All Stories

  1. Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development
  2. Biochemical and Antiparasitic Properties of Inhibitors of the Plasmodium falciparum Calcium-Dependent Protein Kinase PfCDPK1
  3. Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation
  4. Optimization of an Imidazopyridazine Series of Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 (PfCDPK1)
  5. Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)
  6. Human red blood cell-adaptedPlasmodium knowlesiparasites: a new model system for malaria research
  7. Plasmodium falciparum Rab5B Is an N-Terminally Myristoylated Rab GTPase That Is Targeted to the Parasite's Plasma and Food Vacuole Membranes
  8. The structure of Plasmodium yoelii merozoite surface protein 119, antibody specificity and implications for malaria vaccine design
  9. Corrigendum to “Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues” [Bioorg. Med. Chem. Lett. 23 (2013) 6019–6024]
  10. Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach
  11. The apicoplast genome of Leucocytozoon caulleryi, a pathogenic apicomplexan parasite of the chicken
  12. Correction: The Unique Structure of the Apicoplast Genome of the Rodent Malaria Parasite Plasmodium chabaudi chabaudi
  13. Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues
  14. Inducible Knockdown of Plasmodium Gene Expression Using the glmS Ribozyme
  15. RON 12, a novel P lasmodium ‐specific rhoptry neck protein important for parasite proliferation
  16. Identification of New PNEPs Indicates a Substantial Non-PEXEL Exportome and Underpins Common Features in Plasmodium falciparum Protein Export
  17. Melatonin Signaling and Its Modulation of PfNF-YB Transcription Factor Expression in Plasmodium falciparum
  18. Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)
  19. The Unique Structure of the Apicoplast Genome of the Rodent Malaria Parasite Plasmodium chabaudi chabaudi
  20. An Ancient Protein Phosphatase, SHLP1, Is Critical to Microneme Development in Plasmodium Ookinetes and Parasite Transmission
  21. Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivaxN-Myristoyltransferase
  22. Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites
  23. The Plasmodium falciparum Schizont Phosphoproteome Reveals Extensive Phosphatidylinositol and cAMP-Protein Kinase A Signaling
  24. Design and Synthesis of Inhibitors of Plasmodium falciparumN-Myristoyltransferase, A Promising Target for Antimalarial Drug Discovery
  25. A Unique Protein Phosphatase with Kelch-Like Domains (PPKL) in Plasmodium Modulates Ookinete Differentiation, Motility and Invasion
  26. Calcium dependent protein kinase 1 and calcium fluxes in the malaria parasite
  27. Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs
  28. Discovery of Plasmodium vivaxN-Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of their Binding Mode
  29. Subcellular Location, Phosphorylation and Assembly into the Motor Complex of GAP45 during Plasmodium falciparum Schizont Development
  30. Correction: A Putative Homologue of CDC20/CDH1 in the Malaria Parasite Is Essential for Male Gamete Development
  31. Extracellular ATP triggers proteolysis and cytosolic Ca2+ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites
  32. A Putative Homologue of CDC20/CDH1 in the Malaria Parasite Is Essential for Male Gamete Development
  33. Sexual Development in Plasmodium: Lessons from Functional Analyses
  34. The mechanism of erythrocyte invasion by the malarial parasite, Plasmodium falciparum
  35. Deletion of a Malaria Invasion Gene Reduces Death and Anemia, in Model Hosts
  36. Comparative decline in funding of European Commission malaria vaccine projects: what next for the European scientists working in this field?
  37. The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP119)
  38. Transgene Optimization, Immunogenicity and In Vitro Efficacy of Viral Vectored Vaccines Expressing Two Alleles of Plasmodium falciparum AMA1
  39. Targeted Disruption of py235ebp-1: Invasion of Erythrocytes by Plasmodium yoelii Using an Alternative Py235 Erythrocyte Binding Protein
  40. Structure ofPlasmodium falciparumADP-ribosylation factor 1
  41. Fine specificity of anti-MSP119 antibodies and multiplicity of Plasmodium falciparum Merozoite Surface Protein 1 types in individuals in Nigeria with sub-microscopic infection
  42. The Armadillo Repeat Protein PF16 Is Essential for Flagellar Structure and Function in Plasmodium Male Gametes
  43. Merozoite surface proteins of the malaria parasite: The MSP1 complex and the MSP7 family
  44. Suppressive and additive effects in protection mediated by combinations of monoclonal antibodies specific for merozoite surface protein 1 of Plasmodium yoelii
  45. Interaction and dynamics of the Plasmodium falciparum MTIP–MyoA complex, a key component of the invasion motor in the malaria parasite
  46. Malaria vaccines – how and when to proceed?
  47. Cellular responses to modified Plasmodium falciparum MSP119 antigens in individuals previously exposed to natural malaria infection
