. SCAP is required for timely and proper myelin membrane synthesis

    Article • Proceedings of the National Academy of Sciences, December 2009, Proceedings of the National Academy of Sciences

    Professor D.A. Kirschner

  10. Rapid assessment of internodal myelin integrity in central nervous system tissue

    Article • Journal of Neuroscience Research, September 2009, Wiley

    Professor D.A. Kirschner

  11. Myelin: A One-Dimensional Biological “Crystal” for X-Ray and Neutron Scattering

    Article • April 2009, World Scientific Pub Co Pte Lt

    Professor D.A. Kirschner

  12. Myelin Structural Integrity in a Model for Human Early-Onset CMT1B

    Article • Biophysical Journal, February 2009, Elsevier

    Professor D.A. Kirschner

  13. O3‐05–01: A novel approach to screening inhibitors of amyloid formation

    Article • Alzheimer s & Dementia, July 2008, Wiley

    Professor D.A. Kirschner

  14. Fiber Diffraction As a Screen for Amyloid Inhibitors

    Article • Current Alzheimer Research, June 2008, Bentham Science Publishers

    Professor D.A. Kirschner

  15. Myelin structure and composition of myelinated tissue in the African lungfish

    Article • Neuron Glia Biology, May 2008, Cambridge University Press

    Professor D.A. Kirschner

  16. Peripheral myelin of Xenopus laevis: Role of electrostatic and hydrophobic interactions in membrane compaction

    Article • Journal of Structural Biology, April 2008, Elsevier

    Professor D.A. Kirschner

  17. Molecular characterization of myelin protein zero in Xenopus laevis peripheral nerve: Equilibrium between non-covalently associated dimer and monomer

    Article • International Journal of Mass Spectrometry, December 2007, Elsevier

    Professor D.A. Kirschner

  18. Cytoplasmic Domain of Zebrafish Myelin Protein Zero: Adhesive Role Depends on β-Conformation

    Article • Biophysical Journal, November 2007, Elsevier

    Professor D.A. Kirschner

  19. Refined Fibril Structures: The Hydrophobic Core in Alzheimer's Amyloid β‐Protein and Prion as Revealed by X‐ray Diffraction

    Article • September 2007, Wiley

    Professor D.A. Kirschner

  20. Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis

    Article • Journal of Negative Results in BioMedicine, July 2007, Springer Science + Business Media

    Professor D.A. Kirschner

  21. Cytoplasmic Domain of Human Myelin Protein Zero Likely Folded as β-Structure in Compact Myelin

    Article • Biophysical Journal, March 2007, Elsevier

    Professor D.A. Kirschner

  22. Myelin Structure and Composition in Zebrafish

    Article • Neurochemical Research, January 2007, Springer Science + Business Media

    Professor D.A. Kirschner

  23. Myelin Structure and Composition in Zebrafish

    Article • Neurochemical Research, September 2006, Springer Science + Business Media

    Professor D.A. Kirschner

  24. Gerstmann-Straussler-Scheinker Disease Amyloid Protein Polymerizes According to the "Dock-and-Lock" Model

    Article • Journal of Biological Chemistry, November 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor D.A. Kirschner

  25. Structure and Stability of Internodal Myelin in Mouse Models of Hereditary Neuropathy

    Article • Journal of Neuropathology & Experimental Neurology, November 2005, Oxford University Press (OUP)

    Professor D.A. Kirschner

  26. Poly‐(L‐alanine) expansions form core β‐sheets that nucleate amyloid assembly

    Article • Proteins Structure Function and Bioinformatics, August 2005, Wiley

    Professor D.A. Kirschner

  27. P3-357 Structural properties of gerstmann-Sträussler-Scheinker disease amyloid protein

    Article • Neurobiology of Aging, July 2004, Elsevier

    Professor D.A. Kirschner

  28. O2-06-01 Protein folding and amyloid formation: studies on poly(L-alanine) and poly(L-glutamine)

    Article • Neurobiology of Aging, July 2004, Elsevier

    Professor D.A. Kirschner

  29. The P0 Gene

    Article • January 2004, Elsevier

    Professor D.A. Kirschner

  30. Structural Properties of Gerstmann-Sträussler-Scheinker Disease Amyloid Protein

    Article • Journal of Biological Chemistry, September 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor D.A. Kirschner

