All Stories

  1. Design, construction, and functional characterization of a tRNA neochromosome in yeast

    Article • Cell, November 2023, Elsevier

    Prof Conrad A Nieduszynski

  2. Systematic Analysis of Copy Number Variations in the Pathogenic Yeast Candida parapsilosis Identifies a Gene Amplification in RTA3 That is Associated with Drug Resistance

    Article • mBio, October 2022, ASM Journals

    Prof Conrad A Nieduszynski

  3. Effectiveness of glass beads for plating cell cultures

    Article • May 2021, American Physical Society (APS)

    Prof Conrad A Nieduszynski

  4. Tos4 mediates gene expression homeostasis through interaction with HDAC complexes independently of H3K56 acetylation

    Article • Journal of Biological Chemistry, January 2021, Elsevier

    Prof Conrad A Nieduszynski

  5. Sir2 mitigates an intrinsic imbalance in origin licensing efficiency between early- and late-replicating euchromatin

    Article • Proceedings of the National Academy of Sciences, June 2020, Proceedings of the National Academy of Sciences

    Catherine Fox, Prof Conrad A Nieduszynski

  6. The Beacon Calculus: A formal method for the flexible and concise modelling of biological systems

    Article • PLoS Computational Biology, March 2020, PLOS

    Prof Conrad A Nieduszynski

  7. DNA copy-number measurement of genome replication dynamics by high-throughput sequencing: the sort-seq, sync-seq and MFA-seq family

    Article • Nature Protocols, February 2020, Springer Science + Business Media

    Prof Conrad A Nieduszynski

  8. Sir2 mitigates an intrinsic imbalance in origin licensing efficiency between early and late replicating euchromatin

    Article • January 2020, Cold Spring Harbor Laboratory Press

    Prof Conrad A Nieduszynski

  9. Genome-wide analysis of DNA replication timing in single cells: Yes! We’re all individuals

    Article • May 2019, Springer Science + Business Media

    Prof Conrad A Nieduszynski

  10. Interspecies conservation of organisation and function between nonhomologous regional centromeres

    Article • Nature Communications, May 2019, Springer Science + Business Media

    Prof Conrad A Nieduszynski

  11. Capturing the dynamics of genome replication on individual ultra-long nanopore sequence reads

    Article • Nature Methods, April 2019, Springer Science + Business Media

    Prof Conrad A Nieduszynski

  12. The Beacon Calculus: A formal method for the flexible and concise modelling of biological systems

    Article • March 2019, Cold Spring Harbor Laboratory Press

    Prof Conrad A Nieduszynski

  13. Cohesin-Mediated Genome Architecture Does Not Define DNA Replication Timing Domains

    Article • Genes, March 2019, MDPI AG

    Prof Conrad A Nieduszynski

  14. Rapid high-resolution measurement of DNA replication timing by droplet digital PCR

    Article • Nucleic Acids Research, July 2018, Oxford University Press (OUP)

    Prof Conrad A Nieduszynski

  15. Evolution of Genome Architecture in Archaea: Spontaneous Generation of a New Chromosome in Haloferax volcanii

    Article • Molecular Biology and Evolution, April 2018, Oxford University Press (OUP)

    Prof Conrad A Nieduszynski

  16. Investigating the role of Rts1 in DNA replication initiation

    Article • Wellcome Open Research, March 2018, Faculty of 1000, Ltd.

    Prof Conrad A Nieduszynski

  17. Rif1 acts through Protein Phosphatase 1 but independent of replication timing to suppress telomere extension in budding yeast

    Article • Nucleic Acids Research, February 2018, Oxford University Press (OUP)

    Prof Conrad A Nieduszynski

  18. Rapid high-resolution measurement of DNA replication timing by droplet digital PCR

    Article • October 2017, Cold Spring Harbor Laboratory Press

    Prof Conrad A Nieduszynski

  19. DNA replication timing influences gene expression level

    Article • The Journal of Cell Biology, May 2017, Rockefeller University Press

    Prof Conrad A Nieduszynski

  20. Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome

    Article • Science, March 2017, American Association for the Advancement of Science

    Prof Conrad A Nieduszynski

  21. Global and Local Regulation of Replication Origin Activity

    Article • January 2016, Springer Science + Business Media

    Prof Conrad A Nieduszynski

  22. Discovery of an Unconventional Centromere in Budding Yeast Redefines Evolution of Point Centromeres

    Article • Current Biology, August 2015, Elsevier

    Prof Conrad A Nieduszynski

  23. A global profile of replicative polymerase usage

    Article • Nature Structural & Molecular Biology, February 2015, Nature

    Prof Conrad A Nieduszynski

  24. Accelerated growth in the absence of DNA replication origins

    Article • Nature, November 2013, Nature

    Prof Conrad A Nieduszynski

  25. High-Resolution Replication Profiles Define the Stochastic Nature of Genome Replication Initiation and Termination

    Article • Cell Reports, November 2013, Elsevier

    Dr Renata Retkute, Prof Conrad A Nieduszynski

  26. The dynamics of genome replication using deep sequencing

    Article • Nucleic Acids Research, October 2013, Oxford University Press (OUP)