  48. Malaria Vaccines: Where Next?
  49. The role of the cGMP-dependent protein kinase in development of the malaria parasite
  50. Characterization of the repertoire diversity of the Plasmodium falciparum stevor multigene family in laboratory and field isolates
  51. Formin’ an invasion machine: actin polymerization in invading apicomplexans
  52. Formation of the Food Vacuole in Plasmodium falciparum: A Potential Role for the 19 kDa Fragment of Merozoite Surface Protein 1 (MSP119)
  53. Effective induction of high-titer antibodies by viral vector vaccines
  54. ChemInform Abstract: N-Myristoyltransferase: A Prospective Drug Target for Protozoan Parasites
  55. N-Myristoyltransferase: a Prospective Drug Target for Protozoan Parasites
  56. Hyperreactive malarial splenomegaly is associated with low levels of antibodies against red blood cell and Plasmodium falciparum derived glycolipids in Yanomami Amerindians from Venezuela
  57. Site-specific N-terminal labelling of proteinsin vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry
  58. Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum
  59. Optical trapping studies of acto-myosin motor proteins
  60. Epigenetic Silencing of Plasmodium falciparum Genes Linked to Erythrocyte Invasion
  61. The Importance of Human FcγRI in Mediating Protection to Malaria
  62. Structural studies on Plasmodium vivax merozoite surface protein-1
  63. Extensive proteolytic processing of the malaria parasite merozoite surface protein 7 during biosynthesis and parasite release from erythrocytes
  64. Plasmodium thrombospondin related apical merozoite protein (PTRAMP) is shed from the surface of merozoites by PfSUB2 upon invasion of erythrocytes
  65. Dual acylation of the 45kDa gliding-associated protein (GAP45) in Plasmodium falciparum merozoites
  66. A member of the py235 gene family of Plasmodium yoelii encodes an erythrocyte binding protein recognised by a protective monoclonal antibody
  67. Peptide-based inhibitors ofN-myristoyl transferase generated from a lipid/combinatorial peptide chimera library
  68. The MTIP–Myosin A Complex in Blood Stage Malaria Parasites
  69. Antibody-based therapies for malaria
  70. Apical expression of three RhopH1/Clag proteins as components of the Plasmodium falciparum RhopH complex
  71. Malaria Parasite Actin Filaments are Very Short
  72. A novel Sushi domain-containing protein of Plasmodium falciparum
  73. Precise Epitope Mapping of Malaria Parasite Inhibitory Antibodies by TROSY NMR Cross-Saturation
  74. Malaria parasite-inhibitory antibody epitopes on Plasmodium falciparum merozoite surface protein-119 mapped by TROSY NMR
  75. FUNCTIONAL CHARACTERIZATION OF AN LCCL–LECTIN DOMAIN CONTAINING PROTEIN FAMILY IN PLASMODIUM BERGHEI
  76. Inhibitory and neutral antibodies to Plasmodium falciparum MSP119 form ring structures with their antigen
  77. An improved chloramphenicol acetyltransferase assay for Plasmodium falciparum transfection
  78. The Plasmodium falciparum clag9 gene encodes a rhoptry protein that is transferred to the host erythrocyte upon invasion
  79. Disulfide bonds in merozoite surface protein 1 of the malaria parasite impede efficient antigen processing and affect thein vivoantibody response
  80. Systems biology and malaria
  81. Glycosylphosphatidyl-inositols in murine malaria: Plasmodium yoelii yoelii
  82. Characterisation of the rhoph2 gene of Plasmodium falciparum and Plasmodium yoelii
  83. A proteomic view of the Plasmodium falciparum life cycle
  84. PSLAP, a protein with multiple adhesive motifs, is expressed in Plasmodium falciparum gametocytes
  85. Definition of T cell epitopes within the 19 kDa carboxylterminal fragment of Plasmodium yoelii merozoite surface protein 1 (MSP119) and their role in immunity to malaria
  86. The high molecular mass rhoptry protein, RhopH1, is encoded by members of the clag multigene family in Plasmodium falciparum and Plasmodium yoelii
  87. The 22 kDa component of the protein complex on the surface of Plasmodium falciparum merozoites is derived from a larger precursor, merozoite surface protein 7
  88. Inhibitory and blocking monoclonal antibody epitopes on merozoite surface protein 1 of the malaria parasite Plasmodium falciparum11Edited by J. A. Wells
  89. Sequence diversity and antigenic polymorphism in the Plasmodium yoelii p235 high molecular mass rhoptry proteins and their genes
  90. The merozoite surface protein 6 gene codes for a 36 kDa protein associated with the Plasmodium falciparum merozoite surface protein-1 complex
  91. Structure of the E8 gene encoding a high molecular mass rhoptry protein of Plasmodium yoelii
  92. Construction and immunogenicity in mice of attenuated Salmonella typhi expressing Plasmodium falciparum merozoite surface protein 1 (MSP-1) fused to tetanus toxin fragment C
  93. Plasmodium yoelii: Effects of Red Blood Cell Modification and Antibodies on the Binding Characteristics of the 235-kDa Rhoptry Protein
  94. Characterization of N-myristoyltransferase from Plasmodium falciparum
  95. Plasmodium falciparum: Merozoite Surface Proteins 1 and 2 Are Not Posttranslationally Modified by Classical N- or O-glycans