  31. Molecular Organization of Amyloid Protofilament-Like Assembly of Betabellin 15D: Helical Array of β-Sandwiches

    Article • Biophysical Journal, September 2002, Elsevier

    Professor D.A. Kirschner

  32. Myelin protein zero exists as dimers and tetramers in native membranes ofXenopus laevis peripheral nerve

    Article • Journal of Neuroscience Research, February 2002, Wiley

    Professor D.A. Kirschner

  33. Expression and Purification of the Extracellular Domain of Human Myelin Protein Zero

    Article • Protein Expression and Purification, December 2001, Elsevier

    Professor D.A. Kirschner

  34. Twist and Sheet: Variations on the Theme of Amyloid

    Article • Journal of Structural Biology, June 2000, Elsevier

    Professor D.A. Kirschner

  35. Electron microscopy and X-ray diffraction studies further confirm the efficacy of PTI-000703™ (Cat's claw derivative) as a potent inhibitor of Alzheimer's beta-amyloid protein fibrillogenesis

    Article • Neurobiology of Aging, May 2000, Elsevier

    Professor D.A. Kirschner

  36. Multilamellar packing of myelin modeled by lipid-bound MBP

    Article • Journal of Neuroscience Research, February 2000, Wiley

    Professor D.A. Kirschner

  37. Histidine residues underlie Congo red binding to Aβ analogs

    Article • Amyloid, January 2000, Taylor & Francis

    Professor D.A. Kirschner

  38. Laminin inhibition of ?-amyloid protein (A?) fibrillogenesis and identification of an A? binding site localized to the globular domain repeats on the laminin a chain

    Article • Journal of Neuroscience Research, January 2000, Wiley

    Professor D.A. Kirschner

  39. Tetrameric Assembly of Full-Sequence Protein Zero Myelin Glycoprotein by Synchrotron X-Ray Scattering

    Article • Biophysical Journal, January 1999, Elsevier

    Professor D.A. Kirschner

  40. In VitroAmyloid Fibril Formation by Synthetic Peptides Corresponding to the Amino Terminus of apoSAA Isoforms from Amyloid-Susceptible and Amyloid-Resistant Mice

    Article • Journal of Structural Biology, December 1998, Elsevier

    Professor D.A. Kirschner

  41. Analysis of x-ray diffraction patterns from amyloid of biopsied vitreous humor and kidney of transthyretin (TTR) Met30 familial amyloidotic polyneuropathy (FAP) patients: axially arrayed TTR monomers constitute the protofilament

    Article • Amyloid, January 1998, Taylor & Francis

    Professor D.A. Kirschner

  42. Structural Analysis of Alzheimer's β(1–40) Amyloid: Protofilament Assembly of Tubular Fibrils

    Article • Biophysical Journal, January 1998, Elsevier

    Professor D.A. Kirschner

  43. Kinetic theory of fibrillogenesis of amyloid β-protein

    Article • Proceedings of the National Academy of Sciences, July 1997, Proceedings of the National Academy of Sciences

    Professor D.A. Kirschner

  44. Spinal cord myelin is vulnerable to decompression

    Article • Molecular and Chemical Neuropathology, April 1997, Springer Science + Business Media

    Professor D.A. Kirschner

  45. Membrane adhesion in peripheral myelin: good and bad wraps with protein P0

    Article • Structure, November 1996, Elsevier

    Professor D.A. Kirschner

  46. On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants.

    Article • Proceedings of the National Academy of Sciences, February 1996, Proceedings of the National Academy of Sciences

    Professor D.A. Kirschner

  47. 526 Kinetic analysis of all fibrillogenesis

    Article • Neurobiology of Aging, January 1996, Elsevier

    Professor D.A. Kirschner

  48. Immunolocalization of 17 and 21.5 kDa MBP isoforms in compact myelin and radial component

    Article • Journal of Neurocytology, January 1996, Springer Science + Business Media

    Professor D.A. Kirschner

  49. Effects of Rumpshaker Mutation on CNS Myelin Composition and Structure

    Article • Journal of Neurochemistry, January 1996, Wiley

    Professor D.A. Kirschner

  50. Implications of the sequence similarities between tau and myelin basic protein

    Article • Medical Hypotheses, September 1995, Elsevier

    Professor D.A. Kirschner

  51. Conformation and Fibrillogenesis of Alzheimer Aβ Peptides with Selected Substitution of Charged Residues

    Article • Journal of Molecular Biology, November 1994, Elsevier

    Professor D.A. Kirschner

  52. Mutations in demyelinating peripheral neuropathies support molecular model of myelin PO‐glycoprotein extracellular domain