    Dr Renata Retkute, Prof Conrad A Nieduszynski

  27. Stochastic association of neighboring replicons creates replication factories in budding yeast

    Article • The Journal of Cell Biology, September 2013, Rockefeller University Press

    Dr Renata Retkute, Prof Conrad A Nieduszynski

  28. A Link between ORC-Origin Binding Mechanisms and Origin Activation Time Revealed in Budding Yeast

    Article • PLoS Genetics, September 2013, PLOS

    Prof Conrad A Nieduszynski

  29. Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts

    Article • Nucleic Acids Research, August 2013, Oxford University Press (OUP)

    Prof Conrad A Nieduszynski

  30. Avoiding chromosome pathology when replication forks collide

    Article • Nature, July 2013, Nature

    Dr Christian J Rudolph, Prof Conrad A Nieduszynski

  31. Kinetochores Coordinate Pericentromeric Cohesion and Early DNA Replication by Cdc7-Dbf4 Kinase Recruitment

    Article • Molecular Cell, June 2013, Elsevier

    Dr Renata Retkute, Prof Conrad A Nieduszynski

  32. High quality de novo sequencing and assembly of the Saccharomyces arboricolus genome

    Article • BMC Genomics, January 2013, Springer Science + Business Media

    Prof Conrad A Nieduszynski

  33. Mathematical modeling of genome replication

    Article • Physical Review E, September 2012, American Physical Society (APS)

    Dr Renata Retkute, Prof Conrad A Nieduszynski

  34. Conservation of replication timing reveals global and local regulation of replication origin activity

    Article • Genome Research, July 2012, Cold Spring Harbor Laboratory Press

    Prof Conrad A Nieduszynski

  35. A Putative Homologue of CDC20/CDH1 in the Malaria Parasite Is Essential for Male Gamete Development

    Article • PLoS Pathogens, February 2012, PLOS

    Dr Anthony A Holder, Prof Conrad A Nieduszynski

  36. OriDB, the DNA replication origin database updated and extended

    Article • Nucleic Acids Research, November 2011, Oxford University Press (OUP)

    Prof Conrad A Nieduszynski

  37. From sequence to function: Insights from natural variation in budding yeasts

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, October 2011, Elsevier

    Prof Conrad A Nieduszynski

  38. Dynamics of DNA Replication in Yeast

    Article • Physical Review Letters, August 2011, American Physical Society (APS)

    Dr Renata Retkute, Prof Conrad A Nieduszynski

  39. Comparative Functional Genomics of the Fission Yeasts

    Article • Science, April 2011, American Association for the Advancement of Science

    Dr Elizabeth Bayne, Prof Conrad A Nieduszynski

  40. Mathematical modelling of whole chromosome replication

    Article • Nucleic Acids Research, May 2010, Oxford University Press (OUP)

    Dr Renata Retkute, Prof Conrad A Nieduszynski

  41. The Origin Recognition Complex Interacts with a Subset of Metabolic Genes Tightly Linked to Origins of Replication

    Article • PLoS Genetics, December 2009, PLOS

    Prof Conrad A Nieduszynski

  42. Detection of Replication Origins Using Comparative Genomics and Recombinational ARS Assay

    Article • January 2009, Springer Science + Business Media

    Prof Conrad A Nieduszynski

  43. Analysis of Chromosome III Replicators Reveals an Unusual Structure for the ARS318 Silencer Origin and a Conserved WTW Sequence within the Origin Recognition Complex Binding Site

    Article • Molecular and Cellular Biology, June 2008, ASM Journals

    Prof Conrad A Nieduszynski

  44. OriDB: a DNA replication origin database

    Article • Nucleic Acids Research, January 2007, Oxford University Press (OUP)

    Prof Conrad A Nieduszynski

  45. Genome-wide identification of replication origins in yeast by comparative genomics

    Article • Genes & Development, July 2006, Cold Spring Harbor Laboratory Press

    Prof Conrad A Nieduszynski

  46. The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription

    Article • Nucleic Acids Research, April 2005, Oxford University Press (OUP)

    Prof Conrad A Nieduszynski

  47. The Cyclin A1-CDK2 Complex Regulates DNA Double-Strand Break Repair

    Article • Molecular and Cellular Biology, October 2004, ASM Journals

    Prof Conrad A Nieduszynski

  48. Cyclin A1 protein shows haplo-insufficiency for normal fertility in male mice

    Article • Reproduction, March 2004, Bioscientifica

    Prof Conrad A Nieduszynski

  49. Ku complex controls the replication time of DNA in telomere regions

    Article • Genes & Development, October 2002, Cold Spring Harbor Laboratory Press

    Prof Conrad A Nieduszynski

  50. Article • Genome Biology, January 2002, Springer Science + Business Media

    Prof Conrad A Nieduszynski

  51. Article • Genome Biology, January 2001, Springer Science + Business Media

    Prof Conrad A Nieduszynski