  96. Antigenic and sequence diversity at the C-terminus of the merozoite surface protein-1 from rodent malaria isolates, and the binding of protective monoclonal antibodies
  97. Solution structure of an EGF module pair from the Plasmodium falciparum merozoite surface protein 1 1 1Edited by P. E. Wright
  98. Chromosomal organisation of a gene family encoding rhoptry proteins in Plasmodium yoelii
  99. Human antibodies to the 19 kDa C-terminal fragment of Plasmodium falciparum merozoite surface protein 1 inhibit parasite growth in vitro
  100. A Plasmodium chabaudi protein contains a repetitive region with a predicted spectrin-like structure1Note: Nucleotide sequence data reported in this paper are available in the EMBL, GenBank™ and DDJB databases under the accession number U43145.1
  101. Malaria
  102. Isolation, Expression and Characterization of the Gene for an ADP-Ribosylation Factor from the Human Malaria Parasite, Plasmodium Falciparum
  103. A 22 kDa protein associated with the Plasmodium falciparum merozoite surface protein-1 complex
  104. Current status of the Plasmodium falciparum genome project
  105. A high molecular mass Plasmodium yoelii rhoptry protein binds to erythrocytes
  106. Comparison of two members of a multigene family coding for high-molecular mass rhoptry proteins of Plasmodium yoelii
  107. Structural analysis of the glycosyl-phosphatidylinositol membrane anchor of the merozoite surface proteins-1 and -2 of Plasmodium falciparum
  108. Epitopes in the 19kDa fragment of the Plasmodium falciparum major merozoite surface protein-1 (PfMSP-119) recognized by human antibodies
  109. Multiple genes code for high-molecular-mass rhoptry proteins of Plasmodium yoelii
  110. The sequence of Plasmodium falciparum histone H3
  111. N-terminal amino acid sequence of the Plasmodium falciparum merozoite surface protein-1 polypeptides
  112. A gene coding for a high-molecular mass rhoptry protein of Plasmodium yoelii
  113. Expression of the 19-kilodalton carboxy-terminal fragment of the Plasmodium falciparum merozoite surface protein-1 in Escherichia coli as a correctly folded protein
  114. Developments with Anti-Malarial Vaccines
  115. A conserved parasite serine protease processes the Plasmodium falciparum merozoite surface protein-1
  116. Export of parasite proteins to the erythrocyte in Plasmodium falciparum-infected cells
  117. Monoclonal antibodies that inhibit Plasmodium falciparum invasion in vitro recognise the first growth factor-like domain of merozoite surface protein-1
  118. Structure of the gene encoding a putative Schistosoma mansoni tegumental antigen precursor
  119. Lymphocyte response in vitro toPlasmodium falciparum merozoite antigens in donors from a holoendemic area
  120. The role of calcium in the invasion of human erythrocytes by Plasmodium falciparum
  121. Secondary processing of the Plasmodium falciparum merozoite surface protein-1 (MSP1) by a calcium-dependent membrane-bound serine protease: shedding of MSP133 as a noncovalently associated complex with other fragments of the MSP1
  122. A malaria merozoite surface protein (MSP1)-structure, processing and function
  123. Processing of thePlasmodium falciparum major merozoite surface protein-1: identification of a 33-kilodalton secondary processing product which is shed prior to erythrocyte invasion
  124. Proteolytic processing of thePlasmodium falciparum merozoite surface protein-1 produces a membrane-bound fragment containing two epidermal growth factor-like domains
  125. Identification of the gene for a Plasmodium yoelii rhoptry protein. Multiple copies in the parasite genome
  126. Immunization against Plasmodium falciparum with recombinant polypeptides produced in Escherichia coli
  127. An S antigen genome from Plasmodium falciparum contains a novel repetitive sequence
  128. The Precursor to Major Merozoite Surface Antigens: Structure and Role in Immunity
  129. Primary structure of the precursor to the three major surface antigens of Plasmodium falciparum merozoites
  130. Isolation of a Plasmodium falciparum rhoptry protein
  131. Expression of cloned cDNA for a major surface antigen of Plasmodium falciparum merozoites
  132. Serological cross-reaction between high molecular weight proteins synthesized in blood schizonts of Plasmodium yoelii, Plasmodium chabaudi and Plasmodium falciparum
  133. Characterisation of the cross-reacting carbohydrate groups on two variant surface glycoproteins of Trypanosoma brucei
  134. Immunization against blood-stage rodent malaria using purified parasite antigens
  135. Glycopeptides from variant surface glycoproteins of Trypanosoma brucei. C-terminal location of antigenically cross-reacting carbohydrate moieties
  136. Peptide mapping of the ribulose bisphosphate carboxylase large subunit from the genus Oenothera
  137. Somatic hybrid plants of potato and tomato regenerated from fused protoplasts
  138. Peptide mapping of the major components of in vitro synthesized barley hordein: Evidence of structural homology
  139. Ribulose 1,5-diphosphate carboxylase from Oenothera. Purification and a peptide mapping procedure for the subunits
  140. Mutational amino acid replacements in Neurospora crassa NADP-specific glutamate dehydrogenase