    Article • Journal of Neuroscience Research, September 1994, Wiley

    Professor D.A. Kirschner

  53. Membrane topology of PLP in CNS myelin: Evaluation of models

    Article • Neurochemical Research, August 1994, Springer Science + Business Media

    Professor D.A. Kirschner

  54. Mice deficient for the glycoprotein show subtle abnormalities in myelin

    Article • Neuron, July 1994, Elsevier

    Professor D.A. Kirschner, Dirk Montag

  55. Restricted hypotonic swelling of peripheral nerve myelin in streptozocin-induced diabetic rats

    Article • Journal of Neuroscience Research, June 1994, Wiley

    Professor D.A. Kirschner

  56. Protein and Lipid Composition of Radial Component‐Enriched CNS Myelin

    Article • Journal of Neurochemistry, March 1994, Wiley

    Professor D.A. Kirschner

  57. Myelin P0‐Glycoprotein: Predicted Structure and Interactions of Extracellular Domain

    Article • Journal of Neurochemistry, December 1993, Wiley

    Professor D.A. Kirschner

  58. Thioridazine induces lipid peroxidation in myelin of rat brain

    Article • Neuropharmacology, February 1993, Elsevier

    Professor D.A. Kirschner

  59. Structure of beta-crystallite assemblies formed by Alzheimer beta-amyloid protein analogues: analysis by x-ray diffraction

    Article • Biophysical Journal, February 1993, Elsevier

    Professor D.A. Kirschner

  60. Fibril formation by primate, rodent, and Dutch-hemorrhagic analogs of Alzheimer amyloid .beta.-protein

    Article • Biochemistry, November 1992, American Chemical Society (ACS)

    Professor D.A. Kirschner

  61. Effects of Sulfate Ions on Alzheimer β/A4 Peptide Assemblies: Implications for Amyloid Fibril‐Proteoglycan Interactions

    Article • Journal of Neurochemistry, October 1992, Wiley

    Professor D.A. Kirschner

  62. Is myelin basic protein crystallizable?

    Article • Neurochemical Research, February 1992, Springer Science + Business Media

    Professor D.A. Kirschner

  63. Amyloid-like properties of a synthetic peptide corresponding to the carboxy terminus of β-amyloid protein precursor

    Article • Archives of Biochemistry and Biophysics, January 1992, Elsevier

    Professor D.A. Kirschner

  64. pH-dependent structural transitions of Alzheimer amyloid peptides

    Article • Biophysical Journal, November 1991, Elsevier

    Professor D.A. Kirschner

  65. Morphology and antibody recognition of synthetic β‐amyloid peptides

    Article • Journal of Neuroscience Research, April 1991, Wiley

    Professor D.A. Kirschner

  66. P0-glycoprotein of myelin: Orientation of its extracellular domain in homophilic adhesion

    Article • Journal of Neuroimmunology, January 1991, Elsevier

    Professor D.A. Kirschner

  67. Quantitative Differences between Homozygous 'USA' and 'Swiss' <i>mld</i>Mutant Mice

    Article • Developmental Neuroscience, January 1991, Karger Publishers

    Professor D.A. Kirschner

  68. Folding and function of the myelin proteins from primary sequence data

    Article • Journal of Neuroscience Research, January 1991, Wiley

    Professor D.A. Kirschner

  69. Morphology, conformation and stability of Alzheimer β-amyloid peptide fibrils

    Article • January 1991, Springer Science + Business Media

    Professor D.A. Kirschner

  70. Fine‐Structure and Supramolecular Organization of the Radial Component of CNS Myelina

    Article • Annals of the New York Academy of Sciences, November 1990, Wiley

    Professor D.A. Kirschner

  71. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

    Article • Science, October 1990, American Association for the Advancement of Science

    Professor D.A. Kirschner

  72. Radial component of CNS myelin: Junctional subunit structure and supramolecular assembly

    Article • Journal of Neurocytology, April 1990, Springer Science + Business Media

    Professor D.A. Kirschner

  73. Molecular determinants of amyloid deposition in Alzheimer's disease: conformational studies of synthetic .beta.-protein fragments

    Article • Biochemistry, March 1990, American Chemical Society (ACS)

    Professor D.A. Kirschner

  74. Phylogenetic Aspects of Myelin Structure

    Article • January 1990, Springer Science + Business Media

    Professor D.A. Kirschner

  75. Myelin Membrane Structure and Composition Correlated: A Phylogenetic Study

    Article • Journal of Neurochemistry, November 1989, Wiley

    Professor D.A. Kirschner

  76. X‐ray diffraction analysis of myelin lipid/proteolipid protein multilayers

    Article • Journal of Neuroscience Research, October 1989, Wiley

    Professor D.A. Kirschner

  77. Membrane structure in isolated and intact myelins

    Article • Biophysical Journal, July 1989, Elsevier

    Professor D.A. Kirschner

  78. Proton magnetic resonance in myelin deficient brains of mutant mice

    Article • Journal of the Neurological Sciences, June 1989, Elsevier

    Professor D.A. Kirschner

  79. Orientation of Proteolipid Protein in Myelin: Comparison of Models with X-Ray Diffraction Measurements

    Article • Developmental Neuroscience, January 1989, Karger Publishers

    Professor D.A. Kirschner

  80. Membrane Interactions Are Altered in Myelin Isolated from Central and Peripheral Nervous System Tissues

    Article • Journal of Neurochemistry, July 1988, Wiley

    Professor D.A. Kirschner

  81. Membrane interactions in nerve myelin: II. Determination of surface charge from biochemical data

    Article • Biophysical Journal, February 1988, Elsevier

    Professor D.A. Kirschner

  82. Membrane interactions in nerve myelin. I. Determination of surface charge from effects of pH and ionic strength on period

    Article • Biophysical Journal, February 1988, Elsevier

    Professor D.A. Kirschner

  83. Comparison of amyloid from Alzheimer’s disease with synthetic peptide

    Article • January 1988, Springer Science + Business Media

    Professor D.A. Kirschner

  84. Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.

    Article • Proceedings of the National Academy of Sciences, October 1987, Proceedings of the National Academy of Sciences

    Professor D.A. Kirschner

  85. 171 Hl-NMR RELAXATION TIMES IN MYELIN DEFICIENT BRAINS OF MUTANT MICE

    Article • Investigative Radiology, September 1986, Wolters Kluwer Health

    Professor D.A. Kirschner

  86. X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation.

    Article • Proceedings of the National Academy of Sciences, January 1986, Proceedings of the National Academy of Sciences

    Professor D.A. Kirschner

  87. Shiverer and Normal Peripheral Myelin Compared: Basic Protein Localization, Membrane Interactions, and Lipid Composition

    Article • Journal of Neurochemistry, December 1985, Wiley

    Professor D.A. Kirschner

  88. Effects of ZnCl2 on membrane interactions in myelin of normal and shiverer mice

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, October 1984, Elsevier

    Professor D.A. Kirschner

  89. Diffraction Studies of Molecular Organization and Membrane Interactions in Myelin

    Article • January 1984, Springer Science + Business Media

    Professor D.A. Kirschner

  90. Myelin Membrane from Adrenoleukodystrophy Brain White Matter—Biochemical Properties

    Article • Journal of Neurochemistry, February 1983, Wiley

    Professor D.A. Kirschner

  91. Triethyl tin-induced myelin oedema: an intermediate swelling state detected by X-ray diffraction

    Article • Journal of Neurocytology, August 1982, Springer Science + Business Media

    Professor D.A. Kirschner

  92. Myelin labeled with mercuric chloride

    Article • Journal of Molecular Biology, June 1982, Elsevier

    Professor D.A. Kirschner

  93. Structure of myelin lipid bilayers

    Article • Journal of Molecular Biology, February 1982, Elsevier

    Professor D.A. Kirschner

  94. Processing for electron microscopy alters membrane structure and packing in myelin

    Article • Journal of Ultrastructure Research, November 1980, Elsevier

    Professor D.A. Kirschner

  95. Compact myelin exists in the absence of basic protein in the shiverer mutant mouse

    Article • Nature, January 1980, Springer Science + Business Media

    Professor D.A. Kirschner

  96. X-ray diffraction study of the kinetics of myelin lattice swelling. Effect of divalent cations

    Article • Biophysical Journal, November 1979, Elsevier

    Ph.D. Raúl Padrón, Professor D.A. Kirschner

  97. Structural states of myelin observed by x-ray diffraction and freeze- fracture electron microscopy

    Article • Journal of Cell Biology, July 1979, Rockefeller University Press

    Professor D.A. Kirschner

  98. Diffraction Studies of Molecular Organization in Myelin

    Article • January 1977, Springer Science + Business Media

    Professor D.A. Kirschner

  99. Morphological evidence of alteration in myelin structure with maturation

    Article • Brain Research, September 1976, Elsevier

    Professor D.A. Kirschner

  100. X-ray diffraction study of myelin structure in immature and mutant mice

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, September 1976, Elsevier

    Professor D.A. Kirschner

  101. Myelin structure transformed by dimethylsulfoxide.

    Article • Proceedings of the National Academy of Sciences, September 1975, Proceedings of the National Academy of Sciences

    Professor D.A. Kirschner

  102. COMPARATIVE X-RAY AND NEUTRON DIFFRACTION FROM NERVE MYELIN MEMBRANES

    Article • January 1974, Elsevier

    Professor D.A. Kirschner

  103. COMPARATIVE DIFFRACTION STUDIES ON MYELIN MEMBRANES*

    Article • Annals of the New York Academy of Sciences, June 1972, Wiley

    Professor D.A. Kirschner

  104. Alzheimer’s β-Amyloid: Insights into Fibril Formation and Structure from Congo Red Binding

    Article • Springer Science + Business Media

    Professor D.A. Kirschner

  105. Electron Microscopy and X-ray Diffraction Studies further Confirm the Efficacy of PTI-00703® (Cat's Claw Derivative) as a Potential Inhibitor of Alzheimer's β-Amyloid Protein Fibrillogenesis

    Article • Wiley

    Professor D.A. Kirschner